BGC0000443: thanamycin biosynthetic gene cluster from Pseudomonas sp. SHC52
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 40,038 nt. (total: 40,038 nt).
This entry is originally from NCBI GenBank HQ888764.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000443
Short description thanamycin biosynthetic gene cluster from Pseudomonas sp. SHC52
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Beta-lactam)
Loci NCBI GenBank: HQ888764.1
Compounds
  • thanamycin
Species Pseudomonas sp. SHC52 [taxonomy]
References
Chemical products information
thanamycin
Copy SMILES
C60H91Cl1N10O22
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AED89996.1
 65 - 949 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AED89997.1
 984 - 1301 (-) HlyD family secretion protein
copy AA seq
copy Nt seq
  • AED89998.1
 1300 - 2094 (+) AraC family transcriptional regulator
copy AA seq
copy Nt seq
  • AED89999.1
 2143 - 2754 (-) putative aspartyl b-hydroxylase
copy AA seq
copy Nt seq
  • AED90000.1
 2872 - 4242 (-) putative MFS transporter
copy AA seq
copy Nt seq
  • AED90001.1
 4239 - 5243 (-) putative transcription factor
copy AA seq
copy Nt seq
  • AED90002.1
 5609 - 21733 (+) non-ribosomal peptide synthetase ThaA
copy AA seq
copy Nt seq
  • AED90003.1
 21737 - 35314 (+) non-ribosomal peptide synthetase ThaB
copy AA seq
copy Nt seq
  • AED90004.1
 35640 - 37484 (+) non-ribosomal peptide synthetase ThaC1
copy AA seq
copy Nt seq
  • AED90005.1
 37502 - 38437 (+) non-ribosomal peptide synthetase ThaC2
copy AA seq
copy Nt seq
  • AED90006.1
 38497 - 39708 (+) non-ribosomal peptide synthetase ThaD
copy AA seq
copy Nt seq
NRP-specific information
Subclass Beta-lactam
Cyclic? yes
Thioesterase genes
  • AED90003.1 (Unknown)
NRP-synthases
Gene Modules
AED90002.1
Module 1
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Module 2
Specificity: ornithine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Module 3
Specificity: aspartic acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Module 4
Specificity: homoserine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 5
Specificity: histidine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
AED90003.1
Module 6
Trans-activates threonine

Condensation domain type: Unknown
Module 7
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 8
Specificity: aspartic acid / 3-hydroxyaspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 9
Specificity: 4-chlorothreonine / threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Modification domains: Unknown
AED90004.1
Module 10 [inactive]
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: H2TUQKOCLKJUFX3XAH52M5HN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Fixed NRP substrates
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.