Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000443.1:
Cluster 1NRP140038

BGC0000443, thanamycin biosynthetic gene cluster from Pseudomonas sp. SHC52. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: thanamycin
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP
Beta-lactam (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
AED90002.1
Module 1
A specificity: Serine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 2
A specificity: Ornithine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 3
A specificity: Aspartate
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 4
A specificity: Lysine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 5
A specificity: Histidine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
AED90003.1
Module 6
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 7
A specificity: Didehydroaminobutyric acid
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 8
A specificity: Hydroxyaspartate
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 9
A specificity: 4-Chlorothreonine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Scaffold-modifying domain: Other
AED90004.1
Module 10
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A
Module is skipped
Evidence for skipping: Unknown

Gene cluster description

thanamycin (BGC0000443). Gene Cluster 1. Biosynthetic class = NRP. GenBank HQ888764, positions 5609-39708. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jos Raaijmakers (NIOO-KNAW)

Literature references

1. Mendes R et al. (2011) Deciphering the rhizosphere microbiome for disease-suppressive bacteria. Science 332(6033):1097-100. doi: 10.1126/science.1203980. Epub 2011
2. Watrous J et al. (2012) Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A 109(26):E1743-52. doi:
3. Le CN et al. (2012) Involvement of phenazines and lipopeptides in interactions between Pseudomonas species and Sclerotium rolfsii, causal agent of stem rot disease on groundnut. J Appl Microbiol 112(2):390-403. doi: 10.1111/j.1365-2672.2011.05205.x.