BGC0000444 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000444 (Streptomyces turgidiscabies Car8)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	20,623	thaxtomin A	NRPS:Type I	100%

BGC0000444 - Region 1 - NRPS

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Location: 1 - 20,623 nt. (total: 20,623 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,624
Label		BGC0000444

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000444	1.00	NRP	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0000465	0.40	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001133	0.33	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.33	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002089	0.26	NRP	thaxtomin D, thaxtomin A, thaxtomin C, thaxtomin B	Streptomyces scabiei 87.22
BGC0001085	0.26	NRP, Terpene	teleocidin B1	Streptomyces blastmyceticus
BGC0000396	0.25	NRP	nodularin	Nostoc sp. 73.1
BGC0001806	0.24	NRP	tolaasin A	Pseudomonas tolaasii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000444	1.00	NRP	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0000465	0.72	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001133	0.66	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.66	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002089	0.59	NRP	thaxtomin D, thaxtomin A, thaxtomin C, thaxtomin B	Streptomyces scabiei 87.22
BGC0001085	0.59	NRP, Terpene	teleocidin B1	Streptomyces blastmyceticus
BGC0000396	0.58	NRP	nodularin	Nostoc sp. 73.1
BGC0001806	0.57	NRP	tolaasin A	Pseudomonas tolaasii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 20623:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Phe) + (NMe-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

stPAI029

Search NORINE for peptide: strict or relaxed

AMP-binding (22..421): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVAAVCK
Nearest Stachelhaus code(s):: Phe DAWTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

stPAI030

AMP-binding (49..448): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGWAVVAVSK
Nearest Stachelhaus code(s):: nitroTrp DGWTVVAVSK (97% 8Å match)
Stachelhaus code match:: 90% (moderate)