LOCUS       BGC0000446             25846 bp    DNA     linear   BCT 12-SEP-2014
DEFINITION  Klebsiella oxytoca tilivalline biosynthetic gene cluster, strain
            AHC-6.
ACCESSION   BGC0000446
VERSION     BGC0000446
KEYWORDS    .
SOURCE      Klebsiella oxytoca
  ORGANISM  Klebsiella oxytoca
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:39:23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 25846
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..25846
                     /db_xref="taxon:571"
                     /mol_type="genomic DNA"
                     /organism="Klebsiella oxytoca"
                     /strain="AHC-6"
     misc_feature    1..25846
                     /note="tilivalline biosynthetic gene cluster"
     subregion       1..25846
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..25846
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(2..74)
                     /gene="tRNA-Asn (GUU)"
     tRNA            complement(2..74)
                     /gene="tRNA-Asn (GUU)"
                     /product="tRNA-Asn"
     CDS             405..1322
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 210.8; E-value: 4.1e-64)"
                     /gene_kind="regulatory"
                     /product="Nitrogen assimilation regulatory protein Nac"
                     /protein_id="CDG76945.1"
                     /transl_table=11
                     /translation="MNLRRLKYFVKIVDIGSLTQAAEVLHIAQPALSQQVATLEGELDQ
                     QLLIRTKRGVTPTEAGKILYTHARTILRQCEQAQLAVNNVGQTLSGQVSIGLAPGTAAS
                     AITMPLLQTVRNELPEVMVYLQESSGTLLNDKLIDGQLDMAVLYERSPVAGIISQPLLK
                     EDLYLVGTRDCPGQSVDLTAVAEMNLFLPRDYSAVRARVTEAFTLRRLSAKIIGEIESI
                     TTLTAAIASGMGVTVLPESAARSLCSAANGWMARISTPSMSLSLSLNMSARGSLSPQAQ
                     AVKEILMSLVSRPSLENRELQLVS"
     CDS             1429..2379
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 210.4; E-value: 5.3e-64)"
                     /gene_kind="regulatory"
                     /product="Alkanesulfonate utilization operon LysR-family
                     regulator CbI"
                     /protein_id="CDG76946.1"
                     /transl_table=11
                     /translation="MNFQQLKIIREAARQDYNLTEVANMLYTSQSGVSRHIRELEEELG
                     IEIFIRRGKRLLGMTEPGKALLSIAERILNEASNVRRLADLFTNDASGVLTIATTHTQA
                     RYSLPPVIKAFRELFSDVRLELVQGTPQEIETLLHNGGADIGIASERLSNDPTLVAFPW
                     FRWHHSLLVPKDHPLTQVTPLTLEAIARWPLITYRQGITGRSRIDEAFNRKGLMPDIVL
                     SAQDSDVIKTYVELGLGVGLVAEQSGDERESDTFTRLDTRHLFDANTVWLGLKRGQLQR
                     NYVWRFIELCNAGLSLEEIKRQAMEPEEAAIDYQI"
     CDS             2458..3381
                     /codon_start=1
                     /product="L,D-transpeptidase ErfK"
                     /protein_id="CDG76947.1"
                     /transl_table=11
                     /translation="MRRVKLLCSFIMLLTSQSALAVSYPLPPEGSRLVGSPLTITIPQN
                     NTQPLEAFAAQYGQGLSNMLEANPGVDVFLPKSGTTLVVPQQLILPATVRNGIVINVAE
                     MRLYYYPPEGTTVEVLPIGIGQAGRETPRNWVTAVERKQEAPTWTPTANTRREYASRGE
                     SLPAFVPAGPDNPMGLYAIYIGRLYAIHGTNANFGIGLRVSQGCIRLRNDDIKYLFDTV
                     PVGTRVQIIDQPVKYTAEPDGSRWVEVHEPLSRNRAEYESDRKVPLPVTPAMQAFVKGE
                     GVDVNRAGQALERRSGMPVEIGRSAL"
     CDS             complement(3499..4106)
                     /EC_number="2.5.1.18"
                     /codon_start=1
                     /gene="pseudo3498_4106"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_kind="biosynthetic-additional"
                     /product="Glutathione S-transferase, unnamed subgroup 2"
                     /pseudogene="unprocessed"
                     /sec_met_domain="GST_N_3 (E-value: 1.7e-20, bitscore: 63.6,
                     seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKLIGMMDSPYVRRVAISLELYGVEFESHPLSVFSSFDAFSQIN
                     PAVKAPTLVLDNGIRLMDSSLILDYFEAQAARERKLLPIAADALARDLQVLGLCSPRVR
                     RRCKMCMNIIFARRKNSIIHG"
     CDS             4283..5188
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 233.8; E-value: 4.6e-71)"
                     /gene_kind="regulatory"
                     /product="Glycine cleavage system transcriptional activator
                     GcvA"
                     /protein_id="CDG76949.1"
                     /transl_table=11
                     /translation="MADFPPIASLRSFEAVARLGSVTLAAKELHVTHSAISQQIKVLEE
                     RVGLKLFIRHGRGLQINEEGRLYALQVREALNHIADATRLVQVKPRRQELTIAVVPSFG
                     GHWLLPRLERFRAKYPQITLRIQANLAVTHLQQEGADLAIRMGKGDWEGTESHYLFSDE
                     LIVVAAPSYNGGELPRTPSEIAQSKIIFSMESWKTWCIKAGLEREIVPGGLCINDSNLV
                     LEAVRLGKGVALERRSLVQDAIARGELEQLTPFAAPYPWPYWLVSSQVAEKKNEAVLFK
                     DWLSEEVVAWRQQTATVEER"
     gene            5613..6845
                     /gene="mfsX"
     CDS             5613..6845
                     /codon_start=1
                     /gene="mfsX"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 108.4; E-value:
                     4.9e-33)"
                     /gene_kind="transport"
                     /product="permease of the major facilitator superfamily
                     protein"
                     /protein_id="CDG76950.1"
                     /transl_table=11
                     /translation="MRPKEVQASAVSTMFRDESRGLLSSKVVIVLGLLSAVAALSTDMY
                     LPLFPAIASDLHTTPDKVQLSITAFMVGLGIGQLFIGPLSDHYGRRKLLLGGMALLTIA
                     SLAGAISTNIQLLIVTRFFQGLGGAAGIVLSRAIISDLCPGTKAARYFNLVLAIQGIAP
                     VIAPLLGGVAAWFIWPVVFVFMATISLVSTLLSSHFISETLPRHQRLPFNLNEFISQFI
                     ELLSNKKYIGYTLIFSIQFGALFAYISASPFIYQSTFDLSSGKFAVIFSINAGAMMFGS
                     IVSARYVMKFGEDNLITMGVISTLVISILLCIVDNISHFQFEIAAVLLLMMMFTMALTF
                     GNAASMAMAASSHLKGTGSAILGAFQFGIAAITPSLLGFGDPLSLLPMSLIIAGCCLIA
                     IMALLLTGKKG"
     gene            6850..9072
                     /gene="uvrX"
     CDS             6850..9072
                     /codon_start=1
                     /gene="uvrX"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 50.7; E-value: 2e-15)"
                     /gene_kind="transport"
                     /product="Excinuclease ABC subunit A paralog of unknown
                     function"
                     /protein_id="CDG76951.1"
                     /transl_table=11
                     /translation="MKTHDAIKIIGARQNNLQDIDVEVPKNKITVFTGVSGSGKSSLVF
                     GTIAAESQRQLNDTFPPFIRHRLPHYGNPEVDEIENLSVAIIIDQKRIGGNARSTVGTA
                     SDIYTLLRLLFSRVGEPFVGYSNVFSFNHPAGMCATCDGLGIASTIDINHLIDSNLSLN
                     EGAIRYPSFAPGSWRWKRYVYSGLFDADKKIADYSKEERELLLYADNLTPEAPLAGWPK
                     SAKFEGVITRFTRSYLKQETKDTKTEEFQRVVSLQVCPSCQGMRLNEEILSCRIRGKNI
                     GECATLPVTELKLFVEKLDYPEVRPLIEALLERLDAMCAVGLGYLDLNRTTPSLSGGES
                     QRLKMVRHLGSSLTGIVYIIDEPSTGLHPADIVKLNVLIGKLRDKGNTILMVEHDPDMI
                     AIAEHVIDLGPGAGKQGGNIVFEGDLSALKQSQTLTGRYFSSRAEINKKPRCAKGYISV
                     RNATLHNLHNLSVDVPLSVMVAVTGVAGSGKSSFVMGALAPQCPEAIVIDQKPIHTSIR
                     SHIASWCGAFDTIRSLFAEKNHVSASWFSANAKGACPECNGLGVIQTDLAFMDTVTLPC
                     EACQGQRYNPQALKYRYQGKSIAEVLSLSINDACEFFLNEPQLRPIFRSLVEVGLGYLR
                     LGESLNHLSGGECQRLKLASQLNHDSDMYIFDEPTTGLHPSDVASLLKLFNRLVARGNT
                     VIIIEHNMELIAQADWIIDIGPYAGKEGGDYCLAVHPNRCWPVAIH"
     gene            complement(9195..10712)
                     /gene="hmoX"
     CDS             complement(9195..10712)
                     /EC_number="1.14.14.9"
                     /codon_start=1
                     /gene="hmoX"
                     /product="4-hydroxyphenylacetate 3-monooxygenase"
                     /protein_id="CDG76952.1"
                     /transl_table=11
                     /translation="MENKSVSLPTGNDFLAGLNDGREIWAYGEKVDNVITHPAFRNSAL
                     SIAKLYDALHDEKYQAILTTPCDTGSGGVTHPFFRVPHSVEDLIRDRDAIAQWARLSYG
                     WLGRSPDFKASFLTTLGANPEAYGEYTDNARHWYKRSQEELLYWNHAIINPPIDRNLPP
                     DQIEDICIHVEKECDDGVIVSGAKVVATGSALTHYNFIAHYGLPVKKREFALVCTLPMN
                     APGLKLVCRPSYSLAAEKVGSPFDYPLSSRYDENDMIFILDKVKIPWENIFIYGDTAKA
                     ATFLPSSGFLHRSTFHGVTRLAVKIDFICGLFIKGVEATGVADFRGIQTRVGEMLAWRN
                     LFWAISDAMAKSPNPWHNGALLPNLDYGLAYRWFMSLGYPRIKEIIEQDLGSALIYINS
                     HAKDFAAPELEPYLKKYMRGSNGMDAVERVKLMKLIWDSVGTEFASRHELYERNYTGSH
                     ENVRIELLLAAQMSGQVQEYKGFAEQCMMDYDLDGWLDRDYHWPLDE"
     gene            complement(10751..12700)
                     /gene="adsX"
     CDS             complement(10751..12700)
                     /EC_number="4.1.3.-"
                     /codon_start=1
                     /gene="adsX"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 255.8; E-value:
                     1.8e-77)"
                     /gene_kind="biosynthetic-additional"
                     /product="2-Amino-2-deoxy-isochorismate synthase"
                     /protein_id="CDG76953.1"
                     /transl_table=11
                     /translation="MLSKDSANPDELSAHLANLDRPFACIYRPQCEPINAVLFLEGDIE
                     LSQSLSELALDPPLDATGKCSFNKLILLPFNQLKEKGYACIDDGEQTIVMHIERQDYYP
                     IDSFIAAINDHDIKPRNLHFDLDDQTYGDIVDTVIDQEISSGEGSNFVISRSLEGDIID
                     FSIRHALTLYKRLLQSECGSYWTWMIFTGSRYFMGSTPEQHIQVDEQNVAMNPISGTLK
                     YPDTGNMAHVLDDFLQDKKERDELFMVVDEELKMMSSICQRDIQVSGPKLKAMSHIAHT
                     EYFIHGKSDRSLKEIIRQSLFAPTVTGSPIESACKVIARRERRGRGYYSGIVAITGAQE
                     GKRYLDSAIMIRTADISAQGHFRLTAGSTIVRSSIAQSEAGETRAKLQGLMHSFFSEPS
                     AGTPNRTGLSAELCHRADQILAQRNARTSAFWLDNSQLGPRTLLSHHAITLIDMEDNFT
                     AMIAYQLRSAGCAVTLIPWYDCPSKLTQLTDRDILFIGPGPGDPTNIQLEKIRVGRKII
                     AQRLREQRPLIGTCLGHQLICAELGIPIERLVNNRQGSQHQISIQGKPHTVGFYNSFSA
                     LHQRPCWYSPEHDKTVQLERLPSGEIVALSSGNVASIQFHNESFLTQDAFSIYQWLIQN
                     ALTTTATLSQQDAV"
     gene            complement(12730..13362)
                     /gene="icmX"
     CDS             complement(12730..13362)
                     /EC_number="3.3.2.1"
                     /codon_start=1
                     /gene="icmX"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 267.4; E-value: 1.8e-81)"
                     /gene_kind="biosynthetic-additional"
                     /product="Isochorismatase of siderophore biosynthesis"
                     /protein_id="CDG76954.1"
                     /transl_table=11
                     /translation="MEKIRPYPLPTERQLPKSIADWRPNSSRAALLIHDMQRYFLDFYT
                     ADASPIAQVIDNIYRLLSVARRLHIPVFYTAQPGDMTPQQRGLLHSLWGSGMNGSQEHK
                     QIVPPLTPLENEWVLTKWRYSAFFNSPLLSTLHELKCDQLIVCGVYAHIGCLCTAQEAY
                     SNDIETFFIADALADFSEEKHRLALELAAETSSVVLSTRQAIDALEH"
     gene            complement(13381..14166)
                     /gene="dhbX"
     CDS             complement(13381..14166)
                     /EC_number="1.3.1.28"
                     /NRPS_PKS="Domain: PKS_KR (9-168). E-value: 4.7e-13. Score:
                     41.3. Matches aSDomain: nrpspksdomains_dhbX_PKS_KR.1"
                     /codon_start=1
                     /gene="dhbX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EntA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     220; E-value: 5.9e-67)"
                     /gene_kind="biosynthetic-additional"
                     /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"
                     /protein_id="CDG76955.1"
                     /sec_met_domain="EntA (E-value: 1.4e-96, bitscore: 313.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.6e-35, bitscore:
                     112.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFDKDYIAVITGACGGIGESVAHALAKEGLSLALLDNNATQLAT
                     LVATLQDNHPQPIAGFTVDVADDRCVAEAFTAVGHQLGPVGYLVNGAGVLCHASVAETQ
                     PQDWAKTFAVNATGVFNTSRHAANLMMAQRKGSIVTIASNAARVPRATMAAYCASKAAA
                     QAFTYALGLEVAPYGIRCNVVAPGSTDTPMLRGMWHSESDKQNTLNGNPQQFRIGIPLN
                     KVATAEEIAAAVCFYLCEESGQTTLSTLLVDGGAALGSC"
     aSDomain        complement(13663..14139)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dhbX_PKS_KR.1"
                     /evalue="4.70E-13"
                     /label="dhbX_PKS_KR.1"
                     /locus_tag="dhbX"
                     /protein_end="168"
                     /protein_start="9"
                     /score="41.3"
                     /tool="antismash"
                     /translation="VITGACGGIGESVAHALAKEGLSLALLDNNATQLATLVATLQDNH
                     PQPIAGFTVDVADDRCVAEAFTAVGHQLGPVGYLVNGAGVLCHASVAETQPQDWAKTFA
                     VNATGVFNTSRHAANLMMAQRKGSIVTIASNAARVPRATMAAYCASKAAAQAFTY"
     CDS_motif       complement(14077..14139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_dhbX_0001"
                     /evalue="2.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="dhbX"
                     /protein_end="30"
                     /protein_start="9"
                     /score="13.6"
                     /tool="antismash"
                     /translation="VITGACGGIGESVAHALAKEG"
     gene            complement(14156..15325)
                     /gene="aroX"
     CDS             complement(14156..15325)
                     /EC_number="2.5.1.54"
                     /codon_start=1
                     /gene="aroX"
                     /product="2-keto-3-deoxy-D-arabino-heptulosonate-7-
                     phosphate synthase II"
                     /protein_id="CDG76956.1"
                     /transl_table=11
                     /translation="MTSFPGNKSNWQQPFWSDKDMLALVKSELDNLPELLSFAEISELK
                     KALAAVYAGKTMIFQAGDCAERICESGALHVRKKLIFLEQMSREFSTLTGLPILTVGRI
                     AGQYAKPRSQQNEVDGDRVLPVWRGDSVNRPEATPEARRNDPQRMLLSYRAAAETLAEI
                     KRYEREYPRDIHHIWTSHEALLLDYETTQIRTNPYGESYLASTHWPWIGIRTLAPDSPH
                     IAMLANIANPVACKIDASVTPSFIASLCRQLNPQRIPGRLTFISRFGRSHIHRLGALIQ
                     AAQATETPVLWMCDPMHGNTGKTRAGNKRRELSDMMAEISGFLRQVKSHNACAAGLHLE
                     ATPNPVIECFSENNHPEEHELKQILCDPRLNVAQTQMLLTHWKEGQHDF"
     gene            15783..17303
                     /gene="npsA"
     CDS             15783..17303
                     /NRPS_PKS="Domain: AMP-binding (16-411). E-value: 2e-76.
                     Score: 249.1. Matches aSDomain:
                     nrpspksdomains_npsA_AMP-binding.1"
                     /codon_start=1
                     /gene="npsA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     255.5; E-value: 1.3e-77)"
                     /gene_kind="biosynthetic-additional"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="CDG76957.1"
                     /sec_met_domain="AMP-binding (E-value: 4e-77, bitscore:
                     249.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHSAYVYQLKAVPDIFDEISQRFPDRVALIFDQRKITYRELAEQ
                     CSALAAVLQNNCLIKGDIVAIKIERSPELYIFMLALMKIGAVMVPVNSNSPERYIGEVL
                     SAAGARYLISDDVTSVPGGAWHVLSSRTLIQNCTQQRSGNYPVLSADDPALILMTSGST
                     GKPKSVLIAHRGIARLGLPVPALGNSERDCYLQIADISFAASANEIWMALLTGACLAIA
                     PPGLPDLMALARQIESDNVTMLFLSGGLFRLFVEVSVETLHIPDCVVVSGDFVNPRLFS
                     VAVQAGKAKIFNGLGCTENSAISSLYHIQSEEQLSSESPVPVGTPLPLVEMVVFNERLQ
                     PCTCGEYGELFIAGAGVALGYSDPQLTAERFITIPYQGTDVLFYRTDDRATYDQDCNIV
                     LVGRGNHICKIRGFRINIAGIEHLLRLHHAVEDVLIVVEETPDEPRLHACYVTQDDGLS
                     VADLKNHLAMHAPAWMIPEKFSRLAVLPMTANGKKDRLRLKNSLLEQV"
     aSDomain        15831..17015
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsA_AMP-binding.1"
                     /evalue="2.00E-76"
                     /label="npsA_AMP-binding.1"
                     /locus_tag="npsA"
                     /protein_end="411"
                     /protein_start="16"
                     /score="249.1"
                     /tool="antismash"
                     /translation="FDEISQRFPDRVALIFDQRKITYRELAEQCSALAAVLQNNCLIKG
                     DIVAIKIERSPELYIFMLALMKIGAVMVPVNSNSPERYIGEVLSAAGARYLISDDVTSV
                     PGGAWHVLSSRTLIQNCTQQRSGNYPVLSADDPALILMTSGSTGKPKSVLIAHRGIARL
                     GLPVPALGNSERDCYLQIADISFAASANEIWMALLTGACLAIAPPGLPDLMALARQIES
                     DNVTMLFLSGGLFRLFVEVSVETLHIPDCVVVSGDFVNPRLFSVAVQAGKAKIFNGLGC
                     TENSAISSLYHIQSEEQLSSESPVPVGTPLPLVEMVVFNERLQPCTCGEYGELFIAGAG
                     VALGYSDPQLTAERFITIPYQGTDVLFYRTDDRATYDQDCNIVLVGRGNHICKIR"
     CDS_motif       16242..16301
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsA_0001"
                     /evalue="9.90E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="npsA"
                     /protein_end="173"
                     /protein_start="153"
                     /score="21.3"
                     /tool="antismash"
                     /translation="ALILMTSGSTGKPKSVLIAH"
     CDS_motif       16815..16895
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsA_0002"
                     /evalue="2.00E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="npsA"
                     /protein_end="371"
                     /protein_start="344"
                     /score="32.9"
                     /tool="antismash"
                     /translation="GEYGELFIAGAGVALGYSDPQLTAERF"
     CDS_motif       16983..17045
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsA_0003"
                     /evalue="9.30E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="npsA"
                     /protein_end="421"
                     /protein_start="400"
                     /score="15.1"
                     /tool="antismash"
                     /translation="VGRGNHICKIRGFRINIAGIE"
     CDS             17306..17536
                     /NRPS_PKS="Domain: PCP (4-73). E-value: 4.7e-18. Score:
                     57.0. Matches aSDomain: nrpspksdomains_CDG76958.1_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="PCP domain"
                     /protein_id="CDG76958.1"
                     /sec_met_domain="PP-binding (E-value: 1e-16, bitscore:
                     51.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNVEQQLLSIWQAIIHSEAINPHENLLDQGGNSLHFIKLASMVS
                     KTFNLSVSPADIFTAGTIAALAQTIRQRQKL"
     aSDomain        17318..17524
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CDG76958.1_PCP.1"
                     /evalue="4.70E-18"
                     /label="CDG76958.1_PCP.1"
                     /locus_tag="CDG76958.1"
                     /protein_end="73"
                     /protein_start="4"
                     /score="57.0"
                     /tool="antismash"
                     /translation="EQQLLSIWQAIIHSEAINPHENLLDQGGNSLHFIKLASMVSKTFN
                     LSVSPADIFTAGTIAALAQTIRQR"
     gene            17602..21972
                     /gene="npsB"
     CDS             17602..21972
                     /NRPS_PKS="Domain: Condensation_LCL (25-318). E-value:
                     7.4e-64. Score: 207.5. Matches aSDomain:
                     nrpspksdomains_npsB_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (483-883). E-value: 1.4e-84.
                     Score: 275.9. Matches aSDomain:
                     nrpspksdomains_npsB_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (996-1061). E-value: 2.5e-18. Score:
                     58.0. Matches aSDomain: nrpspksdomains_npsB_PCP.1"
                     /NRPS_PKS="Domain: TD (1099-1338). E-value: 7.8e-79. Score:
                     256.2. Matches aSDomain: nrpspksdomains_npsB_TD.1"
                     /codon_start=1
                     /gene="npsB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     281.9; E-value: 1.9e-85)"
                     /gene_kind="biosynthetic"
                     /product="non-ribosomal peptide synthetase, terminal
                     component"
                     /protein_id="CDG76959.1"
                     /sec_met_domain="Condensation (E-value: 1.1e-52, bitscore:
                     169.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-92, bitscore:
                     300.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.4e-17, bitscore:
                     52.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.3e-62, bitscore:
                     200.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSFNSGESKKGCLNKECGESAVTYLPATPGQQAMWWLDNTLEQP
                     QCYNVPVLLTVNATLDADIMQRAVAELTLRHEIFRTRFVYLDGKLQQRIGADGYLSFSH
                     RQPEQTETPESVTAQLAASRLSLAEGPLSIINMLSSDSGTTWLACCFHHIIIDAPSVRI
                     VLHDLLRIYCALDEKRVLPAFNGTGSYQEFTRWQAASLAAAECEDMRVYWRQALHPAPP
                     LSDLPVDFPRRLREDTKAAYTMLALNEQEADSLQRHARSLSMTPFMYMSMCWQFFLSRM
                     SGQNDITVGVPFTLRDRSEFAETPGYMINTLPVRVQVNEDDTVSTLAAKVRQSFIGAHF
                     NKLLPFNEIVALSRENAGQDSPLFRTLLVMPDTRGDIFNDLPFKVMLDDYFSQMAKYDL
                     TLFFEAQPQWKLTLEYKTALYHPQTIDYWLKIFRHLLSAMGEDGEVLLSSLRLLDAPLS
                     RELVVRSSLKSCTEAWRFDALAAFNQHAISHSADTALITANGTRSYGWLAERSGQIAAY
                     LQQQLNIAPGKRVALLLERNAEAIATLFGVLKTGAAYIPIDPQYPQERIGYMLQDASVD
                     CIATTRSLVAKFPVSGSVPLLLIDDIPPEYPGEYSYIKRMPDDELYIIYTSGSTGQPKG
                     VRLLNKTLNNLIKWQRDVSECDQGDCTLHFMSLSFDVSVQEIFGTLAGGGCLYIASEEE
                     RRDLDLLQEVIQEQGINRLYFPYVALQQFAHLSVLANRQFPSLKEVYSTGEQLVLTADI
                     KHFFRQPVRLINLYGPSESHVCSAYVLPPESDKWGDAASIGYPLPGFTLLVVDEHLQLV
                     PAGVAGELLIVSDFLSPGYHNKSEESARRFISAEGFATQSCHAYRTGDLVRLEHDDRFS
                     YLGRIDNQLKIRGFRIEPSEVEAAINALEGVQVSAVVGRADTSGSKQLVAFIAGLMDDK
                     SNQKDKIKRGLRLVLPEYMVPTELVFLDKLPTTPSGKIDRKALLKVDIIVESSAQMPER
                     SLTKTQEQVRALWETLFPGRHIALHDDFFAIGGHSLLATQLVFLLRKAFNCDIPLRLLF
                     NHPTLLAMAECIDGYVVSEKGPVDTVDRSFVQDGYERIHWLGGECSTPGLTLLTGATGF
                     LGIYLLRSLLLAGTQSVICLVRARTDKHALARLRENAMRYGIADEIDFSRVEVCLGDIG
                     QRDLGLSPDAYSRLAERVDTVFHAAAQINFLLSYSSVKQSNVQGTLNILAFCGCGGRKT
                     LHYLSTIAVFSPRYPESPIVEHCVPGHPEALSIGYTQSKWVAERYVIQAREQGLDANVF
                     RIGRIGGDSRTGACQSDDFLWRQIKSFIQMGLAPDPSSLSTDLLPVDFVAEAIVALARS
                     EATRQENFHIFHPQSIRFDPVYRAIRSLGYPLETTSDGEWLQQLELCVTQGREVALGPV
                     IHLFKENLLDTGDNAYGNPETTKRITQLGLRFPELSEETFKRMIVYFQRQKEIV"
     aSDomain        17677..18555
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="7.40E-64"
                     /label="npsB_Condensation_LCL.1"
                     /locus_tag="npsB"
                     /protein_end="318"
                     /protein_start="25"
                     /score="207.5"
                     /tool="antismash"
                     /translation="LPATPGQQAMWWLDNTLEQPQCYNVPVLLTVNATLDADIMQRAVA
                     ELTLRHEIFRTRFVYLDGKLQQRIGADGYLSFSHRQPEQTETPESVTAQLAASRLSLAE
                     GPLSIINMLSSDSGTTWLACCFHHIIIDAPSVRIVLHDLLRIYCALDEKRVLPAFNGTG
                     SYQEFTRWQAASLAAAECEDMRVYWRQALHPAPPLSDLPVDFPRRLREDTKAAYTMLAL
                     NEQEADSLQRHARSLSMTPFMYMSMCWQFFLSRMSGQNDITVGVPFTLRDRSEFAETPG
                     YMINTLPVRVQV"
     aSModule        17677..21615
                     /complete
                     /domains="nrpspksdomains_npsB_Condensation_LCL.1"
                     /domains="nrpspksdomains_npsB_AMP-binding.1"
                     /domains="nrpspksdomains_npsB_PCP.1"
                     /domains="nrpspksdomains_npsB_TD.1"
                     /final_module
                     /locus_tags="npsB"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       17743..17853
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0001"
                     /evalue="1.40E-11"
                     /label="C2_LCL_024-062"
                     /locus_tag="npsB"
                     /protein_end="84"
                     /protein_start="47"
                     /score="36.8"
                     /tool="antismash"
                     /translation="YNVPVLLTVNATLDADIMQRAVAELTLRHEIFRTRFV"
     CDS_motif       18052..18117
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0002"
                     /evalue="9.30E-06"
                     /label="C3_DCL_135-156"
                     /locus_tag="npsB"
                     /protein_end="172"
                     /protein_start="150"
                     /score="18.3"
                     /tool="antismash"
                     /translation="FHHIIIDAPSVRIVLHDLLRIY"
     CDS_motif       18457..18546
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0003"
                     /evalue="6.10E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="npsB"
                     /protein_end="315"
                     /protein_start="285"
                     /score="31.5"
                     /tool="antismash"
                     /translation="DITVGVPFTLRDRSEFAETPGYMINTLPVR"
     aSDomain        19051..20250
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_AMP-binding.1"
                     /evalue="1.40E-84"
                     /label="npsB_AMP-binding.1"
                     /locus_tag="npsB"
                     /protein_end="883"
                     /protein_start="483"
                     /score="275.9"
                     /tool="antismash"
                     /translation="QHAISHSADTALITANGTRSYGWLAERSGQIAAYLQQQLNIAPGK
                     RVALLLERNAEAIATLFGVLKTGAAYIPIDPQYPQERIGYMLQDASVDCIATTRSLVAK
                     FPVSGSVPLLLIDDIPPEYPGEYSYIKRMPDDELYIIYTSGSTGQPKGVRLLNKTLNNL
                     IKWQRDVSECDQGDCTLHFMSLSFDVSVQEIFGTLAGGGCLYIASEEERRDLDLLQEVI
                     QEQGINRLYFPYVALQQFAHLSVLANRQFPSLKEVYSTGEQLVLTADIKHFFRQPVRLI
                     NLYGPSESHVCSAYVLPPESDKWGDAASIGYPLPGFTLLVVDEHLQLVPAGVAGELLIV
                     SDFLSPGYHNKSEESARRFISAEGFATQSCHAYRTGDLVRLEHDDRFSYLGRIDNQLKI
                     R"
     CDS_motif       19234..19275
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0004"
                     /evalue="3.50E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="npsB"
                     /protein_end="558"
                     /protein_start="544"
                     /score="14.0"
                     /tool="antismash"
                     /translation="FGVLKTGAAYIPID"
     CDS_motif       19465..19512
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0005"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="npsB"
                     /protein_end="637"
                     /protein_start="621"
                     /score="24.2"
                     /tool="antismash"
                     /translation="YIIYTSGSTGQPKGVR"
     CDS_motif       20038..20127
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0006"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="npsB"
                     /protein_end="842"
                     /protein_start="812"
                     /score="24.7"
                     /tool="antismash"
                     /translation="PAGVAGELLIVSDFLSPGYHNKSEESARRF"
     CDS_motif       20215..20280
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0007"
                     /evalue="9.80E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="npsB"
                     /protein_end="893"
                     /protein_start="871"
                     /score="33.7"
                     /tool="antismash"
                     /translation="YLGRIDNQLKIRGFRIEPSEVE"
     aSDomain        20590..20784
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_PCP.1"
                     /evalue="2.50E-18"
                     /label="npsB_PCP.1"
                     /locus_tag="npsB"
                     /protein_end="1061"
                     /protein_start="996"
                     /score="58.0"
                     /tool="antismash"
                     /translation="QVRALWETLFPGRHIALHDDFFAIGGHSLLATQLVFLLRKAFNCD
                     IPLRLLFNHPTLLAMAECID"
     aSDomain        20899..21615
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_TD.1"
                     /evalue="7.80E-79"
                     /label="npsB_TD.1"
                     /locus_tag="npsB"
                     /protein_end="1338"
                     /protein_start="1099"
                     /score="256.2"
                     /tool="antismash"
                     /translation="LLTGATGFLGIYLLRSLLLAGTQSVICLVRARTDKHALARLRENA
                     MRYGIADEIDFSRVEVCLGDIGQRDLGLSPDAYSRLAERVDTVFHAAAQINFLLSYSSV
                     KQSNVQGTLNILAFCGCGGRKTLHYLSTIAVFSPRYPESPIVEHCVPGHPEALSIGYTQ
                     SKWVAERYVIQAREQGLDANVFRIGRIGGDSRTGACQSDDFLWRQIKSFIQMGLAPDPS
                     SLSTDLLPVDFVAEAIV"
     CDS             22516..23013
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 70.7; E-value: 1.6e-21)"
                     /gene_kind="regulatory"
                     /product="transcriptional regulator, MarR family"
                     /protein_id="CDG76960.1"
                     /transl_table=11
                     /translation="MEMNKKVASGSEREISLNRQFEDALGNLQCVLVARRSLINPDGIN
                     WPQYDTLYILRQFQPMTPSAIGEKLGFARSKMSKILRMLKDKHFVEQESAESDKREMLT
                     RITEKGIEFLNSAESSRRIMAEQVASCMSQGEIAIFAELCTRAANILHENIKGKLEDTS
                     EN"
     gene            complement(23926..23998)
                     /gene="tRNA-Asn (GUU)"
     tRNA            complement(23926..23998)
                     /gene="tRNA-Asn (GUU)"
                     /product="tRNA-Asn"
     CDS             24005..24184
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="CDG76961.1"
                     /transl_table=11
                     /translation="MESYLSGEKTFVKHQFAFRRATGASINKLLLLATIYREKCFAGLA
                     FLYHHLKCSFNFSH"
     CDS             24193..25644
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 424.3; E-value: 7.7e-129)"
                     /gene_kind="transport"
                     /product="Putative inner membrane protein"
                     /protein_id="CDG76962.1"
                     /transl_table=11
                     /translation="MNVTSALRQSVERTSWFKKRKTYRVLYWREISPLAVPILLENACV
                     LLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMSFFAAIDLGTTVVVAFSLGKRDRRRA
                     RAAARQSLAIMTLFSIILAAVIHAFGAEIINFVAGDATEEVKGLALTYLELTVLSYPAA
                     AIALIGSGALRGAGTTKIPLLINGGMNILNIIISSILIYGIFSWPGMGFVGAGLGLTIA
                     RYIGAVATIWVLMIGFNPALRISLKSYFKPFNFAIIWEVMGIGIPASIESVLFNGGKLL
                     TQMFVAGMGTNVIAGNFIAFSVAALINLPGNALGSASTIITGRRLGKGQIGQAERQAWH
                     VFWLSTIVLTLIAWGTAPFAGLIASFYTSEEDVKVVVKELLWLNAFFMPIWAMAWTLPC
                     AFKGARDVRYTMWVSMLGMWGCRVVAGYTLGIVLGMGVIGVWLGMVLDWAVRGVLFYCR
                     MVSGRWLWKYPRTKLQVEESQAQAE"
     gene            25774..25846
                     /gene="tRNA-Asn (GUU)"
     tRNA            25774..25846
                     /gene="tRNA-Asn (GUU)"
                     /product="tRNA-Asn"
ORIGIN
        1 gctcctctga ctggactcga accagtgaca tacggattaa cagtccgccg ttctaccgac
       61 tgaactacag aggaatcgtg tgaacggggc gcatattaac gatgcccttc cgccttgtca
      121 aagggtgaat cggctaaggt cgtttgtttg ctgacaattt caacagagtg cccgtttttt
      181 ctgcatcatg ccgcgtcgtg caccgttgca gtgcatttat acccctaatg gggcataccg
      241 caatccgctg accgggcaaa aaaatcgcgc tttgctatca ctatccctta ttacgcggct
      301 tacagcggcg tttagctctc cggccaaaag ctggcaagca aattgcaaaa ccttctgcat
      361 ctaaacggcc agtgttggta ctggtgttcc ttacaggagg caaaatgaac ttaagacgac
      421 tgaagtattt cgtaaaaatc gtcgatatcg gcagtctgac ccaggccgct gaagtcttgc
      481 acatcgcaca accggcgctg agccagcagg ttgcgaccct ggaaggcgag ctggaccagc
      541 agttgttgat tcgcaccaaa cgcggcgtca cgccgaccga agcgggcaag atcttgtata
      601 cccacgcccg tactattctg cgccagtgcg agcaggcgca gctggcggta aataatgtcg
      661 gtcaaacgct aagtggccag gtatcgattg gcctggcgcc tggcacggcg gcttcggcca
      721 tcactatgcc gctgctgcaa acggtgcgta acgagctgcc ggaagtgatg gtctatctcc
      781 aggaaagtag cggaaccctc ctcaacgata agcttatcga cggtcagctg gatatggccg
      841 tactttatga acgttccccg gttgccggga tcatcagcca gccgctgcta aaagaagatc
      901 tctacctggt cggtacccgg gattgtccgg ggcagagcgt ggatctgacg gcggtcgcgg
      961 agatgaatct gttcttgccg cgcgattaca gcgccgttcg cgcaagggtg accgaagcct
     1021 tcaccctgcg tcgcttatcg gccaaaatta tcggtgaaat tgaatccatt accaccctga
     1081 cggcagccat tgccagcggc atgggcgtca ccgttctgcc ggagtccgcc gcccgttcgt
     1141 tgtgcagcgc ggccaacggc tggatggcgc gcatcagcac gccgtcaatg agcctgtcgc
     1201 tgtcgctcaa tatgtcggct cgcggcagtc tgtcgccgca ggcgcaggcg gtgaaggaga
     1261 tcctgatgtc gctggtgagt cgcccgtcgc tggagaatcg tgaattacag ttagtcagtt
     1321 gagctatatt cctgaatgga ataagttgct ggtttttatt atttgttagc aaggacaaca
     1381 gactttaaca atagagcata tgttatgtct gatagcccgg aggaaagggt gaacttccag
     1441 cagctcaaaa ttattcgtga agcggcccgt caggattaca acctgacgga agtcgccaat
     1501 atgctctata catcgcagtc gggcgttagc cgccatattc gtgaactgga agaagagctg
     1561 gggatcgaga tttttatccg ccgcggcaaa cgtctgctgg ggatgaccga gccgggcaaa
     1621 gcgttgctgt cgattgccga gcgtatcctc aatgaagcca gcaacgttcg tcgcctggcg
     1681 gacctgttta ccaacgatgc ctccggcgtc ttaaccatcg ccactacgca tacccaggcg
     1741 cgctatagtc tgccgccggt gattaaagcc ttccgtgaac tcttttctga tgtccgtctt
     1801 gaactggtgc agggaacgcc gcaggaaatt gaaacgctgc tgcataacgg cggcgcggat
     1861 attggtatcg ccagcgagcg tctgagcaac gatccgacgc tggtggcttt tccctggttc
     1921 cgctggcacc acagtctgct ggttcccaaa gatcatcctc tgacccaggt gacgccgttg
     1981 acccttgagg cgattgcccg ttggccgctc atcacctatc gccagggcat aaccggccgt
     2041 tcacgcatcg atgaagcctt taaccgtaaa gggttgatgc cggatatcgt attgagcgca
     2101 caggactcag acgtcatcaa aacctacgtt gagctggggc tgggcgtggg gctggtggcg
     2161 gaacagtcgg gagatgagcg ggagtctgat acctttacgc gtcttgatac ccgccatctg
     2221 ttcgatgcca ataccgtctg gctgggcctg aagcgcggac agctgcagcg aaattacgtc
     2281 tggcgtttta ttgaactctg taatgcaggc ctgtcgctgg aggagattaa acgccaggcg
     2341 atggagccgg aagaggcggc gatcgattat caaatttagc aggatgataa atcagatatg
     2401 acatagcaaa cgaagctata attcattcac gataatcgcc acagaggaag ggaaattgtg
     2461 cggcgcgtga aactgctttg ttcttttatt atgcttctca ccagccagag cgctctggcg
     2521 gtgagctacc cgctgccgcc ggaaggaagc cgtctggtag gcagcccgtt gaccatcacg
     2581 attccgcaga acaataccca gccgcttgag gcctttgccg ctcagtacgg ccagggcctg
     2641 agcaatatgc tggaggccaa cccgggcgtc gatgtgttcc tgccgaaatc gggcaccacg
     2701 ctggtggtgc cgcagcagct tatcctgccc gccacggttc gcaacggcat tgtgatcaac
     2761 gttgctgaaa tgcgccttta ctactatccg cctgaaggca caacggtcga ggttctgccg
     2821 attggtattg gccaggcagg gcgcgaaacc ccgcgtaact gggtgaccgc cgttgagcgt
     2881 aagcaggagg cgccaacctg gacgccaacc gccaatactc gccgggaata tgccagccgg
     2941 ggcgaaagtc tgccggcatt tgtgccggcc gggccggata acccgatggg actgtacgcc
     3001 atttatatcg gcaggctgta cgccattcat ggcaccaacg ccaatttcgg cattggcctg
     3061 cgggtgagcc agggctgcat tcgcttgcgc aatgacgaca tcaagtacct gtttgatacc
     3121 gttccggtag gcacgcgggt gcagattatc gatcagccgg tgaaatatac cgccgagccg
     3181 gacggtagcc gctgggttga agttcatgag ccgctgtcgc gaaaccgcgc ggagtatgaa
     3241 tcggaccgca aggtaccgct tcccgtcacg ccggcgatgc aggcttttgt gaagggcgag
     3301 ggcgttgatg tgaatcgcgc cgggcaagcg cttgaacgcc gctccggtat gccggtggag
     3361 attggccgtt cagcgttgta agccggcagc ggctggtcgc cttttcctgc aaactcgcag
     3421 caacagaacg cgcccgtggt tttcgggcgc catcggttgt cgtgaatagc gctctttatt
     3481 attccgcttt aactcatctc agcgataggg atgtttttta aacgcagcat gattttcaaa
     3541 taattcggca agcgactgaa tgtgacgaaa ctcttgcgca tcaacaatat cggggatcct
     3601 ggcctgaata aaggtccaga taaccgtact tgtcacggca acctgatcgg ggtccgtagc
     3661 aatcggacga tcttccagta gcgtattcca ttccctgcag gccgctagca gttgacgggt
     3721 aatgcgctct atccatggat gatgctgttt ttccgtcggg cgaagatgat gttcatacac
     3781 attttgcacc gccttctcac ccgcggcgag cataaaccca gtacctgcag gtctcttgcc
     3841 agcgcatccg cagcgatcgg caggagtttt cgctccctgg cagcctgtgc ttcgaaatag
     3901 tccagtatca gcgatgaatc catcagacgt attccgttat ccagcaccaa cgtcggcgct
     3961 ttgaccgcag ggttgatctg cgaaaacgcg tcaaagctgc tgaataccga cagcggatgg
     4021 ctttcaaact cgacgccgta aagttcaaga gaaatcgcca cgcgccttac ataaggcgag
     4081 tccatcatgc caataagctt attcatgatt cctgttttcc tgtgctggtg aaatatgctg
     4141 gggttaacgc ttcgttactg acgatgaaaa gacagtacag taaattcatt caggcgaata
     4201 tcttcagtat cttacgggtt aggttagtat tactgacagg ttatgggtca ccttttaagc
     4261 gtcacggtga gggagtagta acatggcgga ttttcccccg attgcgagtt tacgtagttt
     4321 tgaagccgtg gctcgtcttg gcagcgttac gctggcggcg aaagaactac acgttacgca
     4381 ctcagctatc agtcagcaga ttaaagtgct ggaggagagg gtcggcttaa agctgtttat
     4441 tcgtcacggt cgcggcctgc agattaatga agagggacga ctctacgcct tgcaggtacg
     4501 cgaggccctt aaccatatcg ctgacgccac ccgactggtg caggtaaagc cccgcagaca
     4561 ggagctgacg atagcggtgg taccctcttt tggaggccac tggcttttgc ctcgtcttga
     4621 gcggtttcgg gcgaaatacc ctcaaatcac gctgcgaata caggcaaacc tggcggtcac
     4681 tcatctgcag caggaagggg cagatttggc catccgcatg ggaaaagggg actgggaagg
     4741 cacggagagt cattatcttt tctccgatga gcttatcgtt gtggctgctc catcttataa
     4801 cggcggtgag ctaccccgta cgccgtcaga gatagcgcag agcaagatta tcttttccat
     4861 ggaatcgtgg aaaacctggt gtatcaaggc agggcttgaa agagagattg tgcccggcgg
     4921 gctatgcata aacgactcaa atctggtgct ggaggccgtc cggctcggta aaggtgttgc
     4981 gctggaacgc cgatctttag tccaggatgc tattgcccgg ggagagctgg aacagcttac
     5041 ccctttcgcc gcgccttatc cgtggcctta ctggctggtc tcatcgcaag ttgcagaaaa
     5101 gaaaaacgaa gctgtgcttt ttaaggactg gcttagtgag gaggttgttg cctggcgtca
     5161 gcaaacggca acggtagaag agagataaga gacgtttttt ggtaaacagt gaaggtgagt
     5221 gtttttctga cggctcccgc aacattattc cgcgtaagtg agctttcacc ttcagctgcg
     5281 cacagcgcta cccttccgga tgtatgacac tccaggacct cgatcattat gaactatgtc
     5341 gtggttatct gttccttgct caaaagcgct cctgataacg aaaaaagtta ttgatatcgc
     5401 gactttcaat aatttacatc tgaatgagtg taatatgcat tatatgtctt tttggtaatt
     5461 aaatttgaaa acagacaagg attatttgtt tatcttattg ttttttatag atttaaattt
     5521 ataagtcata agttttgatt tcttttttgc aattactttt gctggtggta tagttattac
     5581 agaccacaga tggtaaaagg attacgctca tcatgcgacc gaaagaagtt caggcatcgg
     5641 cagtcagtac gatgttcaga gatgaaagta gaggtttgct ttccagtaaa gtcgttattg
     5701 ttctcggttt acttagcgcc gttgctgcat tatccactga tatgtacttg cctttatttc
     5761 cagctatcgc cagcgatctg catacgacgc ctgacaaagt tcagcttagc atcaccgctt
     5821 ttatggtagg cttaggtatt gggcagctgt ttattggacc attatccgat cattacggca
     5881 gacgtaaatt attgctgggc gggatggccc tattaaccat cgcttcatta gctggcgcta
     5941 tatctacgaa cattcagctg ctcattgtta cacggttctt tcagggactg ggaggagcgg
     6001 ctggtatcgt tctttcccga gcaattattt ctgatctgtg cccggggact aaagccgctc
     6061 gatattttaa tctggtgcta gcgatacagg ggatcgcccc tgttattgca ccattacttg
     6121 gaggagtggc tgcatggttt atctggccgg tagtttttgt ttttatggct acaatatcat
     6181 tagtttccac tctgctcagt agtcatttta ttagcgaaac cttaccccgt catcagcgat
     6241 tacctttcaa tctgaatgag tttatcagtc agtttatcga gttgctaagc aataagaaat
     6301 atattggtta tactctaatt ttttcaatcc agtttggggc gctatttgct tatatatcag
     6361 catcaccatt tatctatcaa tcgacgttcg atttatcctc aggaaagttc gctgtaatat
     6421 tctctatcaa cgccggagca atgatgtttg gtagtatagt cagcgctcgc tatgttatga
     6481 aatttggtga agataacctc ataaccatgg gggtgataag cacgctggtg atatctatat
     6541 tgctttgtat cgttgacaat atttctcatt tccagtttga gatcgcggcg gtactactgt
     6601 taatgatgat gtttactatg gctttgacat ttggcaatgc cgcgagtatg gccatggcgg
     6661 catcctctca cttaaaggga acgggttctg ctattttagg ggcttttcag tttggtatcg
     6721 ctgcgataac cccgtcactg cttggatttg gagacccgtt gtcattactg cctatgtcgc
     6781 tgattatcgc gggatgttgt ttaattgcca tcatggcatt gttattgaca ggtaaaaaag
     6841 gatagtgtga tgaaaaccca tgacgctata aaaatcattg gtgcaaggca aaataatttg
     6901 caagatattg atgtagaggt ccctaaaaat aaaataacag tttttaccgg tgtttccgga
     6961 tcgggtaaaa gctctttagt attcggaact atagcggcgg aatctcagcg acagttaaat
     7021 gacacgtttc caccttttat tcgccatcgc ttaccacatt atggtaatcc tgaagtcgat
     7081 gaaattgaaa acctgtcggt ggccattatt attgaccaaa aacgtattgg tggcaacgca
     7141 cgttcgacgg tgggcaccgc atcagatatt tataccctac tacggctact cttttctcgt
     7201 gtcggcgaac ctttcgtagg ttattcgaat gttttttcat tcaatcatcc tgcggggatg
     7261 tgtgcgacat gcgacgggtt gggcattgcc agtactattg atatcaacca tctgattgat
     7321 tcaaatctgt cgttaaatga aggagctatt cgttatcctt cttttgcgcc aggctcatgg
     7381 cgctggaaac gttatgttta ttcaggactt tttgatgccg ataaaaaaat cgcggattat
     7441 tcaaaagagg agcgagaatt attactttat gcggataatc tcactcctga agcgccgtta
     7501 gccggttggc ctaagagtgc aaagtttgaa ggcgtcatta cgcgctttac gcgaagttat
     7561 ttaaaacaag aaactaaaga tactaaaact gaggaatttc agcgagtcgt tagtttgcag
     7621 gtttgccctt cttgtcaggg tatgaggctt aacgaggaaa tactttcctg ccggattaga
     7681 gggaaaaata ttggcgaatg cgcaacgctg cctgtcacag agttaaagct gtttgtagaa
     7741 aagctcgatt accctgaagt caggccgctg atcgaagcat tgctggaaag gttggatgcc
     7801 atgtgtgcag taggcttggg atatctggat ttgaaccgta cgacccctag cttatcgggc
     7861 ggtgagtccc agcggttgaa aatggtccga catctgggaa gtagtctgac cgggatcgtt
     7921 tatataattg atgaacccag taccggcctg catccagcag atatagtgaa attgaatgtt
     7981 ttaattggaa aactacgcga caaaggcaat accattctga tggtggagca cgacccggac
     8041 atgatagcga tagccgagca tgttattgat ttagggccag gagcgggtaa gcaaggcggg
     8101 aatattgtct ttgagggcga cctgtcggca cttaagcaat cccaaacctt gacgggtcga
     8161 tatttctctt cacgggcaga gataaataag aaaccgagat gtgccaaggg ttatatatcg
     8221 gtaagaaacg ccacattgca taacctgcat aacttatcgg tagacgtgcc tttaagcgtt
     8281 atggtcgctg tgacgggagt cgctggatcg ggcaaaagtt cattcgttat gggggccctg
     8341 gcgccacaat gtccggaggc gatcgttatc gatcaaaaac cgatacatac ctcaattcga
     8401 tcgcatattg cttcctggtg cggtgcattt gatacgatcc gttcgctgtt tgccgaaaaa
     8461 aaccatgtgt cagcgtcgtg gtttagcgct aatgccaaag gggcttgtcc ggaatgtaat
     8521 gggctagggg taatacaaac cgatctggca tttatggata cggttacgtt gccatgtgag
     8581 gcctgccagg ggcagcgcta taacccacaa gcgctgaaat atcgttatca gggaaaaagt
     8641 attgctgagg tattatccct gtcgattaat gatgcctgcg aatttttcct taatgagcca
     8701 cagctcaggc caatttttcg tagcctggtc gaagtcgggt tgggatattt acgcttgggt
     8761 gaatcgttaa atcatctttc aggcggtgaa tgccagcggc tgaagttagc gtcacaatta
     8821 aatcatgata gtgacatgta tattttcgat gagccaacca cgggtcttca tcccagtgat
     8881 gtagcctcgc tgttgaaact atttaaccga ctggtagcgc gcggaaacac cgtcattatt
     8941 attgaacata atatggagtt gatcgctcag gctgactgga ttattgatat tggaccttat
     9001 gccgggaaag aaggggggga ttattgttta gcggtacacc cgaatcgatg ctggcctgtc
     9061 gccattcatt aaccgcagag tggttgcgca aacattgccg gatggagtga gaaatggtgg
     9121 tcgggacagc cagtagagac tggcaataat gtgatgcatg cccattatta tactgatgta
     9181 ttgtcccgtt aatcttattc gtctaaaggc cagtggtaat cgcgatccag ccagccatcc
     9241 aggtcataat ccatcataca ttgttcggcg aaacctttat attcttgtac ctgccccgac
     9301 atctgtgcgg cgagcaacag ctcgatacga acattttcat gactaccggt ataatttcgt
     9361 tcatagagtt cgtgtctgct ggcgaattct gttcctacgg agtcccagat tagcttcatg
     9421 agcttgacgc gttcaacggc atccataccg ttggagcccc gcatatattt tttcagataa
     9481 ggttccagtt ccggcgcagc gaaatctttg gcatgcgaat tgatataaat aagcgcgctg
     9541 ccaagatctt gttcaataat ttctttgatc cgtggatagc cgagactcat aaaccaacgg
     9601 taggctaaac cataatccag gttaggcagg agggcgccgt tgtgccaggg gttcggcgat
     9661 ttagccatag catcacttat ggcccagaag aggttgcgcc aggccagcat ttccccgacg
     9721 cgcgtctgta tgccgcggaa atcggctacg ccggtggctt ccacgccttt aatgaataaa
     9781 ccacaaataa aatcaatttt taccgccaga cgcgtcactc cgtggaaggt tgagcggtgc
     9841 aggaagccag aactgggtaa aaacgtggcc gctttagcgg tatcgccgta aataaaaatg
     9901 ttttcccagg gaatcttcac cttatccaga atgaagatca tgtcattctc gtcatagcgt
     9961 gaggatagtg gatagtcaaa aggactgccg accttttcgg cggctaagga gtaagagggg
    10021 cggcaaacca gcttcagtcc tggggcattc atgggtaatg tgcataccag ggcaaattct
    10081 ctttttttga caggtaaacc gtaatgcgcg atgaaattgt aatgcgtcaa agctgagccg
    10141 gtagcaacca ccttggcacc gctaacaatt acgccatcat cacactcttt ttcgacgtga
    10201 atgcagatat cttcaatctg gtcgggcggg agattgcggt cgataggggg gttaatgatg
    10261 gcatgattcc agtaaagtag ctcctcttgc gaacgtttgt accagtgcct ggcgttatcc
    10321 gtatattcgc cgtaggcctc gggattggcg cccagagtcg taagaaacga cgctttgaaa
    10381 tcagggcttc ttcccaacca gccatagcta agccgtgccc actgcgcgat tgcgtcgcga
    10441 tcgcgtatca gatcctcaac agaatgagga acgcggaaga acggatgagt gacaccaccg
    10501 ctgccggtat cacaaggcgt ggttaatata gcctgatact tttcgtcatg gagcgcgtcg
    10561 tataatttag ctatggacag tgctgaattg cgaaacgctg gatgtgtaat aacattgtcc
    10621 accttttcac cataagccca tatttctcgc ccatcattta gacccgctaa aaagtcatta
    10681 ccggtaggta atgatactga tttattttcc atgtcagctc tctccgaatg tcggttttca
    10741 acacttcctt ttaaacggca tcttgttggc taagagttgc cgttgttgtt aaggcgttct
    10801 gtatcagcca ttgataaata gaaaatgcgt cttgcgtcag gaatgattcg ttatgaaatt
    10861 gtatggaggc aacgttgcct gacgataatg cgacaatttc accggaagga agtcgctcca
    10921 gctggactgt tttgtcatgc tccgggctgt accagcatgg ccgctgatgt agtgcggaga
    10981 aactgttata gaaaccaacg gtatgaggtt tcccctgaat ggatatctga tgttggctac
    11041 cctgacggtt attgaccagc cgctcgatcg gaatgcctaa ttcggcgcaa attaactgat
    11101 gtcccagaca agttccgatt agcggacgct gctcccggag ccgttgcgca ataatttttc
    11161 ggcccacgcg tattttttcg agttgtatat tggttggatc gccaggcccg ggaccaatga
    11221 ataggatgtc gcgatcggtg agttgcgtta gcttgctcgg acagtcatac cagggaatga
    11281 gggtgacggc gcaacccgcg ctgcgtaact gataggcaat catggcggtg aagttgtcct
    11341 ccatgtcgat cagtgtgatg gcatgatgag agagtagagt gcgcgggccc aattgcgagt
    11401 tatccagcca aaaggcggag gtgcgtgcat tccgttgtgc cagtatctgg tcagcccgat
    11461 ggcaaagttc tgcagacaat cctgtccggt ttggcgtccc ggcgcttggt tcagagaaga
    11521 acgaatgcat tagcccttgt aatttggcgc gtgtttcacc ggcttcactt tgcgcgatgg
    11581 aacttctgac gatggttgaa cccgccgtaa gccgaaaatg tccctgagcg gaaatatcgg
    11641 ccgtgcggat catgatggcc gagtccagat agcgtttacc ttcttgcgca cccgttatag
    11701 caacgatgcc gctgtaataa ccgcgtccgc ggcgttctcg ccgggcgata actttacagg
    11761 cgctttctat tgggctgccg gtcactgttg gcgcaaatag cgattgcctg atgatttctt
    11821 tcagactgcg atctgatttt ccatggataa aatattcggt atgcgcgatg tgcgacatag
    11881 ccttgagctt cggcccggat acctgaatat cacgttgaca gatgctactc atcattttga
    11941 gttcttcatc taccaccata aatagttcgt cgcgctcttt tttatcctgc agaaaatcat
    12001 ccagcacgtg cgccatattc ccggtatcgg ggtattttaa tgtgccgctg ataggattca
    12061 tcgccacgtt ctgctcatca acctggatat gctgttcagg cgtactaccc atgaaatagc
    12121 ggctgccggt aaagatcatc catgtccagt atgatccgca ttcagattgc agcagccgtt
    12181 tgtacagcgt cagcgcgtgg cggatactaa agtcgattat atcgccctcc aggctgcgtg
    12241 aaatcacaaa gttgctgcct tccccggagc tgatttcctg atcaatcacg gtatcaacaa
    12301 tgtcgccata cgtttggtca tcaagatcga agtgcaggtt tcgtggcttg atatcatggt
    12361 cattaatggc tgcgataaat gaatctatag gataatagtc ttgccgctca atgtgcatta
    12421 cgatcgtctg ttcaccatcg tcaatgcagg catatccttt ttctttcagc tgattaaatg
    12481 gcaataatat caatttgtta aatgagcatt tgcccgtcgc gtccagggga ggatccagcg
    12541 ctaattctga aagggactgg cttagctcaa tatccccttc aagaaacaat actgcgttga
    12601 taggttcgca ttgggggcga taaatacagg caaagggtct atcaagattg gccagatgag
    12661 ccgaaagctc gtcgggattt gctgaatctt tagataacat catcatctcc tgaagtgccg
    12721 tgaggatctt taatgttcca atgcgtcgat agcttgtcgg gttgacagca cgactgagct
    12781 ggtttccgca gctagctcaa gcgctagacg atgcttttct tcggagaaat cggcgagcgc
    12841 atcggcaata aaaaatgtct cgatatcatt ggaataggcc tcttgcgctg tgcacaaaca
    12901 accgatatgg gcgtaaacgc cgcagacgat cagctgatcg catttgagtt cgtgcaaagt
    12961 actcagaaga ggagagttaa agaaggcgct gtaacgccac ttcgttaata cccactcatt
    13021 ttccagaggc gtcaacggag gaacaatctg tttatgttcc tggctgccgt tcatgcctga
    13081 accccataga ctgtgcagca agccgcgctg ttgtggcgtc atgtcgccgg gttgggcagt
    13141 ataaaatact ggaatatgca gacgtcgggc gacgctaagc aagcggtaga tgttgtcgat
    13201 gacctgcgct atcggcgagg cgtcagcagt gtaaaaatcg agaaaataac gctgcatatc
    13261 atgtatgagt agcgccgctc ttgaactgtt gggtcgccag tctgcaattg atttgggtaa
    13321 ttgacgttct gtcggcaatg gatagggccg tatcttttcc atgttattct ccttgtacgc
    13381 ttagcagctg ccgagtgcgg caccaccgtc gaccaataac gttgatagcg tggtttgccc
    13441 tgattcttcg cacaggtaaa agcagaccgc ggcagcaatt tcttccgccg tagcgacttt
    13501 gttgagtgga ataccaatgc gaaattgttg tgggttaccg ttgagcgtgt tttgcttgtc
    13561 actttcgcta tgccacatgc cgcgcagcat cggcgtatcg gttgagccgg gagcgacaac
    13621 attacaacgg atcccatacg gagcgacctc cagccccaga gcataggtaa atgcctgggc
    13681 agcggctttt gaagcgcagt aggcggccat cgtcgcccgc ggcacgcgcg ctgcatttga
    13741 ggcgatagtt acgatgctgc ctttacgctg agccatcatc agattggccg catggcggct
    13801 ggtgttaaat acgccagtcg cgttgacggc aaatgttttc gcccaatcct gaggttgtgt
    13861 ttcggccacg ctggcgtggc acagtacgcc ggcgccgttg accagatacc ctaccgggcc
    13921 cagttgatga ccgactgcgg taaaggcctc tgctacgcag cggtcgtcgg caacgtctac
    13981 agtaaagcct gcaatgggct gcggatggtt atcttgtagt gtggctacaa gggttgccag
    14041 ctgagtggcg ttattatcaa gaagcgctag tgacagccct tctttcgcca gcgcgtgggc
    14101 aacggattcg ccaatgccac cgcatgcgcc ggtaataacg gcaatataat ctttatcaaa
    14161 agtcatgttg tccctctttc cagtgagtta ataacatctg cgtttgcgct acgttcaggc
    14221 gtgggtcgca gagaatttgc ttaagttcat gttcttcagg gtgattattt tcactgaagc
    14281 attcgatgac cgggttcggc gttgcttcca gatggagtcc tgcggcgcag gcgttatgtg
    14341 atttcacctg cctcaggaaa ccggagattt cagccatcat gtcgctaagc tcgcggcgtt
    14401 tattgcccgc ccgtgttttc ccggtattcc catgcattgg atcgcacatc cataacaccg
    14461 gcgtttcggt tgcttgcgcg gcctgaatca acgcgcccaa ccgatgaatg tgtgaacggc
    14521 caaaacgcga aataaaagtc agacgcccag gaatacgctg aggattgagc tgtcggcaaa
    14581 gtgacgcgat gaacgatggc gttacgctgg cgtcaatctt gcaggcaaca gggttggcga
    14641 tattcgccag catggcgata tgtgggctgt caggcgcaag agtacgaatg cctatccagg
    14701 gccaatgggt gctggctaag tatgattctc cgtagggatt agtgcggatt tgagtggttt
    14761 catagtccag caacagcgct tcatggctgg tccaaatgtg atgaatatcg cggggatatt
    14821 cccgttcgta acgtttaatt tcggccagcg tttccgcagc agcacgatag ctcagcagca
    14881 tccgttgcgg atcgttacgc ctggcttctg gtgtcgcttc gggccggttg actgaatcac
    14941 cgcgccacac gggaagtacc ctgtcgccat cgacttcgtt ttgttgcgag cggggtttag
    15001 catattgacc ggcaattcta cctaccgtca atatcggcag ccccgtcagt gttgagaatt
    15061 cgcgggacat ttgctcaagg aagatcaatt ttttccgtac atgtaacgcg ccagattcgc
    15121 aaattctttc agcgcagtcg ccggcctgaa atatcattgt ttttcctgca taaacggcgg
    15181 ctaatgcttt cttgagttca cttatttctg caaaacttaa taattctgga agattgtcta
    15241 attcactttt gaccagggca agcatgtcct tatcgctcca gaacggctgt tgccagttgg
    15301 acttattgcc aggaaatgat gtcatttcta atctctcact cgaaatttaa caggtttttc
    15361 gtttgttttt taacaaaaaa gcgatgagaa agtgctattc cttgtctgtt tactggacat
    15421 gaaagacgat acggtttgca caaatattgc acgccaatgg gtgccttatg tcaatcaaaa
    15481 aaatttatat ttgatttatg ttttttcatg ttattgattt ttatggttat tatttttgtt
    15541 ggttttttat tttttgctat atgatttttt tttggaaatc aaattgactg gggatgaggt
    15601 tcgaagatag actattgaaa gcaacgctta gttatgcttg tgttgcttat atgttgcttg
    15661 ttttgcggtg tttgcttaga ggcatctcac ggtaagctgg cggcatttct ttagatcttt
    15721 aatttcttct tcaagagaag attttatgcg tgtgaacgtt cctaattctc caggagagag
    15781 tgatgacgca ttcagcatat gtctatcagt taaaggctgt ccctgatata tttgatgaga
    15841 tttcgcaacg ttttccggac agggttgcgt taattttcga tcaaagaaaa ataacctatc
    15901 gagaacttgc tgagcaatgt tcagcgctgg ctgctgtgtt gcaaaataat tgcctgataa
    15961 aaggcgatat cgttgcaata aaaatagaac gtagcccgga gttatatatt tttatgctgg
    16021 cgctcatgaa aataggcgct gttatggttc ccgtgaactc gaatagtccc gaacgctata
    16081 ttggtgaggt tttaagtgcg gcgggagcca gatacctgat tagcgatgat gtaacaagcg
    16141 tgcccggcgg agcatggcac gtcttgtcga gcaggacgct gatacaaaac tgcacgcaac
    16201 aaagaagcgg gaattacccg gtattaagtg ctgatgatcc ggcgctcata ttgatgacct
    16261 ctggttcaac aggaaaaccg aaaagcgtac tgattgctca tcgcgggatt gccagactgg
    16321 gtctgccggt accggcgttg gggaatagcg agcgggactg ctatttgcaa attgcagata
    16381 tttctttcgc tgcctcagct aatgaaatct ggatggcttt attgaccgga gcatgtctcg
    16441 cgattgcgcc gcctggcttg ccggatttaa tggccctggc acggcagatc gaatcggata
    16501 acgtgacgat gctattcctc tctggcgggc tgttccggct atttgtcgag gtttcggtcg
    16561 aaacactgca tatacctgat tgtgtggtgg tgtcgggaga ctttgtcaat cctcgcttat
    16621 ttagcgtggc ggtgcaggcc ggtaaagcca aaatatttaa tggattagga tgcacggaaa
    16681 attcagcgat ctcgtctctc tatcatattc agtcggagga gcaattatcc agtgaatctc
    16741 ctgtgccggt tggtactcca ctccctctgg ttgagatggt ggtattcaat gaacggttgc
    16801 aaccctgtac ctgcggtgaa tatggggaat tatttatcgc aggggctgga gtggctctgg
    16861 ggtattccga tccgcaactg acggcggaaa ggtttatcac cataccgtat caaggcactg
    16921 acgtgctttt ctatcgtacc gatgatcggg caacttacga ccaggattgc aatatcgtcc
    16981 tggtcggacg aggcaaccat atttgtaaaa tacgtggctt ccgcatcaat atcgccggta
    17041 ttgagcacct gttgcgctta catcacgctg tagaagatgt gctgattgtg gtagaggaga
    17101 cgccggatga accgcgatta catgcttgtt atgtcacgca ggatgacggg ctatccgtag
    17161 cggatttaaa gaatcacctc gcaatgcatg ctcctgcctg gatgatacct gaaaaattta
    17221 gccgtctggc ggtactgcca atgaccgcta acggtaaaaa agatcgttta cggttaaaaa
    17281 attctttact ggagcaggtg taaatatgga caacgttgag caacagctac tctcgatttg
    17341 gcaggcgatt attcattcag aggcgattaa cccgcacgaa aatttactag accagggtgg
    17401 taactcatta catttcataa agttggcgtc aatggtaagc aagacattta atttgtctgt
    17461 ctcgccggcg gacattttca ctgccggaac tattgctgcg ctggctcaga ccattcggca
    17521 acggcaaaag ctctaatacc tggagttggg actaccagca aacaggaagg attttacagg
    17581 gaattttaag agggggataa aatgccatca ttcaatagcg gcgagtcaaa aaagggctgt
    17641 ttgaacaagg agtgtggaga aagtgcggta acgtatctgc cagctacgcc cgggcagcag
    17701 gcaatgtggt ggctggataa tacgctggag cagccccaat gctataacgt gccggtgctg
    17761 ctgaccgtta atgcgacact ggacgctgat attatgcagc gcgctgtggc tgagctgacc
    17821 ttgcgccatg aaatattcag aacgcgtttt gtttatcttg acggtaaatt acaacagcgt
    17881 atcggcgctg atggctatct ctctttttcc catcgacaac cagagcagac ggaaacccct
    17941 gaatccgtca cggcacaact ggcggctagc cgtttatcat tagctgaggg gccgctgagt
    18001 atcattaata tgctcagttc agactcaggt acaacctggt tagcatgctg cttccaccac
    18061 atcattattg atgccccctc agtacgtatt gtcttgcatg atttgctgcg aatctattgt
    18121 gcgcttgacg agaagcgcgt tctgccagcg tttaacggca cgggaagcta tcaggaattt
    18181 actcgttggc aggccgcgtc ccttgcggcg gctgagtgcg aagatatgcg ggtttattgg
    18241 cgacaggcac tgcatccagc tccacccttg tcggacctcc cggtcgattt tccccgtcgt
    18301 cttcgggaag ataccaaagc cgcctatacc atgctggcgc tgaacgaaca ggaagcggac
    18361 tcactgcagc ggcacgcgag atcgttgtca atgactccat ttatgtatat gtccatgtgc
    18421 tggcaatttt tcctcagccg tatgagcggg cagaacgata ttaccgttgg cgtgcctttt
    18481 actctgcggg atcgcagcga gtttgccgaa acgccgggat atatgatcaa tactctgccg
    18541 gttcgcgtgc aggtcaatga agatgacacg gtcagcacgc tggctgcaaa ggtacgtcaa
    18601 tcttttattg gcgcacattt caataagctg ctccctttca atgaaattgt cgcactgtcg
    18661 cgtgaaaacg cggggcagga cagtcctcta ttcagaacac tgttggttat gcccgatacc
    18721 cggggcgata ttttcaacga cttgcctttt aaagtcatgc tggatgacta ttttagccag
    18781 atggcaaaat acgatctgac gctgttcttt gaagcgcaac cgcagtggaa gctgacgctg
    18841 gagtataaga cggcgttgta tcacccgcag accattgact actggttgaa aatctttcgc
    18901 catttattaa gcgcgatggg tgaggacggc gaggtattac tgtcatccct gaggctgttg
    18961 gatgcaccgt taagtcgtga actggttgtt cgatctagtc ttaaatcgtg cacggaggcc
    19021 tggcgatttg acgccctggc ggctttcaat cagcatgcta taagccactc tgcggatact
    19081 gcgttaatta ccgctaatgg cacacgatcg tatggttggt tagcggaacg ttcagggcag
    19141 attgccgctt acctacagca gcagttaaat atcgcacctg gcaaacgtgt tgcattatta
    19201 ctggaaagga atgccgaggc gattgccact ctgtttggcg tgttaaaaac cggcgcggcc
    19261 tacattccga tcgatccgca atacccgcaa gagcgaattg gttacatgtt gcaggacgcc
    19321 agtgtggatt gcatcgctac gacgcgatcg ctggtagcaa aattcccagt gtctggctcc
    19381 gtacctctgt tgttaatcga tgatattccc ccggagtacc ctggggaata ctcttatatc
    19441 aaaagaatgc ccgacgatga gctgtatatc atttatacat caggttcaac cgggcagccc
    19501 aagggagtac ggttattaaa taaaacgctc aataacctga ttaagtggca acgagatgtt
    19561 tctgagtgcg atcaaggaga ttgtactctg cattttatgt cactttcttt tgatgtctcg
    19621 gttcaggaga tcttcggcac gttagctggc ggtgggtgct tatatattgc cagtgaagaa
    19681 gaacggagag atctggatct tctgcaagag gttatccagg agcaggggat taatcgtctc
    19741 tattttccct atgttgcttt gcaacagttc gcgcatttga gcgtattggc caacaggcaa
    19801 ttcccgagtt taaaagaggt ctactccacc ggggaacagc tcgtactcac cgcggatatt
    19861 aaacattttt tcaggcaacc cgttcgcctg attaatctct atggtccctc agaaagtcac
    19921 gtctgttccg cgtatgtgct gccaccggaa agcgataaat ggggagatgc agcgtccatt
    19981 ggttaccctc tacccggatt tacgttgttg gtggtggatg agcatttgca gctggttccc
    20041 gccggtgtcg ccggtgaact gctcatcgtt agcgattttc tctctcccgg ctatcacaat
    20101 aaaagtgaag aaagcgctcg acgttttatc tctgctgagg gctttgccac acaaagttgc
    20161 cacgcatatc gtaccggtga tctggtgagg ctggagcatg acgatcggtt cagctatctt
    20221 ggcaggatag acaatcagtt aaaaattcgc ggttttagga tcgaaccgtc tgaagtagaa
    20281 gcggccatca atgccctgga aggcgtgcag gtttcagcgg tagttggcag ggcagatact
    20341 tcaggaagca agcagctcgt cgcttttatt gctggcttaa tggatgataa aagcaatcaa
    20401 aaggataaga tcaaacgcgg ccttcgcctg gttctgccgg agtatatggt tcccacagag
    20461 ttggtctttc tggataagct gcctactacc cctagtggga aaatcgatcg taaggcgttg
    20521 cttaaggtgg atattatcgt tgaatcatcc gcgcagatgc cagaacggtc tctgacgaaa
    20581 acgcaggagc aggtcagggc gctatgggaa acgctatttc cgggtcgtca catcgcactg
    20641 cacgatgatt ttttcgccat tggcggacat tccttgttgg ctacgcagct ggtttttctg
    20701 ctccgtaagg cattcaattg cgatattcct ctacgtttgt tatttaatca tccgacgttg
    20761 ttggctatgg cagagtgcat cgacggctat gttgtcagtg aaaaggggcc cgtcgatacc
    20821 gttgatcgtt cctttgttca ggatggatac gaacgcatac attggctggg gggagagtgt
    20881 tcaacccctg ggctgacgtt gctcaccggg gcgacaggat ttttaggcat ctacctgctg
    20941 cgttcactgc tattggccgg gacccaatcc gtgatttgcc tggtaagagc caggacagat
    21001 aagcacgcat tggctcgttt acgtgaaaat gcgatgcgct acggaatcgc cgatgagatt
    21061 gatttttccc gggttgaagt ttgtctcggt gatattggtc agcgcgattt aggattaagc
    21121 cctgacgcgt atagtcggtt ggcagagcga gtggacacgg tattccatgc agccgcacag
    21181 attaattttt tgctctctta ttcttctgtt aaacagtcaa atgtgcaggg tacgctaaat
    21241 attttagctt tctgcggttg tggcggacga aaaacgctcc actatttatc cactatcgcc
    21301 gtattttctc cacgctatcc tgaatcgcct atcgtggaac attgtgtgcc ggggcatccg
    21361 gaagcactgt cgattggtta tacgcaaagt aagtgggtgg ctgaacgcta tgttatacag
    21421 gccagagaac aaggacttga tgctaacgta tttcgcatcg gacgtattgg cggagacagc
    21481 cgaactgggg cctgccagag cgatgatttt ttgtggcgac agataaaaag ctttatccag
    21541 atgggattgg cgcccgatcc gtcttccctg tcaacggacc tgctgcctgt cgactttgtc
    21601 gctgaagcga tagttgcttt agcgcgttca gaggctactc gacaggagaa cttccatatt
    21661 ttccatcctc agagcatccg gtttgacccg gtgtatcggg cgattcgttc tctgggctat
    21721 ccgttagaaa cgacttctga cggcgagtgg ttgcaacaac ttgagctgtg tgtcacccaa
    21781 gggcgcgagg ttgcgctggg gccggtcatt catctcttta aagagaattt gttggatact
    21841 ggcgataacg cctatggtaa tccagagacg actaagcgta ttacacaact gggcttgcgc
    21901 tttcctgaac tgtcggagga gactttcaaa cgtatgattg tttatttcca gcggcagaaa
    21961 gaaattgtct agcaaaccgt ttatcaattt catcaagagg ataatacaat ggttccagca
    22021 ctatttgata aatatatttc ggcagtgatg gagaagtcat cggataagct ggcatccctt
    22081 ttctctgtta atggacgttt gtcgttgcct ttccgtcgca atagagaggt gattgttggc
    22141 cgtgaaaata ttcgcttaca ctatgctaat ggctttggcg ttgcgccctt acgctttacc
    22201 tctatagagg atgaacgatt ccactatacg aataatcccg atgtcgtcat tgttgaatat
    22261 aaactacatg ggaatactct gccagatggg aaacagttct ctttgttata tgttaatgtg
    22321 attgaaataa atgatggcaa gataactgaa ttaatagatt atgaggatgt tttgaacaga
    22381 gaatatatct ttcaggatta gcaggatgat tcttatgtta ttaatggggg cgaaggttat
    22441 gataactttt cattccttga agggttatgg taaaatggta agcttaactt attgtatacg
    22501 gcatcaggag aatgtatgga aatgaataaa aaagtggcta gtggttccga gcgcgaaata
    22561 tcattgaatc gtcaatttga agatgcttta gggaatttgc aatgcgtact tgttgcacgt
    22621 cgatcgttga ttaatcctga tggtattaac tggccgcaat acgatacgtt gtatatttta
    22681 cgtcagttcc agccgatgac tccaagcgca attggtgaaa agctcggatt tgcgcgtagt
    22741 aaaatgtcca agatcctgcg gatgttgaaa gataagcact ttgttgagca ggagtcggca
    22801 gaaagcgaca agcgagaaat gctgacgagg attacggaaa agggtattga attcctgaat
    22861 tctgcagagt ccagcaggcg cataatggct gagcaggtgg catcctgtat gtcgcaggga
    22921 gagattgcta ttttcgctga gctttgtaca agggctgcca atatattaca cgagaatatt
    22981 aaaggtaaac tcgaagatac cagtgaaaat taataaagtt tatggtgatg aagcgttaaa
    23041 cggagcgctg gcgtggtatt ctctttgccg aatatggaat cgaatatatg gcattggaat
    23101 tttgctaaaa tgttgctatg cgacgatggt gaaagtggac ccgatactcc gatactaagg
    23161 aaagattttt accgcagatg gtaaaaaaat gctgattcgt atcgttaata ttttgtttgc
    23221 taaaaccttg tctcattgca acgtgcgttg atgtgcccga aacaggcttg agcggatagt
    23281 tttctgtcaa tataaaatca aagctgtctg gcatactggc gataatggga gcaggccatt
    23341 gctcggatca tggccgcagt ttttattttt cacataatag ccttcaatcg tatcctctcg
    23401 tttagcgtat tctcgcacta cgtctggtga gcacaggagt tttggcgaat acctgtagca
    23461 gatatttctt tactttcaat atatcgatga ataaatgtga aagtagcagg tatgcaactg
    23521 gtgcattttg ttctcttcct tcattgcccc cgcaaaacag acagccgagt aaatgattgc
    23581 ccctgctgat aatgatcgat tcagctcttg cgtacagaga aatgatcccg ctaccgggtg
    23641 catctgaggt gctcaagcac ggaacggcca ctcgatgcag atctgccgtc aggattaacc
    23701 agaagttaac gttcgtgcta tgtgaaaatc ttcgcaggct tcaggctgac aattggcgtg
    23761 ttgttaaggg agaagtggga catgctatgc gcaacaaaga tagtgcccgc atttcccggc
    23821 acggaggaga aaaaaccaga aatgcaccga gatgtgttcc catgctagcc tgttgaatca
    23881 atatctgaaa aagattcgca tagatagctg aaaacaggaa tttggctcct ctgactggac
    23941 tcgaaccagt gacatacgga ttaacagtcc gccgttctac cgactgaact acagaggaat
    24001 cgttgtggag tcgtatctta gcggcgaaaa aacttttgtc aaacatcaat tcgccttccg
    24061 ccgcgcaact ggcgcatcca tcaacaaatt gttgttatta gcgacaatct atcgggaaaa
    24121 atgctttgca ggattagctt ttctctatca tcatttgaaa tgtagtttca acttttctca
    24181 ctaaggtctc ccttgaacgt cacttccgca ttacgccagt ccgtcgaacg cacgtcctgg
    24241 tttaaaaaac gcaagaccta tcgcgtcctc tactggcgtg aaatcagtcc acttgcggtc
    24301 ccgattttgc tggaaaacgc ctgcgtgttg ctgatgggcg tgctgagtac ttttttggtc
    24361 agctggctcg gtaaagaagc gatggcgggc gttggcctgg ccgatagctt caacatggtg
    24421 atcatgtcct tttttgccgc catcgatctc ggtacgaccg tggtggtagc cttcagtctg
    24481 ggcaagcgtg accggcggcg ggcaagggcg gcagcgcgac agtcgctggc gataatgacc
    24541 ctgttctcga ttattctcgc tgcggttatc catgcttttg gcgcggaaat tattaatttt
    24601 gtcgccggag atgcgacaga agaagtgaaa ggcctggcgc tgacctatct tgagctaacg
    24661 gtattgagct atccggcagc ggcaatcgcc ctgatcggca gcggtgcgct gcgcggagcc
    24721 ggaaccacta aaattccgct gttgatcaac ggcgggatga atattctgaa tatcattatc
    24781 agcagcatcc tgatttacgg cattttttcg tggcccggca tggggtttgt cggcgcgggt
    24841 ctgggattaa ccatcgcccg ctatattggc gcggtggcta ctatctgggt attaatgatc
    24901 ggctttaacc cggcgctgcg catttcgctg aagagctact ttaagccgtt caacttcgcc
    24961 attatctggg aagtgatggg cattggtatt cccgccagca ttgaatcggt tttgttcaac
    25021 ggcggcaagc tgctgactca gatgttcgtt gccgggatgg ggactaacgt gattgctggc
    25081 aactttatcg ccttctccgt ggctgcgctg attaacctgc ccgggaacgc cctgggttcc
    25141 gcatcgacaa ttattaccgg caggcgtctc ggaaaaggtc agatcggcca ggctgaacgt
    25201 caggcgtggc acgtcttctg gctatcgacg atcgtattga cgctgatcgc ctggggaacc
    25261 gcaccgtttg ctggcctgat cgcttcgttc tataccagcg aagaggatgt caaggtagtg
    25321 gtgaaagagc tgctgtggct caacgccttc tttatgccga tttgggcgat ggcctggacg
    25381 ctgccgtgcg cctttaaagg cgcacgtgac gtgcgctaca ccatgtgggt atccatgctc
    25441 ggcatgtggg gctgtcgcgt cgtggcgggc tacacgctgg ggattgtgct gggtatggga
    25501 gtgattggcg tctggttggg gatggtgctt gactgggcgg tgcgcggcgt tttgttttac
    25561 tgccgaatgg tcagcgggcg gtggctgtgg aagtatccac gtaccaaatt gcaggtagag
    25621 gagagtcagg cgcaggctga ataggcgagt gataagcgga taaacgctac tttttgcgca
    25681 aagtggagga tttttcggca aacggtttga aatgtgcaaa cagcctttga caagatcggg
    25741 cgtcatcgat aatatgcgcc tcgttcaaac gattcctctg tagttcagtc ggtagaacgg
    25801 cggactgtta atccgtatgt cactggttcg agtccagtca gaggag
//
