BGC0000446 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000446 (Klebsiella oxytoca)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	25,846	tilivalline/9-deoxy tilivalline/dihydroxy tilivalline/dehydro tilivalline/dihydroxy-dehydro tilivalline	NRPS:Type I	100%

BGC0000446 - Region 1 - NRPS

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Location: 1 - 25,846 nt. (total: 25,846 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,847
Label		BGC0000446

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000446	1.00	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001637	0.61	NRP	kleboxymycin	Klebsiella oxytoca
BGC0000343	0.36	NRP	enterobactin	Pseudomonas sp. J465
BGC0002493	0.32	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002474	0.27	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001869	0.27	Other (Phenazine), NRP	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338
BGC0001627	0.26	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001444	0.26	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001442	0.25	NRP	actinonin	Streptomyces sp. strain ATCC 14903
BGC0002476	0.23	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000446	1.00	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001637	0.85	NRP	kleboxymycin	Klebsiella oxytoca
BGC0000343	0.69	NRP	enterobactin	Pseudomonas sp. J465
BGC0002493	0.65	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002474	0.61	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001869	0.60	Other (Phenazine), NRP	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338
BGC0001627	0.60	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001444	0.59	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001442	0.58	NRP	actinonin	Streptomyces sp. strain ATCC 14903
BGC0002476	0.56	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25846:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

npsA

Search NORINE for peptide: strict or relaxed

AMP-binding (16..411): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AANFVSGAIK
Nearest Stachelhaus code(s):: diOH-Bz AANFVSGAIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

npsB

Search NORINE for peptide: strict or relaxed

AMP-binding (483..883): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVQYYTLVCK
Nearest Stachelhaus code(s):: Pro DVQYYTLVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)