BGC0000446: tilivalline biosynthetic gene cluster from Klebsiella oxytoca
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Location: 1 - 25,846 nt. (total: 25,846 nt).
This entry is originally from NCBI GenBank HG425356.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000446
Short description tilivalline biosynthetic gene cluster from Klebsiella oxytoca
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Pyrrolobenzodiazepine)
Loci NCBI GenBank: HG425356.1
Compounds
  • tilivalline
  • 9-deoxy tilivalline
  • dihydroxy tilivalline
  • dehydro tilivalline
  • dihydroxy-dehydro tilivalline
Species Klebsiella oxytoca [taxonomy]
References
Chemical products information
tilivalline
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C20H19N3O2
Chemical database entries
PubCHEM
9-deoxy tilivalline
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C20H19N3O1
dihydroxy tilivalline
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C20H19N3O3
dehydro tilivalline
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C20H17N3O2
dihydroxy-dehydro tilivalline
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C20H17N3O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CDG76945.1
 405 - 1322 (+) Nitrogen assimilation regulatory protein Nac
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  • CDG76946.1
 1429 - 2379 (+) Alkanesulfonate utilization operon LysR-family regulator CbI
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  • CDG76947.1
 2458 - 3381 (+) L,D-transpeptidase ErfK
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  • pseudo3498_4106
 3499 - 4106 (-) Glutathione S-transferase, unnamed subgroup 2
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  • CDG76949.1
 4283 - 5188 (+) Glycine cleavage system transcriptional activator GcvA
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  • CDG76950.1
  • mfsX
 5613 - 6845 (+) permease of the major facilitator superfamily protein
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  • CDG76951.1
  • uvrX
 6850 - 9072 (+) Excinuclease ABC subunit A paralog of unknown function
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  • CDG76952.1
  • hmoX
 9195 - 10712 (-) 4-hydroxyphenylacetate 3-monooxygenase
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  • CDG76953.1
  • adsX
 10751 - 12700 (-) 2-Amino-2-deoxy-isochorismate synthase
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  • CDG76954.1
  • icmX
 12730 - 13362 (-) Isochorismatase of siderophore biosynthesis
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  • CDG76955.1
  • dhbX
 13381 - 14166 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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  • CDG76956.1
  • aroX
 14156 - 15325 (-) 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II
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  • CDG76957.1
  • npsA
 15783 - 17303 (+) non-ribosomal peptide synthetase
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  • CDG76958.1
 17306 - 17536 (+) PCP domain
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  • CDG76959.1
  • npsB
 17602 - 21972 (+) non-ribosomal peptide synthetase, terminal component
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  • CDG76960.1
 22516 - 23013 (+) transcriptional regulator, MarR family
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  • CDG76961.1
 24005 - 24184 (+) hypothetical protein
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  • CDG76962.1
 24193 - 25644 (+) Putative inner membrane protein
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NRP-specific information
Subclass Pyrrolobenzodiazepine
Cyclic? yes
Release type
  • Reductive release
NRP-synthases
Gene Modules
npsA
Module 0
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Feeding study
npsB
Module 1
Specificity: proline
Evidence for specificity:
  • Feeding study
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: O7W664GPYKX3NUS2LLMP5XCG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed annotation for duplicate of pseudogene
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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