BGC0000450: triostin A biosynthetic gene cluster from Streptomyces triostinicus
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Location: 1 - 36,746 nt. (total: 36,746 nt).
This entry is originally from NCBI GenBank AB366635.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000450
Short description triostin A biosynthetic gene cluster from Streptomyces triostinicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB366635.1
via
Compounds
  • triostin A
Species Streptomyces triostinicus [taxonomy]
References
Chemical products information
triostin A Evidence:
Copy SMILES
C50H62N12O12S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAH04156.1
  • trsD
 1 - 984 (+) putative ABC transporter
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    • BAH04157.1
    • trsE
    		 981 - 1805 (+) putative ABC transporter
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      • BAH04158.1
      • trsF
      		 1912 - 3117 (+) putative esterase
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        • BAH04159.1
        • trsG
        		 3236 - 3739 (-) putative DNA-binding response regulator
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          • BAH04160.1
          • trsH
          		 3883 - 4095 (-) MbtH-like protein
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            • BAH04161.1
            • trsI
            		 4142 - 13600 (-) putative non-ribosomal peptide synthetase
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              • BAH04162.1
              • MIPLSYAQRRMWFINRFEGPSSTYNIPLLLRFHGSLDTAALRAAFQDVLV
              		 13608 - 21665 (-) trsJ
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                • BAH04163.1
                • trsK
                		 21676 - 22374 (+) putative SAM-dependent methyltransferase
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                  • BAH04164.1
                  • trsL
                  		 22438 - 23823 (+) hypothetical protein
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                    • BAH04165.1
                    • trsM
                    		 24008 - 26386 (+) UvrA-like protein
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                      • BAH04166.1
                      • trsN
                      		 26468 - 27406 (+) putative oxidoreductase
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                        • BAH04167.1
                        • trsO
                        		 27803 - 29182 (-) putative FAD-dependent oxidoreductase
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                          • BAH04168.1
                          • trsP
                          		 29169 - 30257 (-) putative dehydrogenase
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                            • BAH04169.1
                            • trsQ
                            		 30254 - 31000 (-) putative thioesterase
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                              • BAH04170.1
                              • trsB
                              		 31154 - 32359 (+) putative cytochrome P450
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                                • BAH04171.1
                                • trsA
                                		 32373 - 33956 (+) AMP-binding ligase
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                                  • BAH04172.1
                                  • trsC
                                  		 34035 - 34778 (-) putative tryptophan 2,3-dioxygenase
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                                    • BAH04173.1
                                    • trsR
                                    		 34968 - 36746 (+) putative non-ribosomal peptide synthetase
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      trsI
                                      Substrates
                                      cysteine (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      trsI
                                      Substrates
                                      valine (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      MIPLSYAQRRMWFINRFEGPSSTYNIPLLLRFHGSLDTAALRAAFQDVLV
                                      Substrates
                                      serine (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk04
                                      Type
                                      nrps-type1
                                      Genes
                                      MIPLSYAQRRMWFINRFEGPSSTYNIPLLLRFHGSLDTAALRAAFQDVLV
                                      Substrates
                                      alanine (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk05
                                      Type
                                      nrps-type1
                                      Genes
                                      trsA
                                      Substrates
                                      quinoxaline-2-carboxylic acid (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk06
                                      Type
                                      nrps-type1
                                      Genes
                                      trsR
                                      Substrates
                                      tryptophan (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated reference publication(s) (MIBiG Annotathon)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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