BGC0000452: tyrocidine biosynthetic gene cluster from Brevibacillus brevis NBRC 100599
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Location: 2,867,472 - 2,916,558 nt. (total: 49,087 nt).
This entry is originally from NCBI GenBank AP008955.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000452
Short description tyrocidine biosynthetic gene cluster from Brevibacillus brevis NBRC 100599
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AP008955.1
Compounds
  • tyrocidine
Species Brevibacillus brevis NBRC 100599 [taxonomy]
References
Chemical products information
tyrocidine
Copy SMILES
C66H87N13O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBR47_27790
  • BAH43756.1
 2867472 - 2869136 (+) hypothetical protein
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  • BBR47_27800
  • BAH43757.1
 2869274 - 2869480 (+) putative truncated ABC transporter ATP-binding protein
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  • BBR47_27810
  • BAH43758.1
 2869578 - 2870147 (+) putative truncated ABC transporter ATP-binding protein
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  • BBR47_27820
  • BAH43759.1
  • tyrS
 2870409 - 2871677 (+) tyrosyl-tRNA synthetase
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  • BBR47_27830
  • BAH43760.1
 2871742 - 2873856 (-) hypothetical protein
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  • BBR47_27840
  • BAH43761.1
 2873934 - 2874299 (+) putative transcriptional regulator
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  • BBR47_27850
  • BAH43762.1
 2874303 - 2875493 (+) conserved hypothetical membrane protein
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  • BBR47_27860
  • BAH43763.1
 2875714 - 2875821 (+) hypothetical protein
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  • BBR47_27870
  • BAH43764.1
  • tycA
 2876081 - 2879359 (+) tyrocidine synthetase I
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  • BBR47_27880
  • BAH43765.1
  • tycB
 2879454 - 2890223 (+) tyrocidine synthetase II
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  • BBR47_27890
  • BAH43766.1
  • tycC
 2890329 - 2909792 (+) tyrocidine synthetase III
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  • BBR47_27900
  • BAH43767.1
  • tycD
 2909876 - 2911657 (+) ABC transporter ATP binding/permease protein
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  • BBR47_27910
  • BAH43768.1
  • tycE
 2911708 - 2913459 (+) ABC transporter ATP-binding/permease protein
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  • BBR47_27920
  • BAH43769.1
 2913456 - 2914148 (+) probable 4'-phosphopantetheinyl transferase
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  • BBR47_27930
  • BAH43770.1
  • tycF
 2914194 - 2914922 (+) putative type II thioesterase
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  • BBR47_27940
  • BAH43771.1
 2914975 - 2916558 (+) conserved hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
tycA
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
tycB
Module ?
Specificity: proline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
tycC
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: asparagine
Evidence for specificity:
Module ?
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: glutamine
Evidence for specificity:
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
Module ?
Specificity: ornithine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: ornithine
Evidence for specificity:
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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