BGC0000453: valinomycin biosynthetic gene cluster from Streptomyces tsusimaensis
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Location: 1 - 39,345 nt. (total: 39,345 nt).
This entry is originally from NCBI GenBank DQ174261.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000453
Short description valinomycin biosynthetic gene cluster from Streptomyces tsusimaensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: DQ174261.1
Compounds
  • valinomycin
Species Streptomyces tsusimaensis [taxonomy]
References
Chemical products information
valinomycin
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C54H90N6O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABA59532.1
 1 - 949 (-) putative conserved protein
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  • ABA59533.1
 1366 - 2244 (+) putative conserved protein
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  • ABA59534.1
 2789 - 3520 (-) TetR-family regulatory protein
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  • ABA59535.1
 3781 - 4410 (+) unknown
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  • ABA59536.1
 4427 - 5272 (+) N5,N10-methylenetetrahydromethanopterin reductase
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  • ABA59537.1
 5475 - 6959 (+) penicillin-binding protein
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  • ABA59538.1
 7184 - 8311 (+) putative conserved protein
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  • ABA59539.1
 8509 - 11103 (+) 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
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  • ABA59540.1
 11670 - 13808 (-) putative conserved protein
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  • ABA59541.1
 13860 - 14288 (-) putative conserved protein
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  • ABA59542.1
 14516 - 15310 (+) necrosis inducing factor
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  • ABA59543.1
 15380 - 15877 (+) conserved membrane-associated protein
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  • ABA59544.1
 15877 - 16086 (+) transcriptional regulator
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  • ABA59545.1
 16138 - 18186 (-) putative conserved protein
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  • ABA59546.1
 18814 - 19548 (+) discrete type II thioesterase
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  • ABA59547.1
  • vlm1
 19526 - 29812 (+) NRPS
  • Scaffold biosynthesis
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  • ABA59548.1
  • vlm2
 29835 - 37802 (+) NRPS
  • Scaffold biosynthesis
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  • ABA59549.1
 37938 - 39266 (+) putative transposase
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
NRP-synthases
Gene Modules
vlm1
Module ?
Specificity: 2-ketoisovaleric acid
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
vlm2
Module ?
Specificity: pyruvic acid
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: DUUOEWRWRZA5NTLPQCYGT6Z6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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