BGC0000453: valinomycin biosynthetic gene cluster from Streptomyces tsusimaensis
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Location: 1 - 39,345 nt. (total: 39,345 nt).
This entry is originally from NCBI GenBank DQ174261.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000453
Short description valinomycin biosynthetic gene cluster from Streptomyces tsusimaensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
DQ174261.1
via Knock-out studies
Compounds
  • valinomycin
Species Streptomyces tsusimaensis [taxonomy]
References
Chemical products information
valinomycin Evidence:
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C54H90N6O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABA59532.1
 1 - 949 (-) putative conserved protein
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    • ABA59533.1
    		 1366 - 2244 (+) putative conserved protein
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      • ABA59534.1
      		 2789 - 3520 (-) TetR-family regulatory protein
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        • ABA59535.1
        		 3781 - 4410 (+) unknown
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          • ABA59536.1
          		 4427 - 5272 (+) N5,N10-methylenetetrahydromethanopterin reductase
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            • ABA59537.1
            		 5475 - 6959 (+) penicillin-binding protein
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              • ABA59538.1
              		 7184 - 8311 (+) putative conserved protein
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                • ABA59539.1
                		 8509 - 11103 (+) 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
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                  • ABA59540.1
                  		 11670 - 13808 (-) putative conserved protein
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                    • ABA59541.1
                    		 13860 - 14288 (-) putative conserved protein
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                      • ABA59542.1
                      		 14516 - 15310 (+) necrosis inducing factor
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                        • ABA59543.1
                        		 15380 - 15877 (+) conserved membrane-associated protein
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                          • ABA59544.1
                          		 15877 - 16086 (+) transcriptional regulator
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                            • ABA59545.1
                            		 16138 - 18186 (-) putative conserved protein
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                              • ABA59546.1
                              		 18814 - 19548 (+) discrete type II thioesterase
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                                • ABA59547.1
                                • vlm1
                                		 19526 - 29812 (+) NRPS
                                • Scaffold biosynthesis
                                • Knock-out
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                                • ABA59548.1
                                • vlm2
                                		 29835 - 37802 (+) NRPS
                                • Scaffold biosynthesis
                                • Knock-out
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                                • ABA59549.1
                                		 37938 - 39266 (+) putative transposase
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  vlm1
                                  Substrates
                                  2-ketoisovaleric acid (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  vlm1
                                  Substrates
                                  valine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  vlm2
                                  Substrates
                                  pyruvic acid (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: DUUOEWRWRZA5NTLPQCYGT6Z6)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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