Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000453.1:
Cluster 1NRP139345

BGC0000453, valinomycin biosynthetic gene cluster from Streptomyces tsusimaensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Valinomycin
SMILES string: Copy to clipboard
Molecular formula: C54H90N6O18
Exact molecular mass: 1111.5 Da (None)
Molecular activity: Antibacterial, Antifungal, Cytotoxic, Other

Class-specific details

Biosynthetic class(es):
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type II
Release / cyclization type:

Gene cluster description

valinomycin (BGC0000453). Gene Cluster 1. Biosynthetic class = NRP. GenBank DQ174261, positions 14516-37802. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Yi-Qiang Cheng (University of North Texas Health Science Center)

Literature references

1. Cheng YQ. (2006) Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141. Chembiochem 7(3):471-7. doi: 10.1002/cbic.200500425.