BGC0000454: vanchrobactin biosynthetic gene cluster from Vibrio anguillarum RV22
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Location: 1 - 19,890 nt. (total: 19,890 nt).
This entry is originally from NCBI GenBank AM168450.2.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000454
Short description vanchrobactin biosynthetic gene cluster from Vibrio anguillarum RV22
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM168450.2
via
Compounds
  • vanchrobactin
Species Vibrio anguillarum RV22 [taxonomy]
References
Chemical products information
vanchrobactin Evidence:
Copy SMILES
C16H23N5O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ45633.1
  • dahP
 25 - 942 (+) DAHP synthetase
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    • CAJ45634.1
    • vabA
    		 1002 - 1778 (-) 2,3-dihydroxybenzoate-2,3-dehydrogenase
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      • CAJ45635.1
      • vabC
      		 1961 - 3142 (+) isochorismate synthase
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        • CAJ45636.1
        • vabE
        		 3152 - 4777 (+) 2,3-dihydroxybenzoate-AMP ligase
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          • CAJ45637.1
          • vabB
          		 4954 - 5814 (-) 2,3-dihydro-2,3-dihydroxybenzoate synthetase
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            • CAJ45638.1
            • vabS
            		 6078 - 7391 (-) putative siderophore exporter
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              • CAJ45639.1
              • vabF
              		 7494 - 16001 (-) vanchrobactin non ribosomal peptide synthetase
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                • CAL44982.1
                • mbtH
                		 16083 - 16277 (-) MbtH protein
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                  • CAJ45640.1
                  • vabH
                  		 16299 - 17504 (-) putative vanchrobactin esterase
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                    • CAL44983.1
                    • fvtA
                    		 17803 - 19884 (+) putative vanchrobactin receptor
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      vabE
                      Substrates
                      2,3-dihydroxybenzoic acid (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      vabF
                      Substrates
                      arginine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      vabF
                      Substrates
                      serine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
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                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
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                      Detailed domain annotation
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