BGC0000455: vancomycin biosynthetic gene cluster from Amycolatopsis orientalis HCCB10007
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Location: 1 - 65,044 nt. (total: 65,044 nt).
This entry is originally from NCBI GenBank HQ679900.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000455
Short description vancomycin biosynthetic gene cluster from Amycolatopsis orientalis HCCB10007
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: HQ679900.1
Compounds
  • vancomycin
Species Amycolatopsis orientalis HCCB10007 [taxonomy]
References
Chemical products information
vancomycin
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C66H75Cl2N9O24
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEI58859.1
  • vanH
 1 - 1032 (+) D-lactate dehydrogenase
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  • AEI58860.1
  • vanA
 1034 - 2080 (+) D-alanyl-D-alanine ligase
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  • AEI58861.1
  • vanX
 2070 - 2678 (+) D-alanyl-D-alanine dipeptidase
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  • AEI58862.1
  • vtrR
 3664 - 4638 (+) StrR family transcriptional regulator
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  • AEI58863.1
  • vcm1
 4784 - 5635 (+) prephenate dehydrogenase
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  • AEI58864.1
 5595 - 7733 (+) ABC transporter
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  • AEI58865.1
  • vcm2
 7730 - 17188 (+) peptide synthetase
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  • AEI58866.1
  • vcm3
 17541 - 29693 (+) peptide synthetase
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  • AEI58867.1
  • vcm4
 29714 - 35290 (+) peptide synthetase
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  • AEI58868.1
  • vcm5
 35584 - 36759 (+) p450 monooxygenase
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  • AEI58869.1
  • vcm6
 37090 - 38313 (+) p450 monooxygenase
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  • AEI58870.1
  • vcm7
 38440 - 39660 (+) p450 monooxygenase
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  • AEI58871.1
  • vcm8
 39705 - 41180 (+) halogenase
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  • AEI58872.1
  • vcm9
 41236 - 42462 (+) glycosyltransferase
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  • AEI58873.1
  • vcm10
 42515 - 43741 (+) glycosyltransferase
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  • AEI58874.1
  • vcm11
 43767 - 44993 (+) C-3 methyl transferanse
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  • AEI58875.1
 44999 - 45820 (+) hypothetical protein
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  • AEI58876.1
  • vcm12
 45860 - 46702 (+) N-3 methyltransferase
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  • AEI58877.1
  • vcm13
 46683 - 47987 (-) phenylglycine amino transferase
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  • AEI58878.1
  • vcm14
 48218 - 49048 (+) hydrolase
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  • AEI58879.1
  • vcm15
 49099 - 50781 (+) peptide synthetase
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  • AEI58880.1
  • vcm16
 50795 - 51985 (+) p450 monooxygenase
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  • AEI58881.1
  • vcm17
 52104 - 53138 (+) hydrooxyphenyl pyruvate dioxygenase
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  • AEI58882.1
  • vcm18
 53135 - 54214 (+) phenylglycolate oxidase
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  • AEI58883.1
 54431 - 55618 (+) putative antiporter
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  • AEI58884.1
  • vcm19
 55798 - 57204 (+) NDP-hexose 2,3-dehydrolase
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  • AEI58885.1
  • vcm20
 57205 - 58176 (+) 4-ketoreductase
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  • AEI58886.1
  • vcm21
 58173 - 59282 (+) C-3 amino transferase
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  • AEI58887.1
  • vcm22
 59306 - 59923 (+) epimerase
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  • AEI58888.1
  • vcm23
 60011 - 61129 (+) dihydrophenylactic synthase
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  • AEI58889.1
  • vcm24
 61156 - 61785 (+) enoyl-CoA hydratase
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  • AEI58890.1
  • vcm25
 61782 - 63008 (+) hydroxyacyl-dehydrogenase
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  • AEI58891.1
  • vcm26
 63005 - 63796 (+) enoyl-CoA hydratase
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  • AEI58892.1
 63968 - 65044 (+) putative aldolase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
vcm2
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
vcm3
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
vcm4
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
vcm15
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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