BGC0000455: vancomycin biosynthetic gene cluster from Amycolatopsis orientalis HCCB10007 (ATCC43491)
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Location: 1 - 65,044 nt. (total: 65,044 nt).
This entry is originally from NCBI GenBank HQ679900.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000455
Short description vancomycin biosynthetic gene cluster from Amycolatopsis orientalis HCCB10007 (ATCC43491)
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
  • NRPS (Type I)
Loci
HQ679900.1
1 - 65044
via Knock-out studies
Compounds
  • vancomycin
Species Amycolatopsis orientalis HCCB10007 (ATCC43491) [taxonomy]
References
Chemical products information
vancomycin Evidence: NMR [1]
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C66H75Cl2N9O24
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEI58859.1
  • vanH
 1 - 1032 (+) D-lactate dehydrogenase
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    • AEI58860.1
    • vanA
    		 1034 - 2080 (+) D-alanyl-D-alanine ligase
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      • AEI58861.1
      • vanX
      		 2070 - 2678 (+) D-alanyl-D-alanine dipeptidase
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        • AEI58862.1
        • vtrR
        		 3664 - 4638 (+) StrR family transcriptional regulator
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          • AEI58863.1
          • vcm1
          		 4784 - 5635 (+) prephenate dehydrogenase
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            • AEI58864.1
            		 5595 - 7733 (+) ABC transporter
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              • AEI58865.1
              • vcm2
              		 7730 - 17188 (+) peptide synthetase
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                • AEI58866.1
                • vcm3
                		 17541 - 29693 (+) peptide synthetase
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                  • AEI58867.1
                  • vcm4
                  		 29714 - 35290 (+) peptide synthetase
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                    • AEI58868.1
                    • vcm5
                    		 35584 - 36759 (+) p450 monooxygenase
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                      • AEI58869.1
                      • vcm6
                      		 37090 - 38313 (+) p450 monooxygenase
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                        • AEI58870.1
                        • vcm7
                        		 38440 - 39660 (+) p450 monooxygenase
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                          • AEI58871.1
                          • vcm8
                          		 39705 - 41180 (+) halogenase
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                            • AEI58872.1
                            • vcm9
                            		 41236 - 42462 (+) glycosyltransferase
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                              • AEI58873.1
                              • vcm10
                              		 42515 - 43741 (+) glycosyltransferase
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                                • AEI58874.1
                                • vcm11
                                		 43767 - 44993 (+) C-3 methyl transferanse
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                                  • AEI58875.1
                                  		 44999 - 45820 (+) hypothetical protein
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                                    • AEI58876.1
                                    • vcm12
                                    		 45860 - 46702 (+) N-3 methyltransferase
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                                      • AEI58877.1
                                      • vcm13
                                      		 46683 - 47987 (-) phenylglycine amino transferase
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                                        • AEI58878.1
                                        • vcm14
                                        		 48218 - 49048 (+) hydrolase
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                                          • AEI58879.1
                                          • vcm15
                                          		 49099 - 50781 (+) peptide synthetase
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                                            • AEI58880.1
                                            • vcm16
                                            		 50795 - 51985 (+) p450 monooxygenase
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                                              • AEI58881.1
                                              • vcm17
                                              		 52104 - 53138 (+) hydrooxyphenyl pyruvate dioxygenase
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                                                • AEI58882.1
                                                • vcm18
                                                		 53135 - 54214 (+) phenylglycolate oxidase
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                                                  • AEI58883.1
                                                  		 54431 - 55618 (+) putative antiporter
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                                                    • AEI58884.1
                                                    • vcm19
                                                    		 55798 - 57204 (+) NDP-hexose 2,3-dehydrolase
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                                                      • AEI58885.1
                                                      • vcm20
                                                      		 57205 - 58176 (+) 4-ketoreductase
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                                                        • AEI58886.1
                                                        • vcm21
                                                        		 58173 - 59282 (+) C-3 amino transferase
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                                                          • AEI58887.1
                                                          • vcm22
                                                          		 59306 - 59923 (+) epimerase
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                                                            • AEI58888.1
                                                            • vcm23
                                                            		 60011 - 61129 (+) dihydrophenylactic synthase
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                                                              • AEI58889.1
                                                              • vcm24
                                                              		 61156 - 61785 (+) enoyl-CoA hydratase
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                                                                • AEI58890.1
                                                                • vcm25
                                                                		 61782 - 63008 (+) hydroxyacyl-dehydrogenase
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                                                                  • AEI58891.1
                                                                  • vcm26
                                                                  		 63005 - 63796 (+) enoyl-CoA hydratase
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                                                                    • AEI58892.1
                                                                    		 63968 - 65044 (+) putative aldolase
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                                                                      Biosynthesis information

                                                                      Biosynthetic modules

                                                                      Name
                                                                      Unk01
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm2
                                                                      Substrates
                                                                      leucine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk02
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm2
                                                                      Substrates
                                                                      R-beta-hydroxytyrosine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk03
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm2
                                                                      Substrates
                                                                      asparagine (evidence: Structure-based inference)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk04
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm3
                                                                      Substrates
                                                                      4-hydroxyphenylglycine (evidence: Structure-based inference)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk05
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm3
                                                                      Substrates
                                                                      4-hydroxyphenylglycine (evidence: Structure-based inference)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk06
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm3
                                                                      Substrates
                                                                      R-beta-hydroxytyrosine (evidence: Structure-based inference)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk07
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm4
                                                                      Substrates
                                                                      3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk08
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      vcm15
                                                                      Substrates
                                                                      tyrosine (evidence: Homology)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Annotation changelog

                                                                      Entry version: next

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2024-06-14
                                                                      MIBiG v4 annotathon
                                                                      • (ID: 37IOAS4X5OHP34DPN55OLFBF)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: next

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2023-10-24
                                                                      Added 'Saccharide' as additional biosynthetic class. Specified BGC evidence according to 'pubmed:24884615'. Added strain information.
                                                                      • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                                                      • (ID: 25OPJFS6AQU3ROUADEVDYF5E)

                                                                      Entry version: 4

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Update chemical activity to schema version 2.11
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 3

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Updated bioactivity data
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-09-15
                                                                      Added NRP substrate specificities
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2019-10-16
                                                                      Migrated from v1.4
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2015-06-12
                                                                      Submitted
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      Detailed domain annotation
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