BGC0000459: griseoviridin biosynthetic gene cluster from Streptomyces griseoviridis
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Location: 1 - 123,563 nt. (total: 123,563 nt).
This entry is originally from NCBI GenBank JX508597.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000459
Short description griseoviridin biosynthetic gene cluster from Streptomyces griseoviridis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "VG is synthesised by the NRPS within this cluster whereas GV is hybrid PK-NRP and as such utilises the PKS machinery also."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
JX508597.1
13530 - 118200
via Knock-out studies
Compounds
  • griseoviridin
  • fijimycin A
Species Streptomyces griseoviridis [taxonomy]
References
Chemical products information
griseoviridin [synonyms: pristinamycin IIA, virginiamycin m] Evidence: NMR [2]
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C22H27N3O7S1
Chemical database entries
NPAtlas
fijimycin A Evidence: MS/MS [3]
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C44H62N8O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGN74872.1
 13530 - 14696 (+) SARP-type regulator
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    • AGN74873.1
    		 14816 - 16408 (-) major facilitator transporter
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      • AGN74874.1
      		 16726 - 17847 (-) branched-chain amino acid aminotransferase
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        • AGN74875.1
        		 17916 - 18935 (-) methyltransferase
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          • AGN74876.1
          		 19073 - 26989 (-) nonribosomal peptide synthetase
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            • AGN74877.1
            		 27311 - 28057 (+) type ii thioestrerase
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              • AGN74878.1
              		 28052 - 29134 (-) flavin-dependent oxidoreductase
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                • AGN74879.1
                		 29368 - 29613 (-) hypothetical protein
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                  • AGN74880.1
                  		 29782 - 31404 (+) 3-hydroxypicolinic acid:AMP ligase
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                    • AGN74881.1
                    		 31408 - 32709 (+) L-lysine 2-aminotransferase
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                      • AGN74882.1
                      		 32763 - 32951 (+) 4-oxalocrotonate tautomerase
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                        • AGN74883.1
                        		 33036 - 34343 (-) phenylacetyl-CoA dioxygenase
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                          • AGN74884.1
                          		 34358 - 34609 (-) MbtH domain-containing protein
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                            • AGN74885.1
                            		 34683 - 51854 (-) nonribosomal peptide synthetase
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                              • AGN74886.1
                              		 51851 - 56554 (-) nonribosomal peptide synthetase
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                                • AGN74887.1
                                		 57108 - 58265 (+) branched-chain alpha-keto acid dehydrogenase E1 subunit alpha
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                                  • AGN74888.1
                                  		 58262 - 59317 (+) branched-chain alpha-keto acid dehydrogenase E1 subunit beta
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                                    • AGN74889.1
                                    		 59323 - 60720 (+) branched-chain alpha-keto acid dehydrogenase E2
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                                      • AGN74890.1
                                      		 60959 - 62614 (+) ABC transporter
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                                        • AGN74891.1
                                        		 62773 - 63963 (-) Heterocyclase
                                        • Heterocyclization
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                                        • AGN74892.1
                                        		 64158 - 77825 (+) nonribosomal peptide synthetase/polyketide synthase hybrid protein
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                                          • AGN74893.1
                                          		 77828 - 84568 (+) nonribosomal peptide synthetase/polyketide synthase hybrid protein
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                                            • AGN74894.1
                                            		 84740 - 91246 (+) nonribosomal peptide synthetase/polyketide synthase hybrid protein
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                                              • AGN74895.1
                                              		 91257 - 99092 (+) nonribosomal peptide synthetase/polyketide synthase hybrid protein
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                                                • AGN74896.1
                                                		 99089 - 104953 (+) nonribosomal peptide synthetase/polyketide synthase hybrid protein
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                                                  • AGN74897.1
                                                  		 104950 - 105900 (+) acyltransferase
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                                                    • AGN74898.1
                                                    		 105894 - 108320 (+) nonribosomal peptide synthetase
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                                                      • AGN74899.1
                                                      		 108570 - 109964 (+) EmrB/QacA subfamily drug resistance transporter
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                                                        • AGN74900.1
                                                        		 109996 - 110889 (-) streptogramin B lyase
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                                                          • AGN74901.1
                                                          		 111137 - 112285 (-) sarcosine oxidase
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                                                            • AGN74902.1
                                                            		 112395 - 113237 (-) SARP-type regulator
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                                                              • AGN74903.1
                                                              		 113627 - 114274 (-) TetR-type regulator
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                                                                • AGN74904.1
                                                                		 114756 - 115520 (+) ketoreductase
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                                                                  • AGN74905.1
                                                                  		 115710 - 116678 (+) AfsA-like gamma-butyrolactone biosynthetic protein
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                                                                    • AGN74906.1
                                                                    		 116703 - 117386 (-) gamma-butyrolactone receptor
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                                                                      • AGN74907.1
                                                                      		 117511 - 118200 (-) phosphatase
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                                                                        Biosynthesis information

                                                                        Biosynthetic modules

                                                                        Name
                                                                        0
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74880.1
                                                                        Substrates
                                                                        3-hydroxypicolinic acid (evidence: Sequence-based prediction)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        adenylation
                                                                        Name
                                                                        1
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74876.1
                                                                        Substrates
                                                                        threonine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (LCL), adenylation
                                                                        Name
                                                                        2
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74876.1
                                                                        Substrates
                                                                        leucine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (LCL), adenylation, epimerase
                                                                        Name
                                                                        A3
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74886.1
                                                                        Substrates
                                                                        4R-hydroxyproline (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (DCL), adenylation, epimerase
                                                                        Name
                                                                        4
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74885.1
                                                                        Substrates
                                                                        glycine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (DCL), adenylation, methyltransferase
                                                                        Name
                                                                        5
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74885.1
                                                                        Substrates
                                                                        3-methylleucine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (LCL), adenylation, methyltransferase
                                                                        Name
                                                                        6
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74885.1
                                                                        Substrates
                                                                        alanine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (LCL), adenylation
                                                                        Name
                                                                        A7
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74885.1
                                                                        Substrates
                                                                        phenylglycine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (LCL), adenylation, methyltransferase
                                                                        Name
                                                                        B3
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74892.1
                                                                        Substrates
                                                                        glycine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation, adenylation
                                                                        Name
                                                                        B7
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74895.1
                                                                        Substrates
                                                                        serine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        adenylation
                                                                        Name
                                                                        B9
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        AGN74898.1
                                                                        Substrates
                                                                        cysteine (evidence: Structure-based inference)
                                                                        Integrated Monomers
                                                                        Domains
                                                                        adenylation
                                                                        Name
                                                                        B1
                                                                        Type
                                                                        pks-trans-at
                                                                        Genes
                                                                        AGN74892.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        ketosynthase, ketoreductase, carrier (ACP)
                                                                        Name
                                                                        B2
                                                                        Type
                                                                        pks-trans-at
                                                                        Genes
                                                                        AGN74892.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                                        Name
                                                                        B4
                                                                        Type
                                                                        pks-trans-at
                                                                        Genes
                                                                        AGN74893.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                                        Name
                                                                        B5
                                                                        Type
                                                                        pks-trans-at
                                                                        Genes
                                                                        AGN74894.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        ketosynthase, ketoreductase, carrier (ACP)
                                                                        Name
                                                                        B6
                                                                        Type
                                                                        pks-trans-at
                                                                        Genes
                                                                        AGN74894.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        ketosynthase, carrier (ACP)
                                                                        Name
                                                                        B8
                                                                        Type
                                                                        pks-trans-at
                                                                        Genes
                                                                        AGN74895.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        ketosynthase, carrier (ACP)
                                                                        Name
                                                                        0
                                                                        Type
                                                                        pks-trans-at-starter
                                                                        Genes
                                                                        AGN74892.1
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        carrier (ACP)
                                                                        Annotation changelog

                                                                        Entry version: 5

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2024-05-14
                                                                        MIBiG v4 annotathon
                                                                        • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                                        • (ID: 4ZBJCWV5NZUBDJXCSIV4TKIA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 4

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-10-07
                                                                        Update chemical activity to schema version 2.11
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 3

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-09-15
                                                                        Corrected NRP module activity
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Sorted modules by module number
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Corrected gene identifiers
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Updated bioactivity data
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Updated NRP substrate specificities
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 2

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2019-10-16
                                                                        Migrated from v1.4
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2019-10-16
                                                                        Updated compound(s) information (NPAtlas curation)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 1

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2015-06-12
                                                                        Submitted
                                                                        • (ID: AADADFAEMFE2AOMR24EUYNFH)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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