BGC0000460: vulnibactin biosynthetic gene cluster from Vibrio vulnificus CMCP6
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 890,623 - 914,333 nt. (total: 23,711 nt).
This entry is originally from NCBI GenBank AE016796.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000460
Short description vulnibactin biosynthetic gene cluster from Vibrio vulnificus CMCP6
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AE016796.2
890623 - 914333
via
Compounds
  • vulnibactin
Species Vibrio vulnificus CMCP6 [taxonomy]
References
Chemical products information
vulnibactin Evidence:
Copy SMILES
C35H39N5O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • VV2_0828
  • AAO07752.1
 890623 - 890961 (+) hypothetical protein
    copy AA seq
    copy Nt seq
    • VV2_0829
    • AAO07753.1
    		 891012 - 891707 (-) Phosphopantetheinyl transferase component of siderophore synthetase
      copy AA seq
      copy Nt seq
      • VV2_0830
      • AAO07754.1
      		 891712 - 894780 (-) Non-ribosomal peptide synthetase module, siderophore biosynthesis vulnibactin-specific
        copy AA seq
        copy Nt seq
        • VV2_0831
        • AAO07755.1
        		 894850 - 899412 (-) Non-ribosomal peptide synthetase module, siderophore biosynthesis vulnibactin-specific
          copy AA seq
          copy Nt seq
          • VV2_0833
          • AAO07756.1
          		 899638 - 900708 (+) 3-deoxy-7-phosphoheptulonate synthase
            copy AA seq
            copy Nt seq
            • VV2_0834
            • AAO07757.1
            		 900940 - 901728 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
              copy AA seq
              copy Nt seq
              • VV2_0835
              • AAO07758.1
              		 902100 - 903281 (+) Isochorismate synthase
                copy AA seq
                copy Nt seq
                • VV2_0836
                • AAO07759.1
                		 903291 - 904928 (+) 2,3-dihydroxybenzoate-AMP ligase
                  copy AA seq
                  copy Nt seq
                  • VV2_0837
                  • AAO07760.1
                  		 905047 - 905862 (-) Vulnibactin utilization protein VuuB
                    copy AA seq
                    copy Nt seq
                    • VV2_0838
                    • AAO07761.1
                    		 905926 - 906813 (-) Isochorismatase
                      copy AA seq
                      copy Nt seq
                      • VV2_0839
                      • AAO07762.1
                      		 906916 - 907245 (-) Isochorismate pyruvate-lyase of siderophore biosynthesis Vulnibactin-specific
                        copy AA seq
                        copy Nt seq
                        • VV2_0840
                        • AAO07763.1
                        		 907474 - 909102 (-) 2,3-dihydroxybenzoate-AMP ligase
                          copy AA seq
                          copy Nt seq
                          • VV2_0841
                          • AAO07764.1
                          		 909328 - 909570 (+) Aryl carrier domain protein
                            copy AA seq
                            copy Nt seq
                            • VV2_0842
                            • AAO07765.2
                            		 909626 - 910534 (+) ABC-type enterochelin transport system, periplasmic component
                              copy AA seq
                              copy Nt seq
                              • VV2_0843
                              • AAO07766.1
                              		 910619 - 912676 (-) Ferric vulnibactin receptor VuuA
                                copy AA seq
                                copy Nt seq
                                • VV2_0844
                                • AAO07767.2
                                		 913017 - 914333 (-) Amide synthase component of siderophore synthetase Vulnibactin-specific
                                  copy AA seq
                                  copy Nt seq
                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  VV2_0836
                                  Substrates
                                  salicylic acid, 2,3-dihydroxybenzoic acid (evidence: Structure-based inference, ATP-PPi exchange assay, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  VV2_0840
                                  Substrates
                                  2,3-dihydroxybenzoic acid, salicylic acid (evidence: Structure-based inference, ATP-PPi exchange assay, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                  Selected features only
                                  Show module domains
                                  Similar known gene clusters from MIBiG 4.0
                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                  Click on reference genes to show details of similarities to genes within the current region.
                                  Click on an accession to open that entry in the MiBIG database.