BGC0000461: WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes
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Location: 1 - 63,720 nt. (total: 63,720 nt).
This entry is originally from NCBI GenBank JN596952.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000461
Short description WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JN596952.1
via
Compounds
  • WAP-8294A2
Species Lysobacter enzymogenes [taxonomy]
References
Chemical products information
WAP-8294A2 Evidence:
Copy SMILES
C73H111N17O21
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEP18654.1
 466 - 684 (-) MbtH-like protein
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    • AEP18655.1
    		 784 - 22974 (-) WAPS2
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      • AEP18656.1
      		 22955 - 50851 (-) WAPS1
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        • AEP18657.1
        		 50987 - 51958 (-) taurine catabolism dioxygenase
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          • AEP18658.1
          		 52154 - 53974 (-) efflux transporter
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            • AEP18659.1
            		 54663 - 56360 (-) pectin lyase fold/virulence factor
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              • AEP18660.1
              		 57001 - 58227 (+) lytic endopeptidase preproenzyme
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                • AEP18661.1
                		 58657 - 61752 (+) TonB-dependent receptor
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                  • AEP18662.1
                  		 61886 - 62659 (+) SapC-related protein
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                    • AEP18663.1
                    		 62643 - 63653 (+) Pass1-related protein
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      AEP18655.1
                      Substrates
                      glutamic acid (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      AEP18655.1
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      AEP18655.1
                      Substrates
                      tryptophan (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      AEP18655.1
                      Substrates
                      ornithine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      AEP18655.1
                      Substrates
                      valine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      serine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk07
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      3R-hydroxyasparagine, asparagine (evidence: Structure-based inference, Knock-out studies)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk08
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      serine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk09
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      glycine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk10
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      phenylalanine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk11
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      leucine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk12
                      Type
                      nrps-type1
                      Genes
                      AEP18656.1
                      Substrates
                      ornithine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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