Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000463.1:
Cluster 1NRP143207

BGC0000463, xantholysin biosynthetic gene cluster from Pseudomonas putida. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: xantholysin A
SMILES string: Copy to clipboard
Molecular formula: C84H146N18O23
Exact molecular mass: 1775.0764 Da (None)
Molecular activity: Antibacterial, Antifungal

Class-specific details

Biosynthetic class(es):
NRP
Nonribosomal peptide subclass:
Other lipopeptide (cyclic)
3-hydroxydecanoic acid (xantholysin A, xantholysin B); 3-hydroxydodec-5-enoate (xantholysin C)
Thioesterase type:
Type II
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
xtlA (AGM14925.1)
Module 1
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Starter
Module 2
A specificity: Glutamate
Evidence for specificity: Structure-based inference
C domain subtype: Dual
xtlB (AGM14933.1)
Module 10
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 3
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 4
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 5
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 6
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 7
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 8
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 9
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
xtlC (AGM14934.1)
Module 11
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 12
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 13
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 14
A specificity: Isoleucine; Valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual

Gene cluster description

xantholysin (BGC0000463). Gene Cluster 1. Biosynthetic class = NRP. GenBank KC297506, positions 4624-47830. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Comments:Xantholysin A as main product. Additional minor products of which two congeners identified as xantholysin B and xantholysin C.
Contact for this cluster:Rene De Mot (University of Leuven (KU Leuven))

Literature references

1. Li W et al. (2013 TI) The antimicrobial compound xantholysin defines a new group of Pseudomonas cyclic lipopeptides. PLoS One 8(5):e62946. doi: 10.1371/journal.pone.0062946. Print 2013.