BGC0000464: xenoamicin A biosynthetic gene cluster from Xenorhabdus doucetiae
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Location: 2,329,335 - 2,435,321 nt. (total: 105,987 nt).
This entry is originally from NCBI GenBank FO704550.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000464
Short description xenoamicin A biosynthetic gene cluster from Xenorhabdus doucetiae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FO704550.1
2329335 - 2435321
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • xenoamicin A
  • xenoamicin B
Species Xenorhabdus doucetiae [taxonomy]
References
Chemical products information
xenoamicin A Evidence:
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C64H109N13O15
xenoamicin B Evidence:
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C65H111N13O15
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XDD1_2270
  • CDG17969.1
 2329335 - 2329775 (-) conserved exported protein of unknown function
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    • XDD1_2271
    • CDG17970.1
    		 2329772 - 2330617 (-) conserved protein of unknown function
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      • XDD1_2272
      • CDG17971.1
      		 2330620 - 2330739 (-) protein of unknown function
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        • XDD1_2273
        • CDG17972.1
        		 2330761 - 2331357 (-) putative haemolysin co-regulated protein (hcp-like)
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          • XDD1_2274
          • CDG17973.1
          • adiC
          		 2331600 - 2332928 (-) Arginine/agmatine antiporter
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            • XDD1_2275
            • CDG17974.1
            • adiA
            		 2332946 - 2335219 (-) Biodegradative arginine decarboxylase
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              • XDD1_2276
              • CDG17975.1
              		 2335560 - 2335682 (+) protein of unknown function
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                • XDD1_2277
                • CDG17976.1
                		 2335820 - 2336227 (-) conserved protein of unknown function
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                  • XDD1_2278
                  • CDG17977.1
                  		 2336273 - 2336629 (-) protein of unknown function
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                    • XDD1_2279
                    • CDG17978.1
                    • hol
                    		 2337055 - 2337372 (+) holin
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                      • XDD1_2280
                      • CDG17979.1
                      • V
                      		 2337369 - 2337764 (+) Protein P5
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                        • XDD1_2281
                        • CDG17980.1
                        		 2338091 - 2360989 (+) Putative Ornithine racemase (fragment)
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                          • XDD1_2282
                          • CDG17981.1
                          		 2360989 - 2367717 (+) Non-ribosomal peptide synthetase
                          • Scaffold biosynthesis
                          • Knock-out
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                          • XDD1_2283
                          • CDG17982.1
                          		 2367714 - 2382539 (+) Non-ribosomal peptide synthetase
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                            • XDD1_2284
                            • CDG17983.1
                            		 2382517 - 2384196 (+) Pyridoxal-dependent decarboxylase
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                              • XDD1_2285
                              • CDG17984.1
                              		 2384422 - 2384577 (-) protein of unknown function
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                                • XDD1_2286
                                • CDG17985.1
                                		 2384549 - 2406481 (+) Putative Ornithine racemase (fragment)
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                                  • XDD1_2287
                                  • CDG17986.1
                                  		 2406468 - 2413187 (+) Non-ribosomal peptide synthetase
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                                    • XDD1_2288
                                    • CDG17987.1
                                    		 2413184 - 2428066 (+) Putative Ornithine racemase (fragment)
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                                      • XDD1_2289
                                      • CDG17988.1
                                      		 2428102 - 2429754 (+) Pyridoxal-dependent decarboxylase
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                                        • XDD1_2290
                                        • CDG17989.1
                                        		 2429846 - 2430928 (-) conserved protein of unknown function
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                                          • XDD1_2291
                                          • CDG17990.1
                                          • frmA
                                          		 2431366 - 2432475 (+) S-(hydroxymethyl)glutathione dehydrogenase
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                                            • XDD1_2292
                                            • CDG17991.1
                                            		 2432604 - 2433416 (-) protein of unknown function
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                                              • XDD1_2293
                                              • CDG17992.1
                                              		 2433648 - 2435321 (+) ABC transporter ATP-binding protein
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                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Corrected NRP module activity
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: SCFYH7235HZBUM2XBV52IUHT)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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