Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000464.1:
Cluster 1NRP1105987

BGC0000464, xenoamicins biosynthetic gene cluster from Xenorhabdus doucetiae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Xenoamicin A
SMILES string: Copy to clipboard
Molecular formula: C64H109N13O15
Exact molecular mass: 1300.822 Da ([M+H]+)
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
NRP
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
XDD1_2281
Module 1
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
xabB (XDD1_2282)
Module 2
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: None
Module 3
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Module 4
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: Unknown
Module 5
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Module 6
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: Unknown
Module 7
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
XDD1_2283
Module 8
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: Unknown
Module 9
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
XDD1_2287
Module 10
A specificity: Unknown
Evidence for specificity: Unknown
AA is epimerized
C domain subtype: Unknown
Module 11
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Module 12
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Module 13
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown

Gene cluster description

xenoamicins (BGC0000464). Gene Cluster 1. Biosynthetic class = NRP. GenBank FO704550, positions 2329335-2435321. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Proven expression in natural host
MIxS-compliance:Unknown
Contact for this cluster:Helge Bode (Goethe Universitaet Frankfurt)

Literature references

1. Zhou Q et al. (2013) Structure and biosynthesis of xenoamicins from entomopathogenic Xenorhabdus. Chemistry 19(49):16772-9. doi: 10.1002/chem.201302481. Epub 2013 Nov