BGC0000465 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000465 (Xenorhabdus nematophila ATCC 19061)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	10,043	nematophin	NRPS:Type I	100%

BGC0000465 - Region 1 - NRPS

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Location: 1 - 10,043 nt. (total: 10,043 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,044
Label		BGC0000465

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000465	1.00	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000396	0.38	NRP	nodularin	Nostoc sp. 73.1
BGC0001434	0.34	NRP	nematophin	Xenorhabdus budapestensis
BGC0002071	0.32	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001834	0.31	NRP	argyrin	Cystobacter sp. SBCb004
BGC0000444	0.30	NRP	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0002089	0.28	NRP	thaxtomin D, thaxtomin A, thaxtomin C, thaxtomin B	Streptomyces scabiei 87.22
BGC0002713	0.27	NRP	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0001843	0.27	NRP	tridecaptin M	Paenibacillus sp. M-152
BGC0001806	0.26	NRP	tolaasin A	Pseudomonas tolaasii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000465	1.00	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000396	0.70	NRP	nodularin	Nostoc sp. 73.1
BGC0001434	0.67	NRP	nematophin	Xenorhabdus budapestensis
BGC0002071	0.66	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001834	0.64	NRP	argyrin	Cystobacter sp. SBCb004
BGC0000444	0.64	NRP	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0002089	0.62	NRP	thaxtomin D, thaxtomin A, thaxtomin C, thaxtomin B	Streptomyces scabiei 87.22
BGC0002713	0.61	NRP	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0001843	0.61	NRP	tridecaptin M	Paenibacillus sp. M-152
BGC0001806	0.60	NRP	tolaasin A	Pseudomonas tolaasii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 10043:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-X) + (NMe-Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XNC1_2299

Search NORINE for peptide: strict or relaxed

AMP-binding (554..949): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFTVAGVCK
Nearest Stachelhaus code(s):: Tyr DASTVAGVCK (79% 8Å match); Phe DAFTVAAVCK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

XNC1_2300

AMP-binding (334..729): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALLMGAVCK
Nearest Stachelhaus code(s):: Leu DAMLVGAVCK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)