BGC0000467 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000467 (Yersinia enterocolitica)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	13,629	yersiniabactin	NRPS:Type I	100%

BGC0000467 - Region 1 - T1PKS

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Location: 1 - 13,629 nt. (total: 13,629 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,630
Label		BGC0000467

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467	1.00	NRP	yersiniabactin	Yersinia enterocolitica
BGC0000343	0.27	NRP	enterobactin	Pseudomonas sp. J465
BGC0002493	0.26	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0001055	0.25	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0002474	0.23	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002476	0.21	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002570	0.21	NRP, Polyketide	yersiniabactin	Pseudomonas syringae pv. tomato str. DC3000
BGC0002715	0.20	NRP, Polyketide	HTTPCA, prepiscibactin, piscibactin	Photorhabdus laumondii subsp. laumondii
BGC0000393	0.19	NRP, Polyketide	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001444	0.18	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467	1.00	NRP	yersiniabactin	Yersinia enterocolitica
BGC0000343	0.60	NRP	enterobactin	Pseudomonas sp. J465
BGC0002493	0.60	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0001055	0.59	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0002474	0.56	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002476	0.54	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002570	0.53	NRP, Polyketide	yersiniabactin	Pseudomonas syringae pv. tomato str. DC3000
BGC0002715	0.53	NRP, Polyketide	HTTPCA, prepiscibactin, piscibactin	Photorhabdus laumondii subsp. laumondii
BGC0000393	0.51	NRP, Polyketide	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001444	0.50	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 13629:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

irp1

PKS_AT (552..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 129.4
Methoxymalonyl-CoA: 47.3
inactive: 45.3
Methylmalonyl-CoA: 41.0
Benzoyl-CoA: 38.6
Propionyl-CoA: 31.1
Isobutyryl-CoA: 26.0
fatty_acid: 21.7
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 19.5
3-Methylbutyryl-CoA: 15.6
CHC-CoA: 12.5
Ethylmalonyl-CoA: 4.3
trans-1,2-CPDA: 0.0

irp5

Search NORINE for peptide: strict or relaxed

AMP-binding (20..422): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLCK
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)