LOCUS       BGC0000467             13629 bp    DNA     linear   BCT 18-APR-2005
DEFINITION  Y.enterocolitica irp1, irp3, irp4 and irp5 genes.
ACCESSION   BGC0000467
VERSION     BGC0000467
KEYWORDS    .
SOURCE      Yersinia enterocolitica
  ORGANISM  Yersinia enterocolitica
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Yersiniaceae; Yersinia.
COMMENT     irp1 homologous to polyketide synthases
            (see M63677, L09654 & X86780)
            irp4 homologous to thioesterase from V.anguillarum (see P19829) &
            ybtT of Yersinia pestis (see U50364)
            irp5 homologous to E.coli enterobactin synthetase (see P10378) &
            ybtE of Y.pestis (see U50364).
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:36:34
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..13629
                     /db_xref="taxon:630"
                     /mol_type="genomic DNA"
                     /organism="Yersinia enterocolitica"
                     /serotype="08"
                     /strain="WA-314"
                     /sub_strain="WA-C"
     protocluster    1..13629
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[612:10098]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      613..10098
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..13629
                     /SMILES="C(C)C(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..13629
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000467"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13629
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            613..10098
                     /gene="irp1"
     CDS             613..10098
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (28-450). E-value:
                     6.3e-158. Score: 517.9. Matches aSDomain:
                     nrpspksdomains_irp1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (552-842). E-value: 4.6e-84.
                     Score: 274.1. Matches aSDomain:
                     nrpspksdomains_irp1_PKS_AT.1"
                     /NRPS_PKS="Domain: cMT (1054-1269). E-value: 3.6e-110.
                     Score: 360.1. Matches aSDomain: nrpspksdomains_irp1_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (1557-1728). E-value: 7.3e-40.
                     Score: 128.7. Matches aSDomain:
                     nrpspksdomains_irp1_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1819-1888). E-value: 2.8e-10.
                     Score: 32.2. Matches aSDomain: nrpspksdomains_irp1_ACP.1"
                     /NRPS_PKS="Domain: Heterocyclization (1910-2206). E-value:
                     1.6e-101. Score: 331.5. Matches aSDomain:
                     nrpspksdomains_irp1_Heterocyclization.1"
                     /NRPS_PKS="Domain: cMT (2552-2767). E-value: 3.1e-93.
                     Score: 304.2. Matches aSDomain: nrpspksdomains_irp1_cMT.2"
                     /NRPS_PKS="Domain: PCP (2827-2894). E-value: 9e-18. Score:
                     56.1. Matches aSDomain: nrpspksdomains_irp1_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (2912-3147). E-value:
                     3.7e-22. Score: 71.7. Matches aSDomain:
                     nrpspksdomains_irp1_Thioesterase.1"
                     /codon_start=1
                     /db_xref="GOA:O54511"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="InterPro:IPR001031"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR013217"
                     /db_xref="InterPro:IPR013624"
                     /db_xref="InterPro:IPR013968"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR018201"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="InterPro:IPR020842"
                     /db_xref="UniProtKB/TrEMBL:O54511"
                     /function="synthesis of siderophore yersiniabactin"
                     /gene="irp1"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     57.7; E-value: 2.1e-17)"
                     /gene_kind="biosynthetic"
                     /product="HMWP1 protein"
                     /protein_id="CAA73127.1"
                     /sec_met_domain="Condensation (E-value: 7.4e-46, bitscore:
                     144.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.9e-16, bitscore:
                     47.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.4e-85, bitscore: 274.1,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 9.2e-173, bitscore:
                     563.0, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.2e-39, bitscore:
                     123.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNLRFSSAPTADSIDASIAQHYPDCEPVAVIGYACHFPESPDGE
                     TFWQNLLEGRECSRRFTREELLAVGLDAAIIDDPHYVNIGTVLDNADCFDATLFGYSRQ
                     EAESMDPQQRLFLQAVWHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQV
                     KGLQSLMGNDKDYIATRAAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVA
                     GGVALSFPQQAGYRYQPGMIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLRDALLSGD
                     PIISVILSSAVNNDGNRKVGYTAPSVAGQQAVIEEALMLAAIDDRQVGYIETHGTGTPL
                     GDAIEIEALRNVYAPRPQDQRCALGSVKSNMGHLDTAAGIAGLLKTVLAVSRGQIPPLL
                     NFHTPNPALKLEESPFTIPVSAQAWQDEMRYAGVSSFGIGGTNCHMIVASLPDALNARL
                     PNTDSGRKSTALLLSAASDSALRRLATDYAGALRENTDASDLAFTALHARRLDLPFRLA
                     APLNRETAAALSDWAGEKSGALVYSGHGASGKQVWLFTGQGSHWRTMGQTMYQHSTAFA
                     DMLDRCFSACSEMLTPSLREAMFNPDSAQLDNMAWAQPAIVAFEIAMAAHWHAEGLKPD
                     FAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQ
                     FELDLAANNGTQHTVFSGPEARLAVFCTTLSQHNINYRRLSVTGAAHSALLEPILDRFQ
                     DACAGLHAEPGQIPIISTLTADVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARV
                     FLEMGPDAQLVASGQREYRDNAYWIASARRNKEASDVLNQALLQLYAAGVALPWTDLLA
                     GDGQRIAAPCYPFDTERYWKERVSPACEPADAALSAGLEVASRAATALDLPRLEALKQC
                     ATRLHAIYVDQLVQRCTGDAIENGVDAITIIRRGRLLPRYQQLLQRLLNNCVVDGDYRC
                     TDGRYVRAHPIEHQQRESLLTELAGYCEGFQAIPDTIARAGDRLYDMMSGAEEPVAIIF
                     PQSASDGVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQSLRILEVGGGTGGTTAWLL
                     PELNGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFQAQSYDLIV
                     AANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPLQDLDAREG
                     ELFLTTAQWQQQCRHAGFSKVAWLPQDGSPTAGMSEHIILATLPGQAVSAVTFTAPSEP
                     VLGQALTDNGDYLADWSDCAGQPERFNARWQEAWRLLSQRHGDALPVEPPLVAAPEWLG
                     EVRLSWQNEAFSRGQMHVEARHPDGEWLPLSPAAPLPAPQTHYQWRWTPLNVASVDHPL
                     TFSAGTLARSDELAQYGIIHDPHASSRLMIVEESEDTLALAEKVIAALIASAAGLIVVT
                     RRAWRVEENEALSASHHALWALLRVAANEQPERLIAAIDLAENTPWETLHQGLSAVSLS
                     QRWLAARGNTLWLPSLALNTGCAAELPANVFTGDNRWHLVTGAFGGLGRLAVNWLREKG
                     ARRIALLAQRVDESWLRDVEGGQTRVCRCDVGDAGQLATVLDDLAANGGIAGAIHAAGV
                     LADAPLQELDDHQLATVFAVKAQAANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHA
                     LACGYLDGLAQQFSTLDAPKTLSVAWGAWGESGRAATPEMLATLASRGMGALSDAEGCW
                     HLEQAVMRGAPWRLAMRVFTDKMPPLQQALFNISATEKAAMPVIPPADDNAFNGSLSDE
                     TAVIAWLKKRIAVQLRLSDPASLRPNQDLLQLGMDSLLFLELSSDIQHYLGVRINAERA
                     WQDLSPHGLTQLICSKPETTPAASQPEVLQHDADKRYAPFPLTPIQHAYWLGRTHLIGY
                     GGVACHVLFEWDKRHDEFDLAILEKAWNQLIARHDMLRMVVDADGQQRVLGTTPEYHIQ
                     RDDLRALSPEEQRIALEKRRHEMSYRVLPADQWPLFELVVSEIDDCHYRLHMNLDLLQF
                     DVQSFKVMMDDLAQVWRGETLAPLAITFRDYVMAEQARRQTSAWHDAWDYWQGKLPQLP
                     LAPELPVVETRPETPHFTTFKSTIGKTEWQAVKQRWQQQGVTPSAALLTLFAATLERWS
                     RTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTLVTLQEQMQQTQQRLWQNM
                     AHSEMNGVEVIRELGRLRGSQRQPLMPVVFTSMLGMTLEGMTIDQAMSHLFGEPCYVFT
                     QTPQVWLDHQVMESDGELMFSWYCMDNVLEPGAAEAMFNDYCAILQAVIAAPESLKTLA
                     SGIAGHIPRRRWPLNAQADYDLRDIEQATLEYPGIRQARAEITEQGALTLDIVMADDPS
                     PSAATPDEHELTQLALSLPEQAQLDELEATWRWLEARALQGIAATLNRHGLFTTPEIAH
                     RFSAIVQALSAQASHQRLLRQWLQCLTERAWLIREGESWRCRVPLSEIPEPQEACPPSQ
                     WSQALAQYLETCIARHDALFSGQCSPLELLFNEQHRVTDALYRDNPASACLNRYTAQIA
                     ALCGAERILEVGAGTAATTAPVLKATRNTRKSYHFTDVSAQFLNDARARFHDESRVSYA
                     LFDINQPLDFTAHPEAGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERN
                     SVFQLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFANELAWPAQESSPLRQ
                     HLLVAHSPGVNRPDKEALSRYLQQRFGTGLPVLQIRQREALFTPLHAPSDALIEPAKPT
                     PVAGGNPALEKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIARANLQ
                     DLFSHSTLSDFCAHLQAATSGEDNPIPLCQGDGDETLFVFHASDGDISAWLPLASALNR
                     RVFGLQAKSPQRFGTLDQMIDEYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKG
                     EQVRIALIDPVCRQDFCCENRAALLRLLAEGQTPLALPEHFDQQTPDSQLADFISLAKT
                     AGMVSQNLTLQAAETWLDNIAHLLRLLTEHTPGENVPVPCLMVYAAGRPARWTPAETEW
                     QGWINNADDAVIEASHWQIMMEAPHVQVCAQHITRWLCATSTQPENTL"
     aSDomain        697..1962
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="6.30E-158"
                     /label="irp1_PKS_KS.1"
                     /locus_tag="irp1"
                     /protein_end="450"
                     /protein_start="28"
                     /score="517.9"
                     /tool="antismash"
                     /translation="VAVIGYACHFPESPDGETFWQNLLEGRECSRRFTREELLAVGLDA
                     AIIDDPHYVNIGTVLDNADCFDATLFGYSRQEAESMDPQQRLFLQAVWHALEHAGYAPG
                     AVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATRAAYKLNLHGPA
                     LSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPGMIFSPDGHCR
                     PFDASAEGTWAGNGLGCVVLRRLRDALLSGDPIISVILSSAVNNDGNRKVGYTAPSVAG
                     QQAVIEEALMLAAIDDRQVGYIETHGTGTPLGDAIEIEALRNVYAPRPQDQRCALGSVK
                     SNMGHLDTAAGIAGLLKTVLAVSRGQIPPLLNFHTPNPALKLEESPFTIPVSAQAWQDE
                     MRYAGVSSFGIGGTNCHMIVASL"
     aSModule        697..6276
                     /complete
                     /domains="nrpspksdomains_irp1_PKS_KS.1"
                     /domains="nrpspksdomains_irp1_PKS_AT.1"
                     /domains="nrpspksdomains_irp1_cMT.1"
                     /domains="nrpspksdomains_irp1_PKS_KR.1"
                     /domains="nrpspksdomains_irp1_ACP.1"
                     /locus_tags="irp1"
                     /monomer_pairings="mal -> Me-ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       1177..1224
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0001"
                     /evalue="1.40E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="irp1"
                     /protein_end="204"
                     /protein_start="188"
                     /score="17.2"
                     /tool="antismash"
                     /translation="GPALSVQTACSSSLVA"
     CDS_motif       1600..1647
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0002"
                     /evalue="1.90E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="irp1"
                     /protein_end="345"
                     /protein_start="329"
                     /score="10.8"
                     /tool="antismash"
                     /translation="YIETHGTGTPLGDAIE"
     CDS_motif       1705..1749
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0003"
                     /evalue="5.20E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="irp1"
                     /protein_end="379"
                     /protein_start="364"
                     /score="9.7"
                     /tool="antismash"
                     /translation="GSVKSNMGHLDTAAG"
     aSDomain        2269..3138
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_PKS_AT.1"
                     /evalue="4.60E-84"
                     /label="irp1_PKS_AT.1"
                     /locus_tag="irp1"
                     /protein_end="842"
                     /protein_start="552"
                     /score="274.1"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSHWRTMGQTMYQHSTAFADMLDRCFSACSEMLTPSLREA
                     MFNPDSAQLDNMAWAQPAIVAFEIAMAAHWHAEGLKPDFAIGHSVGEFAAAVVCGHYTI
                     EQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQFELDLAANNGTQHTVFSGPEA
                     RLAVFCTTLSQHNINYRRLSVTGAAHSALLEPILDRFQDACAGLHAEPGQIPIISTLTA
                     DVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARVFLEMGPDAQLVASGQREYRDN
                     AYWIASARR"
     CDS_motif       2272..2319
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0004"
                     /evalue="7.90E-04"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="irp1"
                     /protein_end="569"
                     /protein_start="553"
                     /score="12.4"
                     /tool="antismash"
                     /translation="FTGQGSHWRTMGQTMY"
     CDS_motif       2503..2625
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0005"
                     /evalue="8.10E-19"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="irp1"
                     /protein_end="671"
                     /protein_start="630"
                     /score="59.8"
                     /tool="antismash"
                     /translation="GLKPDFAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQ"
     CDS_motif       2710..2748
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0006"
                     /evalue="3.70E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="irp1"
                     /protein_end="712"
                     /protein_start="699"
                     /score="10.7"
                     /tool="antismash"
                     /translation="AANNGTQHTVFSG"
     CDS_motif       2971..3006
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0007"
                     /evalue="3.00E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="irp1"
                     /protein_end="798"
                     /protein_start="786"
                     /score="17.3"
                     /tool="antismash"
                     /translation="YWRRHMRQPVRF"
     aSDomain        3775..4419
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_cMT.1"
                     /domain_subtype="cMT"
                     /evalue="3.60E-110"
                     /label="irp1_cMT.1"
                     /locus_tag="irp1"
                     /protein_end="1269"
                     /protein_start="1054"
                     /score="360.1"
                     /tool="antismash"
                     /translation="GVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQSLRILEVGGGT
                     GGTTAWLLPELNGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFQ
                     AQSYDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPL
                     QDLDAREGELFLTTAQWQQQCRHAGFSKVAWLPQDGSPTAGMSEHIILATLP"
     CDS_motif       5212..5250
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0008"
                     /evalue="1.00E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="irp1"
                     /protein_end="1546"
                     /protein_start="1533"
                     /score="-0.1"
                     /tool="antismash"
                     /translation="PSLALNTGCAAEL"
     CDS_motif       5284..5370
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0009"
                     /evalue="6.80E-09"
                     /label="PKSI-KR_m1"
                     /locus_tag="irp1"
                     /protein_end="1586"
                     /protein_start="1557"
                     /score="28.4"
                     /tool="antismash"
                     /translation="HLVTGAFGGLGRLAVNWLREKGARRIALL"
     aSDomain        5284..5796
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_PKS_KR.1"
                     /evalue="7.30E-40"
                     /label="irp1_PKS_KR.1"
                     /locus_tag="irp1"
                     /protein_end="1728"
                     /protein_start="1557"
                     /score="128.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="HLVTGAFGGLGRLAVNWLREKGARRIALLAQRVDESWLRDVEGGQ
                     TRVCRCDVGDAGQLATVLDDLAANGGIAGAIHAAGVLADAPLQELDDHQLATVFAVKAQ
                     AANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHALACGYLDGLAQQFSTLDAPKTLS
                     VAWGAWGE"
     CDS_motif       5641..5739
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0010"
                     /evalue="6.70E-11"
                     /label="PKSI-KR_m4"
                     /locus_tag="irp1"
                     /protein_end="1709"
                     /protein_start="1676"
                     /score="34.7"
                     /tool="antismash"
                     /translation="YLILYSSAAATLGAPGQSAHALACGYLDGLAQQ"
     aSDomain        6070..6276
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_ACP.1"
                     /evalue="2.80E-10"
                     /label="irp1_ACP.1"
                     /locus_tag="irp1"
                     /protein_end="1888"
                     /protein_start="1819"
                     /score="32.2"
                     /tool="antismash"
                     /translation="AWLKKRIAVQLRLSDPASLRPNQDLLQLGMDSLLFLELSSDIQHY
                     LGVRINAERAWQDLSPHGLTQLIC"
     aSDomain        6343..7230
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_Heterocyclization.1"
                     /evalue="1.60E-101"
                     /label="irp1_Heterocyclization.1"
                     /locus_tag="irp1"
                     /protein_end="2206"
                     /protein_start="1910"
                     /score="331.5"
                     /tool="antismash"
                     /translation="YAPFPLTPIQHAYWLGRTHLIGYGGVACHVLFEWDKRHDEFDLAI
                     LEKAWNQLIARHDMLRMVVDADGQQRVLGTTPEYHIQRDDLRALSPEEQRIALEKRRHE
                     MSYRVLPADQWPLFELVVSEIDDCHYRLHMNLDLLQFDVQSFKVMMDDLAQVWRGETLA
                     PLAITFRDYVMAEQARRQTSAWHDAWDYWQGKLPQLPLAPELPVVETRPETPHFTTFKS
                     TIGKTEWQAVKQRWQQQGVTPSAALLTLFAATLERWSRTTAFTLNLTFFNRQPIHPQIN
                     QLIGDFTSVTLVDFN"
     aSModule        6343..10053
                     /domains="nrpspksdomains_irp1_Heterocyclization.1"
                     /domains="nrpspksdomains_irp1_cMT.2"
                     /domains="nrpspksdomains_irp1_PCP.1"
                     /domains="nrpspksdomains_irp1_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="irp1"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6364..6393
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0011"
                     /evalue="1.20E-02"
                     /label="Cy1"
                     /locus_tag="irp1"
                     /protein_end="1927"
                     /protein_start="1917"
                     /score="8.6"
                     /tool="antismash"
                     /translation="PIQHAYWLGR"
     CDS_motif       6499..6552
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0012"
                     /evalue="2.90E-09"
                     /label="Cy2"
                     /locus_tag="irp1"
                     /protein_end="1980"
                     /protein_start="1962"
                     /score="29.0"
                     /tool="antismash"
                     /translation="LIARHDMLRMVVDADGQQ"
     CDS_motif       6733..6777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0013"
                     /evalue="1.20E-03"
                     /label="Cy3"
                     /locus_tag="irp1"
                     /protein_end="2055"
                     /protein_start="2040"
                     /score="12.2"
                     /tool="antismash"
                     /translation="RLHMNLDLLQFDVQS"
     CDS_motif       7060..7119
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0014"
                     /evalue="4.60E-08"
                     /label="Cy4"
                     /locus_tag="irp1"
                     /protein_end="2169"
                     /protein_start="2149"
                     /score="25.8"
                     /tool="antismash"
                     /translation="GVTPSAALLTLFAATLERWS"
     CDS_motif       7132..7170
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0015"
                     /evalue="2.20E-04"
                     /label="afterCy4"
                     /locus_tag="irp1"
                     /protein_end="2186"
                     /protein_start="2173"
                     /score="13.8"
                     /tool="antismash"
                     /translation="FTLNLTFFNRQPI"
     CDS_motif       7171..7227
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0016"
                     /evalue="2.00E-08"
                     /label="Cy5"
                     /locus_tag="irp1"
                     /protein_end="2205"
                     /protein_start="2186"
                     /score="26.4"
                     /tool="antismash"
                     /translation="HPQINQLIGDFTSVTLVDF"
     CDS_motif       7294..7338
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0017"
                     /evalue="3.30E-03"
                     /label="afterCy5"
                     /locus_tag="irp1"
                     /protein_end="2242"
                     /protein_start="2227"
                     /score="10.5"
                     /tool="antismash"
                     /translation="MAHSEMNGVEVIREL"
     CDS_motif       7372..7401
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0018"
                     /evalue="6.20E-03"
                     /label="Cy6"
                     /locus_tag="irp1"
                     /protein_end="2263"
                     /protein_start="2253"
                     /score="9.5"
                     /tool="antismash"
                     /translation="MPVVFTSMLG"
     CDS_motif       7471..7515
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0019"
                     /evalue="6.20E-07"
                     /label="Cy7"
                     /locus_tag="irp1"
                     /protein_end="2301"
                     /protein_start="2286"
                     /score="22.2"
                     /tool="antismash"
                     /translation="TQTPQVWLDHQVMES"
     aSDomain        8269..8913
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_cMT.2"
                     /domain_subtype="cMT"
                     /evalue="3.10E-93"
                     /label="irp1_cMT.2"
                     /locus_tag="irp1"
                     /protein_end="2767"
                     /protein_start="2552"
                     /score="304.2"
                     /tool="antismash"
                     /translation="LFNEQHRVTDALYRDNPASACLNRYTAQIAALCGAERILEVGAGT
                     AATTAPVLKATRNTRKSYHFTDVSAQFLNDARARFHDESRVSYALFDINQPLDFTAHPE
                     AGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERNSVFQLASVGFIEGLS
                     GYRDFRRRDEKPMLTRSAWQEVLVQAGFANELAWPAQESSPLRQHLLVAHSP"
     aSDomain        9094..9294
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_PCP.1"
                     /evalue="9.00E-18"
                     /label="irp1_PCP.1"
                     /locus_tag="irp1"
                     /protein_end="2894"
                     /protein_start="2827"
                     /score="56.1"
                     /tool="antismash"
                     /translation="EKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIA
                     RANLQDLFSHSTLSDFCAHLQA"
     aSDomain        9349..10053
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp1_Thioesterase.1"
                     /evalue="3.70E-22"
                     /label="irp1_Thioesterase.1"
                     /locus_tag="irp1"
                     /protein_end="3147"
                     /protein_start="2912"
                     /score="71.7"
                     /tool="antismash"
                     /translation="TLFVFHASDGDISAWLPLASALNRRVFGLQAKSPQRFGTLDQMID
                     EYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKGEQVRIALIDPVCRQDFCCENR
                     AALLRLLAEGQTPLALPEHFDQQTPDSQLADFISLAKTAGMVSQNLTLQAAETWLDNIA
                     HLLRLLTEHTPGENVPVPCLMVYAAGRPARWTPAETEWQGWINNADDAVIEASHWQIMM
                     EAPHVQVCAQHIT"
     CDS_motif       9511..9585
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp1_0020"
                     /evalue="5.30E-09"
                     /label="NRPS-te1"
                     /locus_tag="irp1"
                     /protein_end="2991"
                     /protein_start="2966"
                     /score="28.5"
                     /tool="antismash"
                     /translation="QPHGPYVLAGWSYGAFLAAGAAQRL"
     gene            10098..11195
                     /gene="irp3"
     CDS             10098..11195
                     /codon_start=1
                     /db_xref="GOA:O54512"
                     /db_xref="InterPro:IPR000683"
                     /db_xref="InterPro:IPR010091"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O54512"
                     /gene="irp3"
                     /gene_functions="other (smcogs) SMCOG1099:hypothetical
                     protein (Score: 449; E-value: 2.2e-136)"
                     /gene_kind="other"
                     /note="part of the siderophore biosynthetic operon"
                     /product="Irp3 protein"
                     /protein_id="CAA73128.1"
                     /transl_table=11
                     /translation="MPSASPKQRVLIVGAKFGEMYLNAFMQPPEGLELVGLLAQGSARS
                     RELAHAFGIPLYTSPEQITGMPDIACIVVRSTVAGGAGTQLARHFLARGVHVIQEHPLH
                     PDDISSLQTLAQEQGCCYWINTFYPHTRAGRTWLRDAQQLRRCLAKTPPVVHATTSRQL
                     LYSTLDLLLLALGVDTAAVECDVVGSFSDFHCLRLFWPEGEACLLLQRYLDPDDPDMHS
                     LIMHRLLLGWPEGHLSLEASYGPVIWSSSLFVADHQENAHSLYRRPEILRDPPGLTRSA
                     APLSWRDCCETVGPEGVSWLLHQLRSHLAGEHPPVACQNVHQIALSRLWQQILRKTGNA
                     EIRRLTPPHHDRLAGFYNDDDKEAL"
     gene            11192..11995
                     /gene="irp4"
     CDS             11192..11995
                     /NRPS_PKS="Domain: Thioesterase (19-246). E-value: 7.2e-59.
                     Score: 191.8. Matches aSDomain:
                     nrpspksdomains_irp4_Thioesterase.1"
                     /codon_start=1
                     /db_xref="GOA:O54513"
                     /db_xref="InterPro:IPR001031"
                     /db_xref="InterPro:IPR012223"
                     /db_xref="UniProtKB/TrEMBL:O54513"
                     /function="yersiniabactin biosynthesis"
                     /gene="irp4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 255.2; E-value: 7.4e-78)"
                     /gene_kind="biosynthetic-additional"
                     /product="Irp4 protein"
                     /protein_id="CAA73129.1"
                     /transl_table=11
                     /translation="MTQSAMCIPLWPARNGNTAHLVMCPFAGGSSSAFRHWRDNQMANS
                     ALSLVTWPGRDRLRHLAPVRSITQLAALLANELEASVSPDTPLLLVGHSMGAQVAFETC
                     RLLEQRGHAPQGLIISGCHAPHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMS
                     LFLPLLRADFYATESYHYDSPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTG
                     PVVIDGDHFYPIQQARSFFTQIVRHFPHAFSAMTALQKQPSTSER"
     aSDomain        11249..11929
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp4_Thioesterase.1"
                     /evalue="7.20E-59"
                     /label="irp4_Thioesterase.1"
                     /locus_tag="irp4"
                     /protein_end="246"
                     /protein_start="19"
                     /score="191.8"
                     /tool="antismash"
                     /translation="HLVMCPFAGGSSSAFRHWRDNQMANSALSLVTWPGRDRLRHLAPV
                     RSITQLAALLANELEASVSPDTPLLLVGHSMGAQVAFETCRLLEQRGHAPQGLIISGCH
                     APHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMSLFLPLLRADFYATESYHYD
                     SPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFF
                     TQIVR"
     CDS_motif       11441..11512
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_irp4_0001"
                     /evalue="3.40E-08"
                     /label="NRPS-te1"
                     /locus_tag="irp4"
                     /protein_end="107"
                     /protein_start="83"
                     /score="25.9"
                     /tool="antismash"
                     /translation="PDTPLLLVGHSMGAQVAFETCRLL"
     gene            11999..13576
                     /gene="irp5"
     CDS             11999..13576
                     /NRPS_PKS="Domain: AMP-binding (20-422). E-value: 5.2e-82.
                     Score: 267.4. Matches aSDomain:
                     nrpspksdomains_irp5_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:O54514"
                     /db_xref="HSSP:1MDB"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="UniProtKB/TrEMBL:O54514"
                     /gene="irp5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     478.1; E-value: 4.3e-145)"
                     /gene_kind="biosynthetic-additional"
                     /note="part of the siderophore biosynthetic operon"
                     /product="Irp5 protein"
                     /protein_id="CAA73130.1"
                     /sec_met_domain="AMP-binding (E-value: 6.8e-93, bitscore:
                     299.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSSFESLIEQYPLAIAEQLRHWAARYASRIAVVDAKGSLTYSAL
                     DARVDELAAGLSSLGLRSGEHVIVQLPNGNAFVTLLFALLRLGVIPVLAMPSQRALDID
                     ALIELAQPVAYVIHGENHAELARQMTHKHACLRHVLVAGETMSDDFTPIFSLHGERQAW
                     PQPDVSATALLLLSGGTTGTPKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHN
                     FPLACPGILGTLACGGKVVLTDSASCDEVMPLIAQEGVTHVALVPALAQLWVQAREWED
                     SDLSSLRVIQAGGARLDPTLAEQVIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQ
                     GRPLSPLDEIRIVDQDENDVEPGETGQLLTRGPYTISGYYRAPAHNAQAFTAQGFYRTG
                     DNVRLDEAGNLHVEGRIKEQINRAGEKIAAAEVESALLRLAEVQDCAVVAAPDTLLGER
                     ICAFIIAQQMPTDYQQLRQQLTRMGLSAWKIPDQIEFLDHWPLTAVGKIDKKRLTALAV
                     DRYRHSAQ"
     aSDomain        12059..13264
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_irp5_AMP-binding.1"
                     /evalue="5.20E-82"
                     /label="irp5_AMP-binding.1"
                     /locus_tag="irp5"
                     /protein_end="422"
                     /protein_start="20"
                     /score="267.4"
                     /specificity="consensus: dhb"
                     /tool="antismash"
                     /translation="RHWAARYASRIAVVDAKGSLTYSALDARVDELAAGLSSLGLRSGE
                     HVIVQLPNGNAFVTLLFALLRLGVIPVLAMPSQRALDIDALIELAQPVAYVIHGENHAE
                     LARQMTHKHACLRHVLVAGETMSDDFTPIFSLHGERQAWPQPDVSATALLLLSGGTTGT
                     PKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHNFPLACPGILGTLACGGKVVL
                     TDSASCDEVMPLIAQEGVTHVALVPALAQLWVQAREWEDSDLSSLRVIQAGGARLDPTL
                     AEQVIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQGRPLSPLDEIRIVDQDENDV
                     EPGETGQLLTRGPYTISGYYRAPAHNAQAFTAQGFYRTGDNVRLDEAGNLHVEGRIKEQ
                     INR"
ORIGIN
        1 gatcaccagg tttatgaatc cgaaggcgaa ctgcgcttta actgggattt tgtcgccgcg
       61 ctgtttcctg ccgggcaggt ggagcgccag tttgaacagt attgcgcatt gctaaaccga
      121 atggccgagg atgaaagcag ctggcaactg ccgctcgccg cgctggtgcc tcccgtaaaa
      181 cacgcagggc aatgcgcaga gcgcccaccg cgcgtatgcc ctgagcactc tcagccacac
      241 attgcggcgg acgagagcac cgtcagcctg atttgcgacg ccttccgcga ggtggttggc
      301 gagtctgtca cacccgcaga aaacttcttt gaggcgggtg caacatcgct gaatctggtg
      361 caactgcacg ttttgttaca acgtcacgaa ttttccaccc tgacgttgct tgacctcttc
      421 acccaccctt ctcctgttgc cctggccgat tatctggccg gcgtcgccac ggtggagaaa
      481 acaaaacgtc ctcgccctgt tcgccgtcgt cagcggcgga tatagcgcga agcaaactga
      541 ttttccccgg aacgccatcg cgaacgcatg gcgttccatt gactttgtga atcttaggaa
      601 acgggaccga ttatggataa cttgcgcttc tcttctgcgc cgacagcaga ttccattgat
      661 gcatcgatcg ctcaacacta cccggactgc gaacctgtcg cggttatcgg ctacgcctgc
      721 cattttcctg aatcgccgga tggcgaaacg ttctggcaaa atctgctgga aggtcgtgaa
      781 tgcagccgac gctttacgcg cgaagaactt ctggccgtcg gtctggatgc cgccatcatt
      841 gacgatcctc attatgtcaa tatcggtacg gtgttagaca acgccgactg cttcgacgcc
      901 accctgtttg gctattcgcg acaggaagcg gaatcgatgg acccgcagca gcgcctgttt
      961 ttgcaggcgg tctggcatgc gctggaacat gccggttatg cccccggcgc cgtcccccat
     1021 aagaccggcg ttttcgcctc ttcccggatg agtacctacc ccggtcgcga agcattgaac
     1081 gtgacagaag tcgcgcaggt aaaaggtctg caatctctga tgggcaatga taaagactat
     1141 attgccaccc gcgccgcgta caaactcaac ctgcacggcc cagcgttatc ggtacagacc
     1201 gcctgctcca gttcgctggt tgccgtgcat ctggcctgtg aaagcctgcg cgcaggcgaa
     1261 tccgatatgg cggttgccgg cggcgtggcg ctctctttcc cccagcaggc gggctaccgc
     1321 taccagcccg gaatgatttt ctctcccgat ggtcactgtc gtccttttga cgcctcggct
     1381 gagggcacct gggccggtaa cggtctcggc tgcgtggtac tgcgtcgcct gagagacgcg
     1441 ctgctgtcag gcgatccgat tatctcggtg atcctctcca gcgcggtcaa caacgacggc
     1501 aacagaaagg tcggctatac cgccccttcc gtcgcagggc aacaggcagt catcgaagag
     1561 gcgttaatgc tggcggccat cgacgacagg caggtaggtt acattgaaac ccacggcacc
     1621 ggcacaccgc tgggcgacgc gattgaaatt gaagcgttac gcaacgtcta tgcgcctcgc
     1681 ccgcaggatc agcgctgtgc gctcggttcc gtgaaaagta atatgggcca tctggatacc
     1741 gcagcgggca ttgccggact gctgaaaacc gttctggcag tcagccgcgg gcaaattcca
     1801 cccttactga attttcatac ccccaacccg gcgctgaaac ttgaagagag tccctttacc
     1861 ataccggtgt cggcgcaggc gtggcaggat gaaatgcgct atgcgggcgt ctcctccttt
     1921 ggtattggcg gcaccaactg ccatatgatc gtcgcctcgc tgcccgacgc gctcaacgcg
     1981 cgcctcccca atacggatag cggcagaaaa agtaccgcgc tgctgctcag cgccgccagc
     2041 gacagcgcgt tgcggcggct ggcgacggat tatgccgggg cgctgagaga gaatacggat
     2101 gccagcgatc tggccttcac ggccctgcac gcgcgccgtc tcgatcttcc ctttcgcctg
     2161 gcggcgccat taaaccgtga aaccgccgcg gcgctcagcg actgggccgg tgagaaatcg
     2221 ggggcgctgg tttatagcgg ccacggcgcc agcggcaagc aggtgtggct gtttaccggc
     2281 cagggctcgc actggcgcac tatgggtcaa acgatgtacc agcactcaac ggcgtttgcc
     2341 gacatgctgg atcgctgttt ttccgcctgt agcgaaatgc tcacgccgtc actgcgcgaa
     2401 gcgatgttta accccgattc ggcgcagctg gacaatatgg cctgggcgca gccggcgatt
     2461 gtcgcgtttg aaatcgcgat ggcggcgcac tggcacgctg aaggactgaa gccagacttc
     2521 gccattgggc attccgtcgg tgaatttgcc gctgccgtcg tctgcggaca ctatacgatt
     2581 gaacaggtca tgccactggt ttgtcgacgc ggcgcactga tgcagcagtg cgcaagcggc
     2641 gcaatggtgg cggtatttgc agacgaagac acgctgatgc cgctggctcg ccagtttgag
     2701 ctggatctcg ccgccaacaa cggtacgcaa catacggtat tttccgggcc ggaagcccgt
     2761 ctcgcggtat tttgcaccac gctctcgcag cataacatta actatcgtcg cctgagcgta
     2821 accggcgcgg cgcactccgc tttactggaa ccgatactcg atcggttcca ggacgcctgc
     2881 gcggggctgc acgcggagcc ggggcaaata ccgattattt ccacgctcac cgccgacgtc
     2941 attgatgagt caacgctcaa ccaggcggat tactggcgcc gacacatgcg ccagccggtg
     3001 cgttttatcc agagtattca gatggcgcat cagctcggcg cccgcgtttt tctggagatg
     3061 gggcccgatg cccagttggt tgcttccggg cagcgcgaat accgcgataa cgcatactgg
     3121 atagccagcg cccggcgtaa caaagaggcg agcgatgtcc tcaatcaggc cctgctccag
     3181 ctttacgctg ccggtgtcgc cttaccgtgg accgacctac tggcgggtga tggacaacgt
     3241 atcgctgcgc catgttatcc gtttgatact gagcgttact ggaaagagcg cgtctccccg
     3301 gcctgcgaac ctgccgacgc agcgctgtct gccgggctgg aggtggcgag tcgcgccgcg
     3361 acagcgctcg atctcccccg tctggaagcg cttaaacagt gcgccacgcg actgcacgcc
     3421 atctacgtcg atcaactggt acaacgctgt accggcgatg ccattgaaaa cggcgtggac
     3481 gccataacca tcatacgccg tggacgtctg ctgccccgct accagcagct actccagcgc
     3541 ctgctgaata actgcgtggt cgacggcgat taccgctgca ccgacgggcg atacgtccgc
     3601 gcccacccca ttgaacatca acagcgggaa tcactgctga cggaacttgc cggttattgt
     3661 gaaggttttc aggctattcc cgacaccatc gcccgtgccg gcgatcggtt atatgacatg
     3721 atgagcggcg cggaagaacc ggtggcgatt atcttcccgc aaagcgcctc cgacggcgtg
     3781 gaagtgctgt atcaggaatt cagctttggc cgctatttca accaaatcgc cgccggggta
     3841 ttacgcggca ttgtccagac gcgtcagccc cgccagtcgt tgcgtattct tgaagttggc
     3901 ggcggaaccg gcggcaccac cgcgtggctg ctgccggaac tcaacggcgt tccggcgctg
     3961 gagtaccact tcaccgatat ctcagcgctg ttcacccgcc gcgcccagca gaaattcgcc
     4021 gactatgatt ttgtgaagta tagcgagctg gatctcgaaa aagaggcgca gtctcagggt
     4081 ttccaggcac agtcttacga tcttatcgtg gcggcgaacg tgattcacgc cacccgccat
     4141 attggccgca cgctcgataa tctgcgcccc ctgctcaagc cgggcgggcg cctgctgatg
     4201 cgcgaaatca cccagccaat gcgtctgttt gacttcgttt tcggcccgct ggttcttccg
     4261 ctacaggatc tcgacgcccg cgaaggtgaa ttattcctca ccaccgctca gtggcagcaa
     4321 cagtgccgcc acgccggatt cagcaaagtg gcatggctac cgcaggatgg cagcccaacc
     4381 gccgggatga gcgaacatat cattctcgcc acgctgcccg gtcaggcggt tagtgccgta
     4441 acattcaccg cgccatcaga acccgtgttg gggcaggcgc tgacggataa cggtgattat
     4501 ctcgccgact ggtctgattg cgcaggtcag cccgaacggt ttaacgcccg ctggcaggag
     4561 gcctggcgtc tgctctcaca gcgtcatggc gacgctctgc ctgtggaacc gcccctcgtc
     4621 gccgccccgg agtggctggg ggaggttcgc ttaagctggc aaaacgaagc cttttcccgc
     4681 ggtcagatgc acgttgaagc ccgtcatcct gatggcgagt ggctgccgct atcgcccgcc
     4741 gcgcctcttc ctgcgccgca gacgcattat caatggcgct ggacgcccct caacgtcgcc
     4801 agcgttgacc atccgcttac cttcagcgcc ggtacgcttg cgcgcagcga cgagctggcg
     4861 caatacggca tcattcacga tccgcacgcc tcttcgcgac tgatgattgt tgaggagagc
     4921 gaggatacgc tggccttagc ggagaaagtg atagcagcgc tcatcgccag cgcagccgga
     4981 ttgattgtgg tcactcgccg cgcgtggcga gtcgaggaaa atgaggcact ctctgcgtcc
     5041 catcacgcgc tatgggcctt gcttcgcgtc gcggccaacg aacagccgga acggttgatt
     5101 gccgccatcg atctcgccga aaacaccccg tgggaaacac tgcatcaagg gttgagcgca
     5161 gtctcactat cacagcgctg gctcgccgcg cggggtaaca ccctctggct cccttcactg
     5221 gcgctcaata cgggatgcgc cgctgaatta ccggcaaacg tgtttaccgg cgataaccgc
     5281 tggcatctgg tgaccggagc gtttggcgga ttaggccgcc ttgccgtgaa ctggctcaga
     5341 gaaaaaggcg cgcgacgcat cgccctgctg gcgcagcgcg tggatgagtc atggctacgc
     5401 gacgtggagg gcgggcagac gcgcgtctgc cgttgtgatg tgggcgatgc cgggcaactg
     5461 gccacggttc ttgacgatct ggcggccaac ggcggcattg ccggagcgat tcatgccgct
     5521 ggcgtattgg ctgacgcgcc cttgcaggag cttgatgacc accagctggc caccgttttt
     5581 gcggtaaaag cgcaggcggc aaaccagctg ttgcaaaccc tgcgcaacca cgacggacgc
     5641 tatcttattc tctactcttc cgctgccgcc accctcggcg cgccgggtca gagcgcccat
     5701 gcgctggcct gcggctacct ggacgggctg gcacagcagt tttccaccct tgatgcgccg
     5761 aaaacgctct ctgtcgcctg gggcgcatgg ggagaaagcg gtcgggcggc cacgccggaa
     5821 atgctggcga cgctcgccag ccgtggtatg ggcgcgttaa gcgatgccga aggctgctgg
     5881 cacctggaac aggcggtgat gcgcggcgcc ccgtggcgac tggcgatgcg cgtttttacc
     5941 gacaaaatgc ccccgttaca acaggctctg tttaacatca gcgccacaga aaaagccgca
     6001 atgcctgtca ttcctcctgc tgatgacaac gcctttaacg gcagcctgag cgatgaaacg
     6061 gcggtgatag catggctgaa aaagcggatt gcggttcagc taaggctgag cgatccggcg
     6121 tcactgcgcc caaaccagga tctgttgcaa ctcggcatgg actcgctgct cttccttgaa
     6181 ctcagtagcg atattcagca ctacctgggt gtacgcatca atgcggaacg ggcgtggcag
     6241 gatctgtctc ctcatggact cacgcagctt atctgttcta agccagagac gacgcctgcc
     6301 gcttcgcagc cggaagtgtt gcagcacgac gccgacaagc gttatgcgcc cttccctttg
     6361 acgcccattc agcacgccta ctggctgggg cgaacccacc tcattggcta tggcggcgtc
     6421 gcctgtcacg tcctgtttga gtgggataaa cgccacgatg agttcgatct cgccatactg
     6481 gagaaagcat ggaaccagct tatcgcacgc cacgatatgt tgcgcatggt ggttgatgcc
     6541 gacgggcagc agcgagtcct ggggacaacg ccggagtatc acatccagcg tgacgatctg
     6601 cgcgcgcttt ccccggaaga acaacgcatc gcgctggaaa aacggcggca tgaaatgagc
     6661 tatcgcgttt tgcctgccga ccagtggcct ctttttgagc tggtggtcag cgaaatcgac
     6721 gattgccatt accgcctgca catgaacctc gaccttttgc agttcgatgt gcagagtttt
     6781 aaagtcatga tggacgatct ggcgcaggtc tggcgcggtg aaacgctggc gccgctcgct
     6841 attaccttcc gtgattatgt gatggctgaa caggcgcgcc gacagacatc ggcatggcac
     6901 gatgcctggg attactggca gggaaaactg ccgcaactgc ccttagcgcc agagctgccg
     6961 gtggttgaga cgcgcccgga aacgccacac ttcaccacct tcaaatcgac gatcggcaag
     7021 acagaatggc aggccgtgaa acagcgctgg cagcagcaag gcgtcacacc gtctgccgcg
     7081 ctgctcacgc tgtttgccgc cacccttgag cgctggagcc gcaccacggc atttacgctg
     7141 aacctgacgt tcttcaatcg ccagccgatc catccgcaaa tcaaccagtt gattggtgat
     7201 tttacctccg tcacgctggt tgattttaac ttctcaacgc tggtgacgtt gcaagagcag
     7261 atgcaacaga cccaacagcg cctctggcaa aacatggcgc acagtgaaat gaacggtgtt
     7321 gaggtgatcc gtgagctggg ccgcctgcgc gggtcacaac gtcaaccgct gatgccggtg
     7381 gtgtttacca gtatgctggg gatgacgctg gaaggcatga ctatcgatca ggcgatgagc
     7441 catctgttcg gcgaaccctg ctatgtattc acgcaaacgc cgcaggtctg gctggatcat
     7501 caggtcatgg agagcgacgg cgagttgatg tttagctggt actgcatgga caacgtgctg
     7561 gaacccggcg ctgccgaggc gatgtttaat gactactgcg ccatcctgca agccgtcatc
     7621 gccgcccctg aaagcctgaa gactctcgcc agcggtatcg ccgggcacat tccccgtcga
     7681 cgctggccgc tgaacgcaca ggcggactac gacctgcggg atattgagca ggcgacgctc
     7741 gaataccccg gcatccggca ggccagagcg gaaataaccg aacagggcgc gttgacgctg
     7801 gatatcgtaa tggccgacga tccgtcgcca tcagcggcga cgcctgatga gcacgaactt
     7861 acccaactgg cgctgtcgtt gcctgagcag gcgcagcttg atgagctgga ggcgacctgg
     7921 cgctggctgg aggcgcgtgc gctacagggg atcgcggcta cgctaaatcg tcacggcctg
     7981 tttaccacgc cggagatcgc ccatcgcttt agcgcaatag tacaggcgct gtccgcgcaa
     8041 gcgtctcacc agcgtctgct gcgccagtgg ctacagtgtc tgacggaaag agcgtggtta
     8101 atccgcgagg gtgaaagctg gcgctgccgc gttccgctca gcgagattcc tgagcctcag
     8161 gaagcgtgcc cgccaagcca atggagccag gcgctggcgc agtatctgga aacctgcatc
     8221 gcccggcacg acgccctctt ctccgggcag tgttcaccgc tggaattgct gttcaacgag
     8281 cagcatcgtg tgaccgacgc gctgtatcgc gacaaccccg ccagcgcctg tctgaatcgc
     8341 tataccgcgc agattgccgc cttgtgcggc gcagaacgga ttctggaggt cggcgccgga
     8401 accgcagcca ctaccgcgcc ggtgctgaag gccacgcgga acacgcggaa gtcgtaccac
     8461 ttcacggacg tctccgcgca gttcctcaat gacgccagag cccgtttcca tgatgaatcg
     8521 cgggtgtctt atgccttgtt cgacatcaac cagccgctgg atttcaccgc ccacccggag
     8581 gcgggttacg acctgatcgt tgccgtcaat gtgctccacg acgccagcca tgtcgtccag
     8641 acgttgcgca gattaaaact gttgctgaaa gccggcggac gtttgctgat cgttgaagcg
     8701 acggagcgaa acagcgtatt ccagctggca agcgtgggct ttattgaggg attaagcgga
     8761 taccgcgatt tccgccgccg ggatgagaaa ccgatgctca cccgctccgc atggcaggag
     8821 gttctcgttc aggccggttt tgcaaacgag ctggcgtggc ccgcgcagga atcgtcgccg
     8881 ctgcgccagc atctgctggt ggcgcattcg cctggcgtaa atcgcccgga taaagaagcc
     8941 ctgagccgct atttacagca gcgctttggc accggtcttc ccgttttaca gatccggcaa
     9001 agagaagcgt tatttacgcc gctgcatgcc ccgtctgatg cgctgattga gccagccaaa
     9061 cccacgccag ttgccggggg gaatccggcg ctggaaaaac aggtggctga actctggcaa
     9121 tcgctgctgt ctcgccccgt ggcaaggcat cacgactttt tcgaactggg cggcgacagc
     9181 ctgatggcga caaggatggt tgcgcagcta aaccggagag ggattgccag ggctaacctt
     9241 caggatctgt tcagccattc gacgctgagc gacttctgcg cccatctaca ggcggctaca
     9301 tcaggagagg acaacccgat tcccctttgc cagggcgacg gcgacgaaac cctgttcgtc
     9361 ttccacgctt cggacggcga tatcagcgcc tggctgccgc tcgccagcgc gctgaacagg
     9421 cgtgttttcg gcctgcaagc aaaatcgccg cagcgctttg gcacgcttga ccagatgatc
     9481 gatgagtatg tcgggtgcat ccgtcgccag cagcctcacg ggccttatgt actggcgggt
     9541 tggtcgtatg gcgcgtttct cgcggcgggc gccgcacagc gcctgtacgc caaaggcgag
     9601 caggttagga tcgcgttaat cgatcccgtg tgccgacagg atttctgttg cgaaaaccgg
     9661 gcggccctgc tgcgcctgtt agccgaagga caaacgcctc tggcactgcc cgaacatttc
     9721 gaccagcaga cgcccgacag ccagcttgcc gactttatca gcctcgctaa aacggccggt
     9781 atggtgtcgc aaaacctgac gctgcaagcg gcagaaacgt ggctcgacaa catcgcgcat
     9841 ctgctgcgtt tactgactga gcatacgccg ggcgaaaacg ttcctgtccc ctgtctcatg
     9901 gtgtatgccg ccgggagacc cgcgcgctgg acgccagcag aaaccgagtg gcagggctgg
     9961 ataaacaacg ccgacgacgc tgtgattgaa gccagccact ggcaaatcat gatggaagcc
    10021 cctcacgttc aggtttgtgc gcaacacatt acgcgctggc tttgcgcaac ctcaacgcaa
    10081 ccggagaaca cgttatgatg ccgtccgcct ccccaaaaca acgcgtactg attgtgggcg
    10141 ccaaatttgg cgaaatgtac ctgaatgcct ttatgcagcc cccggagggg ctggaactgg
    10201 tcggcctgct ggcgcaggga agcgcccgct caagagagct ggcccatgcg tttggcattc
    10261 cgctgtatac ctcgccggaa cagataaccg ggatgccgga tatcgcctgt attgtcgtgc
    10321 gttcgaccgt cgccggagga gctggtacgc agcttgccag acactttctg gcgcgcggcg
    10381 tacacgttat tcaggagcat cccctccacc cggatgacat cagttcctta caaacgctgg
    10441 cgcaggaaca gggctgctgc tattggataa acacgtttta tccgcatacg cgcgcaggac
    10501 gtacatggct tcgcgatgcg cagcagctgc gtcgctgcct ggctaagacg ccgccggtag
    10561 tccacgccac caccagccga cagttgctct actccacgct ggatttgttg ttgctggctc
    10621 tgggcgttga taccgccgcc gtggagtgcg acgtggtcgg cagctttagc gattttcact
    10681 gcctgagact cttctggccg gagggagaag cctgcctgct gcttcagcgc tatctcgatc
    10741 ctgacgatcc agatatgcat agccttatca tgcaccgcct gctgctgggc tggccggaag
    10801 gtcatctttc gctggaggcg agctacggcc ccgtcatctg gtcatccagc ctgtttgtcg
    10861 cagaccatca agagaacgcc cacagtctct accgcagacc ggagatcctg cgcgatccgc
    10921 cgggtctgac gcgcagcgcg gcgcctctga gctggcgtga ctgctgcgaa accgtcgggc
    10981 cggagggcgt cagctggttg ctacaccagt tgcgcagcca tctggcgggc gaacatccac
    11041 cagtggcctg ccaaaacgta catcagatcg cgttatcacg tttatggcag cagattttac
    11101 gtaagaccgg caatgcggag atcagacgcc tgacgccgcc gcaccacgac cggttagccg
    11161 gtttctacaa cgatgatgat aaggaggcgc tgtgacgcaa tctgcaatgt gcatcccgct
    11221 gtggcccgcc cggaacggca atactgcgca tctggtcatg tgccctttcg ctggcggcag
    11281 cagtagcgcg tttcgccact ggcgagacaa tcaaatggcg aacagcgcgc tttctctggt
    11341 gacctggccg gggcgcgatc gccttcgcca tctggcgccg gtcagaagca ttacgcaact
    11401 ggcggcactg ctggcgaacg aactggaagc gtccgtatcg cctgacacgc cgcttttact
    11461 cgtcgggcac agcatggggg cgcaggtggc gtttgaaacc tgccgacttc tggagcaacg
    11521 ggggcatgcg ccgcaaggac tgattatttc cgggtgccat gccccgcatc tgcattctga
    11581 acgccagctc agccatcgcg atgatgccga ctttatcgct gaactgatag acattggcgg
    11641 atgttctcct gaactgcggg aaaaccagga attaatgtcg ctgtttcttc ctcttctgcg
    11701 cgctgatttt tacgccaccg agagctatca ctacgactcg cccgacgtct gtccgccgct
    11761 gcgcacgcct gcgctgttat tgtgcggcag ccacgatcgc gaagcctcct ggcagcaggt
    11821 cgatgcctgg cgtcagtggc tgagccacgt tacaggcccg gtggtgattg acggcgatca
    11881 tttctatccc attcaacaag cccggtcctt ttttacgcag attgtccgcc attttcccca
    11941 cgcattttct gcaatgaccg cgttgcaaaa acagcccagc acttcagaaa ggtgacgcat
    12001 gaattcttcc tttgaatctc tgattgaaca gtatccctta gccattgccg aacagttgcg
    12061 ccactgggcg gcccgttatg cctcgcgaat tgccgtcgtt gatgcaaagg ggtcgttaac
    12121 ctatagcgcg cttgatgcac gggttgacga acttgccgca ggtctgtcat cactgggttt
    12181 gcgttcgggg gagcatgtaa ttgtgcagct tcccaacggc aacgcgtttg ttaccctgct
    12241 gttcgccttg ttaagactgg gcgttatccc cgtgctggcg atgccctcgc aacgggcgct
    12301 ggatatcgac gcgctgattg agctggcgca acccgtcgct tacgttattc acggggaaaa
    12361 ccacgcagag ctggcccgac agatgacgca caaacacgcc tgcttgcgtc atgttctggt
    12421 cgcaggagag accatgagcg acgattttac gccgatcttc tcccttcacg gtgagcgaca
    12481 ggcatggccg cagcctgatg tttcagccac cgcgttgttg ttgctctcag gcggcacaac
    12541 cggcacgccc aaactcatcc cgcgccgaca tgccgactat agctataact tcagcgcttc
    12601 tgctgaactg tgcggcatca gtcaacagag cgtatatctc gccgtcctcc cggtggcgca
    12661 taactttccg ctggcctgcc ccggcattct gggaacgctt gcctgcggcg gaaaagtggt
    12721 gctgaccgac agcgccagct gtgatgaggt gatgccttta atcgcgcagg aaggggtgac
    12781 tcacgtcgcc ctggttccgg cgctggcgca attatgggtg caggccaggg agtgggaaga
    12841 cagcgacctt tcgtcgctgc gcgtcattca ggcaggcggc gcccggctcg acccgacgct
    12901 tgctgagcag gttatcgcca cctttgactg taccctgcaa caggtcttcg gtatggcgga
    12961 aggcctgctc tgttttaccc ggctggacga tccgcatacc actattctcc acagccaggg
    13021 gcgaccgttg tcccctctgg atgaaatccg catcgttgat caagacgaga acgacgtcga
    13081 gccgggcgaa accgggcaat tgttaacgcg cggcccttat accatttcgg gctattaccg
    13141 cgcccctgct cacaacgcgc aggcctttac tgcgcaaggg ttttaccgca caggcgacaa
    13201 tgtcaggctg gatgaggcgg ggaacctgca cgttgagggg cgcataaaag agcagatcaa
    13261 ccgcgccgga gaaaaaatag ccgctgctga agtggaatcg gcactgctgc gtttagcgga
    13321 agtgcaagat tgcgcggtgg tcgccgcgcc ggacacgctg cttggcgagc ggatttgcgc
    13381 gtttatcatc gcgcagcaga tgccaactga ctatcagcag ttgcgtcaac aactgacccg
    13441 tatggggctc agcgcgtgga aaattcctga ccaaatcgag tttctggacc actggccgct
    13501 caccgccgtc ggcaagatag acaaaaaacg cctgacggct ctcgccgtcg accgttatcg
    13561 ccattctgcc caataagtgc aaaccgaccc gaaacaggtt gaaataaacc cgtttcgggt
    13621 agcaccact
//
