LOCUS       BGC0000468             17580 bp    DNA     linear   BCT 17-SEP-2012
DEFINITION  Streptomyces bottropensis bottromycin biosynthesis gene cluster,
            complete sequence, strain DSM40262.
ACCESSION   BGC0000468
VERSION     BGC0000468
KEYWORDS    .
SOURCE      Streptomyces bottropensis
  ORGANISM  Streptomyces bottropensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:42:04
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17580
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1338)
                     /gene="bmbT"
     CDS             complement(1..1338)
                     /codon_start=1
                     /function="bottromycin export and immunity"
                     /gene="bmbT"
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 186.2; E-value: 1.5e-56)"
                     /gene_kind="transport"
                     /inference="protein motif:PFAM:PF05977"
                     /inference="similar to AA sequence:FN554889:CBG72697"
                     /protein_id="CCM09440.1"
                     /transl_table=11
                     /translation="MSGDHRTGHRPPTQNAPMLPLYLISHGLSLLGNTVASIALPWLVL
                     LRTGDATAVGLVAAASALPMLLSAVAGGVLIDRVGRRRLSIGADLASAACVAALPVVDG
                     LLGLTVVWFVVLGVAGAVFDVPGMTAREALAPDIAEATGIGMERLAGLRESIAGGVVIL
                     APAAAGGLIMLVDPATVLWLTAGCSALAALVTLALPKAVGARSARPEQSESAGLRGDLG
                     RGLGVLRADRVLTTVTLVSAGSVAVLAPLQNLVLPVHLVSQNSPGGFGVVVSLLAIGGI
                     TGAGLYAALGTRWSRRTVFVVAQLTSTIGVAGLALLPPVPVMWAAAVLAGAGAGPLPAL
                     FLVLVTERIPEEVRGRVLGLQNAVSMTAVPLGTLAAGLAVDLIGLRQTGGLLAAAWCLV
                     TLAILALPALRRLDTGPVTPASTGPGPETGTTIPGQGSETADTTSG"
     misc_feature    1..17580
                     /note="bottromycin biosynthesis gene cluster"
     protocluster    1..17580
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9850:10852]"
                     /cutoff="20000"
                     /detection_rule="botH"
                     /neighbourhood="10000"
                     /product="bottromycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9851..10852
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="botH"
                     /neighbourhood="10000"
                     /product="bottromycin"
                     /protocluster_number="1"
     cand_cluster    1..17580
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="botH"
                     /kind="single"
                     /product="bottromycin"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..17580
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000468"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17580
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="bottromycin"
                     /region_number="1"
                     /rules="botH"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    1529..5585
                     /note="Sanger-sequenced"
     gene            complement(1792..2631)
                     /gene="bmbA"
     CDS             complement(1792..2631)
                     /codon_start=1
                     /function="O-methyl transferase"
                     /gene="bmbA"
                     /inference="protein motif:PFAM:PF04072"
                     /inference="similar to AA sequence:FN554889:CBG72696"
                     /protein_id="CCM09441.1"
                     /transl_table=11
                     /translation="MKISLTGAAETLLAPLCARALDARSAHPLLGDHIAAELIDRIDYD
                     FGRLGMGEATAVGVALRARYFDRRVRAFLQAHPECTVVHLGCGLDSRFERLAPGAGVRW
                     FDLDQPDVIELRKRLYPARPGHETLAASVTEPDWPAQVPTDRPVLVVAEGLSMYLSAEE
                     GPRMLRTLVARFPHGELLFDTYSRFAVRSTRSLSLFRRTGARLAWGVDDPRELEREIPG
                     LRLIEADSAYATAAGVDVRHLPRRLRLRMRIDTLLLSRLPVLRGIGHLSRFAFGGSG"
     gene            3059..4951
                     /gene="bmbB"
     CDS             3059..4951
                     /codon_start=1
                     /function="C-methyl transferase"
                     /gene="bmbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bottromycin_Methyltransferase_RRE"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 162.9; E-value: 1.9e-49)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF02310"
                     /inference="protein motif:PFAM:PF04055"
                     /inference="similar to AA sequence:FN554889:CBG72695"
                     /protein_id="CCM09442.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.3e-158, bitscore:
                     518.8, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 2.6e-40, bitscore: 126.3, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MPWNSVIRPSIQVGILRSLAENEGWHVDARYSYLDFYGLAQKMLG
                     FSDEQWAEAYELVSEKLYHLSVGDWIFSCRRGDADRREAYFAQLRARRVDDASIELVDA
                     LRAVADRHVERTAAELLKSAPDVIGFTSMFSQNGPSLAVAERLRDLGYGGVIVLGGSNC
                     EGSMGRALLANFPAVDAIVDGPGEDAFVALLHQVGAGDPPRSQGRLITRLPAAPDSTPA
                     APLTAAGALDVPTPDYDGFFEQLRAAGLHSLEPEITLPVEFSRGCWWGAKTHCTFCGLN
                     GATMAYRSKSPDGVADELRHLMDRYGVLDFFAVDNILDLKYLDTALPLVEKLDTDHSLF
                     FEVKANMEWADIRAVRRAGVRSVQPGIESLSTEGLRHLRKGATAYQNIRFLLGCAEYGV
                     RADWNILTGYPHETPDSLTAQLDVVASLTHLTPPHITLIRFDRFSPYVEAPEKYGLTLT
                     SPLPGYRYAYPGLSQEDLWDIAYHFEGDFTDDPANGPVRRRLAARVRLWRAHHESARFG
                     YRLGFDSLTLTDERPGLPPRTTTLRGEEARLFRAVIGGTRFRDLQGQEWQGERWDQALD
                     TLHAWRRKRWVYIEGTKVIALAVREQPSAYRTPPSKGTPRRARPPVPLTLTARP"
     gene            5098..5232
                     /gene="bmbC"
     CDS             5098..5232
                     /codon_start=1
                     /function="Precursor peptide"
                     /gene="bmbC"
                     /note="contains core peptide sequence GPVVVFDC after first
                     M; with 'follower' peptide at Ct"
                     /protein_id="CCM09443.1"
                     /transl_table=11
                     /translation="MGPVVVFDCMTADFLNDDPNNAELSALEMEELESWGAWDGEATS"
     gene            5296..6528
                     /gene="bmbD"
     CDS             5296..6528
                     /codon_start=1
                     /function="Thiazoline biosynthesis"
                     /gene="bmbD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) YcaO"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF02624"
                     /inference="similar to AA sequence:FN554889:CBG72693"
                     /protein_id="CCM09444.1"
                     /sec_met_domain="YcaO (E-value: 4.7e-10, bitscore: 29.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREATATECELREVVHRSYPSERTVTVRCTVRPAEGSAQADGYGT
                     ATTEAVARAKALSEAVERLVACTPFATVARPPTACADPGTGSGPVPPFPAAGVRTAPEG
                     CAGRVYRPLTGGGPRRVPLYWSSPWTAGAELRAGTLTAAEARLSSTVGWAVAPTPEGAL
                     RGALLELTELIDYGVFLHRRLAGPARRPSAGDRTLVVPLGGIGRTPAVLAVAYGRGRLM
                     PATGLGCGATRGEATDRALLELAQAETMWRSNPTAEPAERFFLRRFERWPLLARCATLD
                     FDLPDPRDPPARSGPAGGPGPYDDGPCPASPLEELEAGGIRVWADSGAVDISGPDIPRT
                     RLCFAHVVSDPQPLLGLVRAGIPVFDTGEVRRTLDPSRRPADRPADRGGHRDRSADRGP
                     ARRGHEGRRSA"
     gene            6416..7807
                     /gene="bmbE"
     CDS             6416..7807
                     /codon_start=1
                     /function="Thiazoline biosynthesis"
                     /gene="bmbE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) YcaO"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF02624"
                     /inference="similar to AA sequence:FN554889:CBG72692"
                     /protein_id="CCM09445.1"
                     /sec_met_domain="YcaO (E-value: 2.4e-38, bitscore: 122.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPADPQTAPQTEAATETDPLTAVLLDGATKEDVPPERETDIRQ
                     ALASVGDWLAAEGLTADIRKYGIESAPTYEVRLSEASGALCSRSSGKGLGHRSMASALF
                     ESAEHYHLDWRRDPRASEAEFRPGREIAEQATARRSALLGRLGQIMPDAPVLTRTYRPV
                     EEALTGRAGDGEADGPHRHPVFLRDGGYRNWPHPDDDRSFQPLWHYTSSAGYAAGATRH
                     EALVHAVNELIERDAWSYQLARSYFGLPGEGPELRVVEHGTLPAELRELTRTVEEVRGA
                     PVLIVDITCDTGVPAYVVCDARSREDVRLIGSGASPVRTYAVQRALLEYLQVRTMFENG
                     PVDADTEAGQIGTALARYPRHLAAARFDIHRLPHESTAFEADDGLPAATGPERLLRHLV
                     DRLRESGVEAHHRVLTPPGPVTVVDVVAPGLEMFDKARAGYPVLPTGRLGERLRPRGDG
                     GGARR"
     gene            7804..9816
                     /gene="bmbF"
     CDS             7804..9816
                     /codon_start=1
                     /function="C-methyl transferase"
                     /gene="bmbF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bottromycin_Methyltransferase_RRE"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 113.2; E-value: 2.1e-34)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF02310"
                     /inference="similar to AA sequence:FN554889:CBG72691"
                     /protein_id="CCM09446.1"
                     /sec_met_domain="TIGR03975 (E-value: 4.7e-129, bitscore:
                     421.1, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 4.6e-37, bitscore: 115.9, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLALVAPPWNSLYRPSIQIATLAALEDTADGDPITPVYAYLDWF
                     EYAVDALECDPAEFVTVYDTIGEELYGLGVGDWIFGGVLDGHGPAEEEDARAGYAAFLA
                     GHGVAEELVGRVLALRAVAPGFVSGLAGRLVATGAECFGFTTSFSQLVPALAVARAVKD
                     HAADRLVLLGGANCDRPMGQAVMRAYPFVDAVVQGEGEAAVAAVRAARGAADLAAAPGL
                     VLRHEGELRVSLPAVQPAESAPVPRYAEYFERLRALAHRELIAPHVALPFQMSRGCWWG
                     EKLQCTFCGENGSGMVYRSKPGGQLTQTLRRLTEEHGVFDTYAVDTILARSDNGLAELA
                     AAEVDITTFFEVKANLGPREVGEMRAAGVTMVQPGIESLSSGALKLLRKGATAFHNLRF
                     LVLCQELGIDAQWNLLSAMPEETAAMLLEQLRLIPFITHLAPPSTVSKVRVDRYSPYFE
                     KPGEFGIALEGPEPKYRFVHAGRTAGERAELAYSFDHVELAARGEDTAAEMLALRRRLG
                     ARVGLWKKLHEQSRFSFRFGPNMTVLHDGRPHVGTGRHVLRGGDDQLFRCLVHGGRLHQ
                     AVGRVAAMTGRPEDEVHATVREWAGRGWIHLEGRRGLVLAVRDGMRDELGRAAELREAA
                     DGPERAAAGPERAVEPPQAVESERAGGSGRVGAGR"
     gene            9851..10852
                     /gene="bmbG"
     CDS             9851..10852
                     /codon_start=1
                     /function="Hydrolase for cyclic tetrapeptide formation"
                     /gene="bmbG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     bottromycin: botH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PFAM:PF12697"
                     /inference="similar to AA sequence:FN554889:CBG72690"
                     /protein_id="CCM09447.1"
                     /sec_met_domain="botH (E-value: 3e-159, bitscore: 517.8,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.1e-13, bitscore: 39.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSRDGTPIRGFSRPGPGETLVLVHGVAMDRRIWAESGFLDAVPD
                     AHVLALDLRGRGESGRVGTARGHALARYVEDVRAVLDGFGLARYSLFGTFFGGRIALQT
                     AAVDPRVVRAFSFCAHAEQVEIPEDAVEEEAVAVEGPGGHAYLRDHFTGRGAPPWMVAA
                     CARVDPGELGAATRGLLHGSDRRTERGHPDQELVLITADGDADLAPFHAGEHRLGARLW
                     LVGAPTRIRAAGRLAETGRRVADVLAGTGRGDEDAGVEPGAGTARAGRGGMTATGTTAT
                     EDTMWRRRRGLLPEGDPLVRALEEPAGRGRGHRLRAVCLIDPATGRPGPRTS"
     gene            10855..12102
                     /gene="bmbH"
     CDS             10855..12102
                     /codon_start=1
                     /function="Hydrolase for cyclic tetrapeptide formation"
                     /gene="bmbH"
                     /inference="protein motif:PFAM:PF13147"
                     /inference="similar to AA sequence:FN554889:CBG72689"
                     /protein_id="CCM09448.1"
                     /transl_table=11
                     /translation="MTDGTVSAWAPAGPPADGDTAPRPWYAVPGFVDSHAHVSSAADLA
                     GLLVHGVTGFRQLWGEPAHLYAAGVHRARHAVVPRPWVTAGVVDGPRSRIPQGVTVVDG
                     VRSVRQVVEDALAFGFDGVKVYDDVERPAFENLVRAAERAGLPVVGHVPEAVPLELAHR
                     TMRTSEHLYGIVPNVFRLPPDHRWDALAAALRDRPAPAGTGPGHFVCPTLVCWRARSGE
                     RRYTRPSRTALRAVDQGRSRGWQAAARDALRLDAAEARQRGGLVDGLGRIARALDEAGT
                     PLLAGTDCGNPFVLAGPSFHKELAELSRAGLDFGAVLRAATTHAYAAMGRRAGPVPGEP
                     ADLVLYRRPPDGEVTALARPDAVLVDGVLLDDTDLDRLWALRLAASGLDASDWPRGDLD
                     PPVTTGRPTKEAAHAG"
     gene            12092..13324
                     /gene="bmbI"
     CDS             12092..13324
                     /codon_start=1
                     /function="Cytochrome P450"
                     /gene="bmbI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 224.5; E-value: 3.7e-68)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF00067"
                     /inference="similar to AA sequence:FN554889:CBG72688"
                     /protein_id="CCM09449.1"
                     /sec_met_domain="p450 (E-value: 4.3e-13, bitscore: 38.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQADREPDRTGHEAKRPAGTGPAPEGRGAMCPVDFDFFAAPQQYR
                     DAAAAHAGEQGAFHSDRGFWVLTTYDGIVDAFRDEDTFTVGRVSAAEGAEEERWIPLTV
                     EGREHTAWRQRLGAWFTPQRVRELTPALRAGARRRIEGFLDKGEVSFNEDFARPYVLEN
                     LMTAVGWPGDGFDLLLAIDRAMIDSRSAPDPRVAAYGELGLPALERFAREHIARRRAEP
                     ADDLTTASFGWEIDGVPVTDDDRASLLCTLFLAGVDSTVNHLANAVQHLAHHKEDRRRF
                     LAAPEARPPAVEEFLRVNSCMYPGRQAATGGAGGVADRGDTVLLPLALANHDPEVFPEP
                     ARVDFDRPRNPHIAFGTGPHQCLGAAFARAQILVALEEWHTLVPDYGPPPEQRGTEPAF
                     LRNSYDLRLVW"
     gene            13332..15365
                     /gene="bmbJ"
     CDS             13332..15365
                     /codon_start=1
                     /function="C-methyl transferase"
                     /gene="bmbJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bottromycin_Methyltransferase_RRE"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 160.3; E-value: 1.1e-48)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PFAM:PF02310"
                     /inference="protein motif:PFAM:PF04055"
                     /inference="similar to AA sequence:FN554889:CBG72687"
                     /protein_id="CCM09450.1"
                     /sec_met_domain="TIGR03975 (E-value: 4.4e-162, bitscore:
                     530.2, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 5.6e-36, bitscore: 112.4, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGTAEHPEHPATPATPATPATDRGTGPASATGSAAAGHVALVSM
                     PWNNVRRPSIQVGTLRSVARAEGWRVDAHYAYLSFYGLARTALGMRDAEWSDAYETVSE
                     GLYQLSVGDWIFACRDGGPAPREEYFRMLRAKGVDDTTIELVDALRPVADRHVERTAAE
                     LLKSAPDVIGFTSTFSQNGPTLAVAERLRDLGYGGVIVLGGSNCEGPMGRALLANYPAV
                     DAIVDGPGEDAFVALLHQVRAGDPPRSQGRLITRLPAAPDSTPAVISGGQSLEVPTPDY
                     DDFFEQLRAAGLHSLEPEITLPVEFSRGCWWGAKTHCTFCGLNGASMTYRSKNPDTVAD
                     ELRHLMDRYGVLDFFAVDNILDLKYLDTALPLVEKLDTDHSLFFEVKANMEWADIRAAR
                     RAGVRSVQPGIESLSTEGLRLLKKGATAFQNIRFLLGCAEFGVLPVWNILTGFPHETPE
                     SMLTQIDLLPSLTHLEPPDNDILAVHFDRFSPYVEHPQDYGLTLTSPLPGYRYAYPRLS
                     PGDLWDLAYHFEGDFAEDPRNTAVRARLATAVHHWRTRHHQARFTYRLGFDAVTLTDRR
                     PGLPARTAVLRDEDARLFRAVVGGTRFRDLQSLPWRDDPLEKLHGWQEKRWVYIEGSKV
                     IALPVREMPSAYRTPPRRGTPRRSRSAVPLTLTGVPSAQRSG"
     gene            15507..16061
                     /gene="bmbR"
     CDS             15507..16061
                     /codon_start=1
                     /function="Putative transcriptional regulator"
                     /gene="bmbR"
                     /inference="protein motif:PFAM:PF09860"
                     /inference="similar to AA sequence:FN554889:CBG72686"
                     /protein_id="CCM09451.1"
                     /transl_table=11
                     /translation="MTTAPTEDQSRTEDLPPSCRDLIGILAQTDRRDAFAALALGATSV
                     TEVAQRAGLRPAAAAVALQKLVDGRIAAYDAEARTYRLIDDTFRLAVQAEVRISGRGGG
                     DGAGAYFRKGRLTSIPGKAEVRTRVLTVVADSFEAGVTYSEAKVNAICGQWFDDWVTLR
                     RALVDEELLRRDESGTRYARG"
     gene            16066..17580
                     /gene="bmbK"
     CDS             16066..17580
                     /codon_start=1
                     /function="Aminopeptidase"
                     /gene="bmbK"
                     /inference="protein motif:PFAM:PF00883"
                     /inference="protein motif:PFAM:PF02789"
                     /inference="similar to AA sequence:FN554889:CBG72685"
                     /protein_id="CCM09452.1"
                     /transl_table=11
                     /translation="MTRVVAGDVTADAAGRPADVVAYGRHTGGAVSAFCRRRGFVARPG
                     QVVAEPSADGRSVVLNVGLGPAGAATAATFRTAAAAAVRAAGPARTLRLELAPAGDGGV
                     PAADRDRAVAEGAVLGLYRYDEYRSARAASPLAEVVVATGERRAVAEGLAVAEATCLAR
                     DLVNRPAGALTPPVFADRIRELAGAAGLGCAMYEAAGLTELGLTGLAAVGRGSAEPPRY
                     VELTYEPPEGEPVLTVGLVGKGVTFDSGGLSLKPSGERHAMKADMAGAAAVVAALTALP
                     RLGLPLRVRGHLPLAENMPDGGALRVGDVVRHLDGTTTEITHTDNEGRVVLADVLVRAS
                     GPGPHRADLVIDVATLTSAAVHALGTRTGALFTPDEWLARTVLAASERAGESVCRLPLL
                     AHERRHLRSTVADRVNCSHRHGDTVQAALFLQDFVADGVRWAHLDIAAPAYNDEGPYAE
                     VPHGGTGFAVRTLTETLRALCGGAPDTGPDLREPSGSGSESRSRSW"
ORIGIN
        1 tcagcccgat gtcgtgtcgg ctgtttcgga gccctggccg gggatggtgg tgccggtctc
       61 ggggccgggg ccggtgctcg ccggggtcac cgggcccgtg tcgaggcggc ggagggcggg
      121 cagggccagg atcgcgaggg tgaccaggca ccaggcggcg gcgaggagcc cgccggtctg
      181 ccggaggccg atcaggtcca cggcgagccc ggcggcgagg gtgccgagcg ggacggcggt
      241 catggacacg gcgttctgga ggccgaggac gcggccgcgc acctcctcgg ggatccgttc
      301 ggtgacgagg accaggaaga gggcgggcag ggggcccgcg ccggcgccgg ccaggacggc
      361 ggccgcccac ataacgggca ccgggggcag gagtgcgagt ccggcgacgc cgatcgtgga
      421 ggtgagctgc gcgacgacga agacggtgcg gcgggaccag cgggtgccga gggcggcgta
      481 caggccggcg ccggtgatgc cgccgatggc gaggagggag acgacgacac cgaagccgcc
      541 gggtgagttc tggctcacga ggtggacggg gagcaccagg ttctggaggg gggcgaggac
      601 ggcgacgctg ccggccgaga ccagggtgac ggtggtcagg acgcggtcgg cgcgcaggac
      661 gccgagtcct cgcccgaggt cgcctcgcag gcccgcgctc tcgctctgct cggggcgcgc
      721 gctccgggcg ccgacggcct tgggaagggc gagggtgacg agggcggcga gggccgagca
      781 cccggcggtg agccagagga cggtggccgg gtcgacgagc atgatcagcc cgccggcggc
      841 ggccggggcg aggatcacga cgccgccggc gatgctctcg cggagtccgg cgaggcgctc
      901 catgccgatg ccggtggctt cggcgatgtc cggcgcgagg gcctcccggg cggtcatgcc
      961 gggtacgtcg aagacggcgc cggcgactcc gaggacgacg aaccagacga cggtgagccc
     1021 gaggaggccg tctacgacgg ggagcgcggc gacgcaggcc gcggaggcga ggtcggcgcc
     1081 gatggagagg cgccggcggc cgacccggtc gatgagcacg cctccggcga cggccgacag
     1141 aagcatcggc agagcgctcg cggcggcgac gaggccgacc gcggtggcgt caccggtgcg
     1201 cagcagcacc agccagggga gggcgatgga ggccacggtg ttgcccagca gggacaggcc
     1261 gtgggagatg aggtagagcg gcagcatcgg ggcattctgg gtcgggggcc ggtggcccgt
     1321 tcggtggtcg cccgacatcg gggccggacg gccgggatct cgcggcgggg ggtggcgggg
     1381 gtgggtgcgg gctggggggg ccggttcggg ctgggggcta ggtgcgggct gagggcttga
     1441 gaggtctgag aggcgcaggt gtccgggaga ctcgggtgac ccgggagact cgggtggccc
     1501 gggaggacca ggtgacccgg caggcccggg agatcccgtg atcccggtga tccgggcttc
     1561 gacgagcccc caacgcaccg gcgggacccc gcacgaaccg acggttcccc tggaccgatg
     1621 agccctctcg accgccgaac cccacgaacc gacgggcccc caggaaccga tggccccaca
     1681 cgaaccggtg agccccctcg accgccgaac cccacgaacc gacgggctcc cacgagccga
     1741 gggccatcca ccgcccccgc tcccccgacg aaccgatgag ccccacaccg ctcagccgga
     1801 cccgccgaac gcgaagcggg aaaggtggcc gatgccgcgc aggaccggga gccgggacag
     1861 gagcagggtg tcgatccgca tccgcaggcg cagtcggcgg ggcaggtggc gcacatcgac
     1921 gccggccgcg gtggcgtacg cgctgtcggc ctcgatcagc cgcaacccgg gtatctcgcg
     1981 ctccagttcg cgcgggtcgt ccacgcccca ggccagccgg gcacccgtcc tgcggaagag
     2041 gctcagggag cgggtggacc gtacggcgaa gcgggagtac gtgtcgaaca gcagctcgcc
     2101 gtgcgggaac cgggcgacga gggtgcgcag catgcggggt ccctcctcgg cggagaggta
     2161 catgctgagg ccctcggcga ccacgaggac gggccggtcc gtggggacct gggccggcca
     2221 gtccggttcg gtgacggagg cggcgagggt ctcgtggccg gggcgggcgg ggtagagccg
     2281 cttgcgcagt tcgatgacgt cgggctggtc caggtcgaac cagcgcacgc ccgcgccggg
     2341 ggcgaggcgc tcgaaccggc tgtccaggcc gcagccgagg tggaccacgg tgcactcggg
     2401 gtgggcctgg agaaatgcgc ggaccctgcg gtcgaaatag cgcgcccgca gggccacccc
     2461 gacggcggtg gcctctccca tgccgaggcg gccgaagtcg tagtcgatgc ggtcgatgag
     2521 ttcggccgcg atgtggtcgc cgagcagggg gtgggcggat cgggcgtcga gcgcgcgggc
     2581 acagagaggg gcgaggagtg tctccgccgc accggtcagg gaaatcttca cgcgacttct
     2641 cgcctctctg cgcacagaaa tagggtcggc gggaaatatt cttcggcgag ccatatggta
     2701 aagccctcgg cagactttca tccgtccgaa ggatcagccc gcttcgactc ctgtcacatc
     2761 atggagcgag gaacaccata caccgtacaa cgcgacccgt cggcctgtct accacgcctc
     2821 ccatctgcac atacgtgcac gatcaccgat cttccccgcc ggtcgccgag ccgatcacga
     2881 atgcgtggcc acatgccacc gccaggtaca tggcaggcga atgttttcag ccaacctata
     2941 ccgatccttt tatcactgtt gactcgcgta atcctcgctt ctacggtgat tcgagttgcc
     3001 gcaatcggct ccgggggttg ctttcgtgcc taccgccaaa aacgtttccc ttgtatcaat
     3061 gccatggaac agtgtcatcc gtccttcgat tcaggtcggc attctgcgct cgctcgccga
     3121 gaacgagggc tggcatgtgg atgcccgata ttcctatctg gatttctacg ggctggccca
     3181 gaaaatgctc gggttctccg acgagcaatg ggcggaggcc tatgaactgg tctccgaaaa
     3241 gctctatcac ctttcggtgg gcgactggat cttctcgtgc cgccggggcg acgccgaccg
     3301 gcgggaggcc tacttcgccc agttgcgggc gaggcgggtc gacgacgcgt cgatcgagct
     3361 ggtcgacgcg ctgcgcgcgg tcgcggaccg gcatgtggag cgcacggccg ccgagttgct
     3421 gaagtccgcg cccgatgtca tcggcttcac ctcgatgttc agccagaacg gcccgtcgct
     3481 ggcggtggcc gagcggctgc gggacctcgg ctacggcggg gtgatcgtgc tgggcggcag
     3541 caactgcgag ggctccatgg gccgcgccct gctggccaac ttccccgccg tggacgcgat
     3601 cgtggacggt ccgggcgagg acgccttcgt cgccctcctc caccaggtcg gggccggaga
     3661 cccaccgcgc tcccagggcc ggctgatcac ccgactgccc gccgcccccg acagcacgcc
     3721 ggccgcaccg ctcaccgccg ccggcgccct ggacgtaccc acccccgact acgacggctt
     3781 cttcgagcag ttgcgcgccg ccggtctgca cagcctcgaa cccgagatca ccctgcccgt
     3841 ggagttctcc cgcggctgct ggtggggcgc gaagacccac tgcaccttct gcggcctcaa
     3901 cggcgcgacg atggcgtacc gcagcaagag cccggacggg gtggccgacg aactgcgcca
     3961 cctcatggac cgctacggcg tcctcgactt cttcgccgtc gacaacatcc tcgacctcaa
     4021 gtacctcgac acggccctgc cgttggtgga gaagctcgac accgaccatt ccctgttctt
     4081 cgaggtcaag gccaacatgg agtgggccga catccgggcc gtgcgccggg cgggggtgcg
     4141 ttccgtgcag ccggggatcg agagcctcag cacggagggg ctgcggcatc tcaggaaggg
     4201 cgcgacggcg taccagaaca tccggttcct gctgggctgc gccgagtacg gcgtacgggc
     4261 ggactggaac atcctcaccg gctatccgca cgagacaccg gactcgctga cggcgcagct
     4321 cgatgtcgtc gcgtcgctga cgcatctgac tccgccgcac atcacactga tccgcttcga
     4381 ccggttcagt ccgtacgtcg aggcgcccga gaagtacggg ctcacgctga ccagcccgct
     4441 gccgggctac cggtacgcct atcccggtct gtcgcaggag gatctctggg acatcgcgta
     4501 ccacttcgag ggcgacttca ccgacgaccc ggccaacggg ccggtgcggc gcaggctcgc
     4561 cgcacgcgtc cggctgtggc gcgcccatca cgagtccgcg cgcttcggct accggctcgg
     4621 cttcgactcg ctcaccctca ccgacgaacg acccgggctg ccgccgcgga ccaccaccct
     4681 gcggggtgag gaggcgcggc tgttccgcgc cgtcatcggc ggcacccggt tccgcgacct
     4741 ccaagggcag gagtggcagg gggaacgctg ggaccaggcc ctggacacgc tgcacgcctg
     4801 gcgcagaaag cggtgggtct acatcgaagg cacgaaggtc atcgcactcg cggtacgcga
     4861 gcagccctcg gcctatcgga ccccaccgtc caagggcact ccccggcggg ctcgtccccc
     4921 cgtgcctctc acgctcaccg ctcgaccgta aggaggcacc catcgcgcgg atccgggcca
     4981 ccgcgtcccc atggaggcaa gagcgctgga gccgaaggaa gcgcacggcg acagcgcgca
     5041 gcggcatcgc acagcaaccc ggaagacgga cgagaagaca gacgaaagga ccacaccatg
     5101 ggacccgtag tcgtattcga ctgcatgacc gcagacttcc tcaacgacga ccccaacaac
     5161 gcggaactga gcgcgctgga gatggaggag ctggagtcct ggggcgcctg ggacggcgaa
     5221 gccacctcat gagcgtcggc cggtgagtag ccggccggtg tgaagtcggc gagacggacg
     5281 accgggagag ggagcatgcg cgaagcgacg gcgacggagt gtgagctgcg cgaggtcgtc
     5341 caccgttcgt atccctcgga acgaacggtg accgtgcggt gcaccgtacg ccccgccgag
     5401 ggcagcgccc aggccgacgg ttacggcacc gccacgaccg aggccgtggc acgggcgaaa
     5461 gccctgtccg aagccgtgga gcggctggtg gcgtgcaccc ccttcgcgac ggtcgcccgt
     5521 ccgccgacgg cgtgcgcgga ccccggaacg ggctccggcc cggtcccgcc cttcccggcg
     5581 gccggggtgc gcaccgcgcc ggagggctgt gcgggccggg tgtaccggcc gctgaccggc
     5641 ggcggaccgc gccgggtgcc gctgtactgg tcctcgccct ggaccgccgg tgcggagttg
     5701 cgtgcgggca cgctgacggc ggcggaggcg cggctgtcga gcacggtggg ctgggccgtc
     5761 gccccgacac cggagggagc gctgcgcggc gcgctgctgg aactgaccga actgatcgac
     5821 tacggagtct tcctgcaccg ccggctggcg ggacccgcgc ggcggccgtc ggcgggtgac
     5881 cggacgctgg tggtgccgct cggcgggatc ggccgtacgc cggccgtgct cgccgtggcg
     5941 tacggccgtg ggcggctgat gccggccacc gggctggggt gcggggcgac ccggggcgag
     6001 gcgaccgacc gggcgctgct ggagctggcg caggccgaga cgatgtggcg gtcgaacccc
     6061 accgcggaac cggccgagcg tttcttcctg cgccgcttcg agcggtggcc gctgctcgcg
     6121 cggtgcgcga ccttggactt cgacctgccc gacccgcgtg acccgcccgc acggagcggc
     6181 ccggccggcg ggccgggacc gtacgacgac gggccgtgtc ccgcgtcccc ccttgaggag
     6241 ctggaggccg gcggcatccg ggtgtgggcc gactccggtg ccgtcgacat ctcaggcccg
     6301 gacatcccca ggacccgtct ctgcttcgcc catgtggtgt cggatccgca gcccctcctg
     6361 ggccttgtcc gcgcaggcat ccccgtgttc gacacgggag aagtgaggag gacccttgac
     6421 ccgtcccgcc gacccgcaga ccgccccgca gaccgaggcg gccaccgaga ccgatccgct
     6481 gaccgcggtc ctgctcgacg gggccacgaa ggaagacgtt ccgcctgagc gcgagacgga
     6541 catccggcag gccctggcct ccgtcgggga ctggctggcc gccgaagggc tgacggccga
     6601 catccgcaag tacggcatcg agtccgcgcc cacctacgag gtgcggctgt cggaggcgtc
     6661 gggcgcgctc tgttcccgca gttccggcaa ggggctgggg caccggagca tggcgagcgc
     6721 gctgttcgag agcgccgagc actaccacct ggactggcgc cgggaccccc gcgcgtcgga
     6781 ggcggagttc cggccggggc gggagatcgc ggaacaggcc accgcccggc ggtccgccct
     6841 gctgggccgg ctcggccaga tcatgcccga cgcgcccgtg ctgacccgga cgtaccgccc
     6901 ggtggaggag gccctgaccg ggcgggcggg cgacggtgag gcggacgggc cgcaccggca
     6961 cccggtgttc ctgcgggacg ggggctaccg caactggccc catccggacg acgaccggtc
     7021 cttccagccg ctgtggcact acacctccag cgccggttac gcggcgggcg ccacccggca
     7081 cgaggcgctg gtgcacgccg tgaacgagct gatcgagcgg gacgcctggt cgtaccagct
     7141 ggcccggtcg tacttcggtc tgcccggcga ggggcccgag ctgcgggtgg tggagcacgg
     7201 cacgctcccc gccgagctgc gggagctgac ccgtacggtc gaggaggtcc ggggcgctcc
     7261 ggtgctgatc gtggacatca cctgcgacac cggcgtaccg gcctatgtgg tgtgcgacgc
     7321 gcggagcagg gaggacgtcc ggctgatcgg cagcggggcc tcgccggtgc ggacgtacgc
     7381 ggtgcagcgg gcgctgctgg agtacctcca ggtgcggacg atgttcgaga acgggccggt
     7441 ggacgcggac accgaggccg ggcagatcgg tacggcgctg gcccgctatc cccgtcatct
     7501 ggccgcggcc cggttcgaca tccaccggct gccgcacgag agcacggcgt tcgaggcgga
     7561 cgacgggctg cccgccgcca ccggtcccga gcggttgctg cggcatctgg tggaccggct
     7621 gcgggagtcg ggcgtcgagg cacatcaccg ggtgctgact ccgccggggc cggtcacggt
     7681 cgtcgatgtc gtggcgccgg ggctggagat gttcgacaag gcgcgggcgg gttatccggt
     7741 gctgccgacc gggcgtctgg gcgagcggct gcggccgcgc ggggacggcg ggggtgcgcg
     7801 ccggtgaagc tcgcgctcgt ggcaccgccc tggaacagcc tgtaccgccc gtccatccag
     7861 atcgccaccc tcgcggcgct ggaggacacg gcggacgggg acccgatcac gccggtctac
     7921 gcgtatctgg actggttcga gtacgccgtc gacgcgctgg agtgcgatcc ggcggagttc
     7981 gtcaccgtct acgacacgat cggcgaggag ctgtacgggc tgggcgtcgg ggactggatc
     8041 ttcggcgggg tcctggacgg tcatggcccg gcggaggagg aggacgcccg cgccgggtac
     8101 gccgccttcc tggccgggca cggggtggcc gaggaactgg tgggccgggt gctggcgctg
     8161 cgcgcggtcg cccccgggtt cgtgtcgggg ctggccgggc ggctcgtcgc gaccggcgcc
     8221 gagtgcttcg ggttcaccac gtcgttcagt cagctggtgc ccgcgctggc cgtggcccgg
     8281 gccgtgaagg accacgcggc cgaccggctg gtgctgctgg gcggggcgaa ctgcgaccgg
     8341 cccatggggc aggccgtgat gcgggcgtat ccgttcgtcg acgcggtcgt gcagggtgag
     8401 ggcgaggcgg cggtggcggc ggtccgggcc gcgcgcggcg ccgccgatct cgcggcggcc
     8461 ccgggtctgg tcctgcggca cgagggcgag ctgcgggtgt cgctgccggc cgtgcagccg
     8521 gccgagtcgg cgccggtgcc ccggtacgcg gagtacttcg agcggctgcg ggcgctggcg
     8581 caccgtgagc tgatcgcccc gcacgtggcc ctgccgttcc agatgtcgcg gggctgctgg
     8641 tggggcgaga agctgcagtg caccttctgc ggtgagaacg gcagcggcat ggtctaccgc
     8701 agcaagccgg gcgggcagtt gacgcagacc ctgcgccggc tgaccgagga gcacggtgtg
     8761 ttcgacacgt acgcggtcga cacgatcctc gcccgcagcg acaacggtct ggccgaactc
     8821 gccgccgcgg aggtcgacat caccacgttc ttcgaggtga aggccaacct ggggccgcgg
     8881 gaggtgggcg agatgcgggc ggcgggcgtc accatggtgc agccgggcat cgagagcctc
     8941 agcagtggtg cgctgaagct gctgcgcaag ggggcgacgg ccttccacaa tctgcgtttc
     9001 ctggtgctgt gccaggagtt gggcatcgac gcccagtgga acctgctgtc ggcgatgccc
     9061 gaggagacgg cggcgatgct gctggagcag ctgcggctga tcccgttcat cacgcatctc
     9121 gcgccgccgt cgacggtgag caaggtccgg gtcgaccggt acagcccgta cttcgagaag
     9181 cccggcgagt tcggcatcgc gctggagggg cccgagccga agtaccgctt cgtgcatgcc
     9241 ggccgtacgg ccggtgaacg cgccgagctg gcctactcgt tcgaccatgt ggagctggcg
     9301 gcgcggggcg aggacacggc cgcggagatg ctcgcgctgc gacggcggct gggcgcccgg
     9361 gtgggcctgt ggaagaagct gcacgaacag tcgcggttct ccttccggtt cggtccgaac
     9421 atgaccgtgc tgcacgacgg ccgaccgcat gtcggtaccg ggcgtcacgt actgcggggc
     9481 ggcgacgacc agttgttccg ctgtctggtg cacggcgggc ggctgcacca ggccgtcggc
     9541 cgggtcgccg cgatgacggg ccggccggag gacgaggtgc acgcgacggt gcgggagtgg
     9601 gcgggacgcg gctggatcca tctggagggc cggcgcggtc tggtgctggc ggtgcgtgac
     9661 ggcatgcggg acgagctggg acgggcggcc gagctgcggg aggcggcgga cgggccggag
     9721 cgggcggccg ccgggccgga gcgggctgtc gagccacccc aggctgtcga gtcggagcgg
     9781 gccggtggat cggggagggt cggtgcggga cgctgacggc accctgcggg gtgcgacgga
     9841 gccgttcgag gtggtctccc gcgacggtac gccgatccgc ggcttcagca ggcccggacc
     9901 gggcgagacc ctcgtcctcg tccatggggt ggcgatggac cggcggatct gggcggagtc
     9961 ggggttcctc gacgccgtcc cggacgccca tgtcctcgcg ctcgacctgc gcggacgcgg
    10021 ggagagcggg cgcgtcggca cagcgcgggg gcacgccctc gcccgctacg tcgaggatgt
    10081 ccgcgcggtc ctcgacggct tcggcctcgc ccggtacagc ctgttcggca ccttcttcgg
    10141 cgggcggatc gctttgcaga cggccgccgt ggacccccgg gtggtccggg cgttctcctt
    10201 ctgcgcgcac gccgagcagg tggagatccc cgaggacgcc gtcgaggagg aggcggtggc
    10261 cgtcgagggg ccgggcggtc acgcctatct gcgcgaccac ttcaccggac ggggcgcccc
    10321 gccgtggatg gtcgcggcct gcgcccgtgt cgaccccggc gagctggggg cggccacccg
    10381 gggcctgctg cacggctcgg accggcggac cgaacgcggc cacccggacc aggagctggt
    10441 gctgatcacc gcggacggcg acgcggacct ggcgcccttc cacgccgggg agcaccggct
    10501 cggcgcccgg ctgtggctcg tcggggcccc gacccggatc agggcggccg gccgcctggc
    10561 ggagaccggc cggcgggtgg cggacgtgct ggccggaacg ggacgcggtg acgaggacgc
    10621 cggcgtggag cctggggccg ggaccgcgcg agccgggcgg ggcggtatga cggcgaccgg
    10681 gacgacggcg accgaggaca ccatgtggcg gcggcgccgg gggctgctgc ccgagggcga
    10741 cccgctggtg cgggcgctgg aggagccggc ggggcggggg cgggggcacc ggctgcgggc
    10801 cgtgtgtctg atcgaccccg ccaccgggcg gcccggtccc cgcacgagct gacggtgacc
    10861 gacggcacgg tctccgcctg ggcccccgcc gggccccccg ccgacgggga cacggccccc
    10921 cgcccctggt acgccgtgcc gggcttcgtc gactcccacg cgcacgtctc ctccgccgcc
    10981 gacctggccg gcctcctcgt ccacggggtc accggcttcc ggcagctgtg gggcgagccg
    11041 gcccatctgt acgccgccgg tgtgcaccgc gcccggcacg ccgtcgtccc ccggccctgg
    11101 gtcaccgccg gggtggtcga cgggccccgg tcacggatcc cgcagggggt caccgtggtg
    11161 gacggcgtcc ggtcggtccg gcaggtggtc gaggacgcgc tggccttcgg cttcgacggc
    11221 gtcaaggtgt acgacgacgt cgagcggccg gcgttcgaga acctggtccg ggcggcggag
    11281 cgggccggtc tgcccgtcgt gggccacgtc cccgaggcgg tgccgctgga gctggcccac
    11341 cgcacgatgc gcacctccga gcatctgtac ggcatcgtgc ccaacgtctt ccggctgccg
    11401 cccgaccacc gctgggacgc gctggcggcg gcgctgcgcg accgcccggc acccgccggg
    11461 accggccccg gccacttcgt ctgccccact ctcgtctgct ggcgggcccg cagcggtgaa
    11521 cgccggtaca cccgcccttc ccgcacggcg ctgcgggcag tggaccaggg ccgcagccgg
    11581 ggctggcagg cggcggcccg ggacgccctc cggctggacg ccgccgaggc gcgccagcga
    11641 ggcgggctcg tcgacgggct gggccggatc gcccgcgcgc tcgacgaggc gggtacgccg
    11701 ctgctggccg gcaccgactg cggcaacccg ttcgtcctcg cgggcccctc cttccacaag
    11761 gagctggccg aactgtcccg cgcggggctc gacttcggcg ccgtactgcg ggcggcgacc
    11821 acccacgcgt acgcggcgat ggggcggcgg gcgggaccgg tgcccggtga accggccgac
    11881 ctggtcctct accggcgccc gcccgacggc gaggtgacgg ccctcgcccg gcccgacgcg
    11941 gtgctggtcg acggtgtcct cctcgacgac accgacctcg accggctgtg ggcgctccgg
    12001 ctggccgcgt cggggctcga cgcgtccgac tggccccgcg gcgacctcga cccaccggtc
    12061 accaccggcc gaccgacaaa ggaggcagcg catgcaggct gaccgggaac ccgaccgcac
    12121 cggccacgag gcgaagcgcc ccgcggggac cggccccgcg ccggagggac ggggagcgat
    12181 gtgtcccgtg gacttcgact tcttcgccgc cccgcagcag taccgcgacg cggccgccgc
    12241 gcacgccggt gagcagggcg ccttccacag cgaccggggc ttctgggtgc tgacgacgta
    12301 cgacgggatc gtggacgcgt tcagggacga ggacaccttc accgtcggcc gggtcagtgc
    12361 ggcggagggc gccgaggagg agcgctggat tccgctgacc gtcgagggcc gtgagcacac
    12421 ggcgtggcgg cagcggctgg gcgcctggtt caccccgcaa cgggtgcggg agctgacgcc
    12481 cgcgctgcgg gcgggcgccc gacggcgcat cgaggggttc ctggacaagg gcgaggtgtc
    12541 gttcaacgag gacttcgccc ggccgtacgt cctggagaac ctgatgacgg cggtgggctg
    12601 gccgggggac gggttcgacc tgctcctcgc catcgaccgg gcgatgatcg actcccgctc
    12661 ggcgcccgat ccccgggtgg ccgcctacgg cgagctgggg cttccggcgc tggagcggtt
    12721 cgcccgtgag cacatcgcgc ggcggcgcgc ggagccggcc gacgatctca ccaccgccag
    12781 cttcggctgg gagatcgacg gcgtcccggt caccgacgac gaccgggcct ccctgctgtg
    12841 cacgctgttc ctggccggag tcgactcgac ggtgaaccac ctggccaacg ccgtgcagca
    12901 cctcgcccat cacaaggagg acaggcggcg gttcctggcc gcgcccgagg cccggccacc
    12961 ggcggtcgag gagttcctgc gggtcaactc gtgcatgtac ccgggccggc aggccgcgac
    13021 cggcggcgcg ggcggggtcg cggaccgtgg cgacaccgtg ctgctcccgc tcgcgctcgc
    13081 caaccacgac cccgaggtgt tccccgagcc cgcccgggtc gacttcgacc ggccccgcaa
    13141 cccgcacatc gccttcggca cgggccccca ccagtgcctc ggcgcggcct tcgcgcgggc
    13201 gcagatcctg gtggccctgg aggaatggca cacgctcgtc cccgactacg gcccaccccc
    13261 cgagcagcgc gggaccgagc ccgcgttcct gcgcaactcc tacgacctga ggctcgtgtg
    13321 gtgaggacgc catgaacggc acggccgagc accctgagca ccccgccacg cccgccacgc
    13381 ccgccacgcc cgccacggac cgggggacgg gcccggcctc cgcgaccggt tccgccgctg
    13441 ccggtcacgt ggccctcgtg tccatgccct ggaacaacgt gcggcgcccg tccatccagg
    13501 tgggcaccct gcgttccgtc gcccgcgccg agggatggcg ggtcgacgcg cactacgcct
    13561 acctctcctt ctacggcctc gcccgcaccg ctctcgggat gcgggacgcc gagtggtcgg
    13621 acgcgtacga gacggtgtcc gaggggctgt accaactgtc cgtcggcgac tggatcttcg
    13681 cctgccgcga cggcgggccg gcgccgcgcg aggagtactt ccggatgctg cgcgccaagg
    13741 gcgtcgacga cacgacgatc gagctggtcg acgcgctgcg cccggtcgcg gaccggcatg
    13801 tggagcgcac ggccgccgag ttgctgaagt ccgcgcccga tgtcatcggc ttcaccagca
    13861 ccttcagcca gaacgggccg acgctggcgg tggccgagcg gctgcgggac ctcggctacg
    13921 gcggggtgat cgtgctgggc ggcagcaact gcgagggacc catgggccgc gccctgctcg
    13981 ccaactaccc cgccgtggac gcgatcgtgg acggtccggg cgaggacgcc ttcgtcgccc
    14041 tcctccacca ggtccgggcc ggcgacccac cgcgctccca gggccggctg atcacccgac
    14101 tgcccgccgc ccccgacagc acgccggccg tcatctccgg gggccagtcg ctggaggtgc
    14161 ccaccccgga ctacgacgac ttcttcgagc agttgcgcgc cgccggtctg cacagcctcg
    14221 aacccgagat caccctgccc gtggagttct cccgcggctg ctggtggggc gcgaagaccc
    14281 actgcacctt ctgcggcctc aacggcgcga gcatgacgta ccgcagcaag aaccccgaca
    14341 ccgtcgccga cgaactgcgc cacctcatgg accgctacgg cgtcctcgac ttcttcgccg
    14401 tcgacaacat cctcgacctc aagtacctcg acaccgcgct ccccctggtc gagaaactcg
    14461 acaccgacca ttccctgttc ttcgaggtca aggccaacat ggaatgggcc gacatccggg
    14521 ccgcccgccg ggccggggtc cgttccgtgc aacccgggat cgaaagtctc agcaccgagg
    14581 ggctgcggct gctgaagaaa ggtgcgaccg ccttccagaa catccggttc ctgctcggct
    14641 gcgccgaatt cggtgtcctg cccgtgtgga acatcctcac cggatttccg cacgagaccc
    14701 cggagtcgat gctcacccag atcgatctgc tgccctccct gacccatctg gaaccacccg
    14761 acaacgacat cctggccgtg cacttcgacc ggttcagccc gtacgtggaa cacccgcagg
    14821 actacggcct caccctgacc agccccctgc cgggctaccg gtacgcctac ccccgcctgt
    14881 cccccggcga cctgtgggac ctcgcgtacc acttcgaggg cgacttcgcc gaggaccccc
    14941 gcaacacggc cgtccgcgcc cgtctcgcca cggccgtcca ccactggcgc acccggcacc
    15001 accaggcacg tttcacctac cggctcggct tcgacgcggt gaccctcacc gaccggcgtc
    15061 ccggcctgcc cgcccgcacc gccgtcctgc gcgacgagga cgcccgcctg ttccgcgcgg
    15121 tcgtcggagg cacccgtttc cgcgatctcc agagcctgcc ctggcgggac gaccccctgg
    15181 aaaagctgca cggatggcag gagaaaaggt gggtctacat cgagggcagc aaagtcatcg
    15241 cccttccggt acgggaaatg ccctccgcct atcgcacccc gccccgcaga ggaactcccc
    15301 gcagatcccg gagcgccgtg ccgctcacgc tcaccggtgt gccctccgca cagcggtctg
    15361 gctgaaatcg gtcccgtacg gcgtttcccg attgcggtga ccggccgtcg gcgcggtact
    15421 cgtagaggat cacgcggtac tcgtagagga tcaccgtgca cagcgtcccc gtacaacgcc
    15481 gcaccccgaa ccggaagttg atcaccatga ccacggctcc caccgaggac cagtcccgca
    15541 ccgaggatct gccgccgtcc tgccgcgacc tgatcggcat cctcgcccag accgaccggc
    15601 gcgacgcctt cgcggccctc gcgctcggcg cgacctccgt gaccgaggtg gctcagcggg
    15661 ccggcctgcg cccggcggcc gccgccgtcg ccctgcagaa gctcgtcgac gggcggatcg
    15721 ccgcgtacga cgccgaggcg cgcacctacc ggctgatcga cgacacgttc cggctggccg
    15781 tccaggcgga ggtgcggatc tccgggcggg gcggcggtga cggcgcgggg gcgtacttcc
    15841 gcaaggggcg gctgacgtcg atccccggca aggccgaggt ccgcacccgg gtcctcaccg
    15901 tcgtggccga ctccttcgag gccggggtca cctactccga ggccaaggtc aacgcgatct
    15961 gcgggcagtg gttcgacgac tgggtcaccc tgcgcagggc gctcgtggac gaggaactgc
    16021 tgcggcgcga cgagtcgggc acccggtacg cgcgcggatg accgcatgac ccgggtcgtg
    16081 gccggtgacg tcaccgccga cgcggcgggc cggccggccg acgtcgtcgc gtacggccgc
    16141 cacaccggtg gcgccgtcag cgcgttctgc cgccgccggg gtttcgtggc ccggcccggg
    16201 caggtggtcg cggagccgtc cgccgacgga cgttcggtgg tgctgaacgt gggcctgggg
    16261 cccgcgggtg cggccacggc cgccacgttc cgtaccgcgg cggcggccgc ggtacgggcc
    16321 gcgggcccgg cccgcacgct ccgcctggaa ctcgccccgg ccggcgacgg cggggtcccg
    16381 gcggccgacc gggaccgggc cgtggcggag ggcgcggtgc tgggcctgta tcgctacgac
    16441 gagtaccggt ccgcgcgggc cgcgagcccc ctggccgagg tggtcgtggc gaccggggag
    16501 cggcgggccg tcgccgaggg cctggccgtc gccgaggcca cctgcctggc ccgcgacctc
    16561 gtcaaccgtc cggccggcgc cctcacgccc ccggtgttcg ccgaccggat ccgcgagctt
    16621 gcgggcgccg ccggcctcgg ctgcgcgatg tacgaggccg ccgggctgac ggagctgggc
    16681 ctcacgggcc tggccgccgt gggccggggt tccgcggagc cgccccggta cgtggagctg
    16741 acgtacgaac cgccggaggg cgaaccggtc ctcaccgtcg ggctggtcgg caagggtgtg
    16801 acgttcgact ccggcgggct gtccctgaaa ccgtccggcg agcggcacgc catgaaggcc
    16861 gacatggccg gcgctgcggc cgtcgtcgcg gccctgacgg ccctgccccg cctgggcctg
    16921 cccctgcggg tacgcggcca tctgcccctc gcggagaaca tgccggacgg cggcgccctg
    16981 cgggtgggtg acgtcgtacg gcatctcgac ggtacgacga cggagatcac ccacaccgac
    17041 aacgagggcc gggtggtgct ggccgacgtc ctggtccgcg cgagcggccc cggcccgcac
    17101 cgcgccgacc tggtcatcga cgtggccacg ctgacctcgg ccgcggtgca cgcgctcggc
    17161 acccggacgg gtgcactgtt cacgccggac gagtggctgg cccggacggt gctggccgcg
    17221 tcggagcggg ccggggagtc ggtgtgccga ctgccgctgc tcgcccacga gcgccgccat
    17281 ctgcggtcca ccgtggcgga ccgggtcaat tgttcgcacc ggcacggcga caccgtgcag
    17341 gccgcgctct tcctccagga cttcgtcgcc gacggggtcc gctgggccca cctggacatc
    17401 gccgcgcccg cgtacaacga cgagggcccg tacgccgaag tcccccacgg cggtaccggg
    17461 ttcgcggtgc gcacgctgac cgagacgctg cgcgcgctgt gcggcggcgc tccggacacg
    17521 ggtccggacc tgcgcgagcc gtccgggagc ggctcggaat cccgttcgcg atcctggtag
//
