BGC0000468: bottromycin A2 biosynthetic gene cluster from Streptomyces bottropensis DSM40262
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Location: 1,377 - 18,956 nt. (total: 17,580 nt).
This entry is originally from NCBI GenBank HE983629.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000468
Short description bottromycin A2 biosynthetic gene cluster from Streptomyces bottropensis DSM40262
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
HE983629.1
1377 - 18956
via Knock-out studies, Heterologous expression
Compounds
  • bottromycin A2
Species Streptomyces bottropensis DSM40262 [taxonomy]
References
Chemical products information
bottromycin A2 Evidence:
Copy SMILES
C42H62N8O7S1
Chemical database entries
NPAtlas
ChemSpider
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • CCM09440.1
  • bmbT
 1377 - 2714 (-) putative integral membrane protein
    putatively involved in self-resistance
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    • CCM09441.1
    • bmbA
    		 3168 - 4007 (-) putative SAM-dependent O-methyltransferase
      putatively converts β-COOH of Asp residue to methyl ester
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      • CCM09442.1
      • bmbB
      		 4435 - 6327 (+) putative radical S-adenosylmethionine (SAM) enzyme
        putatively catalyzes β-methylation
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        • CCM09443.1
        • bmbC
        		 6474 - 6608 (+) precursor peptide
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          • CCM09444.1
          • bmbD
          		 6672 - 7904 (+) YcaO-like protein
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            • CCM09445.1
            • bmbE
            		 7792 - 9183 (+) YcaO-like protein
              putatively catalyses ATP-dependent thiazoline formation
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              • CCM09446.1
              • bmbF
              		 9180 - 11192 (+) putative radical S-adenosylmethionine (SAM) enzyme
                putatively catalyzes β-methylation
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                • CCM09447.1
                • bmbG
                		 11227 - 12228 (+) putative protease
                  putative follower peptide removal
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                  • CCM09448.1
                  • bmbH
                  		 12231 - 13478 (+) putative protease
                    putative follower peptide removal
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                    • CCM09449.1
                    • bmbI
                    		 13468 - 14700 (+) putative cytochrome P450
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                      • CCM09450.1
                      • bmbJ
                      		 14708 - 16741 (+) putative radical S-adenosylmethionine (SAM) enzyme
                        putatively catalyzes β-methylation
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                        • CCM09451.1
                        • bmbR
                        		 16883 - 17437 (+) putative negative transcriptional regulator
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                          • CCM09452.1
                          • bmbK
                          		 17442 - 18956 (+) putative aminopeptidase
                            putatively removes N-terminal methionine
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                            Biosynthesis information
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2023-11-17
                            Added precursor peptide sequence, gene annotations, specified exact strain host of BGC ('DSM40262'), specified bioactivity. Added a review paper (doi:10.1039/D0NP00097C) which unifies the bottromycin gene designation.
                            • (ID: C62OJVVH7XOTOTFZSJT727YU)
                            • (ID: DKBFG3K6XTYSVEQEQVCFZBWY)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: RJXZFYIPTBJ27AV3IUUT4BRL)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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