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ACCTCCAAGGGCAGGAGTGGCAGGGGGAACGCTGGGACCAGGCCCTGGAAACGCTGCGCACCTGGCGGCGAAAGCGGTGGGTCTACATCGAAGGCACGAAGGTCATCGCACTGGCGGTACGCGAGCAGCCCTCGGCCTACCGCACCCCACCGCCCAAGGGCACTCCCCGGCGGGCTCGTACCCCCGTACCCCTCACGCTCACCGCTCGACCGTAAGGAGGCCGCCCATCGCGCGGATGCGGGCCGCCGCGTACCCCATGAGGCACGGAACCGAAATCGAACGGCAAGCCAGACCGACGAAAGGATCGAGATATGGGACCCGTAGTCGTATTCGACTGCATGACCGCGGATTTCCTCAACGACGACCCCAACAACGCCGAACTGAGCGCTCTGGAGATGGAGGAGCTGGAGTCCTGGGGTGCCTGGGACGGCGAAGCCACCTCTTGAGCGCCGGCCGGTGAGTAGCCGGCGGGTGTGAAGTCGGCGAGACGGACCACCGGGAGAGGGAGCATGCTCGAAGCGACGGCGACGGAGTGTGAGCTGCGCGAGGTCGTCCACCGTTCGTATCCGTCGGATCGAACGGTGACCGTGCGGTGCACCGTACGCCCCGCCGAGGGCACCGCCCAGGCCGACGGCTACGGCACCGCCACGACCGAGGCCGTGGCACGGGCGAAGGCCCTGTCGGAAGCCGTGGAGCGGCTGGTGGCGTGCACCCCCTTCGCAACGGTCGCCCGTCCGCCGACGACCCCGGCCCCCGGCTCGGGCTCCGGTCCGGTCCCGCCCTTCCCGGCGGCCGGGGTACGGACCGCGCCGGACGGCTGTGCGAGCCGGGAGTACCGGCCGCTGTCCGGGGACGGGCCGCGCCGGGTGCCGCTGTACTGGTCCTCGCCCTGGGTCGCCGGCGAGGAGTTGCGCGCGGGCACGCTGTCGGCCGCGGAGGCGCGGCTGTCGAGCACGGTCGGCTGGGCCGTCGCCCCGACGCCGGAGGCGGCCCTGCGCGGGGCGCTGCTGGAGCTGACGGAACTGATCGACTACGGGGTCTTCCTGCACCGTCGCCTGGCGGGCCCGGCGCGGCCCCGGTCGGCGGGTGACGAGACGCTGGTGGTGCCGCTGGGCGGCGCCGTCCGTACGCCGACCGTGCTCGCCGTGGCGTACGGCCGCGGGCGGCTGATGCCGGCCACCGGGCTGGGCTGCGGGGCGAGTCGGGCCGAGGCGACCGACCGGGCGCTGCTGGAGCTCGCGCAGGCCGAGACGATGTGGCGGTCGAACCCCACCGCCGAGCCGGCCGAGCGTTTCTTTCTGCGCCGCTTCGAGCGGTGGCCGCTGCTCACCCGGTGCGCGACCTTGGACTTCGAGCTCAGCGATCTGAGTGGTCTCGACGGTCTGAGCGGTCTCGACGGTCTGAGTCGTCTCGACGGTCTGAGTCGTCTCGACCATCCGAGTGATCTGAACGATCCGGCCGGCCGCCCGGCGCCGTACGACGACGGGCCACACCCGGCGTCCCCCCTGGAAGAGCTGGAGGCCGGCGGCATCACCGTGTGGGCCGACTCCGGTGCCGTCGACATCTCAGGCCCGGACATCCCCAGGACCCGTCTCTGCTTCGCCCATGTGGTGTCGGATCCGCAGCCCCTCCTGGGCCTTGTCCGCGCAGGCATCCCCGTGTTCGACACGGGAGAAGTGAGGAGGACCCTTGACCCGTCCCGCCGAGACGCCCACCGAGACACACCCCGAGGCGCACCCCGAGACGCAGCCCGAGACCGATCTGCTGACCGCGGCCCTGCTGGACGGGGCCGCCAAGGACGACGTTCCGCCTGAGCGCGAGACGGCCATCCAGCAGGCCCTGTCCTCCGTCGGGGACTGGCTGGCCGCGGAGCGGCTGACGGCCGACATCCGCAAGTACGGCATCGAGTCCGCGCCGACCTACGAGGTGCGGCTGACGGACGCCGAGGGCGCGCTCTGTTCCCGCAGCTCCGGCAAGGGGCTGGGGCACCGGAGCATGGCGAGCGCGCTGTTCGAGAGCGCCGAGCACTACCACCTGGACTGGCGCCGGGATCCGCGGGCGTCGGAGGCGGAGTTCCTGCCGGGCCGGGAGATCGCGGGCCAGGACACCGCCCGGCGGTCCGCGCTGCTGCGCCGGCTCGGCGGCATCATGCCGGACGCGCCCGTGCTGACCCGTACGTACCGCCCGGTGGAGGAGACCCTGACCGGGCGGGCGGACCACGGCCCGGCCGGGCGGCCGCACCGGCACCCCGTGTTCCTGCGTGACGGCGGCTACCGCAACTGGCCCCACCCGGACGACGACCGGTCGTTCCAGCCGCTGTGGCACTACACCTCCAGCGCCGGGTACGCGGCGGGCGCCACCGTGCACGAGGCGCTGGTGCACGCCGTCAACGAGCTGATCGAGCGGGACGCCTGGTCGTACCAGCTGGCCCGGTCGTACTTCGGGCTGCCCGGCGAGGGGCCCGAGCTGCGGGTGGTCGACCACGACACGCTGCCCGCCGAACTGCGGGAGCTGACGGGCACGGTCGAGGAGGTCCGCGAGGCGCCGGTGCTGATCGTCGACATCACCTGTGACACCGGCGTACCGGCCTATGTGGTGTGCGACGCGCGGAGCCGGGAGGAGGTGCGGCTGATCGGCAGCGGGGCCTCGCCGGTGCGGACGTACGCGTTGCAGCGGGCCCTGCTCGAATACCTCCAGGTGCGCACGATGTTCGAGCACGGGCCGGTGGACGCGGACACCGAGGCCGGGCAGATCGCCACCGCGCTGGCCCGCTATCCCCGCCATCTCGCCGCCGCCCGGTTCGACGTCGGTCAACTGCCGCACGAGCGGCGGGCGTTCGACGCGGACGACGGGCTGCCCGCGGCCGCGAGCCCCGAGCAGCTGCTGCGGCATCTCGTGGACCGGCTGCGGGACCTGGGCGTGGACGTCCACCACCGGGTGCTCACGCCGCCGGGGTCCGTCACGGTCGTCGACGTCGTCGCGCCGGGCCTGGAGATGTTCGACAAGGCGCGGGCGGGCTATCCGGTGCTGCCGACCGGGCGGCTCGGCGAGCGGCTGCGACCGCGCAAGGACCATGAAAGGGGCCACGGAGTGGACCACGGAAAGGACCGCGGAGGTGCGCCCCGGTGAAGCTCGCGCTCGTGGCACCACCCTGGAACAGCCTGTACCGCCCGTCCATCCAGATCGCCACCCTCGCGGCGCTGGAGGGCACGGGGGACGGTGATCCGATCACACCGGTGTACGCGTACCTGGACTGGTTCGAGTACGCCGTCGACGCGCTGGAGTGCGATCCGGCGGAGTTCGTCACCGTCTACGACACGATCGGCGAGGAGCTGTACGGGCTCGGGGTCGGGGACTGGATCTTCGGCGGGGTCCTGGACGCCCATGGTCCCGGGGAGGAGGCGGACGTCCGCGACCGGTACGCCGCCTTCCTCACCGAGCACGGTGTGGCCGAGGAGCTGGTGGGCCGGGTGCTGGCGCTGCGCGCGGTGGCGCCCGGGTTCGCGGCGGGGCTCGCCGGGCGGCTCGTGGCGACCGGCGCGGAGTGCTTCGGGTTCACCACGTCGTTCAGTCAGCTGATGCCCGCGCTGGCCGTCGCCCGGGCCGTCAAGGACCAGGCGCCCGAGCGGCTGGTGCTGCTCGGCGGGGCGAACTGCGACCGGCCCATGGGGCAGGCCGTGATGCGGGCGTACCCGTTCGTCGACGCGGTCGTGCAGGGCGAGGGCGAGGCGGCGGTGGCGGCGGTCCGGGCCGCGCGCGGCGCCGGCGACCTCGCGGCGGCCCCGGGCCTGGTCCTGCGGCACGAGGGCGGGCTGCGGGTGTCGCTGCCGACGGTGCAGCCGGCCGAGTCGGCGCCGGTGCCCCGGTACGCGGAGTACTTCGAACGGCTGCGGGCGCTGCCGCACCGTGAGCTGATCGCCCCGCATGTGGCGCTCCCGTTCCAGATGTCGCGGGGCTGCTGGTGGGGCGAGAAGCTGCAGTGCACCTTCTGCGGGGAGAACGGCAGCGGGATGGTCTACCGCAGCAAGCCGGGCGAGCAGCTGACCAAGACCCTGCGCCGGCTGACCGAGGAGCACGGCGTGTTCGACACGTACGCGGTCGACACGATCCTCGCGAGGAACGACAACGGCCTCGCCGAACTCGCCGCGGCGGAGGTCGACATCACCACGTTCTTCGAGGTGAAGGCCAATCTGGGGCCGCGTGAGGTGGGCGAGATGCGGGCGGCGGGCGTCACCATGGTGCAGCCGGGCATCGAGAGCCTGAGCAGCGGTGCGCTGAAGCTGCTGCGCAAGGGGGCGACGGCCTTCCACAACCTGCGTTTCCTGGTGCTGTGCCAGGAGCTGGGCATCGACGCCCAGTGGAACCTGCTGTCGGCGATGCCCGACGAGACGGCGGAGATGCTTCAGGAGCAGCTGCGGCTGATCCCGTTCATCACGCATCTCGCGCCGCCGTCGACGGTGAGCAAGGTCCGGGTCGACCGCTACAGCCCGTACTTCGAGAAGCCCGAGGAGTTCGGTATCGCGCTGGACGGGCCCGAGCCGAAGTACCGCTTCGTGCACGCCGGCCGCACCGCCGCCGAACGCGCCGAGCTGGCCTACTCGTTCGACCATGTGGAGCTGGCGGGGCGGGACGACTCGGCCATGGCCGCGGAGATGCTGGCGCTGCGGCGGCGCCTCGGGGCCCGGGTGGGCCTGTGGAAGAAGCTGCACGATCAGTCGCGGTTCTCGTTCCGGTTCGGGCCGAACATGACCGTGCTGCACGACGGCCGGCCGCATGTCGGCACCGGGCGGCATGTGCTGCGGGGCGGCGACGACCAGCTGTTCCGCTGTCTGGTGCACGGCGGACGGCTGCACCAGGCCGTCGGCCAGGTCGCCGCGATGACGGGCCGGCCGGAGGACGAGGTGCACGCGAGGGTACGGGAGTGGGCGCGGCGCGGCTGGGTCCATCTGGAGGGCCGGCGGGGTCTCGTCCTCGCGGTGCGCGACGGCATGCGGGACGAGCTGGGCCGGGCGGCGGAGCTGCGGGAGGCCGCGGCCGAGTCGGAGCGTGCCGCCGCCGAGTCGGGGATGGCCGGTGCGGGATCGGGGAGGGTCGGTGCGGGACGGTAACGGCACGAGCCGTAGGGACGTCTTCGAGGTGTTCTCCCGCGACGGCACGCCGATCCGGGGCTTCAGCAGGCCCGGGCCGGGCGAGACCGTCGTCCTCGTCCACGGTGTGGCCATGGACCGGCGGATCTGGGCGGAGTCGGGGTTCCTCGACGCGCTCCCGGACGCCCATGTCCTCGCGCTCGACCTGCGGGGACGCGGGGAGAGCGGGCGCGTCGGCACGGCGGAGGGCCACGCCCTGCGCCGGTACGTCGAGGACGTCCGCGCGGTCCTGGACCGGTTCGGCCGCGCACGGTACAGCCTGTTCGGCACGTTCTTCGGCGGGCGGATCGCCCTCCAGGTCGCCGCCGTGGACACCCGGGTGGCCCGGGCGTTCTCCTTCTGCGCGCACGCCGAGCAGGTGGAGATCCCCGAGGACGCCGTCGAGGAGGAGGCGGTGGCCGTCGAGGGCCCCGGCGGGCACGCCTATCTGCGCGACCACTTCACCGGGCGGGGCGCCCCGCCGTGGATGGTCGAGGCCTGCGCACGCGTCGACCCCGGTGAGCTGGGGGCGGCCACGCGGGGTCTGCTGCACGGCTCCGACCGGCGGACCGAACGCGGCCACCCCGACCAGGAGTTGGTACTGATCACCGCCGACGGCGACGCCGACCTGGCCCCCTTCCACGCCGGGGAGCGCCGCCTCGGCGCCCACCTGTGGCTCGTCGACGCCCCGACCCGCATCAAGGCCGCGGGGCGTCTCGCGGAGGTCGGGCGGAGGGTGGCGGGCGTACTGGCGGAGGGTGGGCACGGGACGGGAGACGCACCGGCCGAGGCCCGTACGACCGGAGACGCACCGGCCGAGGCCCGCGCGTCCGGGACGGGGGTCGTATGACGGCGACCGAGGACACCATGTGGCGTCGGCGACGGGGGCTGCTGCCCGACGGGGACCCGCTGGTGCGGGCCCTGGAGGAGCTGGCGGAGCGCGGGCGCGGGCATCGGCTGCGGGCCGTCGGGCTCGTCGACCCCGCCACCGGGCGGCCCGGTCCCCCGCACGATCTGACGGTGACCGACGGCACGGTCACCGCCTGGACCCCGACGCCGCCCGCCGCCGACGGGCGCGCGGCGCCGTACACCTCGTACGCCGTGCCGGGCCTCGTCGACTCCCACGCGCATGTCTCGTCCGCCGCCGACCTGGTCGGTCTCCTCGTCCACGGTGTCACCGGCTTCCGGCAGCTGTGGGGCGAGCCGGCGCATCTGTACGCCGCCGGGGTGCACCGCGCCCGGCACGCCGTCCTGCCCCGGCCCTGGGTCACCGCCGGGGTGGTCGACGGGCCCGGGTCGCGGATCCCGCAGGGGGTCACCGTGGTGGACGGGGTCCGGTCGGTCCGGCAGGTGATCGAGGACGCGCTGGCGTTCGGTTTCGACGGGATCAAGGTGTACGACGACGTCGCGCGCCCGGCGTTCGAGGTTCTGGTCCGGGAGGCCGAGCGGGCCGGTCTGCCGGTCGTGGGCCACATCCCCGAGGCGGTGCCCCTGGACCTGGCCCAGCGCACGTTGCGGTCGTCCGAGCATCTGTACGGCATCGTGCCCAATGTGTTCCGGCTGCCGCCCGAGCGGCGCTGGGACGCGCTGGCGGCGGCCCTGCGCGACCACCCGGCACCCGGGGCCGTACCCGGCCACTTCGTCTGCCCCACCCTCGTCTGCTGGCGGGCCCGCAGCGGTGAGCGCCGGTACACCCGCCCCTCCCGCGCGGCCCTCCAGGCGGTGGACGAGGGCCGCCGCCGGTCCTGGCAGTCGGCGGCCCGGGACGCCCTCCGGCTGGACGCCGCCGAGGCGCACCGGCGCGGCGGCCTCGTCGACGGGCTGGGCCGGATCGCCCGCGCCCTCGCCGACACGGGCACCCGGCTGCTGGCGGGCACCGACTGCGGCAACCCGTTCGTCCTCGCCGGCCCCTCCTTCCACAAGGAGCTGGCCGAACTGTCCCGCGCGGGGCTCGACTTCGGCGCCGTACTGCGGGCGGCGACCACTCACGCGTACGAGGCCATGGGGCGGCGGGCGGGCCCGGTGCCCGGTGATCCGGCGGACCTGGTCCTCTACCGGCGGCCGCCCGACGGCGACGTGACCGCCCTCGCCCGGCCCGACGCGGTGCTCGTCGACGGAGTCCTGCTCGACGGCACCGACCTCGACCGCCTGTGGGCGCTACGCCTGGCCGCGTCCGGCCTCGACCCGTCCGGCTGGGCCCGCGGCACCCTCGACCCACCGGTCACCACCGGCCGACCCACGAAGGAGACAGCCCATGCAGGCTGACCGGGAACCCGACCGCACGGGGCGGGAGGCGAAACGCCCCGCAGAACCCGACCACCCCCCACAGCAGGCCACATGCCCCGTCGACTTCGACTTCTTCGCCGCGCCGCAGACGTATCGCGACGCCGCCGCCGAACACGCCGGTGAGCACGGCGCCTTCTACAGCGACCGGGGCTTCTGGGTGCTGACGACGTACGACGGGATCGTGGACGCGTTCAAGGACGAGGGCACCTTCACCGTCGGGCGGGTCAGCGCGGCGGAGGGCGCCGAGGAGGAGCGCTGGATCCCGCTGACCGTCGAGGGCCGCGAGCACACGGCGTGGCGGCAGCGACTGGGTGCCTGGTTCACCCCGCAGCGGGTGCGGGAGCTGACCCCGTCGATGCGTGCGGGTGCCCGGCGGCGGATCGAGGGGTTCCTGGAGAAGGGCGAGGTGTCGTTCAACGAGGACTTCGCCCGGCCGTACGTCCTGGAGAACCTGATGACGGCCGTGGGCTGGCCCCCGGACGGGTTCGACCTGCTCATCGCCATCAACCGGGCGATGATCGACTCCCGTTCGGCACCGGACCCCAGGGCGGCGGCGTACGGCGAACTCGGGCTTCCGGCGCTGGAGCGGTTCGCCCGGGAACACATTGCCCGGCGGCGCGCGGAGCCCGCCGACGACCTGACCACCGCCAGCTTCGGCTGGGAGATCGACGGTGCCGAGGTCACCGACGACGACCGTGCCTCCCTGCTGTGCACGCTGTTCCTGGCCGGCATCGACTCGACGGTGAACCATCTGGCCAACGCCGTCCAGCACCTCGCCCACCACGAGGAGGACCGGCGGCGGTTCCTCGCCGGGCCCGAGGTCCGGCCGCCGGCGGTCGAGGAGTTCCTGCGGGCCAACTCGTGCATGTACCCGGGCCGGCAGGCCGCGACCGGCGGCGCGGGCGGGGTCGCGGACCGGGGCGACACCGTGCTGCTTCCGCTCGCCCTCGCCAACCACGACCCCGAGGTGTTCCCGGAGCCCGGCCGGATCGACTTCGACCGGACGCGGAACCCGCACATCGCCTTCGGCACCGGCCCCCACCAGTGCCTCGGCGCGGCCTTCGCGCGCGCCCAGATCCTGGTGGCCCTGGAGGAGTGGCACGCCCTCGTCCCGGACTACGCGCCGTCCCCCGAGCAGCGCACGGCCGAACCACCGTTCCTGCGCAACTCCTACGACCTGAGGCTCGTCTGGTGAGGGCGCCATGACCGGAACGACCGAGAGGACCGAGGCGACCGGCCCGGCCGATGTGACCGGCACGACCGAGCCGACCTTGGCCACCACTCCGACAGAACCCGCCACCCCGTCAGTGCCCACCCGACCAGGCCGGGCCGCCCTCGTCTCCATGCCCTGGAACAACGTCCGCCGCCCCTCCATCCAGGTCGGCACCCTGCGCTCCGTCGCCCGCACCGAGGGGTGGCGGGTCGACTCGCACTACGCCTACCTCTCCTTCTACGGCCTCGCCCGCACGGCCCTCGGCATGCGGGACGCCGAGTGGTCGCAGGCGTACGAGACGGTGTCCGAGGGGCTGTACCAGCTCTCCGTCGGGGACTGGATCTTCGCGTGCCGCGACGGCGGGGCGGCGGCGCGCGAGGCGTACTTCCGGATGCTGCGCACCAAGGGCGTCGACGACGCGACGATCGAGCTGGTCGACGCGCTGCGCGAGGTGGCCGACCGCCATGTGGAGCGGACGGCCGCCGAGCTGCTGGAATCAGCCCCCGATCTCATCGGATTCACCAGCACCTTCAGCCAGAACGGCCCGACGCTGGCCGTGGCCGAGCGCCTGCGGGACCTCGGCTACGGCGGCGTGATCGTGCTCGGCGGCAGCAACTGCGAGGGCTCGATGGGCCGCGCCCTGCTCGCCAACTACCCGGCGGTGGACGCCATCGTGGACGGCCCCGGCGAGGACGCCTTCGTCGCCCTGCTCCGCCAGGTCGGGGCCGGCGACCCGCCGCGCTCCCACGGCCGGCTGATCACCCGGCTGCCCGCCCTCGCCGACAGCGCCCCGGCCGGCATCTCCGCCGGTCAGTCGCTGGAGGTGCCCACCCCCGACTACGACGGTTTCTTCGAGCAGTTGCACACCGCCGGCCTGCACACCCTCGAACCGGAGATCACCCTTCCGGTGGAGTTCTCCCGCGGCTGCTGGTGGGGCGCGAAAACCCACTGCACCTTCTGCGGCCTCAACGGCGCGACCATGACGTACCGCAGCAAGAACCCCGACACCGTCGCCGACGAACTCCGCCACCTCATGGACCGCTACGGCGTCCTCGACTTCTTCGCCGTCGACAACATCCTCGACCTCAAATACCTCGACACGGCACTCCCGCTGGTCGAAAAGCTCAACACCGACCATTCCCTGTTCTTCGAGGTCAAGGCCAACATGGAATGGGCCGACATCCAGGCCGCCCGTCGCGCCGGAGTCCGCTCGGTCCAGCCGGGAATCGAAAGTCTCAGCACCGAGGGGCTACGACTGCTGAAGAAAGGCGCGACCGCCTTCCAGAACATCCGTTTCCTGCTCGGCTGCGCGGAATTCGGTGTCCTGCCGGTGTGGAACATCCTCACCGGATTTCCCCACGAAACCCCGGAGTCGATGCTCACCCAGATCGATCTGCTGCCTTCCCTGACCCATCTGGAACCACCCGACAACGACATCCTCGCCGTGCACTTCGACCGGTTCAGCCCGTACGTGGAACACCCGCAGGACTACGGTCTCACCCTGACCCACCCGCTGCCCGGCTACCAGTACGCCTATCCCCGTCTCTCCCCCGGCGACCTGTGGGACCTCGCCTACCACTTCGAGGGCGACTTCACCGAGGACCCCCGCAACACCGCCGTCCGCGAACGCCTCGCCACGGCCGTCCACCACTGGCGCACCGAGCACCACCGGGCCCGTTTCACCTACCGCCTCGGCTTCGACTCCGTCACCCTCACCGACCACCGGCCCGGCCTGCCCGCCCACACCACCGTCCTGCGCGACGAGGACGCCCGGCTCTTCCGCGCGATCATCGGCGGCACCCGATTCCGCGATCTCCAGAATCAGGAAGGGCGAGACGGGCAGCCCCTGGAAAAGCTCCACACCTGGCAGGAGAAAAGGTGGGTCTACATCGAGGGCACGAAAGTCATCGCCCTCCCCGTACGCGAAAAACCCTCCGCCTATCGGACCCCGCCCCGCAAAGGAACTCCCCGCAGGTCCCGAACTACCGTGCCCCTCACGCTCACCGGTCCGCCTCCGCCGCGGCGGCCTGGCTGAAATCCGTCCCGTACGGCGTTTCCCGTTTGCGGTGACCGCCCGTCGGCGCGGTACTCGTAGAGGATCACCGTGCACGGCTCCGAGCACCACACACGACACACCGCACCGACACCACCACGCAGCACCGAGCACAACGCCGCATCACGACCCGGAAGTTGATCACTATGACCACGGCCCCCACCGAGGACCAGACCCGCGCCGAGGACCTGCCGCCGTCCTGCCGCGATCTGATCGGCATCCTCGCCCAGACCGACCGGCGCGACGCCTTCGCGGCCCTCGCGCTCGGCGCGACCTCCGTGGCACAGGTGGCGGAGCGGGCGGGGCTGCGCCCGGCCGCCGCCGCCGTCGCCCTGCAGAAGCTCGTCGACGGGCGGATCGCCGCGTACGACGCCGACGCCCGCACCTACCGGCTGATCGACGACACGTTCCGGCTGGCCGTCCAGGCGGAGGTCAGGATCTCCGGACGGGGCGGCGGTGACGGCGCGGGGGCCTACTTCCGCAAGGGACGGCTGACCTCGATCCCCGGCAAGGCCGAGGTCCGCAGCCGGGTGCTCGCCGTCGTGGCCGACTCCTTCGAGGCCGGTGTCACCTACTCCGAGGCCAAGGTCAACGCGATCTGCGGCCAGTGGTTCGACGACTGGGTGACCCTGCGCCGGGCGCTCGTGGACGAGGACCTGCTGCGCCGCGACGAGTCGGGCACGCAGTACGAACGCGTATGACCGCATGACACGGGTCGTGGCGGGTGACGTCGGCACGGACACGCCGGATAAGGCCGGTACCGCCGATACCGCCAAAGCAGCAGATACCGCCGATACGGCGAGCCGGGCGGCCGACGTCGTCGCGTGCGGCCGGCACACCGGCGCGGCCGTCGGCGCCTTCAGCCGCCGCCGGGGCTTCGTGGCACGGCCCGGGCAGGTGGTCGCCGAGCCGTCCGCCGACGGCCGCGCGGTGGTGCTCAACGTGGGCCTGGGGCCCGCCGGTTCGGCCACGGCCGCCACGTTCCGCGCCGCGGCTGCCGCCTCGGTACGGGCCGTGGGCCCCGCCCGTACGCTCCGCCTCGACCTCGCGCTGGCCGACGGCAGCGGGGTCCCGGCCGCCGAGCGGGCCCGGGCCGTGGCGGAGGGCGCGGTGCTGGGCCTGTACCGCTACGACGAGTACCGCTCCGCTCGGGCCGCGAGCCCGCTGGCCGAGGTGATCGTGGCGACCCCGGAGCGGCGGGCCGTCGCCGAGGGCCTGGCCGCCGCCGAGGCCACCTGTCTGGCCCGCGACCTCGTCAACTGCCCGGCCGGGACCCTCACTCCCCCGGCGTTCGCCGACCGGATCCGGGAGCTGGCGCACACCGCCGGCCTCGACTGCGCGGTGTACGAGGGAGCCGGCCTGACGGAGCTGGGCCTCACGGGCCTGACCGCCGTGGGCCGGGGCTCGGCGGAACCGCCCCGGTACGTGGAGCTGACGTACGACCCGCCGGATGCCGACCCCGCGCTCACGGTCGGCCTGGTCGGCAAGGGCGTCACGTTCGACTCCGGCGGGCTGTCCCTGAAACCGTCCGGCGAGCGGCACGCGATGAAGGCCGACATGGGCGGCGCGGCGGCCGTCGTCGCCGCGCTGACCGCACTGCCCCGCCTCGGCCTGCCCCTGCGGGTACGCGGCCACCTCCCCCTCGCGGAGAACATGCCGGACGGCGGCGCCCTGCGGGTGGGGGACGTCGTACGGCATCTGGACGGTACGACCACGGAGATCACCCACACGGACAACGAGGGCCGGGTGGTGCTGGCCGACGTCCTGGTCCGCGCGAGCCGCCCCGGCCCGCACCGCAGCGACCTCGTCGTCGACGTGGCCACCCTCACCTCCGCCGCCGTCCACGCGCTCGGCACCCGCACCGGGGCCCTGTTCACACCGGACGACCGGCTGGCCCAGACGGTGCTGGCCGCTTCGGAGCGGGCCGGGGAGTCGTTCTGCCGGCTGCCGCTGCTCGCCCATGAGCGGCGGAACCTGCGCTCCGCCGTGGCGGACCGGGTGAACTGCTCGCACCGGCACGGCGACACGATCCAGGCGGCGCTCTTCCTCCAGGACTTCGTCGCGGCCGGTGTCCCCTGGGCCCATCTGGACATCGCCGCGCCCGCGTACAACGACGAGGGCCCGTACGCCGAAGTGCCGTACGGCGGTACCGGGTTCGCGGTGCGCACGCTGATCGAGACGCTGCGCGCCCTCTCCGAAGGCTCACCGGACGTCCCCTGAACTCTCACCGGGCGCTCCGCGAGCCGTCCGCGTGCCGGGTAGGAATCGAGGGTTCCTGATCGCTTCCCCATCTGCTACAACAGGTCTACACCACTGAGTGGTGTAGACCACCACCCGATGGAGGAAGTCTATGAGCACCGCCACCGCGCCCTCGGCGGCGCCCGCGAAAAAGTGGGGATCAGGCCTGATGCAGGGCCTGCAGAAGGTCGGCCGCAGCCTGCAGCTGCCCATCGCCGTACTGCCGGCCGCCGGCCTGCTGGTCCGGCTCGGCCAGCCGGACGTCTTCGGGGCCGAGGGCCTCGGCTGGGACAAGGTCGCCGCGGTCTTCGACAAGGCGGGCGGCGCCATCACCGGCAACCTCGCGATGCTCTTCTGCATCGGCGTCGCGATCGGCTTCGCCAAGAAGGCCGACGGCTCCACCGCCCTCGCCGCGCTGGTGGGCTTCCTGGTCTACAGCAAGGTCCTGGAAGCGTTCCCGGTGACCGAGGCCGAGATCACCAAGGGCGCGGACGTCGCCGCGACGTACAACAACCCCGGTGTCCTCGGCGGCATCGTCATGGGTCTGCTCTCGGCGGTCCTGTGGCAGCGGTACCACCGCAAGAAGCTGCCCGACTGGCTCGGCTTCTTCAACGGCCGCCGCCTGGTGCCGATCATCATGGCCTTCGTCGGTGTCGCGGTCGGTGTCTTCTTCGGGCTCGTCTGGGAGCCGATCGGTGAGGTCATCGGCAGCTTCGGCGAGTGGATGACCGGCCTCGGTTCGGCCGGCGCGGCCCTGTTCGGCGCGATCAACCGGGCGCTCATCCCGATCGGCATGCACCAGTTCGTCAACACGGTGGCGTGGTTCCAGCTCGGCGAGTTCAAGGACGCCTCCGGCGTGGTCTCGCACGGCGACCTGAGCCGCTTCCTGGCCGGTGACCCGACCGCCGGAATGTTCATGTCCGGCTTCTTCCCGATCATGATGTTCGGCCTCCCGGCCGCGGCCCTGGCCATCGCGCACACCGCCCGCCCCGAACGCCGCAAGGTCGTCACGGGCATGATGATCTCGCTCGCCCTGACGTCCTTCGTGACGGGTGTGACCGAGCCGATCGAGTTCTCGTTCATGTTCATCGCCCCGCTCCTCTACGTGATCCACGCGCTGCTGACCGCGCTCTCCATGGCCATCACCTGGGGGCTGGGCGTCCACGCCGGCTTCAACTTCTCCGCCGGCTTCATCGACTACGCCCTGAACTGGAACCTGGCCACCAAACCCTGGCTGATCATCCCCATCGGCCTGGTGTTCGGCGCCATCTACTACGTCGTCTTCCGCTTCGCCATCATCAGGTTCAACCTCCCCACCCCGGGCCGCGAGCCCGACGAGGAGATCGAGGACCTCACCAAGGCGTGAGCAGCCCCGGAAACGACGTCGGGCCCCCGGAGCGTCTCGCTCCGGGGGCCCTCTTCATGCATACGGGCGTACGAACGTACGGGGTCAGATCTCGTACGACATCCTGGGCACCGCCAGCTCCACCGGGCCGTCGTACACCTCGCGGGCGTCGACCAGGTTGACCTGCGGGTCGGTCCACGGCGGGATGTGCGTGAGGACGAGACGGCGGGCGCCCGCCCGGGCGGCCGTCTCACCGGCCTCGCGGCCGTTGAGGTGGAGGTCCGGGATGTTCTCCTTGCCGTGGGTGAAGGCGGCCTCGCACAGGAACAGGTCGCTGTCGCGGGCCAGTTCGTCCAGGGTGTGGGTGACACCGGTGTCCCCGGAGTACGTCAGGACCCGGCCGCCGTGCTCGATCCGGATGCCGTACGCCTCGACGGGGTGGGCGACCCGTTCGGTGTGGATGGTGAAGGGGCCCAGCTCGAACGTGCTCGGCTTGACCGTGTGGAAGTCGAAGACCTCGCTCATGGAGGAGGCCGACGGGGTGTCGGCGTAGGCCGTGGTCAGACGCTGCTCGGTGCCCTCCGGTCCGTAGACCGGGATGGGGTCGCAGCGGCCGCCGTCATGGCGGTAGTAGCGCGCGACGAAGTACGCGCACATGTCGATGCAGTGGTCGGCGTGCAGATGGCTGAGGAAGATCGCGTCGAGGTCGTAGAGACCGCAGTGGCGCTGCAGCTCGCCCAGGGCACCGTTGCCCATGTCGAGAAGCAGCCGGAAGCCGTCGGCCTCTACGAGGTAGCTCGAACAGGCCGATTCCGCGGACGGGAACGACCCCGAGCAGCCGACGACGGTGAGCTTCATGAGAGCTGGAACCTCCGCGCTGGCGTGAAGTCGTGACAGTCGTGTCAGTCGTGACGTGCAGACGGGTTGCGGATTGCAGAGTGCGTGACGGATGCGTGGTGCGGATTGCAGTTGGCGGGGTTGCCAAGGACGGACGTGGGTGCAGCAAGGGTTGTGCGGTCCGATGAGCGTAAGGCGCAAAAGGGTGGGTCGCTCCTCCGCCAGGGGCTGTTGTGGGCGAACTCACCTGTGGTGTCACCGGTTCGGCTGGTGGTGGGGCCGTTGGGGCGCGCGTGGGCCGGGGTGAGGTGGCACCGAAGGGCGCGGGAGCGTGCGACAGGGCGGGCGTGGCGCGGTGTGCGCCGGTACCGTCGGGGCTATGGACACGTCCTGGTGGTTGGCGCTCGCGGCGGTGGTGCTGCTGGCGCTGCTCGCGACCGTGGTCGACGGGTGGGGGCGGTCGCGACGGCCGTCGAGGCGATCGGAGCGGCCGGGTGGGCGGACGCGGCCGCCGGGGCGCCCCGGGCGTGCGCGCGGGCCCGTGCCGCGGCCCCGGCCGTCCGAGATCTGGTGGGCCAGCGTCCCCTTCGAGGACGGGCCCGGCGGCAAGGACCGCCCCTGCCTCGTCCTGGCCGTCCGCGGGGACCGCGCCCGCGTGGCCAAGATCACCAGTCGGTACCGCGACGAGCGGGCCGGTGTGATTCCCCTCCCGCCGGGCACGGTCGGCGATGCCCGCGGCCGTCCCAGCTTCCTGGAGACGGGGGAGCTGCGTGAGGTGCCCGTGGGTGACTTCCGGAGGAAGGCGGGGGTGGTGGACCCGGTGCTGTGGGACCAGATCCGCCGCCTGTCGAACTGACGGCCACGCGTCGGGGGACAGC","alphabet":"DNA"},"features":[{"location":"[0:20882](+)","type":"region","qualifiers":{"candidate_cluster_numbers":["1"],"contig_edge":["True"],"product":["bottromycin"],"region_number":["1"],"rules":["botH"],"subregion_numbers":["1"],"tool":["antismash"]}},{"location":"[0:20882](+)","type":"subregion","qualifiers":{"aStool":["externally annotated by: MIBiG"],"contig_edge":["True"],"label":["BGC0000469"],"subregion_number":["1"],"tool":["antismash"]}},{"location":"[0:20882](+)","type":"cand_cluster","qualifiers":{"candidate_cluster_number":["1"],"contig_edge":["True"],"detection_rules":["botH"],"kind":["single"],"product":["bottromycin"],"protoclusters":["1"],"tool":["antismash"]}},{"location":"[0:20882](+)","type":"protocluster","qualifiers":{"aStool":["rule-based-clusters"],"category":["RiPP"],"contig_edge":["True"],"core_location":["[10000:10882](+)"],"cutoff":["20000"],"detection_rule":["botH"],"neighbourhood":["10000"],"product":["bottromycin"],"protocluster_number":["1"],"tool":["antismash"]}},{"location":"[10000:10882](+)","type":"proto_core","qualifiers":{"aStool":["rule-based-clusters"],"tool":["antismash"],"cutoff":["20000"],"detection_rule":["botH"],"neighbourhood":["10000"],"product":["bottromycin"],"protocluster_number":["1"]}},{"location":"[136:1432](-)","type":"gene","qualifiers":{"gene":["botT"]}},{"location":"[136:1432](-)","type":"CDS","qualifiers":{"codon_start":["1"],"gene":["botT"],"gene_functions":["transport (smcogs) SMCOG1020: major facilitator transporter"],"gene_kind":["transport"],"product":["BotT"],"protein_id":["AFV25478.1"],"transl_table":["11"],"translation":["MLPLYLISHGLSLLGNTVASIALPWLVLLRTGDATAVGLVAAASALPMLLSAVAGGVLIDRVGRRRLSIGADLASAACVAALPVVDGLLGLTVVWFVVLGVAGAVFDVPGMTAREALAPDIAEATGIGMERLAGLRESIAGGVVILAPAAAGGLIMLVDPATVLWLTAGCSALAALVTFALPKTIGAQPTATAQGDGAGLRGDLKRGLGVLRGDRVLTAVTLVSAGSVAVLAPLQNLVLPVHLVGKDSPGGFGVVVSLLAVGGIAGAGLYAAIGTRWSRRTVFVAAQLTSTIGIAGLALLPPVPVMWAAAVLAGAGAGPLPALFLVLVTERIPEEVRGRVLGLQNAVSMTAVPLGTLVAGLTVDWIGLRQTGALLAIAWCVVTLAIVALPALRNLDAGRAKSEPPAEDQPTPDGGSPIPGQGSETADTPTA"]}},{"location":"[136:17804](+)","type":"misc_feature","qualifiers":{"note":["bottromycin biosynthetic gene cluster; may include additional flanking genes"]}},{"location":"[1950:2790](-)","type":"gene","qualifiers":{"gene":["botOMT"]}},{"location":"[1950:2790](-)","type":"CDS","qualifiers":{"codon_start":["1"],"gene":["botOMT"],"gene_functions":["biosynthetic-additional (MITE) MITE0000045: Methylation 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TIGR03975","biosynthetic-additional (rule-based-clusters) Bottromycin_Methyltransferase_RRE","biosynthetic-additional (MITE) MITE0000046: Methylation (100% identity)","other (smcogs) SMCOG1277: Radical SAM domain protein"],"gene_kind":["biosynthetic-additional"],"product":["BotRMT2"],"protein_id":["AFV25484.1"],"sec_met_domain":["TIGR03975 (E-value: 3e-131, bitscore: 428.4, seeds: 14, tool: rule-based-clusters)","Bottromycin_Methyltransferase_RRE (E-value: 2e-37, bitscore: 117.1, seeds: 12, tool: rule-based-clusters)"],"transl_table":["11"],"translation":["MKLALVAPPWNSLYRPSIQIATLAALEGTGDGDPITPVYAYLDWFEYAVDALECDPAEFVTVYDTIGEELYGLGVGDWIFGGVLDAHGPGEEADVRDRYAAFLTEHGVAEELVGRVLALRAVAPGFAAGLAGRLVATGAECFGFTTSFSQLMPALAVARAVKDQAPERLVLLGGANCDRPMGQAVMRAYPFVDAVVQGEGEAAVAAVRAARGAGDLAAAPGLVLRHEGGLRVSLPTVQPAESAPVPRYAEYFERLRALPHRELIAPHVALPFQMSRGCWWGEKLQCTFCGENGSGMVYRSKPGEQLTKTLRRLTEEHGVFDTYAVDTILARNDNGLAELAAAEVDITTFFEVKANLGPREVGEMRAAGVTMVQPGIESLSSGALKLLRKGATAFHNLRFLVLCQELGIDAQWNLLSAMPDETAEMLQEQLRLIPFITHLAPPSTVSKVRVDRYSPYFEKPEEFGIALDGPEPKYRFVHAGRTAAERAELAYSFDHVELAGRDDSAMAAEMLALRRRLGARVGLWKKLHDQSRFSFRFGPNMTVLHDGRPHVGTGRHVLRGGDDQLFRCLVHGGRLHQAVGQVAAMTGRPEDEVHARVREWARRGWVHLEGRRGLVLAVRDGMRDELGRAAELREAAAESERAAAESGMAGAGSGRVGAGR"]}},{"location":"[10000:10882](+)","type":"gene","qualifiers":{"gene":["botH"]}},{"location":"[10000:10882](+)","type":"CDS","qualifiers":{"NRPS_PKS":["Domain: Abhydrolase_1 (33-140). 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rule-based-clusters)"],"transl_table":["11"],"translation":["MRDGNGTSRRDVFEVFSRDGTPIRGFSRPGPGETVVLVHGVAMDRRIWAESGFLDALPDAHVLALDLRGRGESGRVGTAEGHALRRYVEDVRAVLDRFGRARYSLFGTFFGGRIALQVAAVDTRVARAFSFCAHAEQVEIPEDAVEEEAVAVEGPGGHAYLRDHFTGRGAPPWMVEACARVDPGELGAATRGLLHGSDRRTERGHPDQELVLITADGDADLAPFHAGERRLGAHLWLVDAPTRIKAAGRLAEVGRRVAGVLAEGGHGTGDAPAEARTTGDAPAEARASGTGVV"]}},{"location":"[10099:10420](+)","type":"aSDomain","qualifiers":{"aSDomain":["Abhydrolase_1"],"aSTool":["nrps_pks_domains"],"database":["nrpspksdomains.hmm"],"detection":["hmmscan"],"domain_id":["nrpspksdomains_botH_Abhydrolase_1.1"],"evalue":["6.10E-14"],"label":["botH_Abhydrolase_1.1"],"locus_tag":["botH"],"protein_end":["140"],"protein_start":["33"],"score":["44.2"],"tool":["antismash"],"translation":["TVVLVHGVAMDRRIWAESGFLDALPDAHVLALDLRGRGESGRVGTAEGHALRRYVEDVRAVLDRFGRARYSLFGTFFGGRIALQVAAVDTRVARAFSFCAHAEQVEI"]}},{"location":"[10899:12297](+)","type":"gene","qualifiers":{"gene":["botAH"]}},{"location":"[10899:12297](+)","type":"CDS","qualifiers":{"codon_start":["1"],"gene":["botAH"],"gene_functions":["biosynthetic-additional 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P450"],"gene_kind":["biosynthetic-additional"],"product":["BotCYP"],"protein_id":["AFV25487.2"],"sec_met_domain":["p450 (E-value: 9.9e-12, bitscore: 34.0, seeds: 50, tool: rule-based-clusters)"],"transl_table":["11"],"translation":["MQADREPDRTGREAKRPAEPDHPPQQATCPVDFDFFAAPQTYRDAAAEHAGEHGAFYSDRGFWVLTTYDGIVDAFKDEGTFTVGRVSAAEGAEEERWIPLTVEGREHTAWRQRLGAWFTPQRVRELTPSMRAGARRRIEGFLEKGEVSFNEDFARPYVLENLMTAVGWPPDGFDLLIAINRAMIDSRSAPDPRAAAYGELGLPALERFAREHIARRRAEPADDLTTASFGWEIDGAEVTDDDRASLLCTLFLAGIDSTVNHLANAVQHLAHHEEDRRRFLAGPEVRPPAVEEFLRANSCMYPGRQAATGGAGGVADRGDTVLLPLALANHDPEVFPEPGRIDFDRTRNPHIAFGTGPHQCLGAAFARAQILVALEEWHALVPDYAPSPEQRTAEPPFLRNSYDLRLVW"]}},{"location":"[13520:15566](+)","type":"gene","qualifiers":{"gene":["botRMT3"]}},{"location":"[13520:15566](+)","type":"CDS","qualifiers":{"codon_start":["1"],"gene":["botRMT3"],"gene_functions":["biosynthetic-additional (rule-based-clusters) TIGR03975","biosynthetic-additional (rule-based-clusters) Bottromycin_Methyltransferase_RRE","biosynthetic-additional (MITE) MITE0000047: Methylation (100% identity)","other (smcogs) SMCOG1277: Radical SAM domain protein"],"gene_kind":["biosynthetic-additional"],"product":["BotRMT3"],"protein_id":["AFV25488.1"],"sec_met_domain":["TIGR03975 (E-value: 6.4e-161, bitscore: 526.4, seeds: 14, tool: rule-based-clusters)","Bottromycin_Methyltransferase_RRE (E-value: 2.6e-38, bitscore: 119.9, seeds: 12, tool: 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(MITE) MITE0000048: Hydrolysis (100% identity)"],"gene_kind":["biosynthetic-additional"],"product":["BotP"],"protein_id":["AFV25490.1"],"transl_table":["11"],"translation":["MTRVVAGDVGTDTPDKAGTADTAKAADTADTASRAADVVACGRHTGAAVGAFSRRRGFVARPGQVVAEPSADGRAVVLNVGLGPAGSATAATFRAAAAASVRAVGPARTLRLDLALADGSGVPAAERARAVAEGAVLGLYRYDEYRSARAASPLAEVIVATPERRAVAEGLAAAEATCLARDLVNCPAGTLTPPAFADRIRELAHTAGLDCAVYEGAGLTELGLTGLTAVGRGSAEPPRYVELTYDPPDADPALTVGLVGKGVTFDSGGLSLKPSGERHAMKADMGGAAAVVAALTALPRLGLPLRVRGHLPLAENMPDGGALRVGDVVRHLDGTTTEITHTDNEGRVVLADVLVRASRPGPHRSDLVVDVATLTSAAVHALGTRTGALFTPDDRLAQTVLAASERAGESFCRLPLLAHERRNLRSAVADRVNCSHRHGDTIQAALFLQDFVAAGVPWAHLDIAAPAYNDEGPYAEVPYGGTGFAVRTLIETLRALSEGSPDVP"]}}],"name":"BGC0000469","description":"Streptomyces sp. 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