BGC0000469: bottromycin A2 biosynthetic gene cluster from Streptomyces sp. BC16019
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Location: 16,255 - 33,922 nt. (total: 17,668 nt).
This entry is originally from NCBI GenBank JX235926.1.

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core biosynthetic genes
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transport-related genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000469
Short description bottromycin A2 biosynthetic gene cluster from Streptomyces sp. BC16019
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
JX235926.1
16255 - 33922
via Heterologous expression
Compounds
  • bottromycin A2
Species Streptomyces sp. BC16019 [taxonomy]
References
Chemical products information
bottromycin A2 Evidence:
Copy SMILES
C42H62N8O7S1
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV25478.1
  • botT
 16255 - 17550 (-) BotT
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    • AFV25479.1
    • botOMT
    		 18069 - 18908 (-) BotOMT
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      • AFV25480.1
      • botRMT1
      		 19314 - 21239 (+) BotRMT1
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        • AFV25481.1
        • botA
        		 21336 - 21470 (+) precursor peptide
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          • AFV25482.1
          • botC
          		 21534 - 22838 (+) BotC
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            • AFV25483.1
            • botCD
            		 22951 - 24153 (+) BotCD
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              • AFV25484.1
              • botRMT2
              		 24150 - 26132 (+) BotRMT2
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                • AFV25485.1
                • botH
                		 26119 - 27000 (+) BotH
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                  • AFV25486.1
                  • botAH
                  		 27018 - 28415 (+) BotAH
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                    • AFV25487.2
                    • botCYP
                    		 28405 - 29631 (+) BotCYP
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                      • AFV25488.1
                      • botRMT3
                      		 29639 - 31684 (+) BotRMT3
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                        • AFV25489.1
                        • botR
                        		 31849 - 32403 (+) BotR
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                          • AFV25490.1
                          • botP
                          		 32408 - 33922 (+) BotP
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                            Biosynthesis information
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-07-24
                            MIBiG v4 annotathon
                            • (ID: C62OJVVH7XOTOTFZSJT727YU)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2023-11-17
                            Specified biological target, specified start/stop of BGC, added RiPP and gene annotations. Added a review paper (doi:10.1039/D0NP00097C) which unifies the bottromycin gene designation.
                            • (ID: C62OJVVH7XOTOTFZSJT727YU)
                            • (ID: DKBFG3K6XTYSVEQEQVCFZBWY)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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