BGC0000470: bottromycin D biosynthetic gene cluster from Streptomyces sp. WMMB272
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Location: 12,177 - 26,921 nt. (total: 14,745 nt).
This entry is originally from NCBI GenBank JX827389.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000470
Short description bottromycin D biosynthetic gene cluster from Streptomyces sp. WMMB272
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Two genes missing from BGC (a regulatory protein 'botR' and a hydrolase-like protein 'botP') due to location at end of contig."
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
JX827389.1
12177 - 26921
via Knock-out studies
Compounds
  • bottromycin D
Species Streptomyces sp. WMMB272 [taxonomy]
References
Chemical products information
bottromycin D Evidence:
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C40H58N8O7S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFU90407.1
  • bstK
 12177 - 13436 (-) MFS-family/H+ antiporter
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    • AFU90406.1
    • bstB
    		 13697 - 14527 (-) O-methyltransferase
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      • AFU90405.1
      • bstC
      		 15052 - 17013 (+) radical SAM-dependent protein
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        • AFU90404.1
        • bstA
        		 17098 - 17238 (+) precursor peptide
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          • AFU90403.1
          • bstD
          		 17302 - 18477 (+) YcaO protein
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            • AFU90402.1
            • bstE
            		 18395 - 19729 (+) YcaO protein
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              • AFU90401.1
              • bstF
              		 19726 - 21639 (+) radical SAM-dependent protein
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                • AFU90400.1
                • bstG
                		 21626 - 22468 (+) alpha-beta hydrolase
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                  • AFU90399.1
                  • bstH
                  		 22586 - 23857 (+) amidohydrolase
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                    • AFU90398.1
                    • bstI
                    		 23931 - 25070 (+) cytochrome P450
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                      • AFU90397.1
                      • bstJ
                      		 25078 - >26921 (+) radical SAM-dependent protein
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                        Biosynthesis information
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2023-11-17
                        Added biological target, specified start/stop of locus, added RiPP and gene annotation, adding comment regarding missing genes. Added a review paper (doi:10.1039/D0NP00097C) which unifies the bottromycin gene designation.
                        • (ID: C62OJVVH7XOTOTFZSJT727YU)
                        • (ID: DKBFG3K6XTYSVEQEQVCFZBWY)

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Changed subclass from cyanobactin to bottromycin
                        • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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