LOCUS       BGC0000470             26921 bp    DNA     linear   BCT 17-OCT-2012
DEFINITION  Streptomyces sp. WMMB 272 bottromycin D gene cluster, partial
            sequence.
ACCESSION   BGC0000470
VERSION     BGC0000470
KEYWORDS    .
SOURCE      Streptomyces sp. WMMB 272
  ORGANISM  Streptomyces sp. WMMB 272
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:37:03
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 26921
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..26921
                     /db_xref="taxon:1234059"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. WMMB 272"
                     /strain="WMMB 272"
     misc_feature    complement(1..>26921)
                     /note="bottromycin D gene cluster"
     subregion       1..26921
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..26921
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(12177..13436)
                     /gene="bstK"
     CDS             complement(12177..13436)
                     /codon_start=1
                     /gene="bstK"
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 194; E-value: 6.8e-59)"
                     /gene_kind="transport"
                     /product="MFS-family/H+ antiporter"
                     /protein_id="AFU90407.1"
                     /transl_table=11
                     /translation="MLTRYLLSHGLSLLGNTVATIALPWLVYLRTGDAAAVGLVAAASA
                     LPMLVSAVAGGVLIDRVGRRRLSVGADFASAACVAALPIIDHFSGLTVVWFVVLGVAGA
                     LFDVPGMTARETLAPDLAAASGVGIERLAGLRESVGGVVVVVGPAVAGGLIVLVDPATV
                     LWITSGCSAAAALVTLSLPRTVGARSASAPASEGGGLKADIARGFSVLRHDRVVTAVTF
                     VSAGSAAILAPLQNLVLPVYLVGKDSPGGFGLVISFLAVGGIVGSGLYAAIGARLSRRA
                     VFVVAQLLSTAGIVGLALLPPIPILLGAAVVAGIGAGPLPALCLVLVTDRIPESVRGRV
                     LGLQNAVSMTAIPLGTLGASLLIEWGGLRQTGALLGLGWAVVAVSVLALPALRQLDKVR
                     QQEPEEAVGNEPTDPAVAGQ"
     gene            complement(13697..14527)
                     /gene="bstB"
     CDS             complement(13697..14527)
                     /codon_start=1
                     /gene="bstB"
                     /product="O-methyltransferase"
                     /protein_id="AFU90406.1"
                     /transl_table=11
                     /translation="MKVPLTGAAATLLAPLYARALDASSPHPMLADSTAPELVQKIEYD
                     FGALGMRPSNAVGVALRARFFDRRTREFLTAHPNSTVLHLGCGLDNRVDRVERGPGVRW
                     FDVDQPEVIEVREQLFSPRSDHRTIAASVTETDWLAEVPTDLPVLVIAEGLTMYLAADE
                     GPRMLRALVEHFSEGEAVFDTYARYAVRSTRSMALFRKTGARLAWGVDDPRELEREVPG
                     LRLVKSVKAYHTADPADFRRLPFALRTRMRVDAEVLARLPVLGRVGHLSRYAFG"
     gene            15052..17013
                     /gene="bstC"
     CDS             15052..17013
                     /codon_start=1
                     /gene="bstC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Bottromycin_Methyltransferase_RRE"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 169; E-value: 2.5e-51)"
                     /gene_kind="biosynthetic"
                     /product="radical SAM-dependent protein"
                     /protein_id="AFU90405.1"
                     /sec_met_domain="TIGR03975 (E-value: 8e-161, bitscore:
                     525.8, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 8.6e-43, bitscore: 134.0, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPALGGDDSVGNGRSATLVSMPWNSVVRPSIQVGTLRTVAEEEG
                     WQVTSEYAYLSFYGLGREMLGFSESEWADAYETISEKLYHMAVGDWIFARRHGESQQRD
                     RYFAELREMRVDDETIALIDSLRPVAERHVEETAAALLASDPDVIGFTSMFSQNGPTLA
                     VAERLRAEGYPGVIVLGGSNCEGSMGRALLANYPTVEAVVDGPGEDAFVALLRQVAAGG
                     PVRSQGRLLTRRPAEDSSDVGEAKISPTGLSVPVPNYDGFFEQLHAAGLEGLEAEITLP
                     VEFSRGCWWGAKTHCTFCGLNGATMAYRSKDPDSVADELQYLMDRYGVFDFFAVDNILD
                     LKYLDTALPLVEKLNTDHSLFFEVKANMEWADIRSMRRAGVRSVQPGIESLSTEGLRLL
                     KKGSTAFQNVRFLLGCAEYGVRADWNILTGYPKETPESIRAQLDIVASLSHLTPPHITL
                     IRFDRFSPYVESPESFGLSLSKPLPGYRYVYPELSGEDLWNIAYHFEGDFHDDVRNVDI
                     RRRLAARVRLWRNHHEQARFTYRLGFDSLTLSDHRPGLPAHETVLQGDDAALFRAVIGG
                     TRIRDLQANGWPEGQPWDRAWEKLQNWQRRRWIFIEGTKIIALAIREQPSAYRTPPPKG
                     TPRRQARNPVPVTLTSRK"
     gene            17098..17238
                     /gene="bstA"
     CDS             17098..17238
                     /codon_start=1
                     /gene="bstA"
                     /product="hypothetical protein"
                     /protein_id="AFU90404.1"
                     /transl_table=11
                     /translation="MGPAVVFDCMTADFLNDDPNNAELSSLEMEELESWGAWSDDTDQS
                     V"
     gene            17302..18477
                     /gene="bstD"
     CDS             17302..18477
                     /codon_start=1
                     /gene="bstD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /product="YcaO protein"
                     /protein_id="AFU90403.1"
                     /sec_met_domain="YcaO (E-value: 6.5e-14, bitscore: 41.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADSSATDCVLREVAFRSYRAEHTVTVQCTVRPDSGPGQAEGYGT
                     ATTEAVARKKALSEAVERLLACTPFALIARRPTPRTDRSRGTDPWQRGLRSAPAGCQVR
                     NYRSLSGEQPRQVPLFWSSPWVAGEEMRSANLAPQAARLSSTVGWAVAPSPEAALQGAL
                     YELTELLNYGAFLYRCLAAPRERPAPGGGPEPREEGRIQTVPISWATRTPTILAVTRSS
                     DRLMPATGIGSGTTASEAAERAFLELAQAETLWRANSTAVPAERYFMRRFEKWPLLRRC
                     AALDFDLGEHAGPFDDGPHPSPLGALESRAIEVWADPGAVDISGADLRRTRLCFAHVVS
                     DPQPLLGLVRAGIPVFDTGEVRKILVCPRRARSADRSPSGRVAHSGRPTRA"
     gene            18395..19729
                     /gene="bstE"
     CDS             18395..19729
                     /codon_start=1
                     /gene="bstE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /product="YcaO protein"
                     /protein_id="AFU90402.1"
                     /sec_met_domain="YcaO (E-value: 9.4e-36, bitscore: 113.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVHAEHDLLTAALLDGSLTQDVPPERETPIGRALSAASDWLSSE
                     QLTPDIWKYGLDSAPTYEVHLKDAAGTLCSRSSGKGLGHRSMASALFESAEHYHLDWRR
                     DPLADEAAFVPGREVAGQSTAAGSALLHRLGGILGDSPVLTREYRPVAEALGATGGAAP
                     PHRHPVFLRDGGYRNWPHPSDDGSFKPLWHYTTSAGYAAGTTLHEALVHAVNELIERDA
                     WSYQLARSYFGLPDESGRALRVIDHESLPAELRALVDDVEASSGSPILIVSIPCDTGVP
                     AYVVCDAESDEDVRLIGSGASPVQAYALQRGLLEYLQVCTMYQHGPVDAEREAAQIATA
                     LARYPRHLAAAGFDVRQLPHERQPFDSDGLPAAATPEELLRHLIDRLQGVGVDLHFRVL
                     TRPGTITVVDVVAPGLEMLDKARAGYPVLPTGRLGERLRPQRREP"
     gene            19726..21639
                     /gene="bstF"
     CDS             19726..21639
                     /codon_start=1
                     /gene="bstF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Bottromycin_Methyltransferase_RRE"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 122.3; E-value: 3.6e-37)"
                     /gene_kind="biosynthetic"
                     /product="radical SAM-dependent protein"
                     /protein_id="AFU90401.1"
                     /sec_met_domain="TIGR03975 (E-value: 3.2e-137, bitscore:
                     447.9, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 3.5e-36, bitscore: 112.9, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLVLVAPPWNSLYRPSIQIATLAALSTEEQGDPISAVYGYLDWF
                     EYAVGFLECDPEQFAAVYDTIGEELYGLGVGDWIFGGGLPGAGDADEASATAEYGAFLR
                     EQGVDEEIVADVLRLREAAPRFVADLAERLVDDGAECFGFTTSFSQLVPSLAIAVAIKE
                     RAPDRLVLLGGANCDRPMGQAVMHAYPFVDAVVEGEGEQAVNALTRAKSVDDLAAVPGI
                     VLRHEDGLRTALPTIQPVESAPVPKYDAYFERLESLPWGDLIAPHVALPFQMSRGCWWG
                     EKLQCTFCGENGSGMVYRSKPGSQLVDTLRTLTERHGAFNTYAVDTILAKNDNGLAALA
                     DAEVDITTFFEVKANLGPREVGELRAAGVTMVQPGIESLSSGALKLLRKGATSWHNLRF
                     LVLCQELGIDAQWNLLSAMPDESAEMLEEQLRLIPFITHLAPPSTVSKVRVDRYSPYFE
                     KPDEFGIELRGPEKKYRFIHRGEGVDRTALAYSFEHGQQAGKERDDDAAMLALRRRLGA
                     RVGLWKKLHAQSRFSFRFGPNVTVVHDYRPHVGTGRTVLRGADDLLFRSLVHGGRLMQA
                     VGRVGEQTGTPESRLHERVSEWAACGWVHLEGRRGLVLAVRDGMRDELGRAAALRGSDA
                     ES"
     gene            21626..22468
                     /gene="bstG"
     CDS             21626..22468
                     /codon_start=1
                     /gene="bstG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     bottromycin: botH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262:haloalkane dehalogenase (Score: 55.1; E-value:
                     1.1e-16)"
                     /gene_kind="biosynthetic"
                     /product="alpha-beta hydrolase"
                     /protein_id="AFU90400.1"
                     /sec_met_domain="botH (E-value: 7.8e-147, bitscore: 476.9,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.4e-12, bitscore:
                     37.5, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 5e-14, bitscore: 42.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSPDREQTERFEVASVDGTLLRGFSRAARGSSDARGEPETLVLL
                     HGVAMDHRVWSESSFLDALPDDVHVVAPDLRGRGESDPGHSAEGHAIDRYVEDVRAVLG
                     FFGRERYSLFGLYFGGRIALRVAEADRRVQRAFSFCAHGEAVEVPADAVEEEAKEIEGP
                     GGYAYLRDHFSAAGAPAWMVSACDRVDQDELAAATRGLLHGSHQRAERGAADQDLVLIT
                     AEGDADLGTFREGSARLGARLWLVDSRTRVRAAARLAEVGTRTAELLTAAPAAMKGDA"
     gene            22586..23857
                     /gene="bstH"
     CDS             22586..23857
                     /codon_start=1
                     /gene="bstH"
                     /product="amidohydrolase"
                     /protein_id="AFU90399.1"
                     /transl_table=11
                     /translation="MLDAETGEAAPPRDLEVVDGAVARWSPAPDAAYCEWFALPGFVDA
                     HAHVSSVTDLVGMLAYGVTGYRQMWGEPAHLYSAGVHRARHAVLPLPWTTAGVVDGPDS
                     RIPHHVTVVDDARQVRRVVEDVLAFGFDGIKVYDDLARPAFEALVREAERAGIPVVGHV
                     PEAVPLDAAYPGMWSTEHLYGIVPNVFRLPAADRWAVLADALQRHRDDGPAVEGAAGRF
                     VCPTLTAWRARSGERRYTRPSRTLLQSATPSRRPAWHAAARDALSLERAEAQRRSLLVD
                     RLGGIAYDLSRRGARLLVGTDCGNPFVLAGPSYHKELAELSRSGLDFATVLKAATVDAY
                     AATGRDPARADLVLYRRSPAHDVTRLARPDAVLVDGVLLDADDLDHLWGLRLTAAGLDA
                     GTWRRGDVDPAAGDRQNKETADAG"
     gene            23931..25070
                     /gene="bstI"
     CDS             23931..25070
                     /codon_start=1
                     /gene="bstI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 230.9; E-value: 4e-70)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="AFU90398.1"
                     /sec_met_domain="p450 (E-value: 1.1e-11, bitscore: 33.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFEFFNGPSAYREAAATHADEGAFYSASGDGFWVLTTYEGICEA
                     FRDEEQFTVGRVSAADGAEEDRWIPLTIEGRQHTEWRRRLGAWFTPQRVRELTPSIEAN
                     ARRRIEGFVDDGEVSFNEDFARPFVLENLMTAVGWEFDRFDQLLRIDRAMIDSRYAPDP
                     REAAFEEVGIPALEKLAREQVERRRAEPADDLTTATFGWEVEGRPVTDDDRASLLCVLF
                     LAGVDSTVNHLANAVQHLVCHDADKRRFLASREVRPRAVEEFLRANSCMYPGRLAARDG
                     AGGTARRGETVLLPLAVANYDPEVFHDPEQVDFDRERNPHIAFGTGAHQCLGAALARAQ
                     IRTALDVWHELIPHYGFPPQPEPSEPRFLRNAYDLRLVW"
     gene            25078..>26921
                     /gene="bstJ"
     CDS             25078..>26921
                     /codon_start=1
                     /gene="bstJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Bottromycin_Methyltransferase_RRE"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 158.8; E-value: 3.2e-48)"
                     /gene_kind="biosynthetic"
                     /product="radical SAM-dependent protein"
                     /protein_id="AFU90397.1"
                     /sec_met_domain="TIGR03975 (E-value: 6.2e-163, bitscore:
                     532.8, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 3.2e-42, bitscore: 132.2, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSAGSAGRVTLVSMPWNNVRRPSIQVGTLRAVAEEEGWQVTPEY
                     AYLAFYGLAKRMLGYGDAEWSDAYDLISEGLYHFSVGDWIFACRGTEAARRDEYVEELR
                     SRKIDEPTIGLIDSLREVAERHVEETAAALLASDPDVIGFTSTFSQNGPTLAVAERLRA
                     SGYPGVIVMGGSNCEGSMGRALLENYPAVEAVVDGPGEDAFVALLRQVAAGGPVRSQGR
                     LLTRRPAEDSSDVGEAKISPTGLSVPVPNYDGFFEQLHAAGLEGLEAEITLPVEFSRGC
                     WWGAKTHCTFCGLNGATMAYRSKDPDSVADELQYLMDRYGVFDFFAVDNILDLKYLDTA
                     LPLVEKLNTDHSLFFEVKANMEWADIRSMRRAGVRSVQPGIESLSTEGLRLLKKGSTAF
                     QNVRFLLGCAEFGVLPVWNILTGFPKETPELMREQIDLLPSLTHLPPPDNDVLAVHFDR
                     FSPYVESPESFGLSLSKPLPGYRYVYPELSGEDLWNIAYHFEGDFHDDSRNVDIRRRLA
                     ARVRLWRNHHERAHFTYRLGFDSLTLSDHRPGLPAHETLLQGDDAALFRAVIGGTRIRD
                     LQANGWPEGQSWDRAWEKLQNWQRRRWIFIEGTKIIALA"
ORIGIN
        1 cgctcttccg atctgccaac ggtccggcgg cggcaccgac gttgagcgcc gcggtcgcgt
       61 acgagcccgc cagcgtcggg gctcccgccg cctcgtagag cactcgcgtg atcagtgtgc
      121 tgcccagcgc gaatgacagt gcgccctgga cgcacgcgag gaccaacagc gcgaccggct
      181 cgtcggcgag cacggcgagc aggggccacc cgacgagcag caacggccag cagaccgccg
      241 ccaccaggcc gggccgccgg tcggagaagc gcccggcgac ggtgaccccg gcgaacgaac
      301 cggcgccgaa gagcacgagc gcgacggaga cccacagctc gcccagcccc gcgacctcgg
      361 tcacgacggg cgcaaggaag gtgaagcttg cgaaggtcgc cccgttcacc agcgcaccga
      421 gcgtcacgac gagcagcagc cgcggcctcc tcaactgagc gagctctgcg cgcagatccg
      481 gtgtcgcgga ctcctctgcg ccctcgcggg gaatgccccg gaggatgccg agagcagcgg
      541 gcaggcagag cacggtgatg gcccagaagg tcgcccgcca cccgaggagg gtgccgagca
      601 ccgctcctcc cggcaccccg gcgaccgtgg ccaccgtcgt gcccgagagg aggacggcca
      661 gcgcgcgtcc cttcctgtcg gaggggacca gtgcggcggc ggtcgtcaac gccacggcga
      721 ggaacccggc gttggcgagc gcagcgacga cccgagtgac gaaaaggacc gggaaactct
      781 ccgtgcagac cccagcgacg tgggcggctg cgaagacgag gacgaacgtc ggaaggctgg
      841 ccctgcgggg ccagttgcgg gcgagtgccg ccatcagcgg ggcgccgacg atcattccga
      901 ccgcgaaggc cgaggtgagc gtccccgcgg ccccgactgt cacgtcgagt tgcgaggcga
      961 ggtccggcag gaggccggcg agcatgaatt cggaggtgcc catggcgaag accgccaggg
     1021 cgagcagata gagcgggaga ggcatcgagt cggctccggg tgacgcagga acggttacgc
     1081 gtcgtcaccg cagtcagccc tgagggcgcg ctcgccgggc cgcaggggtg cggtcggctc
     1141 gatggttcag ggggctgacg gcgtgaccgg cagccccggc ttggacgcct tgggactcga
     1201 catgctccgc acgctatccg gtcgtcggcc gcctgcaaaa gaggggcaat ccggcgccgc
     1261 gccccccccg gacccgggcg gcgaccccca caccgccgcc gcccgggagc tgtcagtcgg
     1321 taaacaactg ggcgaccttc agcgccagtt cgtagatgcc gtatgcgaac gggaggccca
     1381 cccacagcca gacgaggacg gcgagccagg tccggcgggg tgccgtcggc tcaggagagg
     1441 cgctgctggg agccatcgtc ggcctccgtt tccttcgact cggcgggcgt ttccgtctcg
     1501 gcgggcgttt ccgcaccggc gcccgacggc gcgggctcgt ggtaacgcga attgacgggc
     1561 cggatgcact cgttggcgac gaagccgacc acgaggaggc ccatcatgat gtagagggag
     1621 aggctgtaga gcccgggccc gctgcgcccc gcggcctcct gcgtgtcggc gacccagttg
     1681 acgatgagcg ggccgagcac acccgcggtg gaccacgcgg tgaggaggcg gccgtggatg
     1741 gcgccgacct ggtaggtgcc gaagaggtcc ttcaggtagg cgggcgcggt ggcgaaaccg
     1801 ccgccgtaga aggagaggat caccagcgcg gagaggatga agatcggctt cgaggagtcc
     1861 ccggccgtgg cgatgagcag gtagagcagg gctccgacgc cgaggtagag gcggtagatg
     1921 ttcttccgcc cgacggtgtc ggaggcggcg gaccacgcga ggcgcccgcc catgttggtg
     1981 agcgagagca gcgcgacgaa cccggcggcg gcggagacgg agacgggcgt gctggtgccg
     2041 gagaagaagt cccggatcat cggcgctgcc ttctccagga tgccgatccc cgcggtcacg
     2101 ttcatgcaca ggacgatcca caggcaccag aactggggcg tacgcagcgc gttcttcgcc
     2161 gacacctgag cagtggtgac catagcccgc tgctcggtcg gcggcgtcca gttcggtggg
     2221 cgccagccgt cggcggggac ccgcacgagg aggacgccga gcgccatgaa gaccgcgtag
     2281 acgagcccgt gcacgaggaa ggcgccggcg atcccgctgc tgtcctcgcc gaagctctcc
     2341 aacatctgcg aggaccaggg cgaggcgatg agcgcgccgc cgccgaagcc catgatggcg
     2401 ataccggtcg ccaggccggg acggtcgggg aaccatttga tcagcgtcga gacgggcgag
     2461 atgtagccga tgccgaggcc gatgccgccg acgaacccgt agccgaggac gatgagccag
     2521 aactgctccg tcgccgcacc gagtgcggag aggaggaacc cgctggagaa gcagagcagc
     2581 gatacggcca tcgcccagcg cggacccttg cgttcgacga gggtgcctcc gaacgccgcc
     2641 gagaggccga gcatcacgat ggcgagctgg aacgggagcg cgctcgccgt ccccgagagg
     2701 tcgagggcct tctccagcgc tggcttgaag acactccagg cgtacgcctg gccgatggac
     2761 aaatggatgg agagcgcggc gggcgggacc aaccagcggc tccagccggc gggagcgacc
     2821 gtacgggagc ggctgagcag tcccccgtcc gggacctgtg cggacttcat ggggcggcac
     2881 tctaagtagt tgagccgtga atgaccaggg gtgtgacgcc acccctttca ctcggctcac
     2941 ctgcggtgac acttccgcgg aacccggaaa cgatcaagtg tccttcgagg aggggcagtt
     3001 gtgaccgaag ccggccccgg cgcacccgac acgccggagc cggcccgatc cccgcgtcag
     3061 tgcccggcgc gcgccttctc gtcggcggct ccgcccgccc cgacgagtcc cgtcgccacc
     3121 tcgccggact ccagccgcgg ggcgaaacgg gccacttcgc gcttgccgac gttgccgatc
     3181 agtgccggga ggtacccgcg gatgctctgc atgccgcgga gccaccactg ggcgtagacg
     3241 tgcgccgagc ggcgctcgat gccgtcgacg atgcggtcga tggccgggcc gagcgggtac
     3301 gtcttgttcg tcggccaggg gaggcgctgg cggatgtcgc gcatcaggtc gtcctcgtcg
     3361 gcgccgcgga ccatgtcggt gtcggtccag ctcaaatagc cgacgccgac ccgcacaccg
     3421 cggtaggcga cctcggcgcg caggctgtgc gcgaacgcct caacccccga cttcgacgcg
     3481 cagtacgccg tcatcatcgg cgccggcgtg acggcggcga gggaggcgat ctggaggaag
     3541 tagccgcggg actcgcagag taccggcagg aaggtacgcc ccgtcacggc gcccccgatc
     3601 aggttcacct cgatcacgcg gcgccacgcg acggggtcgg agtcgatgaa cgggccgccg
     3661 ttggcgacac cggcgttggc gacgacgacg tcgaccttgc cgaagcggtc cttcacctcc
     3721 tgtgcgatcc gggccattgc cacgtggtcc gtgacatccg cgtgccagtg ggccgactca
     3781 ccgtggagcg agtcgctgac gcgcttcagc tcctccgcct ccagaccgac gagcgccaac
     3841 ttcgcacccc tcgccgagag tttccgggcg agcagctcgc ccaccccccg tgcggccccc
     3901 gtgacgacga ctacctggcc ctccaggctc atgcggctca tgcgctctcc ttctcggtgc
     3961 cggacactgt gcgggaaccg ttgctgtgca cgggcgggtc ggccccgtcg aggtgcttgg
     4021 ccgccaggcc cttgagcact tcggcgaccg tctcggggga ctcgatgggc gtcatgtggc
     4081 cgaggccctc cagcgcatgg aaaccggcgg gctgcggcag tgcgtcggcg agctcacgcg
     4141 cgtggaccgt gggcgtcatc cggtccgcgg tgccgacgag tacggccgtg gggacggtga
     4201 gtcccgggag tttggcgaag acgtcgagct gggtgaggac ccggccccac gcgcccctga
     4261 ccttcacggg gcacgcgtgg acgaggcgtg cgcacgcctc gacctgggcc gcgtccgaac
     4321 ggcggcccat cgtcgcgtac ttgagggcgc gcctcgtgag cggcgtgctg gggccgagtg
     4381 gcgctttcgc cgtgagcagc agacggtgcg tcctgcggcg gaccgccgcc gagcggaacg
     4441 ggaagaccgt cgactcctgg gcgaggttgc gtccgcccgt gctgcacagc agcaacgccg
     4501 cggcgtgctc gtggagttcg gggcggtcgg cggcggccat gagcgtcatg ccgcccatgg
     4561 agtggccgcc gaggacggcc tgctcgcccg gctccagggt ctcgccgagg accgcgacga
     4621 ggtcgtcgga gagggtggcg ggcgtgtacg cctccgggcg ggccgccggg gtgcggccgt
     4681 gtccgcgctg gtcgtagagg atgacgcggt agccggcctc cacgaggtcg cgggtgacgg
     4741 gggcccagaa ggtggtggcg caggtccagc cgtgcgagag cacgatcgcc gggtccttct
     4801 ccgctccgtg cacctcgacg tggaggcggg cgccgtcggc ggagtgcgcg gtcaactcgc
     4861 gtgcgggcag cggcgcgacg taccgtccgc cggtcccctt cgtcagacgg ctcacttggc
     4921 cccctctccc gtgtagatcg cgtcggcgcc cttgcctgcg gcggccgtgc cggcgagtgc
     4981 ggcgtccttg cccgtgccgg ggcgcaggac gtcgtactcc tccagccgca cctcctgggt
     5041 gaccttccgg aactcggccg tggtgccggg ccacacggtg gtgttgcggc cgttgtcgtc
     5101 gaggtaccag ctgtcgcagc cgccgacgtt ccagacggtg cgagccatgc ggtcctgtac
     5161 gtgcgcgttc catgcgcgga cggactcgcg gcgtgcgtcg agcgccaccc ggccgccggt
     5221 gcggccgccg ccgagggtgt cgagctggcg caggtagtcg accatgtact ggagttgggc
     5281 ctcgatcatg aggatcatcg agctgttgcc gagccccgtg ttggggccga tgatcgtcat
     5341 gaagttgggg aaacccgacg ccgtgcagcc gcgcagcgcc tccatgccgt ccttccagga
     5401 ctcggcgagg gtgctgccgt cggctccctt gacgcgttcg gcgatcggca tgtcggtcac
     5461 gtggaagccg gtgccgaaga cgatcgcgtc gacctccgcc tccgtgccgt cggacgccac
     5521 gagggtgttg cccctcacct ccttgagccc ggagtcgacg aggtcgacgt tgggctcggc
     5581 gagcgccgga tagtagttgt tggagaggag aatgcgcttg cagccgatgc ggtagtccgg
     5641 cgtcaacttc cgtcgcgtcg cagggtcctt gactgcccgt ttcatgtggg ccgaggcgag
     5701 cttctcgacg aggccgagct gcttggggtg cttggtgaac gcgccgacct ggagctcgcg
     5761 gatcatccac agcgcctgcc tgcgcagcgc cctcgtgggc ggcaccttcg cgtggagcca
     5821 gcgctcggcg cccgtgatct tccggtccat ccgcggcatc acccacggcg gggtgcgctg
     5881 gaagagggtg aggctgcgca cctcgggctg gatggcgggg acgacctgga tcgcggaggc
     5941 acccgtaccg atcatcgcga cgcgcttgcc gcgcaggtcg taaccgtggt cccactgcgc
     6001 tgagtggaag accttgccct cgaagctctc cagaccgggt atgtccggga tcttcgggtc
     6061 ggagagcggc ccggtggcgg agacgaccat ctctgccgtg taactgccgc gtgaggtgtc
     6121 gatccgccag tgcagctcct ccgactccca agtcatctgc tgcacctccg tgttgaagcg
     6181 gatgtgctgg cgcagcccga agttgtccgc gacgttctcc aggtaggcgc ggatgtgcgg
     6241 ctgtccggag aagttgcgcg gccagtcggg gttgggcgcg aaggagaagg agtagaggtg
     6301 cgagggtacg tcgcaggcgc accccggata ggtgttgtcg tgccaggtgc ctccgacgtc
     6361 ctctcgccgc tccaggacga cgaagtccgt gactccggcc cggcgcaggc gtacggcagc
     6421 accgaggccg ccgaacccgg tgccgatgac cgccacccgt acgtgcttgt gctcgtgttc
     6481 ggccgccatg ccgcgcctcc cgagaatgct cacacgaccc gtgcttactg tgccagtgat
     6541 tactggcaca gttcggagag tagagcagtg gcataccgat gggtaggggt cgtcgagcgg
     6601 aagttaccgc cggtttcccg aacggcgccg tgtcgccaac cggtgtgcgt cggacggcgg
     6661 ttgtgcgacg ctcgtcggcg gccgggtccg cgggggcgtg ggctgcgaag gcgtgctgcg
     6721 gccggtccgg accgggtgct gggggcggag cgcggaacgc gcttccgggg gagtgggctt
     6781 gaagtccgat cgtcgcgtcc gggtgcggag tggcgcgcac gtcccggttg cgcacttcat
     6841 gaagcgccgg gatggcgggc ttctcgtttc tcccgggctg tcgcgtctgc tggtgacttc
     6901 ctgcgattcc ggtccggcgg caggaaagag tgcgccgccg attccggcgg cgaccggatg
     6961 gttgttgacg tcgccactcg ccaggaacgc cggcgcggcg atgtcggcca gacccggaga
     7021 atgaagcggc agcccttgca acaggaatcc ccggagtcct gctggtgccg ggcctcgtgg
     7081 gggcagttgc tatttcctga agatgccgac tgcgatggct gcggcgatcc cggcgccgat
     7141 cgcgacgatg acgtatgcgc cgatattcat gctttggcct cttccttgcc gtcagacttc
     7201 actgcacgtg tgcgtgtgcg ggggccggcg aacgaataat gaagggatca actagctttg
     7261 gtcgaaagtc agttgcctca ccatcaacgt tgacgacaac gaacggtgcc gtccagggcg
     7321 gcgaaccgtc ctcgcggtat taggctggct ccgtggcgag cacaggacgg gcacaggacc
     7381 ttcatgcggc gggcgcggag ccccggggcg gctcacccgg cccaggcagt gaggagccca
     7441 gtgccctcgt ccggaacgct ccggacgacc ccgcacacgc gtcccggagc gcggacgaga
     7501 agcgggagta ccgcaccgag gaactcgccg ccgaagcagg cattcccatc cggacgctcc
     7561 gcttctaccg cgagcggaaa ctgctgccgc cgccgcggcg cgaggggcgc atcgcctggt
     7621 acaacgagca ccacctcacc cggctccgca ccatcaccgc acttctcgcc cgcggtcaca
     7681 ccctcggcgg gatagccgac ctgctcaccg cgttcgaacg gggcagggac acccggagcg
     7741 ccgccgaact cctcggtctc gaacacgtct tggtggcgcc gttctccgag gaggtgcccg
     7801 tacggctcac ccccgagcag ctcgccgact actaccaggg ccaggtgacc gtcgagaacc
     7861 tcgacgcctc gctcgacatc ggctacgtag ccgtcgacgg ggacgagttc ctccacgtca
     7921 gccgtcgcct cctcgaagcc tcggcggaac tggtccgcga aggggtgccg ctcgccgcgg
     7981 tactggaggc cgggcggcaa ctgcgtgccc acaccgacga cgtcgccgca ctcttcacgc
     8041 ggctcttcag ggagcacctg atgcccggcg gcgccgagac ggcggaaggc gcagcagctc
     8101 agcccgaacc cggcgccgtg gccgaggcgt tggaccgcgt gcgcccactc gccaagcaga
     8161 tcgtcgaggc cgagctggga ctcggtttgg accggcgcat ccgcgcggaa ctggaagcgc
     8221 tttgggggga tgccggcggt gcgccgggcg aggaagcgcc gtccgaggag tcccgggcga
     8281 gggaggaagc gcctggcggg ccttcggaga ccgggggttc ggggactgcg ccgggtgtcg
     8341 gtggggcgta gggcctatcg gtgaaggtcc gtgcggaccc gccgatgcgc atacgcgccc
     8401 accacttgca caacggacgg ccgccgcccg ccccggcgag agcagccgct cgccgtcggg
     8461 tagttatcaa cgcctctgtg tacaggcccg gttgatcccc atcacggctt ccgtgttcag
     8521 cgtgttttca ccgtggcgcg ggcgagcagg taggccgggc gtatctgttc gtgctcctcc
     8581 gcgtccatgc cgcccagttc cacgacggca acctcaccct ttgcgcccgg tatcgcgaac
     8641 gcctgtaccg gcttgcggtc gagttcctcg ccgtcgatcg tcgtcacgcg ttcgtacacc
     8701 gtctccgatg cgtgttccga acccgctgtg aaactgcggt actcgacttt ttcggccttc
     8761 tcctcgggaa cgaaccggcg caacgcgtcg ccgggctcct gtttctctcc cacccatacg
     8821 cggaggtagc cgatgttgcc cgccggcttg gcgtccactt cgcaggccag gcgcagaccg
     8881 ccctgctcgt ggttcccgtc gactgactcg gccgtccact tcttcgccgt ctcgaacgag
     8941 accggcagct cgcacgccga gcccgcggca cctatccgcg tgcccgactc ggcctgttcg
     9001 cctccctcgg cgaacggccc cttgccgggg cccgacccgc cgtcggagcc gccccctccg
     9061 gccggggtct cgttgccgcc gtcaccgccg gagggcgcag ccgtagtctt ctccacattt
     9121 tcttcgctgc acgccgcgag ccccgcgcac agcaaggcgc acagccccat caccacgacc
     9181 gaccgcaccc agcgcattac ttgtcccccg ttctccgcac gagcctccgc ccgcacaccg
     9241 ttcccagctc cgacgccgcg cgtcggccag cttccgccgg tccagcggac cgccatgctg
     9301 ccagccgccg atcaggcgtg ccacccgtat ccacgcccga cggtggtgcc tcaagtcccg
     9361 tcagtcggcg gttccttggc ggatacggca tgcaccaagg gcgccgcccg ccggctggcg
     9421 cgcccaagcc gctaccacgg ctttccccac tcgcccgcga gacccaactc ggcccacacg
     9481 cggccacgga ggacttcgta ctcctcgcgc agccttgcgc cctccaccgg tggacgagac
     9541 accgccaccc cctccgtcac cgactcctcg gggccgaact gctcccgcgt gaggtctatt
     9601 tcgataccgc cggcgagcct gttccaccag tgcatgtccg tccgcgcacc gtccacgtgg
     9661 acctctccca ccatcagctc acccccgaag agatcgttga cgaccatggc cgtgaccccg
     9721 cactgctcgc gggccggatt ctccgtactc caacgctcac gaaattccgg agtgcaggtg
     9781 tccgcgcccc aactgcggcg caccgccgcc tccacgtcgc tcagcaccaa cgtcatggag
     9841 aagagcctcg caccgaccac tgacaatcga ccggcgtccg tccgcgaagt gcgagcaccc
     9901 gccgtgccct cggtgagcga ctccccggca ggaagcgaaa agcgcgtccc gagccgctcg
     9961 actcgggtct cctgcaaccg tcttggcctg cggagacgtg tccacgtcag aggttgtcca
    10021 caggggtcgc gggggagttg cgccggacgt acggtcttcc tcgtcggaac tgatgacggg
    10081 ggactggaat gcgcacatct gtgatcaccg gctcagccgg gacggcacct caggaggcgg
    10141 ttgggccggg ccgcctcgca gggacaccaa gtctgcggtg gcataaggct gtccgagtcc
    10201 tcatgcggtt gttcgaaagc cgtgagggag aggctcgagg gccgtcggac cctccagcgc
    10261 ccgccaatcc gcgtcgacac gtgagtgctc aagccgcatc ggtccggcag gaatcccttc
    10321 cgcgcacggg tgccagagca gggaccctca actgctcggt ccggcgcggc cgttgcccga
    10381 ccccgtgccg gcggtcagtc cccgaagacc gtggtcaccg gcgcgtggtc gctccagcgt
    10441 tccgcgtgcg tggccgcgcg ctcgacgtaa gccttgaggg cgcggtcggc gaggccaggg
    10501 gtggccatgg cgtagtcgat gcgccatccg gcgtcgttgt cgaaagcccg tccccggtag
    10561 gaccaccacg agtagggacc ggcctggtcc gggtggagcg cgcggacgac gtccgtgtat
    10621 ccgccctcct tcggatcgag gaccctggaa agccaggcac gctcctccgg aaggaagccg
    10681 gcgttcttgc ggttggcgcg ccagttcttc aggtcggcct cggtgtgggc gatgttccag
    10741 tccccgcaga cgagtacttc cctcccgtcg gccgccgcct tcgtgcgcag ctcgacgagg
    10801 taggggagga aggcgtcgag aaagcgctcc ttcacctcct ggcgctcggt gccgacctca
    10861 cccgagggaa ggtagaggct ggccacggtg aggccgggca ggtccgcctc tacgtagcgc
    10921 cccgcgtcct cgaactccgg tgtgccgaag cccacacgca cgcggtccgg tgcgcggcgt
    10981 gtgaggagtg ccacgcccgc acgtcccttg gccgcggcgg gtgcgtagaa agcgtgccag
    11041 ccctccggtt cgcggacggc cgccgagagc tgatcggcct ccgcgcgcac ctcctggagg
    11101 cagacggcgt cggcatccgt gccggccagc cactcgctgt accccttctt cgccgcggcc
    11161 cggaggccgt tgacgttcac cgttgtcacc ttgtgcaaga cctgctcccg aatcctcaga
    11221 gggcgacgac cgagcctacg cgaggcacgc gctccggctt ctggtcatgt cccgcctgga
    11281 cgggccgacg caccggccac cgtgcgtcgc ctcttcctcc cctgcgtaca ggcgtggccc
    11341 ttcccacacc gaaggcaccg tgcgctcccg cccactgcgt acggactgtg ccggagggcg
    11401 gcataggatt tccggatgcg catcgttccc gtacatttcg accaccccga cgcgaggaag
    11461 ctcaacgacg aagtgcagct cgagtacgcc gagcggtacg gcgacgaggg ggacgtcaca
    11521 ccactcgacc cgtcgatgtt cacgccgccg cgcggcctct acctgctcgc ctacgacgac
    11581 gcggagaccc cggtggccac cggcggctgg cgcggccagg agcagaacga ggaggggtac
    11641 accgacggcg acgcagagtt gaagcgcatg tacgtggtgc gcagggctcg cgggcagggc
    11701 ctggcccgac gcatcctggc ggagctggag agcgacgccc gggccgccgg gcgcaagcgg
    11761 atggtgctgg agacgggcac gatgcagcct gaggcgctgg cgctctacac ctcctccgga
    11821 tacgcaccga cgcagaagtt cggcctctac cgcttcgagc cccagagcag gtgcttcgcc
    11881 aagcacctct gagccctgcg caccggtggg caccgcgctc cgccggctcc tcgccacatg
    11941 ttgatcgcgc acgacgcccc cggcaccgca gcgtgatgcc tcgggtcggt cacaccaggt
    12001 ccgggacggc cggaagttgg gagctcggta gacctcagtc accctccgac ggcagggggg
    12061 ggcggtccaa ccggactgcg gagaggagcc cctccgacct gcatccgtcg aaggggcatc
    12121 cggcgaagcc cgcacaactc cgctgctgag gcggcaagtt cgggaacgcg ggaccgttac
    12181 tgacccgcaa ctgccggatc cgtcggctcg ttccccacgg cctcctccgg ctcctgttgc
    12241 cggactttgt cgagctggcg cagtgccgga agggccagca ccgagacggc gacgacggcc
    12301 cagccgagcc cgaggagcgc accggtctgg cgcagcccgc cccactcgat caggaggctg
    12361 gcgccgaggg tgccgagcgg gatcgccgtc atggagaccg cgttctgaag ccccaggacc
    12421 cgacctcgca cgctctccgg aatccggtcc gtgaccagga cgaggcagag ggcgggcagt
    12481 ggccctgcac cgattcctgc gactacggcc gcccccagca gaatcggaat cggcgggagc
    12541 agggcgagcc ccacgatgcc cgctgtggag aggagttggg cgacgacgaa gaccgcgcgc
    12601 cgcgacaggc gcgcaccgat ggcggcgtac agaccggaac cgacgatgcc gcccaccgcg
    12661 aggaaggaga tcaccagacc gaagccgccg ggcgaatcct tgcccacgag gtacacgggc
    12721 aggacgaggt tctgcaacgg cgcgaggatg gcggcgctcc ccgcggagac gaaggtgacc
    12781 gcggtgacga cgcggtcgtg ccgcagcacg gagaacccgc gggcgatgtc ggccttcagc
    12841 ccgccaccct cggaagcggg cgcggacgcg gaccgcgctc cgaccgtcct gggaagactc
    12901 agcgtgacga gggccgcggc ggcggagcac cccgaggtga tccacagcac cgtggccggg
    12961 tcgacgagga cgatgagccc gcccgccacc gcaggaccga cgaccaccac cacgccgccg
    13021 acgctctccc tgagcccggc cagccgctcg atgccgaccc cggaggcggc cgcgaggtcg
    13081 ggcgccaacg tctcccgggc cgtcattccc ggcacgtcga agagcgcccc ggcgactccc
    13141 aggacgacga accacacaac cgtcagaccg gagaagtggt cgatgatcgg cagtgcggcc
    13201 acgcaggcgg cggaggcgaa gtccgcgccc accgagaggc gtcggcggcc gacgcggtcg
    13261 atgagcaccc ctccggccac ggcggacacc agcatgggga gcgcgcttgc cgcggcgacg
    13321 aggccgaccg ctgccgcgtc gccggtccgc agatagacca gccacggaag ggcaatggtc
    13381 gccacggtgt ttccgagcag ggacaacccg tgggagagaa ggtatcgggt cagcatcggc
    13441 tcagtatggc accgcggtac cgggataaca gcgaaatttt cggcgtcatc gctgcattcc
    13501 gcgagggacc gtataggtgt ggcactcctg ctgtcgcttt acgagttgac gcaccccgaa
    13561 aaggcgagac tgttcgctcg taatcgcgtt ccttgcaggt actcctgttc aaccttcttt
    13621 cgaatctgct cagttgggag cgggggcgca gggtggtgag catctatgcc cttcttgaag
    13681 ccgattcctt cttcggtcag ccgaaggcgt atcgggaaag gtggccgacc cgtcccaaca
    13741 cgggcaaccg ggcgagcact tcggcatcga ccctcatccg tgtgcgaagg gcgaacggca
    13801 gcctccggaa gtcggcgggg tcggccgtgt ggtaagcctt gaccgacttc accagtcgga
    13861 gccctgggac ctcgcgctcc aactcccgcg gatcgtccac gccccaggcc aacctcgcgc
    13921 cggtcttgcg gaagagcgcc atggagcgcg tggaccgcac ggcgtacctg gcgtaggtgt
    13981 cgaagacggc ctcgccctcg gagaagtgct ccacgagagc gcgcagcatg cgcgggccct
    14041 cgtccgccgc caggtacatg gtgaggccct cggcgatcac gaggaccggg aggtccgtgg
    14101 ggacttcggc gagccagtcg gtctccgtca ccgacgcggc gatcgtccgg tggtcgctcc
    14161 gcggggagaa gagctgctcg cgcacctcga tgacctcggg ctggtccacg tcgaaccagc
    14221 gcactccggg tccccgctcg acgcgatcga cccggttgtc gaggccgcaa cccaggtgca
    14281 gcacggtgga gttcgggtgc gcggtcagga actcgcgggt gcggcggtcg aagaaccggg
    14341 cacgcagggc gactccgacc gcgttggacg gccgcatccc cagggcgccg aagtcgtatt
    14401 cgatcttctg caccagttcc ggcgccgtcg agtcggcgag catcgggtgc ggcgaactcg
    14461 cgtccagcgc gcgggcgtag aggggtgcga ggagggtcgc ggcggcaccg gtcagcggga
    14521 ccttcatacc cggctccggt gcccggcgcc gtcgaccgtg tgcaggtcct gttggggacc
    14581 ggatacctcg atggccgggt caaccatggc cttcgccttt ccgtaagggc cgaccaaaag
    14641 ggaagcagtg tacgacttga ggatctggaa accgagatcg tcaagagatt ccctgatcct
    14701 aggggtaccc ctgttttctg cgcaaggacc gggtgatctc cgaccgactc gtcaactatt
    14761 cagtaacgtg gccgccgtgt aagagagttg agtggcagtt gtcctaggcg cctgcgatga
    14821 cctgcattga caatgccttc gatcttcact agctgtggtt ctccggtttt tatcgatctt
    14881 cacgttgcgc ctgcgtgccc cctgcacaat attcgaactg caacgaaaaa tactggccaa
    14941 gacggccgga accagctctg ctgtacacgg ctcgaaaatt tgatcagcaa ttgcccgacg
    15001 tatcgactct tgacatggat agccggcgtt cagcactctg cttcagagtc cttgccacca
    15061 gctctcgggg gagatgattc cgtgggcaac ggccgtagtg ccacgctggt ttcgatgccg
    15121 tggaacagtg tggtgcgtcc gtcgattcag gtgggcacgc tgcgtacggt ggccgaagag
    15181 gaaggctggc aggtcacctc cgaatacgcc tatctcagtt tctacggcct gggcagggag
    15241 atgctcgggt tcagcgagag cgagtgggcc gacgcctacg aaacgatctc ggaaaagctt
    15301 taccacatgg cggtcggcga ctggatattc gcgcgccgcc acggcgaatc ccagcaacgc
    15361 gaccggtact tcgccgagtt gcgcgagatg cgggtcgacg acgaaacgat agcgctgatc
    15421 gattcgttgc gcccggtcgc cgagcggcat gtggaggaga ccgcggcggc cctgctcgca
    15481 tccgaccccg atgtcatcgg attcacttcg atgttcagcc agaacgggcc gacgctcgcg
    15541 gtcgccgagc gtctgcgtgc ggagggctat ccgggcgtga tcgtgctggg gggcagcaac
    15601 tgcgagggct cgatgggacg agccctgctc gcgaactacc cgaccgtgga ggccgtggtc
    15661 gacggtccgg gtgaggatgc gttcgtggcg ctgctgcggc aggtggcggc cggcggcccc
    15721 gtcaggtcgc aggggcggct gctcacccgc cgtccggcgg aggattcttc ggacgtgggc
    15781 gaggcgaaga tctcgcccac cgggctcagt gttccggtgc cgaactacga cggtttcttc
    15841 gagcagttgc atgcggcggg tttggagggt ctggaagctg agatcacgtt gccggtggag
    15901 ttttcgcggg gttgttggtg gggtgcgaag acgcactgta cgttctgtgg tttgaacggt
    15961 gcgacgatgg cgtaccgcag caaggatcct gattcggtgg cggatgagtt gcagtatctg
    16021 atggatcgct acggggtgtt cgactttttc gcggtcgata acatcctcga tctgaagtat
    16081 ctggatacgg cgcttccgtt ggtggagaaa ttgaacacgg atcactcttt gttcttcgag
    16141 gtgaaggcca acatggagtg ggcggacatc aggagcatgc gtcgtgcggg agtgcgttcc
    16201 gttcaacccg gcatcgagag cctgagcacg gagggtctac gtctgctgaa gaagggttcc
    16261 acggcgttcc agaacgtacg cttcctgctc ggctgcgccg aatacggagt gcgggccgac
    16321 tggaacatcc tcaccgggta cccgaaggag acgcccgaat ccatcagggc gcagctcgac
    16381 atcgtcgcct ccctctccca tctgacgccg ccacacatca cgttgatccg gttcgaccgg
    16441 ttcagtccgt acgtcgagtc cccggagtcg ttcggtcttt cgctgtcgaa gcctcttccg
    16501 gggtatcggt acgtgtaccc ggagctgtcc ggcgaggact tgtggaacat cgcttaccac
    16561 ttcgaaggcg acttccacga cgacgtccgc aacgtcgaca tccggcgtcg tctcgctgcc
    16621 cgtgtccgtc tgtggcgcaa ccaccatgaa caggcccgtt tcacgtacag gttggggttc
    16681 gactccctca ctctgagcga tcaccgcccc ggcctccctg cacacgaaac cgtcctgcaa
    16741 ggcgacgacg ccgcactctt ccgggctgtc atcggcggga cccgcatccg tgacctgcaa
    16801 gccaacggtt ggccggaagg ccaaccctgg gaccgggcct gggagaaact ccagaactgg
    16861 caacgccgcc gctggatctt catcgaaggc accaaaatca tcgccctcgc catccgcgaa
    16921 caaccatccg cctaccggac gccgccgccc aagggcacac ccaggcgaca ggcccgcaac
    16981 cccgtgcccg tcacgctcac cagccggaag tgagggaggt gaggcctatc gcggtgcatt
    17041 cacatgaaca gcgcgacgac ggatggatcg gtacagcgaa aagaaaggat cactgacatg
    17101 ggaccagcgg tcgtattcga ctgtatgacg gcggacttcc tcaacgacga ccccaacaac
    17161 gccgagctca gctctctgga gatggaggaa ctcgagtcgt ggggcgcctg gtccgacgac
    17221 accgaccagt cagtctgatg cccgcctgcg cgtagcacca gacgtgaagt cggcgggccg
    17281 gcgcacaggg aagtgggagt gatggccgat tcttccgcga ccgactgcgt actgcgggaa
    17341 gtcgcgttcc gctcctaccg ggcggagcac acggtgacgg tccagtgcac ggtacggcct
    17401 gactcgggac cggggcaggc cgaaggctac ggcaccgcca cgaccgaggc cgtcgctcgg
    17461 aagaaggccc tttccgaagc cgtggaaagg ctgttggcct gcaccccgtt cgccctcatc
    17521 gcccgtcggc cgacaccgcg cacagaccgg agcaggggca ccgacccctg gcagcgcggg
    17581 ctgcgctccg cgcccgccgg ctgccaggta cgcaactacc gctcgctgag cggcgagcag
    17641 ccgcggcagg tgcccctgtt ctggtcatcg ccctgggtcg ccggcgagga gatgcggtcg
    17701 gcgaacctcg ccccgcaggc ggcccgcctc tccagcacgg tcgggtgggc cgtcgcaccg
    17761 tcgcccgaag cagccctgca gggcgccctc tacgagctga cggagctgct gaactacggc
    17821 gcgttcctct accggtgcct cgcggccccc cgcgaacgcc ccgcgcccgg cggaggcccc
    17881 gagccgcgcg aagagggccg catccagacc gtccccataa gctgggcgac ccgcaccccg
    17941 acgatcctcg ccgtgacgag gagcagcgac cggctgatgc ccgccaccgg tatcggctca
    18001 ggtacgacgg cgtccgaggc ggccgagcgg gccttcctcg aactcgccca ggccgagacg
    18061 ctctggcgcg ccaactcgac cgccgtgccg gccgagcgct acttcatgcg gcgcttcgag
    18121 aagtggcccc tgctgagacg ctgcgccgcc ctggacttcg acctcggcga gcacgccggc
    18181 cccttcgacg acgggcccca cccctctccc ttgggcgcgc tggagtccag agccatcgag
    18241 gtgtgggccg accccggagc cgtcgacatc tcgggcgccg acctgaggag gacccgcctg
    18301 tgcttcgccc acgtggtgtc ggatccgcag ccgctcctcg gccttgtccg cgcaggtatt
    18361 cccgtcttcg acacggggga agtgaggaag atccttgtct gtccacgccg agcacgatct
    18421 gctgaccgca gcccttctgg acgggtcgct cactcaggac gtcccacccg agcgtgagac
    18481 gccgatcggc agagcgctct ccgcggcgag cgactggctg agctccgagc aactgacccc
    18541 ggacatctgg aagtacgggc tcgactccgc gcccacctac gaggtccacc tcaaggacgc
    18601 cgcgggcacg ctgtgctcgc gcagctcggg caagggtctg gggcaccgca gcatggcgag
    18661 cgccctcttc gaaagcgccg agcactacca cctcgactgg cgccgcgacc cgctcgccga
    18721 cgaggccgcg ttcgtccccg gccgcgaggt cgccgggcag tcgacggccg ccggctcggc
    18781 gctgctgcac cgactcggcg gcattctcgg cgactccccg gtcctcaccc gcgaataccg
    18841 cccagtggcc gaggcgttgg gcgccaccgg cggcgccgca cccccgcacc gccaccccgt
    18901 cttcctgcgc gacggcggct accggaactg gccgcacccc tcggacgacg gctccttcaa
    18961 gccgctctgg cactacacga cgagcgccgg ctacgcggcc ggaaccacgc tgcacgaggc
    19021 gctcgtccac gcggtcaacg agctgatcga gcgcgacgcc tggtcctacc aacttgcccg
    19081 ttcctacttc ggcctgcccg acgagagcgg ccgggccctc cgcgtcatcg accacgagag
    19141 cctcccggcg gagctgcgcg ccctcgtcga cgacgtggag gcgtcgagcg gctccccgat
    19201 cctcatcgtc tcgatcccct gcgacacggg ggtgccggcc tacgtggtct gcgacgcgga
    19261 gagcgacgag gacgtgcggc tcatcggcag cggcgcctcg ccggtgcagg cgtacgccct
    19321 ccaacgaggg ctgctggagt acctccaggt gtgcacgatg taccagcacg ggcccgtcga
    19381 cgcggagcgc gaggccgccc agatcgccac ggccctggcc cgctacccga ggcacctcgc
    19441 cgccgccggg ttcgacgtgc gtcaactccc gcacgaacgg cagccgttcg acagcgacgg
    19501 gctccctgcc gcggcgactc cggaagagct gctgcggcac ctcatcgacc ggttgcaggg
    19561 agtgggcgtc gacctccact tccgcgtcct gacgaggccg gggacgatca ccgtcgtcga
    19621 cgtcgtcgca cccgggctcg aaatgctgga caaggcgcgc gccggctacc cggtcctgcc
    19681 gaccgggcgg ttgggcgaga ggctcaggcc gcagaggagg gagccgtgaa gctcgtcctt
    19741 gtggcgccac cgtggaacag cctctaccgg ccctcgatcc agatcgccac cctcgccgcg
    19801 ctgagcaccg aggagcaggg cgatccgatc agcgccgtct acgggtactt ggactggttc
    19861 gagtacgcgg tcggcttcct ggagtgcgac ccggagcagt tcgccgccgt gtacgacacg
    19921 atcggcgagg agctgtacgg gctcggcgtc ggcgactgga tcttcggcgg cgggctgccg
    19981 ggcgccgggg acgcggacga ggcgtcggcg accgcggagt acggtgcgtt cctgcgggag
    20041 cagggcgtcg acgaggaaat cgtcgccgat gtcctgcggt tgcgcgaggc ggcgccacgg
    20101 ttcgtcgccg acctcgccga gcggctcgtg gacgacgggg ccgagtgctt cggattcacc
    20161 acatccttca gtcagttggt gccctcgctg gcgatagccg tggcgatcaa ggaacgggcg
    20221 ccggaccggc tcgtcctcct cggcggggcg aactgcgacc gtccgatggg ccaggccgtg
    20281 atgcacgcct atccgttcgt cgacgcggtc gtcgagggcg agggcgagca ggcggtgaac
    20341 gcgctcaccc gcgcgaagag cgtggacgac ctggcggcgg tccccgggat agtgctgcgg
    20401 cacgaggacg gcctgcgcac cgcgctgccg acgatccaac ccgtggagtc cgctcccgtg
    20461 cccaagtacg acgcgtactt cgagcggttg gagagcctgc cgtggggcga cctcatcgct
    20521 ccgcacgtgg cgctgccgtt ccagatgtcc cgcgggtgct ggtggggcga gaagttgcag
    20581 tgcacgttct gcggtgagaa cggcagcggg atggtctacc gcagcaaacc gggctcccaa
    20641 ctcgtcgaca cgctgcgcac gttgacggag cggcacggcg ccttcaacac ctacgccgtg
    20701 gacacgatcc tggcgaagaa cgacaacggc ctcgcggcgc tcgccgacgc cgaggtcgac
    20761 atcaccacct tcttcgaggt caaggctaac ctcggccctc gggaggtcgg cgagctgcgc
    20821 gccgccggcg tcaccatggt gcagccgggg atcgagagcc tcagctcggg cgcgttgaag
    20881 ctgctgcgca agggcgcgac gagctggcac aacctgcgct tcctcgtcct gtgccaggag
    20941 ttggggatcg acgcgcagtg gaacctgctc tcggccatgc cggacgagtc agcggagatg
    21001 ctggaggagc agctccggct gatccccttc atcacacatc tggcaccacc gtcgacggtg
    21061 agcaaggtcc gcgtcgaccg ctacagcccc tacttcgaga agcccgacga gttcggcatc
    21121 gagctgcggg gccccgagaa gaagtaccgg ttcatccacc ggggcgaggg cgtcgaccgt
    21181 acggcgctgg cgtactcctt cgagcacggg cagcaggcgg ggaaggagcg ggacgatgac
    21241 gcagccatgc tggcgctgcg ccgccggctc ggggcacgtg tcggactgtg gaagaagctg
    21301 cacgcgcagt cccgcttctc cttccgtttc ggcccgaacg tgaccgtggt ccacgactac
    21361 aggccgcacg tcggcacggg ccgcaccgtg ctgcggggag ccgacgacct cctcttccgc
    21421 tccctcgtcc acggcgggcg cctcatgcag gccgtcggcc gggtcggcga gcagacgggg
    21481 acgccggaga gccggctgca cgagagggtg agcgagtggg cggcgtgcgg ctgggtccat
    21541 cttgaggggc ggcgcggtct cgtcctcgcc gtacgggacg gcatgcggga cgagttgggc
    21601 cgcgcggcgg cgctgagggg gtcggatgcg gagtcctgac cgggagcaga cggaacgctt
    21661 cgaagtcgcc tccgtggacg gcacgttgct gcgcgggttc agccgggcgg cccgcgggtc
    21721 gtccgatgcg cggggcgagc cggaaacgct ggtgctgctg cacggtgtcg cgatggacca
    21781 ccgggtctgg tccgagtcgt cgttcctcga cgcgctgccc gacgacgtcc acgtcgtcgc
    21841 ccccgacctg cgcggccgcg gcgaaagcga cccggggcac agcgccgagg gccacgcgat
    21901 cgaccgctac gtcgaggacg tccgcgccgt gctcggcttc ttcgggcggg agcggtacag
    21961 cctcttcggc ctctacttcg ggggccgtat cgcgctgcgg gtcgcggagg cggacaggcg
    22021 ggtgcagcgg gccttctcct tctgcgcgca cggcgaggcg gtggaggtcc cggcggacgc
    22081 cgtcgaggag gaggcgaaag agatcgaagg ccccggcggg tacgcgtacc tccgcgacca
    22141 cttctccgcc gcgggagcgc ctgcgtggat ggtctccgcc tgcgaccggg tcgaccagga
    22201 cgagttggcg gcggcgaccc gcggcctcct gcacggttcg caccagcggg ccgagcgcgg
    22261 agcagccgac caggacctgg tgctgatcac tgccgagggc gacgccgacc tcggcacgtt
    22321 ccgcgagggc tcggcccgcc tcggcgcccg gctctggctg gtggacagcc ggacccgggt
    22381 gcgcgccgct gcccgcctcg ccgaagtcgg cacgcgcacg gcggagttgc tcaccgcggc
    22441 gccggcggcg atgaaagggg acgcatgacg gacgacgccc ctctggaccc accgcagggg
    22501 cctgctcccc gacggcgatc cgctcgtcgg cgcgctggag gagctggcgg gccgcagccg
    22561 cagccacgtc ctccgcgccg tcgggatgct cgacgcggag accggagagg ccgccccgcc
    22621 aagggacttg gaggtggtcg acggcgccgt cgcccgctgg agccctgcgc cggacgccgc
    22681 gtactgcgag tggttcgccc tgcccgggtt cgtcgacgcc catgcgcacg tgtcctcggt
    22741 gaccgacctc gtcggcatgc tcgcgtacgg ggtgacgggc taccggcaga tgtggggcga
    22801 gcccgcacac ctgtacagcg ccggcgtcca ccgtgcgcgc cacgccgtcc tccccctccc
    22861 ctggacgacg gcgggcgtcg tcgacggccc cgactcccgt atcccgcacc acgtcacggt
    22921 cgttgacgac gcgcggcagg tgcgccgggt ggtcgaggac gtcctcgcgt tcggcttcga
    22981 cggcatcaag gtctacgacg acttggcgcg gccggccttc gaggcgctgg tacgcgaggc
    23041 ggagcgcgcc ggcatccccg tcgtcggaca cgtgcccgag gcggtgccgc tcgacgcggc
    23101 ctacccgggc atgtggtcga ccgagcacct gtacggaatc gtgcccaacg tcttccggct
    23161 gcccgcggcc gaccgctggg ccgtcctcgc cgacgcgttg cagcggcacc gcgacgacgg
    23221 ccccgccgtc gagggggccg ccggccgttt cgtctgcccg acgctcaccg cgtggcgggc
    23281 gcggagcggg gagcgccgct acacccggcc gtcgaggacg ctcctccagt cggcgacccc
    23341 gagccgccgc cccgcctggc acgcggccgc gagggacgcc ctctcgctgg agcgggccga
    23401 ggcgcagcgg cggagcctgc tggtcgaccg gctcggaggc atcgcgtacg acctgtcgcg
    23461 ccgcggggcc aggctgctcg tcggcaccga ctgcgggaac cccttcgtcc tcgccgggcc
    23521 ctcgtaccac aaggagctgg ccgaactcag ccgcagcggc ctcgacttcg cgaccgtcct
    23581 caaggccgcg accgtcgacg catacgccgc aacgggccgc gaccccgcac gggccgacct
    23641 ggtcctctac cggcgctccc cggcgcacga cgtcacccgc ctggcccggc cggacgccgt
    23701 actcgtcgac ggagtcctcc tcgacgccga cgacttggac cacctgtggg ggctgcggct
    23761 cacggcggcc ggcctcgacg ccggcacctg gagaaggggc gacgtggacc cggcggccgg
    23821 tgaccgacag aataaggaga ctgccgatgc aggctgaccc atccaccggg acgaccgacc
    23881 ccgaggctcc ccccggggtc tgccccgtca ccggacggcg cgccgacccc gtggacttcg
    23941 agttcttcaa cggcccttcg gcgtaccgcg aagcagcggc cacccacgcc gacgagggcg
    24001 ccttctacag cgccagcggc gacgggttct gggtccttac cacgtacgag ggaatctgcg
    24061 aggcgttcag ggacgaggag cagttcaccg tcgggcgcgt cagcgcagcg gacggcgctg
    24121 aggaggaccg ctggattccg ctgaccatcg agggccgcca gcacacggag tggcgccgca
    24181 ggctgggcgc gtggttcacg ccgcagcgcg tacgcgagct gaccccctcg atcgaggcca
    24241 acgcccggcg ccggatcgag gggttcgtcg acgacggcga ggtgtcgttc aacgaggatt
    24301 tcgccaggcc gttcgtgctg gagaacctga tgaccgcggt gggctgggag ttcgaccgct
    24361 tcgaccaact cctgcgcatc gaccgcgcga tgatcgattc gcggtacgcg cccgacccgc
    24421 gtgaggcggc gttcgaagag gtcggcatcc cggcgctgga aaagctcgcc cgcgagcagg
    24481 tcgagcgccg tcgcgccgaa cccgcagacg acctcaccac cgcgaccttc ggctgggagg
    24541 tggaggggag gcccgtcacc gacgacgacc gggcctcgct gctgtgcgtg ctcttcctcg
    24601 ccggcgtcga ctcgacggtc aaccacctgg ccaacgccgt ccagcacctg gtgtgccacg
    24661 acgccgacaa gcggcggttc ctggcctcca gggaagtacg cccgcgggcg gtcgaggagt
    24721 tcctccgggc caactcgtgc atgtatccgg ggaggttggc cgcgcgcgac ggggcgggcg
    24781 gcaccgcccg gcggggtgag acggtgctgc tgccgctcgc cgtcgccaac tacgatcccg
    24841 aggtcttcca cgaccccgag caggtcgact tcgaccggga gcgcaacccg cacatcgcct
    24901 tcggtacagg agcacaccag tgcctcggcg ccgcgttggc gcgggcgcag atccgcaccg
    24961 ccctcgacgt gtggcacgag ctcatcccgc actacggatt ccctccgcag ccggagccct
    25021 cggagccccg gttcctccgc aatgcatacg acttgaggct cgtctggtga ggtcgccatg
    25081 aagagtgccg gcagtgctgg tcgagtaacg ctcgtttcga tgccgtggaa caacgtgcgc
    25141 cgcccttcga tccaggtggg cacgttgcgt gcggtggccg aggaggaagg ctggcaggtc
    25201 accccggaat acgcctacct cgccttctac ggactcgcca aaaggatgct gggctacgga
    25261 gacgccgagt ggtcggacgc gtacgacctg atctccgagg gcctttacca cttctcggtc
    25321 ggcgactgga tattcgcctg ccggggcacg gaggccgcgc ggcgcgacga gtacgtcgag
    25381 gagctgcgct ccaggaaaat cgacgagccg acgatcgggc tgatcgattc gctgcgcgag
    25441 gtcgccgagc ggcatgtgga ggagaccgcc gcggccctgc tcgcgtccga ccccgatgtc
    25501 atcgggttca cgagcacctt cagccagaac gggccgacgc tggcggtggc cgagcggttg
    25561 cgtgcaagtg gctatcccgg cgtgatcgtc atgggcggta gcaactgcga gggctcgatg
    25621 gggcgggcgc ttctggagaa ctaccccgcg gtggaggcgg tggtcgacgg tccgggtgag
    25681 gatgcgttcg tggcgctgct gcggcaggtg gcggccggcg gccccgtcag gtcgcagggg
    25741 cggctgctca cccgccgtcc ggcggaggat tcttcggacg tgggcgaggc gaagatctcg
    25801 cccaccgggc tcagtgttcc ggtgccgaac tacgacggtt tcttcgagca gttgcatgcg
    25861 gcgggtttgg agggtctgga agctgagatc acgttgccgg tggagttttc gcggggttgt
    25921 tggtggggtg cgaagacgca ctgtacgttc tgtggtttga acggtgcgac gatggcgtac
    25981 cgcagcaagg atcctgattc ggtggcggat gagttgcagt atctgatgga tcgctacggg
    26041 gtgttcgact ttttcgcggt cgataacatc ctcgatctga agtatctgga tacggcgctt
    26101 ccgttggtgg agaaattgaa cacggatcac tctttgttct tcgaggtgaa ggccaacatg
    26161 gagtgggcgg acatcaggag catgcgtcgt gcgggagtgc gttccgttca acccggcatc
    26221 gagagcctga gcacggaggg tctacgtctg ctgaagaagg gttccacggc gttccagaac
    26281 gtacgcttcc tcctcggctg cgccgaattc ggcgtcctcc ccgtgtggaa tatcctcacc
    26341 gggttcccca aagagacacc ggagttgatg cgcgagcaga tcgacctgct tccttcgctc
    26401 acccatctcc cgccgcccga caacgacgtc ctcgccgttc acttcgaccg gttcagtccg
    26461 tacgtcgagt ccccggagtc gttcggtctt tcgctgtcga agcctcttcc ggggtaccgg
    26521 tatgtgtacc cggagctgtc cggcgaggac ttgtggaaca tcgcttacca cttcgagggc
    26581 gacttccacg acgactcccg caacgtcgac atccgccgtc gtctcgctgc ccgtgtccgc
    26641 ttgtggcgca accaccatga acgggcccac ttcacgtaca ggttggggtt cgactccctc
    26701 actctcagcg atcaccgccc cggcctccct gcacacgaaa cccttctcca aggcgacgac
    26761 gccgcgcttt tccgggctgt catcggcggg acccgcatcc gtgacctgca agccaacggt
    26821 tggccggaag gccaatcctg ggaccgggcg tgggagaaac tccagaactg gcaacgccgc
    26881 cgctggatct tcatcgaagg caccaaaatc atcgccctcg c
//
