LOCUS       BGC0000472             13708 bp    DNA     linear   BCT 29-JAN-2010
DEFINITION  Anabaena sp. 90 signal recognition particle protein SRP gene,
            complete cds; anacyclamide biosynthetic gene cluster, complete
            sequence; 30S ribosomal protein S16, and hypothetical protein genes,
            complete cds.
ACCESSION   BGC0000472
VERSION     BGC0000472
KEYWORDS    .
SOURCE      Anabaena sp. 90
  ORGANISM  Anabaena sp. 90
            Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena;
            unclassified Anabaena.
COMMENT     On Dec 14, 2009 this sequence version replaced FJ461733.1.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:37:32
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13708
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..13708
                     /db_xref="taxon:46234"
                     /isolation_source="freshwater"
                     /mol_type="genomic DNA"
                     /organism="Anabaena sp. 90"
                     /strain="90"
     protocluster    1..13708
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2247:12397]"
                     /cutoff="20000"
                     /detection_rule="(cyanobactin_synth or TIGR03678)"
                     /neighbourhood="10000"
                     /product="cyanobactin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2248..12397
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cyanobactin_synth or TIGR03678)"
                     /neighbourhood="10000"
                     /product="cyanobactin"
                     /protocluster_number="1"
     cand_cluster    1..13708
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cyanobactin_synth or TIGR03678)"
                     /kind="single"
                     /product="cyanobactin"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..13708
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000472"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13708
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyanobactin"
                     /region_number="1"
                     /rules="(cyanobactin_synth or TIGR03678)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             113..1561
                     /codon_start=1
                     /product="signal recognition particle protein SRP"
                     /protein_id="ADA00385.1"
                     /transl_table=11
                     /translation="MFDALSDRLESAWKKLRGQDKISQSNIQDALREVRRALLEADVNL
                     QVVKDFISEVETKAQGAEVIAGVRPDQQFIKIVYDELVQVMGEENVPLAEVAGKTTVVL
                     MAGLQGTGKTTATAKLALHLRKQDRSCLLVATDIYRPAAIDQLITLGKQIDVPVFELGI
                     AADPVEIARQGVERARAEGINTVIIDTAGRLQIDEDMMAELARIKEVVQPDETLLVVDA
                     MTGQEAANLTRTFHNQIGITGAILTKMDGDSRGGAALSVRQISGAPIKFVGVGEKVEAL
                     QPFYPDRMASRILGMGDVLTLVEKAQEEIDLADAEQMQEKILSAKFDFTDFLKQMRLLK
                     NMGSLGGIMKMIPGMNKLSEDQLKQGETQLKRCEAMINSMTGKERRDPDLLSSSPSRRR
                     RIASGSGYREADVSKLVADFQKMRSLMQQMGQGGIPGMGGMFGGGNPLAAGGNRPSPGW
                     RGYPGGAPPAKKKKEKKKKGFGTL"
     gene            complement(1611..1799)
                     /gene="acyC"
     CDS             complement(1611..1799)
                     /codon_start=1
                     /gene="acyC"
                     /product="Hypothetical protein"
                     /protein_id="ADA00386.1"
                     /transl_table=11
                     /translation="MSKQKKTPANSSELEPNPPAEIERKLLSTDLEDYGFWSQEMAKQK
                     AQQTEPDKPFRRGRIWC"
     misc_feature    complement(1611..12397)
                     /note="anacyclamide biosynthetic gene cluster"
     gene            complement(1814..2017)
                     /gene="acyB"
     CDS             complement(1814..2017)
                     /codon_start=1
                     /gene="acyB"
                     /product="Hypothetical protein"
                     /protein_id="ADA00387.1"
                     /transl_table=11
                     /translation="MRLPKLSPPVKRPDIIYPHRSVDVIHGRVEDLVSIRMDLLHGANY
                     NDPAAFQNRSYQQIKSSCSCVI"
     gene            complement(2248..4224)
                     /gene="acyA"
     CDS             complement(2248..4224)
                     /codon_start=1
                     /gene="acyA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: cyanobactin_synth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 178.2; E-value: 5.8e-54)"
                     /gene_kind="biosynthetic"
                     /product="N-terminal protease"
                     /protein_id="ACK37888.2"
                     /sec_met_domain="cyanobactin_synth (E-value: 7.7e-241,
                     bitscore: 789.3, seeds: 40, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.2e-42, bitscore:
                     136.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKSSIKTEIQELWDLTQGDSQICVAVLDGLVDQSHNCFNAANLT
                     RLPTLIQGEATANGSMSGHGTHVASIIFGQHNSSELRGIAPQCRGLIVPIFGDNNRKLS
                     QLDLARAIEQAVNAGAHIINVSAGQLTDNGEAEGWLDRAVQLCKDHNVLIVAAAGNDGC
                     ECLHVPASLPTVLAVGAMNDQGKPIDFSNWGESYQNQGILAPGEHILGAKPGGGTQKLS
                     GTSFATPIVSGVAALLLSLQVQRGETPDPAKVRAVLLETAIPCTDKDTDDISRCLLGKL
                     NISGALAYFTGGTMSEELDTVETVDSIEAAGCGCAEITNSAEPEPNPEEFIPPEFFPVV
                     PAVTTSAPFTNSSNSQSTTMSNRTSNYITASQAPSDLAQVNLVYALGTLGYDFGSEARR
                     DSFKQLMPGVQIDGTAIPANPYDARQMVDYLGDNLSEAKSLIWTLNLELTPVYAIEPGG
                     AFARDVYAILQQLLSGQIQAEDSENYVERVSIPGILSGRSVKLFSGQVVPVIEVPNTRG
                     LYGWKVNTLVQAAIQTVQAQATEAQEESIRRTLGSFLSRIYYDLRNLGTTSQDRALNFA
                     STNAFQAASTFAEAVATGMELDSITVEKSPFCRLDSDCWDVKLKFFDPENSRRAKKLFR
                     FTIDVSDIIPVTLGEVRSWSTPY"
     gene            4931..5080
                     /gene="acyE"
     CDS             4931..5080
                     /codon_start=1
                     /gene="acyE"
                     /product="Precursor peptide"
                     /protein_id="ADA00388.1"
                     /transl_table=11
                     /translation="MTKKNIRPQQVAPVERETISTAKDQSGQVQAQTSQIWGSPVPFAG
                     DDAE"
     CDS             complement(5114..5878)
                     /codon_start=1
                     /product="transposase"
                     /protein_id="ADA00389.1"
                     /transl_table=11
                     /translation="MPRKPRNLKSGYSYHITIRCNNREFKLSRRECREVFLYAIKKALD
                     KYNFQLYALCIMSNHVHYLIAPKQPEELPKIMHFLNWYTAMCFNRMLRRTGHFWEKRYY
                     CDGFPASDRDRALNTLRYIHANPKAAKMRQSFFYDFSNYGSYERLTDDGLTQWHPAFLR
                     LGNSLEECAKKYKGFCQKYKPKEKTPTRCYWGSKLLAGVHLTNQGSTTNPKKSKSGFPP
                     PLCQVSETPELTRVVRQFIQANRAPRDTETDF"
     gene            5912..6802
                     /gene="acyF"
     CDS             5912..6802
                     /codon_start=1
                     /gene="acyF"
                     /product="Prenyltransferase"
                     /protein_id="ADA00390.1"
                     /transl_table=11
                     /translation="MIANVTQKDRFQEQKLQFIRNHQQAFDVEPIYPLPLFEDFVMNVE
                     GDCSIEASCKIELDKLIASRFMFFFKDKAQQWQKYLHQSLTFFNRVENLVGVQVDYSLL
                     RQFLGSDFDFRKVTVLSAGIDLRSNIAESSLKMHIRIKDYPEKLDQALSLASNAEDLIS
                     VRPFLSLVGFDFYFNGRSEIELYPEIQAEDFAKSETQNLVWRHFPKFVLDPLEVTGSFL
                     VGFSKANPNPVLYYNLKNKQDLANYFKLNDAAQRVHSFYQNQDILPHMWVGTVQKELEK
                     TRIENVRLYYYKFFN"
     CDS             7008..7403
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="ADA00391.1"
                     /transl_table=11
                     /translation="MTIPITINLPESLAASIQRLGEATAREISDVLLDTLEIVLPTLDN
                     LSEMSINSSIPDISDEEVLELANLKMDVVQNQRLGELQAKGKNTGLTAGERYELLILMS
                     LYQMGQLRKSEGLAEAVKRGIKTPLLP"
     CDS             7497..8180
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="ADA00392.1"
                     /transl_table=11
                     /translation="MISTTAISPILTIPPLENGDKLTRHEFERRYHAMPNLKEAELIEG
                     VVYVASPLRIKSHGEPHAYIMTWLGVYKAATPGIGFADNATVLIDTDNEPQPDALLRIE
                     TGGQSRINKDDYVEGAPELIVEIAASSASYDLHEKLKVYRRNQVQEYLIWRVYDYQFDW
                     FRLQQGEYIQLQPNADNIICSQIFPGLWLDKMALLGGDLGTVLAVLQQGLASPEHENFI
                     SRLSS"
     CDS             complement(8826..9431)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="ADA00393.1"
                     /transl_table=11
                     /translation="MSYSDFTLKKVKQTFGINTVENKKFLPEIQPIAASATLTDFLAES
                     LPLAIATGSEKARSELIISPVLLEVRKILERKISLFSGADFTVDSALGLNGVCDFVLSL
                     SAEQLEVEAPAVMIVEAKKSDLNPGIGQCIAEMIAAQKFNEINNQPIPTIYGSVTNGTV
                     WRFLQLTEQTVTIDFTDYPLPPVDVILGILVWMVTAAN"
     CDS             complement(9474..9809)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="ADA00394.1"
                     /transl_table=11
                     /translation="MEKLEQYRNYVKQVITEYAQLGSAKDEIEQQLIFDSFGDHYQLMY
                     VGWKNRRRQHGCVLHLDIKDQKIWIQHDGTEIGIADELVKLGVPKSDIVLAFHEPLVRQ
                     YTDFAVG"
     gene            10265..12397
                     /gene="acyG"
     CDS             10265..12397
                     /codon_start=1
                     /gene="acyG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: cyanobactin_synth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 94.8; E-value: 1.1e-28)"
                     /gene_kind="biosynthetic"
                     /product="C-terminal protease"
                     /protein_id="ADA00395.1"
                     /sec_met_domain="cyanobactin_synth (E-value: 3.6e-214,
                     bitscore: 701.4, seeds: 40, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.4e-21, bitscore:
                     66.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNLTDIPGISQIWTRTKGDPRIKIAILDGAADLERSCFQGAKFS
                     QFKPYWSEDIELNDEYYYYLNLYLDFNQQQKDKKDDPDHDKEESKKEREAFFAPFPPAI
                     RQRIELSGHATHISSTILGQHGTPAPGIAPLCTALNIPISFANDDFISPINLTHAVNTA
                     WQWGANIIHIAACHPTQTGVAPDLFARAVKQCQDNNMLIVAPGGNDKGECWCIPSILPG
                     VITVGAMRDDGQPFKFSNYGGEYQNKGVMANGENILGAQPGTEEPIRQKGTSCAAPIVT
                     GISALLMSLQLQRGEQPNAEAVREAILNSAIPCNPEEVEEPERCLLGKLNIPGAFQLLT
                     GERLEPHLQPLSYKGVQEPHPQPLSYEERGAGISRSQVLPGNATLEALPLTIPSGRALE
                     TAFPVGDWERETLVISQGINSSTDSITPSAASKLVYALGTIGYDFGNEARRDSFKQLMP
                     AVNMDGAIIPANPYDSQQMVNYLSENPAEAKPLIWTLNQELTPIYALEPVSGFAADIYE
                     TLILMLQGQIQPENSDDFVERVSIPARLTDRTVELFSGQVVPVITLTNTRGMYGWKVNS
                     LVDAALQTVITGETAPAQEIAMRKALSSFLNRVYYDLQNLGQLAKDRALNFSVTNAFQA
                     ASSFSQAISTGMQLDSIEVEKSPFCRINSDCWDVKLKFFDPENGRRAKKVFLFTIDVSD
                     RIPVTLGQVRSWSVRK"
     CDS             12915..13175
                     /codon_start=1
                     /product="30S ribosomal protein S16"
                     /protein_id="ADA00396.1"
                     /transl_table=11
                     /translation="MIKLRLKRFGKKREASYRIVAINNLARRDGRPLEELGFYNPRTDE
                     VKLNIPGIIKRLQQGAQPTDTVRSILVKANVFEQVSATAAS"
     CDS             13183..13569
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="ADA00397.1"
                     /transl_table=11
                     /translation="MKSLATSPNYVGLVEFLVQPFLESPESLSVDCEMSQTLKRAWVRI
                     AFNSTDKEKVFGRGGRNIQAIRTVIAAAAELAGQSVYLDIYGNSSQSRESVSFDEEQEE
                     RILPPKSKERENNIPKPVVKPRLR"
ORIGIN
        1 gtacgggcga agcatttgga ggactatttt tggcaatgac cgataattta tcttccaaat
       61 gcttcgcccc tactgacaac tgacaactga ctaactacgt tgtaactgaa ttatgtttga
      121 tgcactatct gaccgtttag aatccgcctg gaaaaaactg cgaggacagg ataaaatctc
      181 ccaatccaat atacaagacg ctttgcggga agtgcgtcgg gctttattgg aagcagatgt
      241 taacctccag gtagtcaaag attttattag cgaagtcgaa accaaagccc agggggctga
      301 agttatcgct ggtgtacgtc ctgaccaaca attcatcaaa attgtttatg atgaattagt
      361 gcaggtgatg ggggaagaaa atgttcccct cgcagaagtt gcggggaaaa ccaccgttgt
      421 gttaatggct ggtttgcaag gaaccggtaa aaccacagcc accgctaaat tagctttgca
      481 tttacgcaaa caagaccgta gttgcttatt agtggctaca gacatctatc gtcccgcagc
      541 tattgaccaa ttaattaccc ttggtaagca aattgatgtc cccgtatttg aactgggaat
      601 tgcagcagac cccgtagaaa ttgcccgtca aggtgtggaa cgcgccagag ccgaaggcat
      661 aaatacagta attattgata ctgccggacg cttgcaaata gatgaagata tgatggcgga
      721 attagcccgc atcaaagaag tagtccagcc cgatgaaacc ctgttagttg tggatgcaat
      781 gaccgggcaa gaggcagcaa atctgactcg caccttccat aaccaaatcg gcattactgg
      841 ggcaatactg accaaaatgg atggggatag ccgaggtggt gcggcgttgt cagtgcggca
      901 aatttccggt gcgccgatta aatttgtggg tgtgggggaa aaagtcgagg ctctacaacc
      961 gttttatcct gaccgcatgg cttcgcggat tttgggcatg ggggatgttc ttactttagt
     1021 agaaaaagcc caagaagaga tagatttggc agatgcagag caaatgcagg agaaaatcct
     1081 gtcagcaaaa tttgatttta ctgactttct caagcaaatg cggttgttga aaaacatggg
     1141 ttctttgggc ggaattatga agatgattcc gggcatgaac aagctttctg aggatcagtt
     1201 aaagcaggga gaaacccagc taaaacgctg tgaagctatg atcaattcca tgacgggcaa
     1261 agaacgccgt gatccagatt tattatcaag ttctcccagt cgtcgccgcc gcatagcttc
     1321 tggttctggg tatagagaag cggatgtaag caaactggta gcggacttcc aaaaaatgcg
     1381 atcgctcatg cagcaaatgg gacagggtgg cattcccggt atgggaggaa tgtttggcgg
     1441 tggaaatcct ttagcagcag gtggtaatcg tccttcaccc ggctggcgtg gctaccccgg
     1501 tggcgcacca ccagcgaaga aaaagaagga gaaaaagaaa aaaggttttg ggactcttta
     1561 gtttaaaaaa ctagatcccc gacttcttaa agaagtcggg gatctgaaaa ttaacaccaa
     1621 atacgaccac gacgaaaagg tttatcaggt tcagtttgtt gggctttttg tttagccatt
     1681 tcttgtgacc aaaaaccata atcttccaaa tcagtagata ataatttacg ttcaatttct
     1741 gctggtgggt taggttctag ttcgctagaa tttgcggggg ttttcttttg tttactcata
     1801 atattgataa ctcctaaatt acacaactgc aagaagattt aatttgctga taactacgat
     1861 tttgaaatgc agcggggtca ttataattag caccatgtaa taaatccata cgaatgctaa
     1921 ctaagtcctc gactctacca tgaatgacat caacagaccg atgaggataa ataatatctg
     1981 gtctttttac cggaggggaa agtttgggta atctcataat caattttaga ttgtaggttg
     2041 ggttgacgta tgttacccaa cattaaaaaa ctcaacatga tttctcgttc ccatactccg
     2101 tatgggaatg aattctagaa ggctctgcct tctattaaag cagagtcaga gcctctgtaa
     2161 ccgcattccc agtcagagac tgggaacgag ataacgagat aaaagacttt gttgggttgc
     2221 gctgttgctt aacccaacct accactatta ataaggagta gaccaagaac ggacttcgcc
     2281 caaagtaaca ggaataatat cactcacatc aattgtaaac cggaatagct tcttcgcccg
     2341 acggctattt tcagggtcaa agaacttcaa ttttacatcc caacaatcgc tatctaaacg
     2401 acagaaagga cttttctcca ctgtaatact atccaactcc atacctgtag ccacagcttc
     2461 cgcaaaggta gaagccgctt gaaaagcatt cgtagaggca aaattcaacg ccctatcttg
     2521 ggaagttgtc cctaaattcc gtaaatcata ataaatacgg ctgaggaaac tacccaaagt
     2581 ccgacgaata gactcttctt gggcttctgt agcttgcgct tgcactgtct gaatagcagc
     2641 ctgaactaag gtgttaacct tccaaccata aagtccgcga gtgttgggaa cttcaattac
     2701 tggcacaact tgaccagaaa atagtttcac actgcgtcct gataaaatac cgggaatact
     2761 gactctctct acataattct cgctgtcttc tgcttgaatt tgtcctgata ataattgttg
     2821 taaaatagca tagacatctc tggcaaaagc accacctggt tcaattgcat agacaggagt
     2881 taattctaaa ttcaatgtcc aaattaaaga cttagcctca gaaagattat ctcctaaata
     2941 atctaccatc tgccgcgcat cataagggtt agcgggaatc gctgttccgt ctatttgtac
     3001 tcccggcatt aattgtttaa aagagtctct tctggcttct gaaccaaaat cgtaacccag
     3061 tgtacctaaa gcatacacta agttaacttg agcgaggtcg ctgggcgctt gactagcagt
     3121 aatgtaatta gatgtacgat ttgacatggt agtagattga gaattggatg aatttgtgaa
     3181 aggtgcggaa gttgtcacag caggaactac tgggaaaaat tcagggggta taaattcttc
     3241 cgggttgggt tctggttcag cactatttgt aatctctgca caaccgcaac cagcagcttc
     3301 aatactgtca acggtttcta ctgtatctaa ttcttcggac attgttcctc ctgtaaaata
     3361 tgccaatgca ccagaaatat ttaatttacc taataaacag cgactaatat cgtctgtatc
     3421 cttatctgtg caaggtatag cagtttctaa taaaaccgct ctcaccttag cggggtcggg
     3481 tgtttcacca cgctgaactt gcagacttag gagtaaagca gcgacaccgg aaacaatggg
     3541 agtagcaaag ctagtaccac tgagtttttg tgtccctccc cccggttttg ctcctaaaat
     3601 gtgttctccc ggtgcaagaa tgccttggtt ttgatagctt tccccccagt tactaaagtc
     3661 tatgggttta ccttggtcat tcattgcccc tactgctaat acggtgggta aagatgcagg
     3721 aacgtgcaaa cattcgcaac catcgttacc agcagcagcc acaattaaaa cattgtgatc
     3781 tttgcatagt tgcacagccc tatctaacca gccttctgct tcaccattat cagtgagttg
     3841 tccagcactg acattgataa tatgcgcccc ggcattgacg gcttgttcta tggcacgagc
     3901 taaatctagt tgggaaagtt tcctattatt gtcaccaaaa atagggacga ttaaccctcg
     3961 acattgggga gctattcccc gtaattctga ggaattatgt tgaccaaata tgatgcttgc
     4021 gacatgagtt ccatgtccag acatagatcc attagcagta gcttctccct ggataagtgt
     4081 tggcaatctt gttaaatttg ctgcattaaa gcaattatga gattgatcaa ccaatccgtc
     4141 gagtacggct acacatattt gtgaatcacc ctgtgtcaag tcccataatt cctgtatttc
     4201 tgttttaatt gaagattttg gcatttaatt tgttaattat ctgcttaaat atctattttg
     4261 cgccataaat atctatttta tggcattttt attacgattg tgcttctaaa acacaaaagt
     4321 aattgtcata ttattcggct gaaatgtcaa ctcaatttac atattttaac tgatataatt
     4381 ttttcttatg tcaaaaaaaa aaacggtttt agtaagtgtt tattttcttc tgtgctgtgg
     4441 atgaaaatca gtatttacaa atacttgacg ggaggagata gtgatttccg cttcacggaa
     4501 atatcaagta aacaggaatg tcgataaccc gatctattat aagtaatttt tattgataag
     4561 gtcttgcctt gaatcataat tgtccgtatg atgagaatca gggtagcttc acttagccta
     4621 ctgattagta attgcacttt ttatcgtctc atggtaggca gttgcattga ttattcttaa
     4681 aaattcacat tagttaatac taaaactcta cctctcccta accctctcct aagaggagag
     4741 ggaacaggaa aaaacttgag aatttaaaga gtttaaagcc tctttcctac aaggaaacag
     4801 gttttatata aagcttctgg tgaatcacaa ctcgttaaat tacccttcaa cgccaattta
     4861 acgccttcac caaaccagtc ttcttcataa tgaagaagtt aaacgaacaa acaaaaagga
     4921 aaaacacacc atgactaaga agaacatccg cccccaacaa gttgctcccg tagaacgcga
     4981 aaccatctct accgctaagg atcaaagcgg tcaggttcaa gcccagacca gtcaaatttg
     5041 gggtagtccg gttccttttg cgggcgacga cgcggagtaa ctcaccccat tctaccactc
     5101 acctcaaaaa atatcaaaag tctgtttctg tatcccttgg cgcacggttc gcctggatga
     5161 attgacggac aacccttgtc agttcggggg tttctgatac ctggcacagg ggtggcggaa
     5221 aaccggactt ggattttttg gggttggtgg ttgaaccctg atttgtgaga tgaaccccag
     5281 ccaacagctt actaccccag tagcatctgg ttggggtctt ctccttgggt ttatactttt
     5341 ggcagaagcc tttatacttt ttggcacatt cttctaagct gtttcctagt cgtaaaaaag
     5401 ccggatgcca ttgagttaaa ccatcatcag ttaagcgttc ataactgcca taattgctga
     5461 agtcatagaa aaaactctgg cgcattttgg cagctttagg attagcgtga atgtagcgta
     5521 aagtatttaa tgctctgtct ctatctgaag caggaaatcc atcacagtaa tatcgtttct
     5581 cccaaaaatg tcctgttctt cttaacatcc gattgaaaca catcgccgtg taccaattca
     5641 ggaagtgcat aattttgggt aactcttctg gctgtttagg tgcaatcaaa taatgaacat
     5701 gatttgacat aatgcacaaa gcataaagct ggaaattgta tttgtccaaa gcctttttta
     5761 tcgcataaag aaacacttcc cgacattcac gccgtgatag cttaaattca cggttattgc
     5821 aacggatggt aatgtggtaa gaatatccag actttaaatt tcgaggtttt ctaggcatat
     5881 cttttaacaa caatataaaa accagccgtt tatgatagct aatgtaaccc agaaagacag
     5941 atttcaagaa caaaaactac agtttattcg caatcatcaa caagcctttg atgttgagcc
     6001 tatttatcca ctccccttgt ttgaagactt tgtgatgaat gtagaaggag actgtagcat
     6061 tgaagcttct tgtaagatag aattagacaa attgattgcc tcaagattta tgttcttttt
     6121 caaagataag gcacaacaat ggcaaaaata tcttcatcaa tccctcactt ttttcaatcg
     6181 agtagaaaac cttgttggtg tgcaagttga ctactctcta ttgcggcagt ttttaggatc
     6241 tgactttgat tttcgtaaag ttaccgttct ttctgcgggg attgatttaa gaagcaatat
     6301 tgctgaatct agtttaaaaa tgcacattag aatcaaagat tatcccgaaa agttagatca
     6361 agctttatcc ctagccagca acgctgagga tttgatttcc gtacgtccgt ttctctctct
     6421 tgttggtttt gatttctatt tcaacggtcg cagtgaaatt gagctttatc ccgaaattca
     6481 agcagaagat tttgccaaat cagaaaccca aaatttggta tggagacatt ttccgaagtt
     6541 cgttttagac cctctagaag ttaccggatc atttctagtt ggcttctcaa aagctaatcc
     6601 taatccagtt ctctattata atctgaaaaa taagcaagat ttagctaatt atttcaaact
     6661 caacgatgca gcccaacgag ttcacagttt ttatcaaaat caggatattt tacctcatat
     6721 gtgggtaggt actgtccaaa aagagttaga aaaaacaaga atcgaaaatg ttagacttta
     6781 ctattataaa ttcttcaact aatctctcag caacagcgca acccaacaaa attaaatcac
     6841 aaaatcaccg aaatattggg taacatccct caacccaacc tacagaattt aaatgacatc
     6901 ctgtaaatcc tgaaatcctg aacatcctga ttcagacaaa aaaataacaa agaaattcat
     6961 cccaaacatc atctaaacta gaattgtaat caaccatcgt attttctatg acaattccca
     7021 taactattaa cttacccgaa agtttagctg cttctatcca gcgtcttgga gaagcaacag
     7081 cgcgagagat atcagacgtt ttacttgaca ccctagaaat agtattacct accttagata
     7141 atctctcaga aatgagcatt aattcaagca ttcctgatat ttccgatgag gaagttctag
     7201 aattagctaa tttaaaaatg gatgtagtgc aaaatcaacg cttgggagaa ctacaagcta
     7261 aaggaaaaaa taccggttta acagcaggag aacgttatga attattaatt ttaatgtccc
     7321 tttatcaaat gggacaatta agaaaatctg aaggtttagc cgaagctgtc aaacggggaa
     7381 taaaaactcc tttattacca taaccaaaat tactcatgta acatcctgta aatcctgaaa
     7441 tcctggacat cctgattggt gacaatttca ttttctgcaa aattcgagca aattttatga
     7501 tatctactac tgcaatttct cccatcttaa ctattcctcc cctagaaaac ggcgacaaat
     7561 taacccgtca tgaatttgaa cggcgttatc atgccatgcc gaatctcaaa gaagccgaat
     7621 taattgaagg agtagtttac gtggcatcac cattaagaat caaaagtcat ggagaacccc
     7681 atgcttatat tatgacttgg ctgggagttt ataaagcagc tacaccgggc ataggtttcg
     7741 ccgataatgc cacagtgcta atagatacag ataacgaacc acaaccggat gctttattaa
     7801 gaattgaaac aggaggacaa tcaagaataa ataaagatga ttatgtagaa ggtgcgccag
     7861 aattaatagt agaaattgct gcttctagtg cttcctatga tttacatgaa aaactcaaag
     7921 tttatcgtcg taatcaagtc caagaatatt taatctggcg agtttatgac tatcaatttg
     7981 attggtttag gttacaacaa ggggagtata ttcaacttca acccaatgca gataatataa
     8041 tttgttccca aatattcccc ggtttatggt tagataaaat ggcattatta ggaggagatt
     8101 taggtacagt attagctgtt ttgcagcagg gtttagcaag tccagaacat gagaatttta
     8161 ttagtagatt atctagttag tcagaatcag gatatccagg atttttggtg tcaacttaac
     8221 gtaaaatcca tagcccgact gggaatgaat tcccagtctc atagcaaaag tcatctaaag
     8281 atgactaaat aacccagaaa attttcagta aactttagtt tagtttcgct attagcccgg
     8341 aaattcattt ctgggcgggt ttgtcagcca acagataaga catttttagc ctaagttgcc
     8401 tataagcatt gctaaacccc taatagcccg actgggaata aattcccagt ctcatagcaa
     8461 aagtcatcta aagatgacta aataacccag aaaattttca gtaaacttta gtttactttc
     8521 gctattagcc cggaaattca tttctgggcg ggtttgtcag ccaacagata agacattttt
     8581 agcctaagtt gcctataagc attgctaaac ccctaatagc ccgactggga atgaattccc
     8641 agtctcatag caaaagtcat ctaaagatga ctaaataacc cagaaaattt tcagtaaact
     8701 ttagtttagt ttcgctatta gcccgtaaat tcatttctgg gcgggtttgt cagccaacag
     8761 ataagacatt tttagcctaa gttgacacct atgagcattg ctaaacccct attggtgaca
     8821 attatctagt tagcagcagt taccatccaa actaaaattc ctaaaatgac atcaacagga
     8881 ggaagtggat aatctgtaaa atcaattgtt acagtttgtt cggttaattg tagaaatcgc
     8941 caaacagtac cattagtcac gctaccataa attgtaggaa tgggttgatt attaatttca
     9001 ttaaattttt gagcagcaat catttccgca atacactggc caatacccgg atttaagtct
     9061 gattttttag cttccacaat cataactgct ggtgcttcaa cttctaactg ttctgctgaa
     9121 agactgagaa caaaatcaca aactccattc aatcctaaag ccgaatctac agtaaaatcc
     9181 gcaccagaga atagactaat ttttctttct aaaatcttac gtacttctag taaaaccgga
     9241 ctaatgatta attcagaacg agctttttca cttcccgtcg ctatagctaa tggcaaactt
     9301 tctgctaaaa aatcagtcag ggttgcacta gcagcaattg gttggatttc tggcagaaac
     9361 tttttatttt caacggtatt tatgccaaag gtttgcttaa cttttttgag agtaaaatca
     9421 ctatatgaca taatgtaaat atttccaaaa atgatgtaaa atctatgtga aaatcaacca
     9481 acagcaaaat ctgtatattg tcgcactaaa ggttcatgaa atgctaaaac aatatctgat
     9541 tttggcactc ctaatttaac taactcatct gctataccaa tttcagttcc atcatgttgt
     9601 atccaaattt tctgatcttt aatatccaaa tgcaaaacac aaccatgctg ccgtcttctg
     9661 tttttccaac ccacatacat caattgataa tgatcaccaa aactatcaaa aatcaattgt
     9721 tgttcaattt catctttagc tgaacctaat tgagcatatt ctgtgatcac ttgtttgaca
     9781 taattgcgat attgttctag tttttccatg ctacaattac ctcctgaact ggatcataaa
     9841 tcatgatttt aagttgggaa cgctgaacaa ctgttttaat aaactgcaat tgaaagaaag
     9901 agtaataaat tcctgaagga atagctaaat ataaaactcg ttctggttgt tgttattcta
     9961 atgccaaatg ataattaaaa aattgtccaa tggcttgatg aaatattaga tgtaccaata
    10021 aaactcttaa tttccaccgc tattttttct ccagcagcta aaacttgctc cgcaccgaga
    10081 tcaatataca tttccacatc accgacttct atccttaaag gatcatctgt aatcacccaa
    10141 ccttcttttt ctaaccctat cctaacagca tcatgaaaaa catctttagc tggcattaac
    10201 tttataaaaa attagacttt tcacccacaa ttataacatc aattacaaca acacaatcaa
    10261 aaccatgcct aaccttaccg acatccccgg aatttctcaa atttggacac gcacaaaagg
    10321 cgacccccgc attaaaattg ctatccttga tggtgcagca gacttagaac gcagttgttt
    10381 tcaaggggca aaatttagtc aatttaaacc ctactggtca gaagatattg aacttaacga
    10441 tgaatactat tattatctca atttatattt agattttaac caacaacaaa aagacaaaaa
    10501 agacgacccc gaccacgata aagaagaatc aaaaaaagaa cgagaggcat tttttgcacc
    10561 tttccctcca gctattagac aacgcattga attatccggt catgctactc acatttctag
    10621 cactatctta ggacaacacg gtacaccagc ccctggtatt gcccctttat gtacagcatt
    10681 aaatattcct atttccttcg ctaatgatga ttttatttcc cctatcaacc ttacccacgc
    10741 tgttaatacc gcttggcaat ggggagcgaa tattatccat atcgctgctt gtcaccctac
    10801 ccaaaccgga gtagcaccag atttatttgc ccgtgctgtg aaacaatgcc aagataataa
    10861 tatgttaatt gttgccccag gtggtaacga taaaggggaa tgttggtgta ttccctctat
    10921 tcttcctggt gtgattacag tgggtgcaat gcgagatgat ggccaaccgt ttaaatttag
    10981 taattatggg ggagaatatc aaaataaagg ggtaatggct aacggtgaaa atattttagg
    11041 cgcccaaccg ggaacagaag aacctattag acaaaaaggg actagttgcg ctgcacccat
    11101 tgtcacaggt atttctgcct tattaatgag tctgcaattg caacgaggag aacaacccaa
    11161 cgccgaagca gtgcgggaag caattttaaa tagtgctatt ccctgtaacc ccgaagaagt
    11221 ggaagaaccg gaacgctgtt tattaggtaa gttgaatatt cccggtgcgt ttcaattatt
    11281 gacgggagaa aggttagaac ctcacctcca acccctctcc tataagggag tgcaagaacc
    11341 tcacccccaa cccctctcct acgaggagag aggagcagga atctctcgtt cccaggttct
    11401 acctgggaat gctacattag aggctctgcc tctcactata ccgtcaggca gagccttgga
    11461 gacggcattc ccagtcggag actgggaacg agaaacttta gttattagcc agggaattaa
    11521 ttcctcaact gattctatta cccctagtgc agcttctaaa ttggtatatg ctttaggaac
    11581 tattggttat gattttggta atgaagccag aagagactcc tttaaacaat taatgccagc
    11641 agtgaatatg gacggggcaa ttattcccgc taatccctat gatagccagc aaatggtgaa
    11701 ttatctatca gaaaatcccg ccgaagctaa acctttaatt tggactctca accaagaatt
    11761 aactcctatt tatgctttag aacctgtaag cggttttgcc gcagatatct atgaaaccct
    11821 gattttgatg ttacagggac aaattcaacc agaaaacagt gatgattttg tggaacgggt
    11881 aagtatacct gcaaggttaa cagatagaac tgtggagtta ttttctggtc aggttgtgcc
    11941 tgtaattact ctaactaata ctaggggaat gtatggctgg aaagtcaaca gtttggtaga
    12001 tgcggctttg caaactgtaa ttacgggaga aactgcacca gcccaagaaa tagctatgag
    12061 aaaggctttg agtagtttct taaatcgagt atactatgat ttgcaaaatt taggacaatt
    12121 ggcaaaagat cgagcgttga atttttctgt aactaatgct ttccaagctg cttctagttt
    12181 ttctcaagct atttctacag ggatgcagct tgatagtatt gaagtggaaa aaagtccttt
    12241 ctgtcggatt aatagtgatt gttgggatgt gaaattaaag ttttttgacc cggaaaatgg
    12301 ccgcagagct aaaaaggtgt ttttgtttac cattgatgtt agtgacagaa ttcctgtaac
    12361 tttgggtcaa gttcgctctt ggtctgtgcg gaagtaagca cgtagtagtc tgtcaaattt
    12421 attttgacgg gtttttggta gtgcgggcat acttcgacaa gctcagtaca agtcttgccc
    12481 ccgtgagctg tcaaatttat tttgacgggt ttttggtagt gcgggcatac ttcgacaagc
    12541 tcagtacaag tcttgcccgc gtgagcgaga cgctcacact acagtccatc atttttatct
    12601 taacaaacta gtagtatatg ctctgatcaa taatttatca aaattgttta taatgaatta
    12661 gtgcaggtaa tggaggaaag gttaaggtac tacaactgtt ttatcccgaa accacgggag
    12721 tagggggcaa aaagaatatc tttcttactg acaactgaca actgacaact aaactaatag
    12781 ccattcacgg ctaaaaagtg ctaaaattag catttcagtg ttggaagttg tgaaggcggg
    12841 tataatatcc ccatcacttc cttatcaatc agttacaaac tcactcacta ggaacaggag
    12901 aaacagttct caacatgatc aaattgcgtt taaaaagatt tggcaaaaag cgcgaagcaa
    12961 gttaccggat tgttgctatt aacaacctgg cccgtcgtga cggtcgcccc ctagaagaac
    13021 taggatttta taaccccaga actgatgaag taaaattaaa cattcctggt atcattaagc
    13081 gtctacaaca aggcgctcaa cctaccgata cagttcgtag tatcctcgta aaagctaacg
    13141 tttttgaaca ggtcagtgca acagccgcat catagtcttg agatgaaatc cctagcaacc
    13201 agtcccaatt atgttgggct ggtagagttt cttgtgcagc cgtttttaga atctccagaa
    13261 tctttaagcg ttgattgtga aatgtctcaa accctcaagc gggcttgggt tcgcattgct
    13321 tttaatagca cagataaaga aaaagtgttt ggtcgagggg gacgaaatat ccaggcaatt
    13381 cgcactgtaa ttgccgccgc agccgaacta gctgggcaat cagtatacct ggatatttat
    13441 ggcaacagtt cccaaagtcg ggaaagtgtg tcttttgatg aagaacagga agagcggata
    13501 ctaccaccca agtcgaaaga acgagagaac aatattccca aacctgttgt taaaccacgt
    13561 ttacgctagt accgcagggc ggaattaaaa attaaaaatt aaaaattgaa aaagcaaatt
    13621 acaaaagctt tttagtggtt tttaataatt agtgattttt gccgcactct cctagttagt
    13681 ttaaatggtt ggtgacagat tgaattct
//
