LOCUS       BGC0000475             12693 bp    DNA     linear   BCT 18-MAY-2005
DEFINITION  Prochloron didemni subtilisin-like protein (patA), PatB (patB), PatC
            (patC), adenylation/heterocyclization protein (patD), patellamide
            precursor protein (patE), PatF (patF), thiazoline
            oxidase/subtilisin-like protease (patG), and deoxyribopyrimidine
            photolyase genes, complete cds.
ACCESSION   BGC0000475
VERSION     BGC0000475
KEYWORDS    .
SOURCE      Prochloron didemni
  ORGANISM  Prochloron didemni
            Bacteria; Cyanobacteria; Synechococcales; Prochloraceae; Prochloron.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:38:00
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12693
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..12693
                     /db_xref="taxon:1216"
                     /isolate="reef"
                     /mol_type="genomic DNA"
                     /organism="Prochloron didemni"
     protocluster    1..12693
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[226:10801]"
                     /cutoff="20000"
                     /detection_rule="(cyanobactin_synth or TIGR03678)"
                     /neighbourhood="10000"
                     /product="cyanobactin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      227..10801
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cyanobactin_synth or TIGR03678)"
                     /neighbourhood="10000"
                     /product="cyanobactin"
                     /protocluster_number="1"
     cand_cluster    1..12693
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cyanobactin_synth or TIGR03678)"
                     /kind="single"
                     /product="cyanobactin"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..12693
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000475"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12693
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyanobactin"
                     /region_number="1"
                     /rules="(cyanobactin_synth or TIGR03678)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            227..2335
                     /gene="patA"
     CDS             227..2335
                     /codon_start=1
                     /gene="patA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: cyanobactin_synth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 184.5; E-value: 7e-56)"
                     /gene_kind="biosynthetic"
                     /product="subtilisin-like protein"
                     /protein_id="AAY21150.1"
                     /sec_met_domain="cyanobactin_synth (E-value: 2.6e-231,
                     bitscore: 757.1, seeds: 40, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.3e-38, bitscore:
                     120.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRDILRTLSLKGDHNIRVAILDGPVDIAHPCFQGADLTVLPTLA
                     PTAARSDGFMSAHGTHVASIIFGQPETSVPGIAPQCRGLIVPIFSDDRRRITQLDLARG
                     IERAVNAGAHIINISGGELTDFGEADGWLENAVSLCRQNNVLLVAAAGNNGCDCLHVPA
                     ALPAVLAVGAMDDHGHPLDFSNWGSTYEQQGILAPGEDILGAKPGGGTERLSGTSFATP
                     IVSGVAALLLSEQVRRGETPDPQKVRQLLLQSALPCDDDAPEQARRCLAGRLNVSGAFT
                     LLKGGNMSEELATASFPSVEASCGCNGGLVAAEPTTNSGSMPALSVSSFAGASPATMEA
                     AGPLDEPQPLPSPAQPLTQMPAQPLPSPAQPLTQMPAQPLPFPAQPLTQMPAQPLTQMP
                     APTQTLSMTTNQVTPSQAPSELANSQFAYVLGTLGYDFGTEARRDTFKQLMPPFDFAGN
                     MVPANPYDARQMVDYLGNNISEARSLIWTVNIELTPVYAIDPTGPFASSTYHALQELLS
                     GQIQAEDNEEYVERVSIPGVLTNRSVKLFSGQVVPVVEPQSTRGLYGWKVNGLVNAALE
                     AVRAEGGDAGEARIRQTLDGFLNRIYYDLRNLGTTSQDRALNFAVTNAFQAAQTFSQSV
                     AAGMELDSVTVEKSPFCRLDSDCWDIKLKFFDPENNRRAKKIYRFTIDVSDLVPVTMGE
                     VRSWSSSY"
     gene            2570..2806
                     /gene="patB"
     CDS             2570..2806
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="patB"
                     /product="PatB"
                     /protein_id="AAY21151.1"
                     /transl_table=11
                     /translation="MRLPLLSAPVKRPHFIQPAQCVDIENGRLKDLLHIRLYLLDGANY
                     NDPPAFANRSFNQVMHSSASNGWGGFASMGRLF"
     gene            2864..3172
                     /gene="patC"
     CDS             2978..3172
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="patC"
                     /product="PatC"
                     /protein_id="AAY21152.1"
                     /transl_table=11
                     /translation="MVTNNPTAQSKTPPAEKRKSYVMTSMTGMQDYSYWCAYVRERYGE
                     EAKKYERDPKPFRRGGVWA"
     gene            3204..5624
                     /gene="patD"
     CDS             3270..5624
                     /codon_start=1
                     /gene="patD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: NHLP_CD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Goadsporin_CD_RRE"
                     /gene_kind="biosynthetic"
                     /product="adenylation/heterocyclization protein"
                     /protein_id="AAY21153.1"
                     /sec_met_domain="TIGR03604 (E-value: 9.6e-84, bitscore:
                     270.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 5.3e-98, bitscore: 317.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 2.5e-44,
                     bitscore: 138.5, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 2.8e-18,
                     bitscore: 55.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 3.9e-20, bitscore:
                     60.9, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPTALQIKPHFHVEIIEPKQVYLLGEQGNHALTGQLYCQILPFL
                     NGEYTREQIVEKLDGQVPEEYIDFVLSRLVEKGYLTEVAPELSLEVAAFWSELGIAPSV
                     VAEGLKQPVTVTTAGKGIREGIVANLAAALEEAGIQVSDPKAPKAPKAGDSTAQLQVVL
                     TDDYLQPELAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLRGNRE
                     VEASVLQQKRALQERNGQNKNGAVSCLPTARATLPSTLQTGLQWAATEIAKWMVKRHLN
                     AIAPGTARFPTLAGKIFTFNQTTLELKAHPLSRRPQCPTCGDQEILQRRGFEPLKLESR
                     PKHFTSDGGHRATTPEQTVQKYQHLIGPITGVVTELVRISDPANPLVHTYRAGHSFGSS
                     AGSLRGLRNTLRYKSSGKGKTDSQSRASGLCEAIERYSGIFLGDEPRKRATLAELGDLA
                     IHPEQCLHFSDRQYDNRDALNAEGSAAAYRWIPHRFAASQAIDWTPLWSLTEQKHKYVP
                     TAICYYNYLLPPADRFCKADSNGNAAGNSLEEAILQGFMELVERDSVALWWYNRLRRPE
                     VELSSFEEPYFLQLQQFYRSQNRELWVLDLTADLGIPAFAGLSRRTVGSSERVSIGFGA
                     HLDPKIAILRALTEVSQVGLELDKVPDEKLDGESKDWMLEVTLETHPCLAPDPSQPRKT
                     ANDYPKRWSDDIYTDVMACVEMAKVAGLETLVLDQTRPDIGLNVVKVMIPGMRTFWSRY
                     GPGRLYDVPVQLGWLKEPLAEAEMNPTNIPF"
     gene            5756..5971
                     /gene="patE"
     CDS             5756..5971
                     /codon_start=1
                     /gene="patE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: TIGR03678"
                     /gene_kind="biosynthetic"
                     /product="patellamide precursor protein"
                     /protein_id="AAY21154.1"
                     /sec_met_domain="TIGR03678 (E-value: 3.2e-26, bitscore:
                     80.6, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKNILPQQGQPVIRLTAGQLSSQLAELSEEALGDAGLEASVTA
                     CITFCAYDGVEPSITVCISVCAYDGE"
     gene            6232..7194
                     /gene="patF"
     CDS             6232..7194
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="patF"
                     /product="PatF"
                     /protein_id="AAY21155.1"
                     /transl_table=11
                     /translation="MDLIDRLQNNQRKDRRLQFVRTHQEAFDVKPTFPLPLFEEAILEI
                     EGSCSVESSCQVEGDRLQGGRYEVCNNQGTTWPESLTHAFKLLDKIDSQLGVRINRDSF
                     DRFAAAHVNSRKIINNTIGVHLGSKLEDSSVMLYIHIKPEEDTEELARTALVLDGGRYS
                     DELTRVLLRDTMVIGFELFFDGRSRVDLGPCAPGKSGTLKMKGKHLEQYTQKNLSRKVN
                     SIFREGYLFGAFFSKTRVEPILFFYHSIIKDLPKYFTFNSLGDKIYNFCQSQGCITDVA
                     IAVTETELEKSRLENFCFYYDQWDECKPSSDYDTERHLH"
     gene            7226..10801
                     /gene="patG"
     CDS             7226..10801
                     /codon_start=1
                     /gene="patG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: cyanobactin_synth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 91.5; E-value: 1.2e-27)"
                     /gene_kind="biosynthetic"
                     /product="thiazoline oxidase/subtilisin-like protease"
                     /protein_id="AAY21156.1"
                     /sec_met_domain="cyanobactin_synth (E-value: 1.9e-184,
                     bitscore: 602.7, seeds: 40, tool: rule-based-clusters)"
                     /sec_met_domain="PF00881 (E-value: 5e-14, bitscore: 41.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.3e-24, bitscore:
                     74.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSIMITIDYPFTVSLNRDIQVTSTEDYYTLQVTESDPSAWLTFA
                     TTPAMDMAFDHLKAGTTTESLVQTLAELGGPAAREQFALTLQQLDERGWLSYAVLPLAE
                     AIPMVESAELNLPGNPHWMETGVTLSRFAYQHPYEGTMVLESPLSKFRVKLLDWRASAL
                     LAQLAQPQTLGTIAPPPYLGPETAYQFLNLLWATGFLASDHEPVSLQLWDFHNLLFHSR
                     SRLGRHDYPGTDLNVDNWSDFPVVKPPMSDRIVPLPRPNLEALMSNDATLTEAIETRKS
                     VREYDDDNPITIEQLGELLYRAARVTKLLSPEERFGKLWQQNKPVFEEAGVDEGEFSHR
                     PYPGGGAMYELEIYPVVRLCQGLSQGVYHYDPLNHQLEQIVESKDDIFAVSGSPLASKL
                     GPHVLLVITARFGRLFRLYRSVAYALVLKHVGVLQQNLYLVATNMGLAPCAGGAGDSDA
                     FAQVTGIDYVEESAVGEFILGSLASEVESDVVEGEDEIESAGVSASEVESSATKQKVAL
                     HPHDLDERIPGLADLHNQTLGDPQITIVIIDGDPDYTLSCFEGAEVSKVFPYWHEPAEP
                     ITPEDYAAFQSIRDQGLKGKEKEEALEAVIPDTKDRIVLNDHACHVTSTIVGQEHSPVF
                     GIAPNCRVINMPQDAVIRGNYDDVMSPLNLARAIDLALELGANIIHCAFCRPTQTSEGE
                     EILVQAIKKCQDNNVLIVSPTGNNSNESWCLPAVLPGTLAVGAAKVDGTPCHFSNWGGN
                     NTKEGILAPGEEILGAQPCTEEPVRLTGTSMAAPVMTGISALLMSLQVQQGKPVDAEAV
                     RTALLKTAIPCDPEVVEEPERCLRGFVNIPGAMKVLFGQPSVTVSFAGGQATRTEHPGY
                     ATVAPASIPEPMAERATPAVQAATATEMVIAPSTEPANPATVEASTAFSGNVYALGTIG
                     YDFGDEARRDTFKERMADPYDARQMVDYLDRNPDEARSLIWTLNLEGDVIYALDPKGPF
                     ATNVYEIFLQMLAGQLEPETSADFIERLSVPARRTTRTVELFSGEVMPVVNVRDPRGMY
                     GWNVNALVDAALATVEYEEADEDSLRQGLTAFLNRVYHDLHNLGQTSRDRALNFTVTNT
                     FQAASTFAQAIASGRQLDTIEVNKSPYCRLNSDCWDVLLTFYDPEHGRRSRRVFRFTLD
                     VVYVLPVTVGSIKSWSLPGKGTVSK"
     CDS             complement(11028..12455)
                     /codon_start=1
                     /note="putative"
                     /product="deoxyribopyrimidine photolyase"
                     /protein_id="AAY21157.1"
                     /transl_table=11
                     /translation="MSKLILFWHRRDLRISDNMGLAAARKQSSKIVGLFCLDPNILNSN
                     EVAPARVTYMLGCLQELKESYSKIGSQLLIVRGEPIEAIPQLAVALQVTGVFWHKDGEP
                     YARERDGKVEQELLKQGIAVTNYWDQLLHPPEDILTQSGKPYTVYTPFWKNWSQKPKLE
                     VAEKLDRIQGLTAEEIKIAQETGVVSLPTGKDLGYYWDGELILTPGETAAREQLEEFSE
                     RAIAQYQEQRNFPAVEGTSLLSPALRFGVIGIRTVWQATLEATKNSYSEEVRANIETWQ
                     KELAWREFYQHALYHFPQLTVEPYRQQFKDFPWDNNPEHFQAWCEGKTGYPMVDAAMRQ
                     LNETGWMHNRCRMIVASFLTKDLIINWQWGEQYFMQKLCDGDLASNNGGWQWSASCGMD
                     PKPLRIFNPASQAKKFDPEGEYIRQWLPELSSIDTEYLVRGKIPDDERERCDYPQPIVD
                     HNLRQREFKRRYKELSP"
ORIGIN
        1 ttcgtgaaaa ttgctctttg aataaagggt ttcgatattt tgaatgccct aagcaaattt
       61 taatggagct gcaagcctaa ttgtcgtttt tgagtttagt gcacaactac tggtttattt
      121 ttattataat cgtggcgctc tatgtatccg gtattaaaac gcgctcctat ctgtccgggg
      181 aagacagaac ggcattggcc tatagcaaaa atactcgtct atcaccatga atagagatat
      241 tttgcgaact ttaagtctca aaggcgatca caatatccgg gttgctattc ttgacggtcc
      301 tgtcgatata gctcacccct gtttccaagg agctgatctg accgtgcttc ctaccctggc
      361 tcctacggct gcccgtagtg acggctttat gtccgcccac ggcacccacg ttgccagtat
      421 tattttcggt caaccggaaa ctagcgttcc aggtatcgcc ccccagtgtc ggggtctcat
      481 cgtccccata ttttccgacg atcgcaggag gataacccag cttgatctag ctcggggtat
      541 cgagcgggcg gtcaacgccg gagcccacat tatcaacatc agcggcggcg aactcaccga
      601 ctttggcgag gcggatgggt ggctcgaaaa tgccgttagc ctgtgtcggc agaacaatgt
      661 tttgctcgta gctgcggcag gcaacaacgg ctgcgactgc ctgcacgttc ccgccgccct
      721 accggcagta ttggccgtag gcgcaatgga cgatcacggg catcccttgg actttagcaa
      781 ctggggatct acctacgagc agcagggcat tctcgctccc ggtgaagata ttttgggggc
      841 caagcccggt ggcggcacgg aacgcctcag cggcaccagc tttgccactc cgattgtttc
      901 cggtgtcgcc gccttactcc tgagcgagca agttcgccgg ggagaaaccc ccgatcccca
      961 aaaagtccgc caactgttgt tgcagagcgc cctgccctgc gacgacgacg cgccagaaca
     1021 ggctcggcga tgtctggctg gcaggctgaa cgtatctgga gctttcactt tactaaaagg
     1081 aggaaatatg tctgaagaac tcgcaacggc gagtttccct agcgtagaag catcctgtgg
     1141 ctgcaacggc ggacttgtcg ctgcggaacc caccaccaat tccggttcga tgccagctct
     1201 gtcggtttcc tcgttcgcag gggcgagtcc tgccactatg gaagccgctg gccctctcga
     1261 cgaaccccaa cctcttccat cccccgccca acctcttaca caaatgcccg cccaacctct
     1321 tccatccccc gcccaacctc ttacacaaat gcccgcccaa cctcttccat tccccgccca
     1381 acctcttaca caaatgcccg cccaacctct tacacaaatg cccgccccta cacaaacgct
     1441 ctctatgaca accaatcaag tcacgcccag ccaagccccc agcgaacttg ccaacagtca
     1501 gttcgcctat gtcctaggaa ccttgggcta cgacttcggc accgaagctc gccgcgacac
     1561 cttcaagcaa ctgatgccgc cctttgactt tgcaggtaat atggttcccg ccaaccccta
     1621 cgatgcccgt cagatggtgg actacttggg taacaatatc tcagaagcgc ggtctctcat
     1681 ctggaccgtt aacatagaac tgaccccggt ctatgccatc gacccaaccg gtccttttgc
     1741 ctcctcaacc taccacgccc ttcaagaact gctctccggt caaatccaag ctgaagataa
     1801 cgaagaatac gttgagcgtg tcagcattcc cggtgttttg accaatcgct cggtcaagct
     1861 cttctccggt caagttgtcc cggtggtcga accccaaagc actcgcggtc tctacggttg
     1921 gaaggttaat ggcttggtaa atgctgccct ggaggcagtt cgcgctgaag gaggggatgc
     1981 aggggaagca cgcattcgcc aaaccttgga tggctttctc aaccgcatct actacgacct
     2041 gcgcaacctg ggaaccactt cccaagaccg cgcccttaac tttgcggtta ccaacgcctt
     2101 ccaagccgcc caaaccttta gccaatccgt ggcggcgggc atggaactcg acagcgttac
     2161 tgtggagaaa agtcccttct gtcgcctaga tagcgattgc tgggatataa agttaaaatt
     2221 cttcgaccca gaaaacaacc gtcgtgccaa gaagatttac cgatttacca ttgatgtgag
     2281 cgatctggtt ccagtgacta tgggcgaagt tcgttcttgg tcttcttctt actaaggaac
     2341 agccaaatat tagtggaagt acaaactgtg ctttcactaa attactcaaa ttccttaata
     2401 gctcccgacc gtcgaattca aaattaaaaa ttcaaaattc aaaatttaat tcgtgacgaa
     2461 tgtctccgca aaaaatggca gaaacttaaa aagccttatc cctctaggtt ttgagcttgt
     2521 tgtcaatttt tagattcggt cgagtactat atttggagaa tcccgaacta tgcgacttcc
     2581 gctactgtct gcccctgtaa aacgccctca tttcatccag cctgctcaat gtgtagatat
     2641 tgagaatggc cgtcttaaag atttgctaca tattcgccta tatcttcttg atggtgctaa
     2701 ctataatgac ccgccagcct ttgccaaccg cagtttcaac caagtgatgc actcgagtgc
     2761 cagcaatggc tggggcgggt ttgccagtat gggacgctta ttctgattaa ctaaacactc
     2821 agattccccc ccccgctatg agcggggggg gaacgtaccc tgacataccc tgactatcac
     2881 cacctctggt gggaaggggg acggcgcaca ttggctcgac tacctgaagc tcgacgggat
     2941 tgtcgctccc cagcaaagag aaatatccaa ggaaactatg gtcactaaca accctaccgc
     3001 acaatctaaa acgccccctg ctgagaagag aaagtcttac gtcatgactt ctatgacggg
     3061 tatgcaagac tactcttatt ggtgcgccta cgtccgcgag cgctacgggg aagaggcgaa
     3121 aaaatacgaa cgcgatccca agcctttccg acgagggggg gtttgggctt aactctaagg
     3181 ctacttcttt catcttcgcc tgatcgcgaa ggaaagattg cctccttttt aaagacttac
     3241 ttaacttatt agtcatatac cttcgctcta tgcaaccaac cgcgctccaa attaagcccc
     3301 acttccacgt tgagataatt gagcccaagc aagtgtatct cctgggcgaa cagggcaacc
     3361 acgctctcac cgggcagctc tactgccaaa ttctgccttt cttaaacggc gaatacaccc
     3421 gagaacaaat tgtggaaaag ctcgatgggc aggtcccgga ggaatatatc gacttcgtac
     3481 tcagtcgtct ggtggagaag ggctatctaa ctgaggtggc tccagaacta tccctggaag
     3541 tggcagcatt ttggagcgaa ctgggaattg ccccttctgt agtggcagaa gggctaaagc
     3601 agccagtgac agtgacaacg gcgggcaagg gcattaggga agggatagtg gctaacctgg
     3661 cagcagcgct ggaggaagct ggcattcagg tgtcagaccc aaaggcccca aaggctccaa
     3721 aggcagggga ttctactgcc cagcttcagg tggtgctgac cgatgactat ttacagccgg
     3781 aacttgcagc gatcaacaag gaagccttag agcgccaaca accctggttg ctagttaagc
     3841 ctgtgggcag tatcctctgg ttgggaccgt tgttcgttcc tggggaaacc ggatgttggc
     3901 actgtcttgc tcaacgattg cggggcaacc gggaagttga agcatcggta ttgcaacaaa
     3961 agcgagcgct gcaggagcgc aacggtcaaa ataaaaatgg tgcagtgagt tgcttgccca
     4021 cagcacgggc aaccctacct tctactctac aaacaggttt acagtgggct gccaccgaga
     4081 ttgctaagtg gatggtcaag cggcacctca atgccatagc accgggaaca gctcgttttc
     4141 ccactctagc tggcaagata tttacattca accagacgac tctggagttg aaagctcatc
     4201 ctctgagccg acgaccgcaa tgtcccacct gtggcgatca ggaaattctc caacggcgcg
     4261 ggtttgaacc actgaagcta gagtcgcgcc ccaaacactt cacctccgat ggcggtcatc
     4321 gcgccacgac cccagaacaa acggtgcaga agtaccaaca cctcatcggg cccataacgg
     4381 gggtagtgac ggaactggtg cgaatttctg accctgccaa tcccttggtg catacctacc
     4441 gggcggggca tagctttggc agtagtgctg ggtctctgcg agggttacgg aatactttgc
     4501 gctacaagag ttctggtaag ggcaagaccg atagccaatc tcgggccagc gggctttgtg
     4561 aggcgatcga gcgctattcg ggcatttttc tgggagacga accccgcaag cgggcaacct
     4621 tggctgagtt gggagacttg gctattcatc cagaacaatg tttgcacttt agcgacaggc
     4681 agtatgacaa ccgggacgcc ctcaacgctg aagggtccgc agcagcctat cgctggattc
     4741 cccatcggtt tgctgccagt caagccatag actggacgcc cctatggtcc ctgacggagc
     4801 agaagcacaa gtacgtgccc acggctatct gttactataa ttacctgctg cctccggccg
     4861 atcgcttctg taaggccgat tccaacggga acgcagcagg taactccctg gaagaggcaa
     4921 ttttgcaagg gtttatggaa ctggtggagc gggatagcgt cgccctgtgg tggtataacc
     4981 gcctgcgccg tccggaagta gaattgagca gttttgagga gccctatttt ctccagttgc
     5041 agcagttcta ccgcagccaa aatcgcgaac tgtgggtgct ggatttgacc gcagacttgg
     5101 ggattcctgc ctttgcaggt ttatcccggc gcacggtggg tagctcggag cgggtctcca
     5161 tcggttttgg agcccacctc gatcccaaaa ttgccatcct ccgggctcta actgaggtca
     5221 gtcaagttgg gctagagctg gataaagtcc ctgatgagaa acttgatggg gagtccaagg
     5281 actggatgtt ggaagtgact ttagagactc atccctgttt ggctcccgat ccctcccagc
     5341 ctcggaaaac tgccaatgat tatccaaaac gctggagcga tgatatttat acagatgtga
     5401 tggcctgtgt ggagatggcc aaagttgccg gactagaaac gttggtgcta gaccagacgc
     5461 gaccggacat cggcttgaac gttgtcaagg taatgatacc gggaatgcgc accttttggt
     5521 cgcggtatgg tcccgggcga ctctacgatg tccccgtgca gctgggttgg ctgaaggagc
     5581 ctctcgctga agcagagatg aaccctacca atatcccgtt ttaagcattt tcaagtttgg
     5641 gggcaacagg cttccctacg cgccttgccc cagtaggctt cttctcaaat gaagaggggg
     5701 aatgacccac ccgaacgggt caatcaacca aaaaaagaca acgaggttct tttcaatgaa
     5761 caaaaaaaac attctacccc aacaaggcca acccgtcatc cgcttgactg ctggtcagct
     5821 ctccagccag ttggctgaac tgtctgagga agctctcggc gatgctggtt tggaagcatc
     5881 tgtaactgct tgcatcactt tttgcgctta tgatggtgtg gagccatcta taactgtttg
     5941 catcagtgtt tgcgcttatg atggtgaata aggggacgaa taagaacata cagcctcacc
     6001 cacttcgcgc gagaactaac ttatagttgt tatcgaagga attgtaaggg ctgtaatctg
     6061 ttgacgaggt aaaagacaag gttaaagatg tcgaagtgag attaaaatcc ttttgtcctc
     6121 tttgtgcatc taccttgtct tccttagttt cagctcttgg tctttgagtc gatctcgatc
     6181 gactcaagaa ccaaaaacat ctattgtaaa atctttcacg ttgcttaaat tatggactta
     6241 attgacaggc ttcaaaataa tcagcgcaaa gaccgacgac ttcaatttgt ccgaacccat
     6301 caagaagcct ttgatgttaa gccaaccttc cctcttcctc tttttgaaga ggctattctt
     6361 gaaatcgaag gttcttgttc tgttgaatcc tcttgccaag ttgagggaga ccgactgcaa
     6421 ggagggcgct atgaggtttg taataaccag ggcacaactt ggcccgaatc gctcactcat
     6481 gcgtttaaac tcttagataa gattgatagt cagttgggcg tgcgtattaa tcgtgactcc
     6541 ttcgatcggt ttgccgcagc acatgtgaac tcccgcaaaa ttatcaacaa tacgattggc
     6601 gttcacttgg gttccaagct cgaagattct agcgtgatgc tgtatattca tatcaagcct
     6661 gaggaagata ctgaagagtt agcaaggacg gcactcgttc ttgatggcgg tcgctactca
     6721 gatgagttaa cacgggtttt gcttagagat acgatggtta tcggctttga acttttcttt
     6781 gatggtcgca gtcgtgtcga cttaggtcct tgtgctcctg gaaaatctgg aacattaaaa
     6841 atgaaaggaa agcatctcga acaatatacg caaaagaatt tgtcaagaaa agtaaattct
     6901 atttttaggg aaggatattt gtttggggca tttttttcta aaacccgtgt agagccaatc
     6961 ttattctttt accattcaat aatcaaagac ttgccaaaat actttacatt taacagtttg
     7021 ggtgataaaa tatacaattt ttgtcaaagt caaggttgta tcacggacgt ggctatcgct
     7081 gttacagaaa cagagttaga gaaaagcaga ttagaaaatt tttgtttcta ctacgatcaa
     7141 tgggatgaat gtaaaccgag ttcggattat gataccgagc gtcatttgca ttgactcact
     7201 tacctagtca tccttaccta aataactgtt ttccattatg atcacgatag actacccttt
     7261 cactgtttcc ctgaaccgcg atatccaagt tacaagtacc gaagactact acaccctgca
     7321 agtaacagaa tccgatccgt ccgcttggct cacctttgcc acaacgccgg caatggatat
     7381 ggctttcgat cacctcaaag caggcaccac caccgaatcc ctcgtgcaaa ccctagcaga
     7441 acttggcggt cccgcagcca gggaacagtt cgccctgacg ctacaacaac tggacgagcg
     7501 aggatggttg agttacgccg tactgcccct ggcagaagca atccccatgg tggaatccgc
     7561 cgagttgaat ctgccgggca atccccactg gatggaaacg ggtgtcactc tctcccgctt
     7621 tgcctaccaa catccctacg aaggcacaat ggtgttggag tcccccctct ccaagtttcg
     7681 agtaaagctc ctcgactggc gagccagcgc ccttctagct caactggccc agccccaaac
     7741 tctcggaacc attgccccac cgccctacct gggaccagaa accgcctatc agttcctcaa
     7801 cctgttatgg gcaacggggt ttctggccag cgatcacgaa cctgtttcac ttcaactttg
     7861 ggattttcat aacctgctgt tccacagtcg cagccgcttg ggtcgccatg actacccagg
     7921 cacggacttg aatgtggaca actggtcgga ttttccggtg gtgaaaccac ccatgagcga
     7981 tcggattgtg ccgctgccgc gtccaaactt ggaggcattg atgtctaacg atgccaccct
     8041 tacggaagcc attgaaacgc ggaaatcggt aagagaatat gacgacgata atccgatcac
     8101 gatcgagcaa ctgggggaac tactttatcg cgctgcccgc gtcacgaaat tgctttcccc
     8161 agaggagcgt tttggcaagc tttggcagca aaacaagcca gtttttgaag aagcaggcgt
     8221 tgatgaaggc gagtttagcc atcgccccta tccagggggc ggggccatgt acgaactaga
     8281 aatttatcct gtggtacggc tttgtcaagg gttgagtcaa ggggtgtacc actacgaccc
     8341 attaaatcat cagttagagc agattgttga atcaaaggat gatatctttg ctgtctcggg
     8401 ttctccattg gcgagtaaat taggtccaca tgttctcttg gtaattacag cgcgatttgg
     8461 tagattattt cgtttatatc gctctgtcgc ttatgcatta gtgctaaaac acgttggggt
     8521 attgcaacaa aatctttacc tagtagcaac taatatgggt ctagctccct gtgctggagg
     8581 ggcaggagat agcgatgctt ttgctcaagt aacgggcata gattatgtag aagagtcggc
     8641 tgtcggagaa tttatactcg gatcgttggc tagcgaagtg gaatcggatg ttgtagaggg
     8701 tgaggatgaa atcgaatctg cgggtgtttc ggccagcgaa gtcgagagtt ctgcaaccaa
     8761 acaaaaggtg gcactccacc cccacgatct cgacgagcgc atccccggac tggccgacct
     8821 ccacaaccaa accctgggcg accctcagat taccattgtc attatagacg gcgacccaga
     8881 ctataccttg tcttgttttg aaggagccga ggtttctaag gtttttccct actggcacga
     8941 accggcagaa ccgatcaccc cagaagatta tgcagccttc caaagtatcc gggaccaggg
     9001 actgaagggc aaagagaaag aagaggctct cgaagctgtt atcccagata ccaaggatcg
     9061 catcgtactc aatgaccatg cttgccacgt caccagcact atcgttggtc aagaacacag
     9121 ccccgtgttc ggtatagctc ccaactgccg agtcatcaat atgccccaag acgctgtaat
     9181 ccgagggaac tatgacgatg tgatgtctcc cctcaactta gcccgtgcta ttgatttggc
     9241 cttagaatta ggtgcaaata tcattcactg tgccttttgt cgccccaccc aaaccagcga
     9301 aggggaagaa atcctggtcc aagccatcaa aaaatgtcag gacaacaacg ttttaatcgt
     9361 ctcgcccaca ggaaataatt caaacgaaag ctggtgtctg cctgctgttc taccgggaac
     9421 cctggcggta ggggcagcaa aagtcgatgg tacgccctgc cacttcagta actggggcgg
     9481 caacaacaca aaagaaggca ttctggctcc gggtgaagag attctcgggg cgcaaccctg
     9541 tactgaagaa cccgtgcgcc tgaccggaac cagtatggcg gctccggtga tgacgggcat
     9601 ttccgcccta ctgatgagcc tgcaagtaca acaaggcaag cccgtcgatg cagaagcagt
     9661 ccgcactgcc ctactcaaga ccgctattcc ctgcgaccca gaggttgtag aagaaccgga
     9721 acgctgtttg cggggctttg tgaatatccc cggggcaatg aaggtgctgt ttgggcaacc
     9781 ctcggtcact gtttcctttg caggcggtca agcgacccgc acggaacacc ccggttatgc
     9841 cacggtggct ccagcaagca ttcccgagcc aatggcagag agggctaccc cagcagtaca
     9901 agctgccaca gcaactgaga tggtgatcgc cccctccaca gaaccggcca acccagccac
     9961 agttgaggcc agcaccgcct tttccggcaa cgtttatgct ctgggtacaa tcggctacga
    10021 cttcggggac gaagcccgtc gggacacctt caaggaacgc atggcagacc cctacgacgc
    10081 tcgccagatg gtggactacc tcgaccgcaa ccccgacgag gctcgctctt tgatttggac
    10141 cctcaacctc gaaggagacg ttatctacgc cctcgatccc aaagggccgt ttgccacgaa
    10201 tgtttacgag atcttcctac agatgttggc agggcagctg gaaccggaaa ccagtgcgga
    10261 ttttatcgag cgccttagcg ttcccgcccg acggacaact cgcactgtgg aacttttttc
    10321 tggggaagtg atgcccgtgg tcaacgtgcg cgaccctcgg gggatgtacg gttggaatgt
    10381 gaatgcgtta gtggatgcag ccttggcaac tgtagaatat gaagaggctg acgaagactc
    10441 actgcggcaa ggactcaccg cctttttaaa tcgggtgtat cacgacctgc ataatttggg
    10501 acaaacctct cgcgatcgcg ccctcaactt taccgtcacc aatacgtttc aggcagcatc
    10561 tacttttgcc caggcgatcg cctcggggcg gcaactggac accattgagg tgaataaaag
    10621 tccctattgt cgcctcaaca gcgattgctg ggacgtgcta ttaacctttt acgacccgga
    10681 acacgggcgg cgatcgcgcc gggtcttccg tttcaccctg gacgtagtat atgttttacc
    10741 tgtaacagtg ggcagcatca agagttggtc attgcctggt aaaggcaccg tctcaaagta
    10801 gttattgggg tgcggtcaaa aacagttgaa ttttaagtcg cggcttaccc gcgattgtta
    10861 ggcagcccag acttgaccgg gtcgtcgaag gggggctacc ccacggttga taaatatata
    10921 ttcagcccca aacaactact tttgaccaca cctgttgtgt tgggtttcgt tacctcaacg
    10981 gaacctacga aaaacaaact ggaaagtccc cctttgataa gggggattta gggggatagt
    11041 tctttatacc gccgtttaaa ctccctttgc cgtagattgt ggtctacaat gggttgagga
    11101 taatcacacc gttctctttc atcatcaggt atcttgcccc taactaaata ttccgtatct
    11161 atagaactca attctggcaa ccattgacga atatattccc cctcggggtc gaatttcttg
    11221 gcttgactgg cgggattaaa aatgcgcaat ggtttgggat ccattccaca agaagcactc
    11281 cactgccaac cgccattatt agaggctaaa tccccgtcgc acaacttctg catgaaatat
    11341 tgctctcccc actgccagtt aattatcaaa tctttggtga gaaaactggc tacaatcatg
    11401 cgacagcgat tgtgcatcca tcccgtttca tttaactgcc tcatggcggc atccaccatg
    11461 ggataccctg tttttccctc gcaccatgct tgaaaatgtt ctgggttatt gtcccaagga
    11521 aagtctttaa attgctgccg atagggttct actgtcaatt ggggaaaatg ataaagggcg
    11581 tgttgataaa actctcgcca tgctagttct ttttgccagg tttcaatgtt agctctaact
    11641 tcctcgctgt agctgttttt ggtcgcttct agggtggctt gccaaactgt acgaatgccg
    11701 atcaccccga atcttaaggc tggactcaag agagaggttc cttcaactgc gggaaaattt
    11761 cgctgttctt ggtattgggc gatcgccctc tcagaaaatt cctctaactg ttccctggct
    11821 gctgtttctc caggagttag gattaactcc ccatcccaat aataacccaa atctttccct
    11881 gtgggtaaac tcactactcc tgtttcctga gctattttga tttcttctgc tgtcaatcct
    11941 tgaatccgat ctaatttttc tgctacttct agtttgggtt tttgactcca atttttccag
    12001 aaaggagtat agacagtata aggtttgcct gactgagtta aaatatcttc tggcggatgt
    12061 aataattggt cccaataatt agtaacagca attccttgct tgagcaactc ttgttcaact
    12121 tttccatctc tttctcgagc ataaggttcc ccatccttat gccaaaaaac tcctgtcact
    12181 tgtaacgcta ctgctaattg aggaattgct tctatcggtt ctcctcgtac tattaataat
    12241 tggctgccaa ttttgctgta actctccttt aactcttgta aacagcctag catataggtc
    12301 actcttgctg gagcaacttc attgctattt aaaatattcg ggtctaagca aaataaaccc
    12361 acaatcttgc tactttgttt tctcgcagca gcaagtccca tattatccga gatgcgcaaa
    12421 tcccgacgat gccaaaagag aattagttta gacatatagc aatgagcaat gaacaatgaa
    12481 caatgaacaa tgagcaatga gcaatgaaca atgagcaatg agcaattaac aattaacaat
    12541 taacaattaa gagatagttt atctcatggt agtatagatt gaagttattc cgtgggttga
    12601 gaaaccgggt ttctttccaa aattttaaca ttaatcctta aaataatagg agaaacccgg
    12661 cgaattggct tcttggccga aatctaacaa gtt
//
