LOCUS       BGC0000487             12140 bp    DNA     linear   BCT 11-MAY-2011
DEFINITION  Carnobacterium maltaromaticum strain UAL307 hypothetical proteins,
            CclB (cclB), CclI (cclI), CclT (cclT), CclC (cclC), CclD (cclD),
            carnocyclin A precursor (cclA), CclE (cclE), CclF (cclF), CclG
            (cclG), CclH (cclH), hypothetical proteins, and TrxA (trxA) genes,
            complete cds.
ACCESSION   BGC0000487
VERSION     BGC0000487
KEYWORDS    .
SOURCE      Carnobacterium maltaromaticum
  ORGANISM  Carnobacterium maltaromaticum
            Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
            Carnobacterium.
COMMENT     On Oct 7, 2010 this sequence version replaced EU624394.1.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:43:44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12140
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..12140
                     /db_xref="taxon:2751"
                     /isolation_source="fresh pork meat"
                     /mol_type="genomic DNA"
                     /organism="Carnobacterium maltaromaticum"
                     /strain="UAL307"
     subregion       1..12140
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000487"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12140
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..9974
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4779:4974]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4780..4974
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9974
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     CDS             83..262
                     /codon_start=1
                     /note="Orf1"
                     /product="hypothetical protein"
                     /protein_id="ADO17953.1"
                     /transl_table=11
                     /translation="MGIEMGIIVQNTESEKYLVEKKGPINLTVKSKENVIIFKNEIDAK
                     KEASNFDPYRLITL"
     CDS             570..821
                     /codon_start=1
                     /note="Orf2"
                     /product="hypothetical protein"
                     /protein_id="ADO17954.1"
                     /transl_table=11
                     /translation="MEKIKDFYESVGYYKAMGQVLSLVVDNQECSVEDFILKFELNVKE
                     FRKYVDVSEYCTIDNDFHNWYEAAQEMWVSEKYTSEED"
     gene            1223..2674
                     /gene="cclB"
     CDS             1223..2674
                     /codon_start=1
                     /gene="cclB"
                     /product="CclB"
                     /protein_id="ADO17955.1"
                     /transl_table=11
                     /translation="MKIIRKKIINKITVLYYLMNNNRRRLENYYYQRISENLIYLKRKE
                     ISKIAFTLSLVSLVISLSPVIGVVLLSTSKSVIFLTIIIFSNIFLIEKKLNIFKLLHPN
                     FFNTNETFIFNRWNTYKLLSLFSVSDFLFIISTVIIISIRTIVFFSYNELLMLVASLVA
                     IYMLLKKKQEYFFLLLSSMVLLIYVYISSLDIDLSNSKYYFSELRGNLADLEIYFIYFF
                     ISCIVSYFIFSAVSKLAPKKIFKQKKNTEKNINRAQIAFKNYISSISVLKRIMQILPVD
                     AMIVILIFLMINVESKKEIFPILIMMITIYNTKQFITENGYFFHVFIDGKERYSFVISV
                     KNLISIYFIKFKMILVSRLLYIFSVFALYQFNIKEVSIAQYIFIFVCIILGMIIPIFDS
                     KLLMVNLKMLVEFNNVKYDTNFEAFIIVVLLLFSFVTHQIVIQNLIHLLVFLYIFVVLL
                     LLTTIIVKFYLSLFSLKMWRDKLDK"
     gene            2747..2929
                     /gene="cclI"
     CDS             2747..2929
                     /codon_start=1
                     /gene="cclI"
                     /note="immunity protein"
                     /product="CclI"
                     /protein_id="ADO17956.1"
                     /transl_table=11
                     /translation="MTLLNYIFGFVMLGYGIHQYLKYQTMYVKTNKKKYKLISLIFIVA
                     VVCIILGSILRLLNL"
     gene            2958..3584
                     /gene="cclT"
     CDS             2958..3584
                     /codon_start=1
                     /gene="cclT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 80.8; E-value:
                     2.1e-24)"
                     /gene_kind="transport"
                     /note="ATP-binding protein"
                     /product="CclT"
                     /protein_id="ADO17957.1"
                     /transl_table=11
                     /translation="MEYLKIEIIDASYENNEPIIKKAEIQLEKYGIYFLNGKNGSGKST
                     FLKALHGDLLTKVYNISLNGKKLSKYSKDIVFIDDQFVGYEFLKVHEYVIYILELFKKS
                     KRKIDIELLLTELELQEYSHKLIKDLSQGNKQKLSFLATILIDGKIILFDEAFEHVDKE
                     VMHLIKKNLLDISKTHFIFLTSHTSRLFEIYNKEITLKNGVVVIE"
     gene            3562..4140
                     /gene="cclC"
     CDS             3562..4140
                     /codon_start=1
                     /gene="cclC"
                     /note="DUF95 family of membrane proteins"
                     /product="CclC"
                     /protein_id="ADO17958.1"
                     /transl_table=11
                     /translation="MGWLSLNDVKKNIYINVLTSESKIAIALSLIIGVLGVASAVIALL
                     RNQITEDITPVLEKTNFFEAFNHIFLNNLFLSLGVIIAGFLFYWLATVITLLNLFIFSY
                     SLTTNLINSGIKDTFLKYLHSIIEVPAIILTLGISYRISSILIDALRDKKDKRYKEIII
                     NLLLNIVVVVILLFLGAVIEAAFIKFNLF"
     gene            4239..4721
                     /gene="cclD"
     CDS             4239..4721
                     /codon_start=1
                     /gene="cclD"
                     /product="CclD"
                     /protein_id="ADO17959.1"
                     /transl_table=11
                     /translation="MERKLGFFKTIFYLGLIIYATSFLLKLNLIPNEVFNSLDLGKEQI
                     IGVKIIGFLVSVLSMLAIVCIEYILLKFIFKKIFKNEYIELFKKMFFVSYTIKFLLLSV
                     GILLLSTGIKVPDYLVSLILLIILIVINIKMINFIPGASIQKKISTTGCFLIIALL"
     gene            4780..4974
                     /gene="cclA"
     CDS             4780..4974
                     /codon_start=1
                     /gene="cclA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /note="circular bacteriocin; anti-bacterial peptide"
                     /product="carnocyclin A precursor"
                     /protein_id="ACC93994.1"
                     /sec_met_domain="TIGR03651 (E-value: 1.4e-10, bitscore:
                     31.4, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYELVAYGIAQGTAEKVVSLINAGLTVGSIISILGGVTVGLSGV
                     FTAVKAAIAKQGIKKAIQL"
     mat_peptide     4792..4971
                     /gene="cclA"
                     /product="carnocyclin A"
     repeat_region   5148..5180
                     /note="sequence repeat"
                     /rpt_type=inverted
     gene            5402..5854
                     /gene="cclE"
     CDS             5402..5854
                     /codon_start=1
                     /gene="cclE"
                     /product="CclE"
                     /protein_id="ADO17960.1"
                     /transl_table=11
                     /translation="MNKNFFKSTKLCTLFLAIILTIISISMIFSSFGMLVLQSGALNNI
                     EGVNQAEMNQITQSVSFFDSFLVYFQTVLYLILTVFMYIFNSKLKKGVLVSKVPYFIII
                     FLQVYGMVISFLNYTSFALIGILFSIVIILLALFPIINLFKLEPNG"
     gene            5885..7087
                     /gene="cclF"
     CDS             5885..7087
                     /codon_start=1
                     /gene="cclF"
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 77.6; E-value:
                     1.4e-23)"
                     /gene_kind="transport"
                     /note="putative HlyD-type family of accessory proteins"
                     /product="CclF"
                     /protein_id="ADO17961.1"
                     /transl_table=11
                     /translation="MKSISKKKKIIGSILISFVIVLILIGVALYSVSSNKKKDTQSFHA
                     ITLKENDPLLFKGMAIPQKETKTYLDPTLGNLNELYVTEGQSIDIGTPLISYKDDKTQE
                     QINEQARGIERVKTSIANTQERNGEAQKKKETAISNIMTTKAMINQLEQSSEPEDLAKV
                     QQYTQEIAKYEGIVEGQEAQIETLETALQDAQADLTERQAAVDQLQQKVTSNVTAEIAG
                     QVHINEEGKVSSTVPLVTIVSPTILIQGQVSEYDYTKLAVGQAVNLNIPSTGDKISGKI
                     EEVDSLPQRTGATDSVGTTSSNQVLYNFKVIPEREIQYGYSVQIELPQNEINVPAKAVK
                     NDKDELYVFVFQKGRVKKQSIKAIKKENFYVVQEGIVKGEKIIENPSKELKDNQEVAVD
                     E"
     gene            7084..7767
                     /gene="cclG"
     CDS             7084..7767
                     /codon_start=1
                     /gene="cclG"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 203.1; E-value:
                     8.6e-62)"
                     /gene_kind="transport"
                     /note="ATP-binding protein"
                     /product="CclG"
                     /protein_id="ADO17962.1"
                     /transl_table=11
                     /translation="MIELKDINKFYLSGEETFHVLRNIQLSIEEREFLAIMGPSGSGKS
                     TLINLLGFIDRKFDGTYLFEGESLKNTSDNNLSKIRNQTVGFVFQNFSLIENNTVFENV
                     ELPLLYNGYTSRNTKEKVHSILEKVGILDKAQKYPKQLSGGQQQRVAIARALVNNPKFI
                     IADEPTGALDSITSEEILTLFKELNEKEGVTIILVTHDLESVQYCQRLVKILDGKIIED
                     VELIS"
     gene            7764..8960
                     /gene="cclH"
     CDS             7764..8960
                     /codon_start=1
                     /gene="cclH"
                     /note="putative ABC transporter permease"
                     /product="CclH"
                     /protein_id="ADO17963.1"
                     /transl_table=11
                     /translation="MKFSIIWRTSVKALVKNKRRSILTMIGIIIGISSVITIMSLGRGF
                     QKETIKNLSSNDKDEITVNVNFIPEEVNLGANNLVYFQEQDLRNIKEIEGVKKVSIAED
                     TSDTQQVELMIKGKKKNKQLKLIKDKSTNVDYGRPLKASDSQTKNKVAVIDSILAKELY
                     TTEKAALNSAVDIQGELFTIVGIITVSDTDNLFSLNPNIEIPKQSYEYYFPKSSNGESI
                     QVTVEPTSTPDKVTSKVLKELRESGSMRERGEYQVFDMAALTEGIGKILSGLTLFISAI
                     AGISLFIAGVGVMNMMYISVSERTKEIGIRRALGATEKVIQAQFLLEGVTITLIGGLIG
                     YLLGIVSAFIISLFLPFSISVDVFTVLLATGISVLIGIVFSVMPASAAAKKDLIDILR"
     CDS             9197..9319
                     /codon_start=1
                     /note="Orf3"
                     /product="hypothetical protein"
                     /protein_id="ADO17964.1"
                     /transl_table=11
                     /translation="MKKSKVILFLGLIVWGYFGLGPWSKPVDDFYDIKKHKDIK"
     repeat_region   10075..10104
                     /note="sequence repeat"
                     /rpt_type=inverted
     CDS             complement(10211..10642)
                     /codon_start=1
                     /note="Orf4"
                     /product="hypothetical protein"
                     /protein_id="ADO17965.1"
                     /transl_table=11
                     /translation="MKKKLLLSAIILTSLSSVILPTSFTVSASTTVSEQSINQTDSSIG
                     NIESMNRYTDAVNQYLTTQDGVYKLNDLAKDTMTPNDYALLKNIVEDLNNPIATRSSRA
                     NSFRLTLSNQEAKNLAYNLGKATGAAGIIAILVTWFKTK"
     repeat_region   10890..10916
                     /note="sequence repeat"
                     /rpt_type=inverted
     gene            11267..11698
                     /gene="trxA"
     CDS             11267..11698
                     /codon_start=1
                     /gene="trxA"
                     /note="TRX family of thioredoxin proteins"
                     /product="TrxA"
                     /protein_id="ADO17966.1"
                     /transl_table=11
                     /translation="MKKNIVIFVLALITFGTVLTVKYSDKLLYFYNVSSLKELDTNDLK
                     SLTKQEGTHIVYIGRPTCEYCIDFVPKLNKVVKETILEVNYYDTDKNRKDLQMTELLTE
                     LHVETVPAVIVVKDKTVVKQINPTKLSAIDLENEFLKYN"
ORIGIN
        1 tggaataaaa aaaggttact aagattataa atataacaac tatgatacaa tatagagata
       61 acgaaaaatt agaagttaga aagtgggaat agaaatggga attattgttc aaaatactga
      121 atcagagaag tatctagtag aaaagaaagg tccaattaat ttaacagtga aatcgaaaga
      181 aaatgtcatc atttttaaaa atgaaattga tgctaaaaag gaagcatcta attttgatcc
      241 atatagatta attacattgt aaaattcggt tgtgaaatta attgatagtg agatgaaata
      301 atcttactgt ctttttttgt taaagatata aataaacaca aaaaatcagt aaaattgatg
      361 aatacattat tttatcttaa atagtggatt tgaattattg gcacagcatt tgtttttaat
      421 cccattttta gaactttcta gaatgtaata tgggtggtca ttagaaaaat ttattttggg
      481 aattaaaatc aaccaatagg gtgtagctta atataatagt tacttttcct gcatttaagg
      541 gcactaaaaa tacgagggag gatttaatag tggaaaaaat caaagatttt tatgaaagtg
      601 ttggctatta caaggcaatg ggtcaagtgt tatctttagt agtagataat caagagtgta
      661 gtgtagaaga ttttattttg aaatttgagc ttaatgtaaa agagtttaga aaatatgttg
      721 atgtgtcaga atattgtact attgataatg actttcataa ttggtatgaa gctgctcaag
      781 aaatgtgggt atcagaaaaa tacaccagtg aggaggatta aaaatataaa agggtagtca
      841 ttaacttata aattagtgac tacctttctt gctgctgatt ttaattggac caggagtggc
      901 caaatactat tttttgaaat atagacaata ttttttattt aggtcagact atcaaaactt
      961 ataagtattg atagtgtgaa atttaaaaag taaggttcat ttttgtcaat ctctttcgtt
     1021 caagatatat ttaggcgtag ttcaggatgt tttcaattat taagcactta tttatgttac
     1081 tgtaaatttg ttactacaaa aatttaaaga attgagtgga aatctatttc taaatttttt
     1141 agatgttaag ttaacactaa taaatgtttt ttatatttga caaaatgggg cgaaaggaaa
     1201 aagaatatat tttatattca aggtgaaaat cataagaaaa aaaataatta ataaaataac
     1261 tgtattgtat tatctaatga ataataatag gagacggtta gaaaactact attatcaacg
     1321 tatatctgaa aatcttattt atttgaaaag aaaagaaata agtaaaatcg cttttacttt
     1381 aagtttagtt tctttagtca tttccttaag tccagtcatt ggtgtagtgt tgctttcaac
     1441 atctaaatca gtaatttttt taacaataat aattttttct aatatctttc ttatagaaaa
     1501 aaagttgaat atatttaaat tattacatcc gaatttcttc aacactaatg aaacctttat
     1561 tttcaacaga tggaacactt ataaattgtt atcgttattc tctgtatctg attttttatt
     1621 tattatatct accgtaataa ttatttccat tagaacaatc gttttttttt catataatga
     1681 gttacttatg ttagttgcta gtcttgtagc tatatatatg ttacttaaaa aaaagcaaga
     1741 atactttttt ttgctattaa gtagtatggt tctattgata tatgtatata tatcaagcct
     1801 ggatatagat ttgtcgaata gtaaatatta ctttagcgag ttgagaggca atcttgctga
     1861 tttagaaata tattttatat atttctttat aagttgtatc gttagttact ttattttttc
     1921 agcggttagc aaattagctc ctaaaaaaat ctttaaacaa aaaaaaaata ctgagaaaaa
     1981 tataaacaga gcacaaatag catttaaaaa ttacatttct agtatatctg tgttaaagcg
     2041 aattatgcaa atacttcctg tagatgcgat gattgttatc ttaatatttt taatgattaa
     2101 tgtagaatca aaaaaagaaa tattcccgat tttaattatg atgattacta tctataatac
     2161 gaagcaattt atcacagaaa atggttattt ttttcatgtt tttattgatg ggaaagaaag
     2221 gtattcgttt gttatttcag ttaaaaattt aataagtatt tattttatta aattcaaaat
     2281 gatacttgtt tcaagattgt tgtatatttt ttcggtgttt gcattgtatc agttcaatat
     2341 aaaagaagtt agtattgctc agtatatatt tatttttgta tgtattatct taggtatgat
     2401 aataccaatt tttgacagta aattattgat ggtgaattta aaaatgcttg tggaatttaa
     2461 taatgttaaa tatgatacta atttcgaagc ctttatcatt gttgtattac tactttttag
     2521 ttttgttact catcagatag taatccagaa tttaattcat ttgctagttt tcttatatat
     2581 ttttgttgtt ttattactat taactactat tatagtgaaa ttttatttat cgctttttag
     2641 tttaaaaatg tggagagata agcttgataa ataaatcaaa aaggatacat ttgttctcca
     2701 tgtactagta tgctattaat gaatgtgaaa ggaatggata ataactatga ctctattaaa
     2761 ttatatattt gggtttgtaa tgcttggata tggaattcat caatacttaa aatatcaaac
     2821 tatgtatgtt aaaactaata aaaaaaaata caaattgatt agtttaatat ttatagttgc
     2881 tgttgtttgt attattttgg gatcaatctt aagattactt aatttgtagg atttccacta
     2941 tctttggagg taaatgtatg gaatatttaa aaatagaaat tattgatgct agctatgaaa
     3001 ataatgaacc tataattaaa aaggcggaaa ttcaattaga aaaatatggt atatattttc
     3061 tgaacggaaa aaatggatcg ggaaagtcaa catttctaaa agcattacac ggggatttat
     3121 taactaaagt atacaacatt tcgctgaacg gtaaaaaact ttctaaatat tcaaaagaca
     3181 tagtttttat agacgatcaa tttgtgggat atgaattttt aaaagtacat gagtatgtta
     3241 tttatatttt ggagttattc aaaaaaagca agcgtaaaat agatatagaa ttactgttaa
     3301 ctgaattaga attgcaagaa tacagtcata aattaataaa ggatctatct caaggaaata
     3361 aacaaaagtt gtctttttta gcaactattt taatcgatgg aaaaattata ttgtttgacg
     3421 aagcatttga acatgtggat aaggaagtta tgcatttaat aaaaaaaaat cttttagata
     3481 tttcaaaaac acacttcatt tttttgacat cacacacaag caggttattt gaaatataca
     3541 ataaagaaat tacattaaaa aatggggtgg ttgtcattga atgatgtaaa aaaaaatata
     3601 tatataaatg tattaacttc agaaagtaaa attgctatcg cactatcatt aataattggc
     3661 gttttaggag ttgcaagtgc tgtaatagct ctacttagaa atcaaattac agaagatata
     3721 actcctgtat tagagaaaac caattttttt gaagctttta atcatatttt cttgaacaat
     3781 ttatttctta gtttaggagt aattattgca ggtttcttat tttattggtt agcaacagta
     3841 attacattat taaatttatt tatttttagc tattctttaa caacgaacct cattaattct
     3901 ggaattaagg atacattttt aaagtatctt cactctataa tcgaggtacc agcaattata
     3961 ttaactttag gcatttcata tagaatttct agtattctta tagatgcatt aagagataaa
     4021 aaagataaaa gatataagga aataataatt aatttactac taaatattgt tgtggtcgtt
     4081 attttattat ttttaggagc agttattgaa gcagcattta tcaagtttaa tttattttag
     4141 aaacaaatct actgtgatta aatcaaaaat tacagataaa tacaaccaaa tgactgaaat
     4201 aattgggtaa tataaatata caattaaagg agaaagaaat ggaaagaaaa ttaggttttt
     4261 ttaagacgat attttattta ggattaatta tttatgctac ttcattttta ttaaaattaa
     4321 atttaatacc aaatgaggta tttaatagct tggatcttgg taaagaacaa ataattggcg
     4381 tgaagattat tggattttta gtgtctgtac tgtcaatgct tgcaatagtt tgtattgagt
     4441 atatattatt gaaatttatt tttaaaaaaa tcttcaaaaa cgaatatatt gaattgttta
     4501 aaaaaatgtt ttttgttagt tatacaataa aatttttatt attgtctgtc ggaattctat
     4561 tattatcaac tggtataaaa gttcctgatt atttagtaag tttaattttg ctgataattt
     4621 taatcgttat aaacattaaa atgattaatt ttattccagg tgcttcaatt caaaaaaaaa
     4681 tatcaacaac tggttgtttt ctaattattg cgttactttg atgtgaaata tatatggatt
     4741 atatagggtt gctacttgat gaaaagagga ggaaaaaaaa tgttatatga attagttgca
     4801 tatggtatcg cacaaggtac agctgaaaag gttgtaagtc taattaacgc aggtttaaca
     4861 gtagggtcta ttatttcaat tttgggtggg gtcacagtcg gtttatcagg tgtcttcaca
     4921 gcagttaaag cagcaattgc taaacaagga ataaaaaaag caattcaatt ataaaataaa
     4981 ttaaactgta gcaaccctat ataatccata tatataaatt ttaaacatcg atagtggtgt
     5041 ataaatatga aagcaatttt tatgtctatt tcaaagttga tgaataagaa gtattttcga
     5101 gcattgtagg atttatatcc aattatttca catatggatt ctattcgatt tgaaggatat
     5161 ttgaaaaata tccttcaaat tagtcaaggt gtcttttttt ttagtaaaat ttttttccta
     5221 agacagtatt cttataaaca agaagagacc ctagaacgag caactggata ctcatcttat
     5281 gttactttta cagtttcttt ttagcatata gcttacagga agtttgtatg gaatttctgg
     5341 tttatttaaa atgattttat gaaaaaaaca attcaaataa cttaattctc aggaggaact
     5401 tatgaataaa aactttttca aatcaactaa actatgtact ttatttttag caatcatttt
     5461 gacaattatt tcgatttcaa tgattttttc atcttttgga atgcttgtac ttcaaagtgg
     5521 tgcattaaac aatatcgaag gagtgaacca agcggaaatg aatcagataa cgcaatctgt
     5581 ttcatttttt gatagctttt tagtttattt tcaaacagtt ttatatctta tattgactgt
     5641 tttcatgtat atatttaact caaagctaaa aaaaggagtt cttgtttcta aagttcctta
     5701 ttttattatt atttttttac aagtatatgg tatggttatt agctttttaa attatacctc
     5761 gtttgcttta attgggatct tattttcaat agtcattatc ctattggcgt tatttccaat
     5821 tattaatcta tttaaattgg aaccaaatgg ttagaaaaat taagttatga aaggcggaga
     5881 ccagttgaaa tctatttcta agaaaaagaa aattatagga agcattctaa tcagttttgt
     5941 catagtttta attttaatag gtgttgcact atactcagta tcgtcaaata aaaagaaaga
     6001 tactcaatcg tttcatgcta taacacttaa agaaaacgat cctcttttat ttaaagggat
     6061 ggctattcca caaaaggaga caaaaactta cttagatcct acattaggaa atttaaatga
     6121 actgtatgtc acagaaggac aatcaattga tattggaaca cctttaattt cttataaaga
     6181 tgataaaacc caggaacaga taaatgaaca agcacgaggg atagaacgtg taaaaacaag
     6241 tattgcaaat acacaagaaa ggaatggaga agcacaaaaa aagaaagaaa cggctatctc
     6301 aaatataatg acaacgaaag caatgataaa ccaactagaa cagtctagcg aaccagaaga
     6361 tttagcaaaa gtacagcagt acacacaaga aattgcaaaa tatgagggga ttgtggaagg
     6421 gcaagaggct cagatcgaaa cactggaaac agccttacaa gatgcccaag cagatttgac
     6481 agaacgtcaa gcagcagtgg atcaattgca gcaaaaggta acttctaatg taacggctga
     6541 aattgctgga caggtccata ttaatgaaga aggaaaagtt tcttcaacag taccattggt
     6601 caccatagtg agtcctacaa ttctcataca aggccaagtg tcagagtatg attatactaa
     6661 attagcagta gggcaggcag tcaatttaaa tataccaagt acaggagaca agatttctgg
     6721 gaaaatagaa gaagttgatt cactacccca aagaacggga gcaactgatt cagtaggaac
     6781 gacctcttcg aaccaagtac tctataattt taaggtgata cctgaacggg aaattcaata
     6841 tggatatagc gttcaaattg aattgcctca gaatgaaata aacgttccag ctaaagcagt
     6901 taaaaatgat aaggatgaac tttatgtatt tgtctttcaa aaaggaagag tgaagaaaca
     6961 gtctattaaa gcgattaaaa aagaaaattt ttatgttgta caggaaggaa tagttaaagg
     7021 ggagaaaatt attgaaaacc cgtccaaaga gttaaaagat aatcaagaag tggcggtgga
     7081 cgaatgattg aattgaagga tatcaataaa ttttatttat caggagaaga aacgtttcat
     7141 gtcttaagaa atatccaact ttccattgaa gaaagagaat ttttagcaat catgggtcct
     7201 tcaggttctg gaaaatcaac tcttattaat ttattaggat ttatagaccg aaaatttgat
     7261 ggaacttatt tatttgaagg tgaatcatta aaaaatactt ctgataacaa cttatcaaaa
     7321 ataagaaatc aaacagtggg atttgttttt caaaacttca gtctaattga aaacaataca
     7381 gtttttgaga atgtggaact ccccctactc tataatggat atacatcaag gaacacaaaa
     7441 gaaaaagtac attctatttt agaaaaagta ggcattttag ataaagcaca aaaatatcct
     7501 aaacagcttt ctggaggaca acaacaaagg gtcgctattg ctagggcatt agttaataac
     7561 cctaaattta tcattgcaga tgagcctaca ggcgccttag actctatcac atcagaagaa
     7621 atactaacat tatttaaaga gttaaatgaa aaagagggtg ttactattat tttagtaaca
     7681 catgatttgg aatcagttca atattgtcaa cgattagtta aaatattaga cggaaaaatc
     7741 attgaagatg tggagttgat ttcatgaagt tttctatcat atggcgtaca tctgtaaaag
     7801 cattagtaaa aaataaaaga cgtagtattt taacaatgat tggcattatc attggaattt
     7861 cttctgtcat tacaattatg tctttaggaa gagggtttca aaaggagaca attaaaaacc
     7921 tgtcttctaa tgataaagat gagattacag taaatgtgaa ttttattccg gaagaggtta
     7981 atctaggagc gaataattta gtttatttcc aggaacaaga tcttcgaaat atcaaagaaa
     8041 ttgaaggtgt aaaaaaagtt tcgatagcag aagatacctc agatactcag caagtggaat
     8101 tgatgatcaa aggaaagaag aaaaataaac aattaaagtt aattaaagat aagagtacta
     8161 atgtagatta cggacggcct ttaaaagcta gtgatagtca aacaaagaac aaggtagcgg
     8221 taatcgatag catacttgcg aaagaacttt atactactga aaaagctgct ttaaatagtg
     8281 ctgttgatat ccaaggagag ttatttacta ttgttggaat tataaccgtt tcagatacag
     8341 ataatttatt ttcattgaat cccaacattg aaatacctaa acaaagttat gagtattatt
     8401 ttccgaaaag ttcaaatggg gagagcatcc aggtaactgt tgaacctacg agtacgccag
     8461 ataaagttac ttctaaagta ctgaaagaat taagagaatc aggaagcatg cgagaacgcg
     8521 gagaatatca agtgtttgat atggctgcac tgactgaagg aatcggaaaa atattatcag
     8581 gtcttacact ttttatctca gcaattgcgg gaatttcatt atttattgct ggagtagggg
     8641 tcatgaatat gatgtacatt tcagtttcgg aacgaacaaa agagattggg attcggcgag
     8701 cattaggtgc aacggaaaaa gtgatacaag cgcaattttt attagaagga gttactatta
     8761 cattaattgg tggattaata ggatatttgt taggaatagt gagtgctttt atcatttctc
     8821 tctttcttcc cttttctatt tcagtagacg tatttacagt cttattggcc actggaattt
     8881 ctgttttaat tggaatagtg tttagtgtaa tgccagcttc agcagccgct aaaaaagact
     8941 tgattgacat actaagatga ttttaaaata agcaaaaacc tatgaaattt caaaaacgac
     9001 gaacttgaca caaacgtgtt ttgttgagat tatggcctta tattttagtg aaattgaaat
     9061 aaatatttac tatgttataa ttttacttta taagtaaatt tgggatagtt attctttact
     9121 aaattcctaa tagattgaat taaataatga agaaactatt tttttaagta ctaattaaca
     9181 gataggggaa gatgttatga aaaaaagtaa agtaatttta tttttaggat taattgtttg
     9241 gggatatttt ggattaggcc catggagtaa acctgtcgat gatttctatg atataaaaaa
     9301 gcataaagat ataaaatgat aaaggtagag ttaaaatata tttttaaatg ggagggaata
     9361 gcgtgaattt tatagttgat tttttttaat aatacttgat acatttcaaa tgaaaagtaa
     9421 aaagaagtta agaaagaaaa aaattcattc ttaaattttt tcacaattaa ctagaatttt
     9481 tcaagaaaaa cttttttgga aaaatattaa acttaggcaa taaaacttca aacaaccgaa
     9541 cttgacacaa gcgtgttgtg tcaagttcgg taaaatggct caatcccatg tggctctaag
     9601 cgtacgtcca tttattggag gtgcgtgtca tttgtatttt taaatggaat gaattttaag
     9661 ttttatttga cacaaatctg caacttttag ttttagatgg cacagaattt atatcgataa
     9721 atagcacaaa cgaacattat actgagaaga gcgattattt acttgggtac attcagttgt
     9781 tgtaccaaat aagttgaaag aaattgtacc atctaaaact aaaagttaca gcattagctg
     9841 atatttttca ttctaacaaa tgacaatagg gtatacttta ttgtcatttg tttttaatcc
     9901 catttttaga actatctaga gtgtagtatg ggtggtcatt agaaaaattt atttatggaa
     9961 ttaaaatcaa ccaatagggt gtaatccatt ggttgattta gcctaattga tttatgtagg
    10021 tttgtatgcc accattagag tgcgccataa taaaattact agtaaaaaaa aagagtattc
    10081 accaacttat aagttggtga ataccccctg tttttaacta agatagtgct ttaaaagtgg
    10141 tcattaactg tgttttgaaa gtgaaaaatg gaaaagacta cttacctagt ggctagtagt
    10201 cttttccatt ttattttgtt ttaaaccacg taactaagat agcgattatt ccagcagccc
    10261 ctgttgcttt tcctagattg taagcaaggt ttttagcctc ttgatttgaa agagtaagtc
    10321 tgaaggagtt agctcgacta cttctagtcg ctataggatt gtttaggtcc tcaacaatat
    10381 ttttcaagag tgcgtaatca tttggagtca tagtgtcttt agccaaatcg tttaatttat
    10441 aaaccccatc ttgagtagtt aaatattgat ttacagcatc tgtataccta ttcatacttt
    10501 caatatttcc aattgaacta tcagtttgat taatagactg ttccgaaacg gtagttgatg
    10561 ctgaaactgt aaaggaagtt ggtaaaataa ctgaactgag actggtcagg attattgcag
    10621 aaagtaataa tttttttttc atggaaaaca ccattccttt tttactcact tgagtgagta
    10681 atagattttg ttcaaagcta atcctaacat aaataaaatg ttatatgtaa aggtgaatga
    10741 attttatagt aaaaagaaga ttatttatca ataatagtga aatagaagat cataaaaata
    10801 caatcctgta catttcattt atttaatgac gaacttaaga aatattggta gtattttgtt
    10861 tgccaaaaac atttgtttat gctgatttca aaaatagcct taaaaaggct attttttttg
    10921 tttaaaactg tgccaatact tgtggcaaaa tcaaattacc attaactact gtttttgcta
    10981 taaatattac aaggagttgt tcaaaaatgg aatacattta cggatacgct ttaatttata
    11041 taaattgatt ttaatagacg gtttgaattt aaaaatcagt gaccaaagta aatgtttatt
    11101 ttataaaaaa atacaacatt gtataaaaat aatctaaaaa aagggattta attatcgttt
    11161 cataaggaat ttctattgtt ttgtttacaa aataatagag gtttgataat attatttttg
    11221 gtaatgaaat tatattaatt attaaatgta gaaaggtggt taaaaaatga aaaaaaatat
    11281 tgtaatattt gtgcttgctt taatcacgtt tggaacagtt ttgacagtga aatattcaga
    11341 taaattatta tatttttaca atgtaagttc tttaaaagag ttagatacga atgatttaaa
    11401 atcattaaca aaacaagaag ggactcatat tgtttatatt ggtagaccta catgtgaata
    11461 ttgtattgat tttgttccta aattgaataa ggtagtaaaa gaaacaatcc ttgaagtaaa
    11521 ttattatgac acggataaaa atagaaaaga tttgcaaatg acagagttat taactgaatt
    11581 acatgttgaa acggttcctg cagttatagt tgtaaaagat aaaacagttg tcaaacaaat
    11641 taatccaaca aaattgagtg caatcgatct ggaaaatgaa tttttaaaat ataactaata
    11701 gttgaaaggg ggtagcataa atgaagttga aaaaagaaca gatagtattg ttattattct
    11761 tggttctatt atttattgat gcattgtttt catttaaatt atcaaccatg gttttactag
    11821 ggattatgtt ttttgtttgc ataggtatgt tttataaaaa aaaataatgg aggttttaag
    11881 atgaataaaa atttattaaa agtcgttatt aatttttttc aggtgtttaa atcgtgagtt
    11941 ctgctctaat gtattttcca actctaagca atcagagtgc tgaggcaacg gatataggaa
    12001 atatagggga tgcaataagg aattataaat acgaggaaat tagtgttgat agtgaagatg
    12061 ccgttgttag tgaaaaagag gttattgtaa ctaaaaaaat gttgaatgaa ggtggaaact
    12121 ctgtacaaat agaaaaaaat
//
