BGC0000495: actagardine biosynthetic gene cluster from Actinoplanes garbadinensis
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Location: 1 - 38,168 nt. (total: 38,168 nt).
This entry is originally from NCBI GenBank FJ547091.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000495
Short description actagardine biosynthetic gene cluster from Actinoplanes garbadinensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: FJ547091.1
Compounds
  • actagardine
Species Actinoplanes garbadinensis [taxonomy]
References
Chemical products information
actagardine
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C81H132N20O23
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACR33034.1
 42 - 482 (-) hypothetical protein
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  • ACR33035.1
 2375 - 2824 (-) hypothetical protein
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  • ACR33036.1
 2876 - 4432 (-) ATPase AAA
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  • ACR33037.1
 5391 - 6002 (-) sugar hydrolase
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  • ACR33038.1
 5825 - 6484 (-) endoglucanase
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  • ACR33039.1
 6627 - 7112 (+) cytosine/adenine deaminase
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  • ACR33040.1
 7756 - 8997 (+) hypothetical protein
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  • ACR33041.1
 8933 - 9616 (-) hypothetical protein
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  • ACR33042.1
 10108 - 11901 (-) pyruvate oxidase
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  • ACR33043.1
 12195 - 12866 (+) hydrolase
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  • ACR33044.1
 13116 - 14306 (+) aldose epimerase
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  • ACR33045.1
 14385 - 15521 (+) ABC sugar transport periplasmic component
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  • ACR33046.1
 15514 - 16572 (+) ABC sugar transport permease
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  • ACR33047.1
 16569 - 17330 (+) ABC transport protein ATP-binding
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  • ACR33048.1
 17335 - 18102 (-) methyltransferase
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  • ACR33049.1
 18120 - 18962 (-) ABC transport permease
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  • ACR33050.1
 18991 - 19896 (-) ABC transport permease
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  • ACR33051.1
 19899 - 21236 (-) substrate binding ABC transporter
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  • ACR33052.1
  • garA
 21572 - 21766 (+) actagardine prepeptide
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  • ACR33053.1
  • garM
 21837 - 24998 (+) actagardine modification enzyme
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  • ACR33054.1
  • garO
 25024 - 26034 (+) monooxygenase
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  • ACR33055.1
  • garR1
 26096 - 26791 (-) response regulator
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  • ACR33056.1
  • garH
 26885 - 29323 (-) ABC transporter associated permease
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  • ACR33057.1
  • garT
 29326 - 30105 (-) ABC transporter
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  • ACR33058.1
  • garK
 30220 - 31338 (+) response regulator
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  • ACR33059.1
  • garR
 31335 - 31997 (+) response regulator
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  • ACR33060.1
 32084 - 34486 (+) penicillin binding protein
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  • ACR33061.1
 34448 - 35209 (-) methyltransferase
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  • ACR33062.1
 35245 - 36030 (-) hydrolase
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  • ACR33063.1
 36152 - 36820 (+) response regulator
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  • ACR33064.1
 36829 - 37689 (+) fructose bisphosphate aldolase
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  • ACR33065.1
 37590 - >38168 (+) putative hydrolase
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RiPP-specific information
Subclass Lanthipeptide
Cyclic? no
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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