BGC0000495: actagardine biosynthetic gene cluster from Actinoplanes garbadinensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 38,168 nt. (total: 38,168 nt).
This entry is originally from NCBI GenBank FJ547091.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000495
Short description actagardine biosynthetic gene cluster from Actinoplanes garbadinensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
FJ547091.1
via
Compounds
  • actagardine
Species Actinoplanes garbadinensis [taxonomy]
References
Chemical products information
actagardine Evidence:
Copy SMILES
C81H132N20O23
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACR33034.1
42 - 482 (-) hypothetical protein
    copy AA seq
    copy Nt seq
    • ACR33035.1
    2375 - 2824 (-) hypothetical protein
      copy AA seq
      copy Nt seq
      • ACR33036.1
      2876 - 4432 (-) ATPase AAA
        copy AA seq
        copy Nt seq
        • ACR33037.1
        5391 - 6002 (-) sugar hydrolase
          copy AA seq
          copy Nt seq
          • ACR33038.1
          5825 - 6484 (-) endoglucanase
            copy AA seq
            copy Nt seq
            • ACR33039.1
            6627 - 7112 (+) cytosine/adenine deaminase
              copy AA seq
              copy Nt seq
              • ACR33040.1
              7756 - 8997 (+) hypothetical protein
                copy AA seq
                copy Nt seq
                • ACR33041.1
                8933 - 9616 (-) hypothetical protein
                  copy AA seq
                  copy Nt seq
                  • ACR33042.1
                  10108 - 11901 (-) pyruvate oxidase
                    copy AA seq
                    copy Nt seq
                    • ACR33043.1
                    12195 - 12866 (+) hydrolase
                      copy AA seq
                      copy Nt seq
                      • ACR33044.1
                      13116 - 14306 (+) aldose epimerase
                        copy AA seq
                        copy Nt seq
                        • ACR33045.1
                        14385 - 15521 (+) ABC sugar transport periplasmic component
                          copy AA seq
                          copy Nt seq
                          • ACR33046.1
                          15514 - 16572 (+) ABC sugar transport permease
                            copy AA seq
                            copy Nt seq
                            • ACR33047.1
                            16569 - 17330 (+) ABC transport protein ATP-binding
                              copy AA seq
                              copy Nt seq
                              • ACR33048.1
                              17335 - 18102 (-) methyltransferase
                                copy AA seq
                                copy Nt seq
                                • ACR33049.1
                                18120 - 18962 (-) ABC transport permease
                                  copy AA seq
                                  copy Nt seq
                                  • ACR33050.1
                                  18991 - 19896 (-) ABC transport permease
                                    copy AA seq
                                    copy Nt seq
                                    • ACR33051.1
                                    19899 - 21236 (-) substrate binding ABC transporter
                                      copy AA seq
                                      copy Nt seq
                                      • ACR33052.1
                                      • garA
                                      21572 - 21766 (+) actagardine prepeptide
                                        copy AA seq
                                        copy Nt seq
                                        • ACR33053.1
                                        • garM
                                        21837 - 24998 (+) actagardine modification enzyme
                                          copy AA seq
                                          copy Nt seq
                                          • ACR33054.1
                                          • garO
                                          25024 - 26034 (+) monooxygenase
                                            copy AA seq
                                            copy Nt seq
                                            • ACR33055.1
                                            • garR1
                                            26096 - 26791 (-) response regulator
                                              copy AA seq
                                              copy Nt seq
                                              • ACR33056.1
                                              • garH
                                              26885 - 29323 (-) ABC transporter associated permease
                                                copy AA seq
                                                copy Nt seq
                                                • ACR33057.1
                                                • garT
                                                29326 - 30105 (-) ABC transporter
                                                  copy AA seq
                                                  copy Nt seq
                                                  • ACR33058.1
                                                  • garK
                                                  30220 - 31338 (+) response regulator
                                                    copy AA seq
                                                    copy Nt seq
                                                    • ACR33059.1
                                                    • garR
                                                    31335 - 31997 (+) response regulator
                                                      copy AA seq
                                                      copy Nt seq
                                                      • ACR33060.1
                                                      32084 - 34486 (+) penicillin binding protein
                                                        copy AA seq
                                                        copy Nt seq
                                                        • ACR33061.1
                                                        34448 - 35209 (-) methyltransferase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • ACR33062.1
                                                          35245 - 36030 (-) hydrolase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • ACR33063.1
                                                            36152 - 36820 (+) response regulator
                                                              copy AA seq
                                                              copy Nt seq
                                                              • ACR33064.1
                                                              36829 - 37689 (+) fructose bisphosphate aldolase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • ACR33065.1
                                                                37590 - >38168 (+) putative hydrolase
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Similar known gene clusters from MIBiG 4.0
                                                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                                  Click on an accession to open that entry in the MiBIG database.