BGC0000497 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000497 (Streptococcus ratti)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	11,249	SmbA / SmbB	RiPP:Lanthipeptide	100%

BGC0000497 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 11,249 nt. (total: 11,249 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 11,250
Label		BGC0000497

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000497.1	1.00	RiPP	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000552.1	0.76	RiPP	SmbA, SmbB	Streptococcus mutans
BGC0001229.1	0.32	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001579.1	0.31	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.31	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.1	0.31	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000523.1	0.29	RiPP	lactocin S	Lactobacillus sakei
BGC0000539.1	0.29	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000504.1	0.27	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.27	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000497.1	1.00	RiPP	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000552.1	0.92	RiPP	SmbA, SmbB	Streptococcus mutans
BGC0001229.1	0.65	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001579.1	0.64	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000525.1	0.64	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.1	0.64	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000523.1	0.63	RiPP	lactocin S	Lactobacillus sakei
BGC0000539.1	0.62	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000504.1	0.61	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.61	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for bhtM1

bhtA_beta

Leader:

MKSNLLKINNVTEVEKDMVTLIKDEDMELAGG

Core:

STPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

DhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

bhtA_alpha

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysQ

Lanthipeptide(s) for bhtM2

bhtA_beta

Leader:

MKSNLLKINNVTEVEKDMVTLIKDEDMELAGG

Core:

STPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

DhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

bhtA_alpha

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysQ

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

bhtA_beta - Class II

Cleavage pHMM score: 2.60

RODEO score: 0

Monoisotopic mass: 2748.5 Da

Molecular weight: 2750.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2768.3 Da N = 1; 2786.3 Da N = 2; 2804.3 Da N = 3; 2822.3 Da N = 4; 2840.3 Da N = 5

bhtA_alpha - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3323.7 Da

Molecular weight: 3325.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3343.9 Da N = 1; 3361.9 Da N = 2; 3379.9 Da N = 3; 3397.9 Da N = 4

bhtA_beta - Class II

Cleavage pHMM score: 2.60

RODEO score: 0

Monoisotopic mass: 2748.5 Da

Molecular weight: 2750.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2768.3 Da N = 1; 2786.3 Da N = 2; 2804.3 Da N = 3; 2822.3 Da N = 4; 2840.3 Da N = 5

bhtA_alpha - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3323.7 Da

Molecular weight: 3325.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3343.9 Da N = 1; 3361.9 Da N = 2; 3379.9 Da N = 3; 3397.9 Da N = 4