BGC0000500 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000500 (Carnobacterium maltaromaticum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	8,863	High	carnolysin A1/carnolysin A2	ribosomal:RiPP:Lanthipeptide

BGC0000500 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 8,863 nt. (total: 8,863 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,864
Label		BGC0000500

Tailoring functions

Hydrolases: protease

crnP: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

crnM: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	1.00	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001210.5	0.49	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001407.5	0.48	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000517.4	0.48	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002704.2	0.46	ribosomal	archalan β	Halorussus salinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	1.00	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001210.5	0.49	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001407.5	0.48	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000517.4	0.48	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002704.2	0.46	ribosomal	archalan β	Halorussus salinus

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for crnM

crnA1

Leader:

MSELSMEKVVGETFEDLSIAEMTMVQGS

Core:

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

Core with dehydrations:

GDINGEFDhbDhbDhaPACysVYDhaVMVVDhaKADhaDhaAKCysAAGADhaAVDhaGAILDhaAIRCys

antiSMASH-DB 4.0 matches for crnA1

100.0%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12140_lanthipeptide

Lanthipeptides: IV75_RS14640_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

66.7%

NZ_JAFLVY010000007.1:

Lanthipeptides: JZO73_RS03905_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

GD+NGEFTTSPAC+YSVMV K SS C AGAS GA++S RC

GDVNGEFTTSPACLYSVMVTLKTSSVPC-AGASV--GAVVSIARC

62.2%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14440_lanthipeptide

Lanthipeptides: NW963_RS14080_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

GD+NGEFTTSPACVYS + S+ASS C G +A GA+LSA++C

GDMNGEFTTSPACVYSAVFASRASSKACIGGLTAAGGAVLSALKC

with 28 more sequence matches

Only the first 10 are displayed here.

61.2%

NZ_JADNGS010000002.1:

Lanthipeptides: I2D92_RS06835_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKC--AAG--ASAVSGAILSAIRC

GD++GEFTTSPACVY + S+ASS KC A+G AS VS A+LSA++C

GDVSGEFTTSPACVYVSVAASRASSQKCGQASGAIASFVSTAVLSAVKC

57.1%

NZ_QICS01000003.1:

Lanthipeptides: C8E03_RS08695_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCA---AG-ASAVSGAILSAIRC

GD+ EFTTSPACV + ++ASSA+CA AG AS VSGA+ SA++C

GDVGAEFTTSPACVALSVAATQASSARCAIASAGVASLVSGAVHSALKC

51.1%

NZ_CP086395.1and 1 other:

NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11180_lanthipeptide

Lanthipeptides: LMK00_RS10665_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

GD+ TSPAC+YS+ V K SS C AGAS GA++S +RC

GDVQAR--TSPACLYSIAVTIKTSSVWC-AGASV--GAVISIVRC

51.1%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00025_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

GDI E T+P C +V ASSA CA ASAVSG +LS +C

GDITPE--TTPVCAATV-----ASSAYCAGAASAVSGIVLSVFKC

48.0%

NZ_JAFHCX010000012.1and 1 other:

NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04080_lanthipeptide

Lanthipeptides: JXW96_RS06960_lanthipeptide

GDINGEFT-TSPACVYSVMVVSKASSAKCAAGAS----AVSGAILSAIRC

GD++ E T T+PAC S++ +KASS CA A+ A+SGAI+SA++C

GDMSAELTPTTPACYASIIYTAKASSPNCAYAATAISGAISGAIISAVKC

44.4%

NZ_SDJV01000024.1:

Lanthipeptides: ES032_RS12705_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

GD+ E T+PAC+YSV V + SS CA A GA++S ++C

GDVQVE--TTPACLYSVYVTANVSSVWCAG---ATVGAVISIVKC

44.0%

NZ_JAQCQD010000003.1:

Lanthipeptides: PGZ38_RS05485_lanthipeptide

GDINGEFT-TSPACVYSVMVVSKASSAKCAAG----ASAVSGAILSAIRC

GD++ E T T+PAC S++ ++ASS CA +SA+SGA++SA++C

GDMSAELTPTTPACFASIIYTARASSPNCAHALSVISSAISGAVISAVKC

42.2%

NZ_JACWFH010000015.1:

Lanthipeptides: H0185_RS13725_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

GD+ GE TT P ++V SS CA A AV G LS +C

GDVQGETTTFPC--FAVAYYGVQSSVSCAYAAGAVVGVGLSVWKC

37.8%

NZ_JACSJU010000005.1:

Lanthipeptides: KNO78_RS14605_lanthipeptide

GDINGEFTTSPACVYSVMVVSKASSAKCA-AGASAVSGAILSAIRC

GD+ E T + + + V + SS KCA G + VSG +LS +C

GDVGAELTPTTSTYLCIGVGIRLSSQKCAYVGGTIVSG-VLSNAKC

37.3%

NZ_CP091282.1:

Lanthipeptides: L2Z53_RS12185_lanthipeptide

GDINGEFTTSPACVYS---VMVVSKASSAKCAAGASAV----SGAILSAI-RC

GD+N E T+P+ + + + SSA CA G + +GAILS+ RC

GDVNAE--TTPSLIMTSPYYQAAATVSSAGCATGVGGLIGVGAGAILSSTKRC

crnA2

Leader:

MSESNMKKVVGETFEDLSIAEMTKVQGS

Core:

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

Core with dehydrations:

GDVMPEDhaDhbPICysAGFADhbLMDhaDhaIGLVKDhbIKGKCys

antiSMASH-DB 4.0 matches for crnA2

100.0%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

74.2%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00020_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

GD+ PESTP+CA FATL S I LVKTIKG C

GDITPESTPVCAAFATLASGIALVKTIKGNC

64.5%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

GDV PEST +CA FA+ SI LVKT+K KC

GDVTPESTTVCAAFASFAGSIQLVKTLKSKC

with 108 more sequence matches

Only the first 10 are displayed here.

64.5%

NZ_JAFLVY010000007.1:

Lanthipeptides: JZO73_RS03920_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

GDV PES + + FATL SSI LVKT+KG C

GDVNPES--VASFFATLASSIALVKTLKGHC

58.1%

NZ_SDJV01000024.1:

Lanthipeptides: ES032_RS12700_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

GDV E+TP CA A+++ S G+VKTIKG C

GDVQVETTPACAFTASILVSYGVVKTIKGHC

56.2%

NZ_JADMPO010000001.1:

Lanthipeptides: I2I27_RS01390_lanthipeptide

GDVMPE-STPICAGFATLMSSIGLVKTIKGKC

GDV E +TPICA T SI + KT+KGKC

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

54.8%

NZ_CP086395.1and 1 other:

NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11185_lanthipeptide

Lanthipeptides: LMK00_RS10670_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

GDV STPIC A + SI +VKT+KG+C

GDVEVRSTPICTFTAGVTVSIVIVKTLKGRC

54.8%

NZ_FUXI01000002.1:

Lanthipeptides: B5D30_RS01205_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

GDV E+T +CA FAT +I +V+TIK KC

GDVNTETTTVCAVFATACGAIQVVRTIKKKC

48.4%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

GDVMPESTPIC-AGFATLMSSIGLVKTIKG

GDV PE+TP C AGF T+ IG + + G

GDVKPETTPACLAGF-TVGLGIGALASAAG

48.4%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

GDVMPESTPIC-AGFATLMSSIGLVKTIK

DV PE+TP C A FAT GL+ +IK

SDVAPETTPACVAAFAT-----GLLFSIK

48.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIK

GDV PE+TPIC GF T+ IG + ++K

GDVQPETTPIC-GF-TIGIGIGALASVK

48.4%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

GDVMPESTPIC-AGFATLMSSIGLVKTIKG

GDV PE+TP C AGF T+ IG + + G

GDVKPETTPACLAGF-TIGLGIGALASAAG

45.2%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

GDVMPESTPICAGFATLMSSIGLVKTIK

GDV PE+TP+C GF T+ IG + ++K

GDVQPETTPLC-GF-TIGIGIGALVSVK

MIBiG 4.0 matches for crnA2

16.1%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

STPICAGFATLMSSI

+T C G TL++++

ATCECVGLLTLLNTV

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

crnA1 - Class II

Cleavage pHMM score: -0.60

RODEO score: 0

Monoisotopic mass: 4169.1 Da

Molecular weight: 4171.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4189.8 Da N = 1; 4207.8 Da N = 2; 4225.8 Da N = 3; 4243.8 Da N = 4; 4261.9 Da N = 5; 4279.9 Da N = 6; 4297.9 Da N = 7

crnA2 - Class II

Cleavage pHMM score: -1.50

RODEO score: 0

Monoisotopic mass: 3045.6 Da

Molecular weight: 3047.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3065.7 Da N = 1; 3083.7 Da N = 2; 3101.7 Da N = 3; 3119.7 Da N = 4