LOCUS       BGC0000503             17083 bp    DNA     linear   BCT 24-JUL-2016
DEFINITION  Streptomyces cinnamoneus cinnamycin biosynthetic cluster.
ACCESSION   BGC0000503
VERSION     BGC0000503
KEYWORDS    .
SOURCE      Streptomyces cinnamoneus
  ORGANISM  Streptomyces cinnamoneus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces cinnamoneus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:45:11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17083
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(<1..346)
                     /codon_start=1
                     /gene="cinorf3"
                     /note="putative integral membrane protein"
                     /product="Cinorf3 protein"
                     /protein_id="CAD60516.1"
                     /transl_table=11
                     /translation="MTPVFALATSLMWGLADFGGGLLTRRMPALTVVLVSQLLAVLALG
                     AIVIGTGGWSEAGPQLWYAVAAGVVGPAAMLAFYKALALGPMGVVSPLGALGGVAVPLG
                     VGLVLGERPGI"
     gene            complement(<1..359)
                     /gene="cinorf3"
     source          1..17083
                     /db_xref="taxon:53446"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces cinnamoneus"
                     /strain="type strain DSM 40005"
     subregion       1..17083
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000503"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17083
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..15325
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2058:5325]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2059..5325
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..15325
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     regulatory      complement(355..359)
                     /gene="cinorf3"
                     /regulatory_class="ribosome_binding_site"
     regulatory      442..446
                     /gene="cinorf4"
                     /regulatory_class="ribosome_binding_site"
     gene            442..1026
                     /gene="cinorf4"
     CDS             454..1026
                     /codon_start=1
                     /function="putative regulatory protein"
                     /gene="cinorf4"
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 116; E-value: 3.8e-35)"
                     /gene_kind="other"
                     /product="Cinorf4 protein"
                     /protein_id="CAD60517.1"
                     /transl_table=11
                     /translation="MTDLDQLTQSLARNLKRWRGERHFTLDALAARSGVSRGMIIQIEQ
                     ARTNPSVGTTVKLADALGVSITTLLDYEQGARVRLVPEEQVVRMWSTEAGSHTSLLVGA
                     DVRGPLELWDWRLVSGDSSVSDPHPPGTVEMLTVRSGRLTLVVDGEEHEVAAGTSATFE
                     ADAPHTYRNDGTEPVEMTMVVAVPPAG"
     stem_loop       1040..1084
     CDS             1109..1198
                     /codon_start=1
                     /note="smallorf; probably an artifact of a repetitive
                     section of DNA"
                     /product="hypothetical protein"
                     /protein_id="CAD60518.1"
                     /transl_table=11
                     /translation="MKTVLPKAVLPKAVFRKAVLPKTVLLKAE"
     protein_bind    1185..12111
                     /bound_moiety="putative CinR1"
     regulatory      1223..1228
                     /gene="cinorf7"
                     /regulatory_class="minus_10_signal"
     gene            1223..1626
                     /gene="cinorf7"
     regulatory      1250..1254
                     /gene="cinorf7"
                     /regulatory_class="ribosome_binding_site"
     CDS             1267..1626
                     /codon_start=1
                     /gene="cinorf7"
                     /product="Cinorf7 protein"
                     /protein_id="CAD60519.1"
                     /transl_table=11
                     /translation="MKSAKEPTIYQDVDIIRRIQELMVLCSLLPPDGKLREALEFALSL
                     HEEPVLARITPLTNLHPFATKAWLESLWLGDGVSSEEKELVAWQNNSDNMGPAIRELKN
                     AEQQSGIRLVAQLTS"
     regulatory      1660..1664
                     /gene="cinA"
                     /regulatory_class="ribosome_binding_site"
     gene            1660..1907
                     /gene="cinA"
     CDS             1671..1907
                     /codon_start=1
                     /function="cinnamycin precursor"
                     /gene="cinA"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="preprocinnamycin"
                     /protein_id="CAD60520.1"
                     /transl_table=11
                     /translation="MTASILQQSVVDADFRAALLENPAAFGASAAALPTPVEAQDQASL
                     DFWTKDIAATEAFACRQSCSFGPFTFVCDGNTK"
     CDS_motif       1671..1847
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MTASILQQSVVDADFRAALLENPAAFGASAAALPTPVEAQDQASLDFWTKDIAATEAFA
                     "
                     /locus_tag="cinA_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1848..1907
                     /prepeptide="core"
                     /locus_tag="cinA_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="2025.3"
                     /monoisotopic_mass="2023.9"
                     /core_sequence="CRQSCSFGPFTFVCDGNTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTASILQQSVVDADFRAALLENPAAFGASAAALPTPVEAQD
                     QASLDFWTKDIAATEAFA"
                     /leader_location="[1670:1847](+)"
                     /alternative_weights="2043.3"
     stem_loop       1948..1986
     regulatory      2045..2049
                     /gene="cinM"
                     /regulatory_class="ribosome_binding_site"
     gene            2045..5325
                     /gene="cinM"
     CDS             2059..5325
                     /codon_start=1
                     /function="putative preprocinnamycin modification enzyme.
                     Introduces lanthionine residues"
                     /gene="cinM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     748.5; E-value: 2e-226)"
                     /gene_kind="biosynthetic"
                     /note="gene contains the rare Streptomycete leucine codon
                     TTA"
                     /product="CinM protein"
                     /protein_id="CAD60521.1"
                     /sec_met_domain="DUF4135 (E-value: 1.4e-78, bitscore:
                     255.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.1e-82, bitscore:
                     266.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGMGNAYPLDIAARAANLTERLRVVAAAGGEAAVRDNTVELDAFD
                     RWKADTLAGKLADKFHQESLHRGRPPQHTKDELAGVLSAYRRLELGLDTADDDVRTLLG
                     ELQSAWLPAYRAALDAHDAARDDERADAQPGEEPGWRGFDVYYGRLAKACEPFLRELGR
                     GLGAARDAAQGEGAALSPQLAEDIQRHLLDRFELSLAWAVEADANVHCTQAGIDKAEAT
                     REDYLAYLDTTFSDSAAYHRFYLKFPVLGRWLAHTTALLTAFGRDLFDSLAADAEAIGT
                     EFFGQPVTAFTSLRLGDSDPHAGARTVARVAVVLADGRTGEFFYKPRSVRSEAALQDVL
                     ARLADDGVVDFATRPVLPRDGYGYEALIPAGRNRVETPEEVTRIYRELGGYLALFYVLG
                     GSDLHFENVIVADGHAFVCDAETVLGVHPQGRAQSEGTLLDSVFKTGLLEWPRAASPGE
                     EAAAEMRISGYAGGEGYDVPVPVARRTGEGLTFAASVVHKTGVHVETSASNRVYLGEEL
                     VRPEDHVESIMEGFNRVYDWFAEDPDASVDYLMETFSWVTARFINWGTQIYAQLLSAAR
                     HPRCLTEPLEVDLLANTVRTFPRTWDAEGVLAGREVAAMWQMDVPLFTAAAHARQLVHG
                     HGDPLSARLDSSPIDHAAARIRRLSQRNREQQSQYIAASLSTGEISSPAFVATSLDYAA
                     RIGDRLCDELRAPAAPAPWTSYQLSGESLAEVDIEADLYQGSAGVVLFLAYLDQLVPRP
                     AYRKAARQALDHVLVHWDRDRLGAFAGLGGVVYLLTHLHRLWGDEELLDLAVRLSDELP
                     ARIDEDRHFDILHGAAGLIPVLLGLAQETGGHGIEHAHRCAEHLLRHAEDDGTTLSWPP
                     SAADETYGNLTGFSHGSGGIGWALIQLGRHTGRSDYIEAGRKAFAYEDRHVDEQEKDWY
                     DLRINNGSAVKGARHFSNAWCNGAAGIGLARISSWAALDRSDEQLLRDAQQALSATLRN
                     FPRLKNHTLCHGTSGNAELLLRFARLSDEPAFQLEANVQVQALWRSLDEAGGGAGGGSA
                     DFFPGLMIGISGFGMHFLRLAAPDRVPSVLLLDPPSHHEQ"
     misc_feature    2122..2124
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     regulatory      5326..5350
                     /gene="cinX"
                     /regulatory_class="ribosome_binding_site"
     gene            5326..6317
                     /gene="cinX"
     CDS             5340..6317
                     /codon_start=1
                     /gene="cinX"
                     /product="CinX protein"
                     /protein_id="CAD60522.1"
                     /transl_table=11
                     /translation="MALKTCEEFLRDALDPARFGREMKAVTEVPEIVELGRRHGYGFTA
                     EEFLTKAMTFDGTAAGGTAAGGPEAGGQQAPRQTPPPGTPANGAPAPATATSFAHYEYR
                     LDDLPEFAPVVAELPRLKVMPPSARLDRFAGHFREEDARTVSTSPADPAYQAWHRDLAA
                     RGWQDEGAAPGAPRRDFHLVNLDEHVDYPGYEDYFAAKTRVVAALENLFGGEVRASGSM
                     WYPPSSYRLWHTNADQPGWRMYLVDVDRPFADPGQTSFFRYLHPRTREIVTLTESPRIV
                     RFFKVEQDPEKLFWHCIANPTDRHRWSFGYVVPETWMDALRHHG"
     stem_loop       6434..6494
     regulatory      6531..6535
                     /gene="cinT"
                     /regulatory_class="ribosome_binding_site"
     gene            join(6531..6535,6543..7472)
                     /gene="cinT"
     CDS             6543..7472
                     /codon_start=1
                     /function="ABC transporter ATPase subunit"
                     /gene="cinT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 209.8; E-value:
                     7.6e-64)"
                     /gene_kind="transport"
                     /product="CinT protein"
                     /protein_id="CAD60523.1"
                     /transl_table=11
                     /translation="MRGIDLTVAQGETFGFLGPNGAGKTTTISMLTTLATPTTGRIEIA
                     GHDTRTAPQQVRRNLGLVFQETTLDPELTAVENLRFHADLYALPRAGLAGRIAEMLELV
                     GLSARGDSLGRTFSGGMQRRLEIARGLLHRPRLLFLDEPTIGLDPQTRAQVWAHLAEVR
                     EREATTIFLTTHYLDEAEQCDRIAIIDDGRIVAQGSPAELKSVIGADRVDLRTGDDMAA
                     AALLHERFGLAAVRGPNGLSVKVAEGARLVPALCAALDVAVYEVTVTRPSLDDVFLHHT
                     GRGIRDDALPGAAGTAGTAEPSDSGDST"
     gene            7469..8341
                     /gene="cinH"
     CDS             7469..8341
                     /codon_start=1
                     /function="ABC transporter membrane component"
                     /gene="cinH"
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 153.3; E-value: 1.1e-46)"
                     /gene_kind="transport"
                     /note="probably translationally coupled to cinT"
                     /product="CinH protein"
                     /protein_id="CAD60524.1"
                     /transl_table=11
                     /translation="MTHATVALPAADRHAPGRLAAEWRAGSMVWRREMIHFLRSRAGIA
                     VSLLQPLLFLYVLGIGLSRMFSGAGSSDDYMIFLFPGVLVMAAQAPAISVGASIVWDRQ
                     SGFLREMLVAPVRRSTLLIGKCLGGATVAACQGAVVLASAGLVGVPYRVDLFAALLAEL
                     LLASLAMTVLGAVIAVRIQRIQTFHTALTVLTAPMVFLSGLMFPVSAMPAWMAALTLVN
                     PLTYAVDAMRQTITAFHPAPAAGASGAPIFDPVSWGGWDVPPGLSVVLVAVFSALALAA
                     ASRRFSRTD"
     regulatory      8432..8436
                     /gene="cinY"
                     /regulatory_class="ribosome_binding_site"
     gene            8432..9466
                     /gene="cinY"
     sig_peptide     8444..8554
                     /gene="cinY"
     CDS             8444..9466
                     /codon_start=1
                     /gene="cinY"
                     /note="secreted protein; gene contains the rare
                     Streptomycete leucine codon TTA in the region encoding the
                     putative signal peptide"
                     /product="CinY protein"
                     /protein_id="CAD60525.1"
                     /transl_table=11
                     /translation="MRSTRRLSLRRRSALLMGAASLAAPALLTVQAGEAQAFGTINSLG
                     QRAEHERITRAALACAAGTSSDGSCFEARSIDQVAGHTGTFGAVGSPDSDEIFTPEAHC
                     DDADYLTASGYPRTRQQASDQLVACISKLQGRFSQGVAAGSGTLNGDGTVSPGNSDLSQ
                     DCTFTGGVPGRGKCNAIEGFGRALHGVQDFYSHSNWADKADPNQAVGVNNPPGLNMSGP
                     APLLSLKSGRPPAASSVPAQLSTGCFSLNPWGCSGRVTHSTLNKDTGLIDPASGATSDP
                     TTNRGRITGNFDRAVKGAIADTRRQWADFRTALTERYGQERGQRIACVLTHDNPVRDCR
                     "
     misc_feature    8468..8470
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     stem_loop       9485..9519
     CDS             complement(9545..10171)
                     /codon_start=1
                     /gene="cinZ"
                     /product="CinZ protein"
                     /protein_id="CAD60526.1"
                     /transl_table=11
                     /translation="MQDEYRTVALEGVHEIEISRSRFICALAPAATEEEAQAFLARIRK
                     EHPTARHHCWAYVLGADGSVQKASDDGEPGGTAGVPMLQMLLRRDMRYVVAVVTRYFGG
                     VKLGAGGLIRAYGGVVGEALDELGTVTHKRFRLATVTVDHQRAGKLQNDLRATGREVRE
                     VAYGEGVRIGIGLPEADVEGFRAWLADTTAGTAVLELGGEAYGDA"
     gene            complement(9545..10184)
                     /gene="cinZ"
     regulatory      complement(10180..10184)
                     /gene="cinZ"
                     /regulatory_class="ribosome_binding_site"
     regulatory      10237..10241
                     /gene="cinorf8"
                     /regulatory_class="ribosome_binding_site"
     gene            10237..10665
                     /gene="cinorf8"
     CDS             10246..10665
                     /codon_start=1
                     /function="putative CoA binding protein"
                     /gene="cinorf8"
                     /product="Cinorf8 protein"
                     /protein_id="CAD60527.1"
                     /transl_table=11
                     /translation="MFAEPGIIQKIIEGTGDTWALVGLSANEQRAAYGVAEVLQRHGKR
                     IVPVHPKAETVHGELGYASLADIPFDVDVVDVFVRSELAGAVADEAVEIGAKAVWFQLG
                     VIDEEAYDRTRGAGLLMVMDRCPAIELGRPRGRAV"
     stem_loop       10724..10756
     regulatory      10739..10743
                     /gene="cinorf9"
                     /regulatory_class="ribosome_binding_site"
     gene            10739..11078
                     /gene="cinorf9"
     sig_peptide     10758..10844
                     /gene="cinorf9"
     CDS             10758..11078
                     /codon_start=1
                     /gene="cinorf9"
                     /note="secreted protein"
                     /product="Cinorf9 protein"
                     /protein_id="CAD60528.1"
                     /transl_table=11
                     /translation="MRKSLAVAAASAVAGLTLMAGTPANAAPAAATTVPSCVTSTFSTP
                     FFAMVRVDMENKCTTEQRVKPSFNYELKDVPCYALQPGQKAVFSRDVIFASGYTFAGLV
                     SC"
     gene            complement(11111..11761)
                     /gene="cinR"
     CDS             complement(11111..11761)
                     /codon_start=1
                     /function="response regulator"
                     /gene="cinR"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 171.9; E-value:
                     1.8e-52)"
                     /gene_kind="regulatory"
                     /note="probably translationally coupled to cinK"
                     /product="CinR protein"
                     /protein_id="CAD60529.1"
                     /transl_table=11
                     /translation="MIRTLIVDDDSLVRLALADILDDVPGIEVVAQAGDGLEAVQRAGA
                     LRVDVALMDVRMPRMDGIAATERLRALPSPPEVVMLTTFDLDQYVYDALAAGASGFLLK
                     DTDPAEIIRAIQVVAAGQAMLHPAAARRLVDRYHRTASRDVQAAQQRLARLTPRESDVL
                     GLLAAGASNAEIADGLGMRESTVKAHVSRILAALEVGNRVQAALCARDAGLTV"
     CDS             complement(11758..12822)
                     /codon_start=1
                     /function="histidine kinase"
                     /gene="cinK"
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 177; E-value: 1.1e-53)"
                     /gene_kind="regulatory"
                     /product="CinK protein"
                     /protein_id="CAD60530.1"
                     /transl_table=11
                     /translation="MGAGATLWGPDTAVAAVGSLSLAVRYRVPLVTVVVTVCAAVVVGA
                     LLPLLVMLFYLASRGWRALGCACAAVALAGNWFAQPEQLLWSTRAYGPVLPFALVMVLG
                     LWADSRRRLEASLTAQVEHLRVERELRAKQARLSERARIAAEMHDVLAHRLSLLALHAG
                     ALQRRAATLPEPVADRLALLRTTSTEALGDLRDVLGVLRDPDHPELQGQRVPGLRELPA
                     LFDEARAAGQEIDAVVEGAAGPLPASHRLAVHRLVQEALTNARKHAPGAPVRVVVRYGP
                     PASSVEVHNRAGDPASAAGEPPVSSGYGLVGLAERVTALGGRLDYGPSGGGGWNIAADI
                     PVSTVEEHLAPGAA"
     gene            complement(join(11758..12822,12828..12832))
                     /gene="cinK"
     regulatory      complement(12828..12832)
                     /gene="cinK"
                     /regulatory_class="ribosome_binding_site"
     CDS             complement(12972..13058)
                     /gene="allorf_12972_13058"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_12972_13058"
                     /protein_id="allorf_12972_13058"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRQIHDHETRGRRGAHHRPLCDARSVRK"
     CDS_motif       complement(13014..13058)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MRQIHDHETRGRRGA"
                     /locus_tag="allorf_12972_13058_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12972..13013)
                     /prepeptide="core"
                     /locus_tag="allorf_12972_13058_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="1556.8"
                     /monoisotopic_mass="1555.8"
                     /core_sequence="HHRPLCDARSVRK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRQIHDHETRGRRGA"
                     /leader_location="[13013:13058](-)"
     regulatory      13246..13250
                     /gene="cinorf10"
                     /regulatory_class="ribosome_binding_site"
     gene            join(13246..13250,13257..13754)
                     /gene="cinorf10"
     CDS             13257..13754
                     /codon_start=1
                     /gene="cinorf10"
                     /product="Cinorf10 protein"
                     /protein_id="CAD60531.1"
                     /transl_table=11
                     /translation="MTRVLAGAVGPADRLDVVEINPRFVEILNGALRTDPAMSAASDRI
                     RIIPESITEMPIDHSYDVVVSCLPFTNFAPETVRSILDRYLSVLVPGGHLTFFGYLGTH
                     ATRSLLSSRKEAARHREVTDLLHDFTRRYASRQSVVWRNIPPARVWHVRAPEHATRAAD
                     AA"
     gene            13742..13746
                     /gene="cinorf11"
     regulatory      13742..13746
                     /gene="cinorf11"
                     /regulatory_class="ribosome_binding_site"
     gene            13754..14944
                     /gene="cinorf11"
     CDS             13754..14944
                     /codon_start=1
                     /gene="cinorf11"
                     /gene_functions="other (smcogs) SMCOG1188:hypothetical
                     protein (Score: 148; E-value: 3e-45)"
                     /gene_kind="other"
                     /note="overlaps cinR1 by 570bp"
                     /product="Cinorf11 protein"
                     /protein_id="CAD60532.1"
                     /transl_table=11
                     /translation="MPTADELLHGVPPAAAYGLVLGLVLLESVLLLGSFVPTLSLMLCA
                     GVLAQEGTLRLPLVVLCATTGVVAGDLLAQRTGRRLGPGLRRSRLGRRLPEAAWERAWS
                     VLQRRGGPALLVCRFVPVVRTFAPHLAGAAGMPYRRLAPYSLVAGLVWAGGEAGAGYVL
                     GASYDRLTAPGGGLPTVCAAAGVLLAAAAGLLVHRRRARRAVGGSGRAGQRQADVGAQD
                     RDVQMTQLAPGVHPELVAEDAADLRVRGQGLAPAAAAVEGEHQPLPQALAQRVLRGQRP
                     QVADDLVVAAEGEAGVVVALDGPDPLLHQPRHHVPVERVRAHAAERLAVPEGQCLGEGG
                     VLQCAVAELGGEPGAGGGFTEKSEIQTAGGDLDQVTAGRGVQQSGEPRAGCVQALS"
     CDS             complement(14375..15160)
                     /codon_start=1
                     /function="SARP"
                     /gene="cinR1"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     278; E-value: 3.3e-84)"
                     /gene_kind="regulatory"
                     /note="gene contains rare Streptomycete leucine codon TTA.
                     A potential binding site for CinR1 lies upstream of
                     cinorf7."
                     /product="CinR1 protein"
                     /protein_id="CAD60533.1"
                     /transl_table=11
                     /translation="MNRAISFRVLGPLSVTVGRKNVSLPSGRQRSLLAALLVHPGEIVP
                     VEKLVDLVWGDELPHSPRPALHTLLTRLRQSLDAAGAGLSGLLHTSPSGYLIEVPTGCL
                     DLTLFRESAARARLAAELGDRALEHSALTEALALWHGQPLGGVRSDALHRDVVPGLMEE
                     WIRAIERYHDACLALGRHDEIVGDLRTLTAKYPLRESLWQRLMLALYRCGRRGEALAAY
                     AEVSGVFRDELGVDPGRELRHLHVAILRTDVSLSLARSA"
     gene            complement(join(14375..15160,15165..15169))
                     /gene="cinR1"
     misc_feature    complement(14942..14944)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     regulatory      complement(15165..15169)
                     /gene="cinR1"
                     /regulatory_class="ribosome_binding_site"
     stem_loop       15207..15247
     regulatory      15372..15376
                     /gene="cinorf12"
                     /regulatory_class="ribosome_binding_site"
     gene            15372..15872
                     /gene="cinorf12"
     CDS             15381..15872
                     /codon_start=1
                     /gene="cinorf12"
                     /product="Cinorf12 protein"
                     /protein_id="CAD60534.1"
                     /transl_table=11
                     /translation="MSDSRPAPDRNDRPLLRQFDQRLSELIATTAGAEGNKRPGYARLA
                     KEIRDTTGRTISGTYLWELATGKKRNVTLEQLDVLAEFFGVPPEYFLDDETGRRIDDRR
                     RLAIALRDAKVRNLALRADGLSPDCLDALIAMVNEARKTQNLSSIDDDDDTATTLTSSG
                     "
     regulatory      15903..15907
                     /gene="cinorf13"
                     /regulatory_class="ribosome_binding_site"
     gene            15903..16496
                     /gene="cinorf13"
     CDS             15912..16496
                     /codon_start=1
                     /gene="cinorf13"
                     /product="Cinorf13 protein"
                     /protein_id="CAD60535.1"
                     /transl_table=11
                     /translation="MPRRTYVAYRRCLRKGQREPEMPYTSDAALRRRCRALLARVSLPE
                     PFSVEVLCRHLGEQRGRPIHLHPLPEQAALAGACGLWLATATDDHIFHERHTVRPHQEH
                     IVLHEIGHMLFDHHSLAPAGGPAGALLADLDPRLIRRLLARTNYSTRQEREAEMLASLI
                     RTSVRAGTGERPPGALGRLQAALGVVGSHGR"
     regulatory      16538..16542
                     /gene="cinorf14"
                     /regulatory_class="ribosome_binding_site"
     gene            16538..>17083
                     /gene="cinorf14"
     CDS             16549..>17083
                     /codon_start=1
                     /gene="cinorf14"
                     /product="Cinorf14 protein"
                     /protein_id="CAD60536.1"
                     /transl_table=11
                     /translation="MVLRCPYAVRHPAQRGLWLAVATAALAMTLTTSIGSVVPEAALGL
                     AGNLTGMVSAGAVLGFVITIMGGRRLHTWACGTVAATALALTVLGVTSRAHLSYGTIAE
                     IPPTATAYRLLLIGTHLAVNAACIAVCWRYGRGPSRSPLALGLRLFGIGTVLAELYWLR
                     LFAGLFTTSDALLRY"
ORIGIN
        1 ggatcccggg ccgttcgccc agcacgagcc ccacacccag cgggaccgcg acgccgccga
       61 gcgcgccgag gggggaaacc acgcccatgg ggcccagggc cagggccttg tagaaggcga
      121 gcatcgccgc cgggccgacg acgccggccg ccaccgcgta ccagagctgg ggcccggcct
      181 cggaccagcc gccggtgccg atcacgatcg cgcccagggc gaggacggcc agcagctggg
      241 agaccaggac cacggtcagg gcgggcatgc gccgggtgag cagcccgccg ccgaagtcgg
      301 ccagccccca catgaggctg gtggccaggg cgaagaccgg tgtcatgggg gagacctcgc
      361 agtacagtgt gatgaacggt ggcgtccacg acaccgtagt acacgatact cgacttacga
      421 gaataatatt ttggacggga tggatcgacc gacgtgacgg acctcgacca gctcacgcaa
      481 tcgctcgccc gcaacctcaa gcgctggcgc ggtgagcgcc acttcaccct cgacgccctg
      541 gcggcccgct ccggcgtcag ccgcggcatg atcatccaga tcgagcaggc ccggacgaac
      601 cccagcgtcg gcaccacggt gaagctcgcc gacgccctgg gcgtcagcat caccacgctg
      661 ctcgactacg agcagggcgc ccgcgtgcgg ctcgtgcccg aggagcaggt ggtgcgcatg
      721 tggtccaccg aggcgggcag ccacacctca ctgctcgtcg gcgccgatgt gcgcggccca
      781 ctggagctgt gggactggcg cctcgtgtcc ggcgacagca gcgtctcgga cccccacccg
      841 cccggcacgg tcgagatgct gaccgtacgg tcgggccgcc tcacgctcgt cgtcgacggc
      901 gaggagcacg aggtcgccgc cggcacctcg gccaccttcg aggccgacgc cccgcacacc
      961 taccgcaacg acggcaccga gcccgtcgag atgacgatgg tggtggccgt cccgcccgcg
     1021 ggctgacccc cgagcgcacg gggcccgccg ggagacgtcg agcgacgctc tcccggcggg
     1081 cccctgtgcg tggtggctcc gtgcgccggt gaagacggtg ctcccgaagg cggtgctccc
     1141 gaaggcggtg ttccggaagg cggtgctccc gaagacggtg ctcctgaaag cggagtgaaa
     1201 ccgtagtgaa agcggacgct cctagtgtcg ttctcaccgg gaaccgactg gatggggaaa
     1261 cgggccatga aaagtgccaa ggaaccgacg atctaccagg acgtggatat catccgccgc
     1321 atccaggagc tcatggttct gtgctccttg ctgccgcccg acggcaagct gcgtgaagcg
     1381 ctggagttcg ctctctcgct ccacgaggag ccggtactgg cccggatcac tcccctcacc
     1441 aatctccatc ccttcgcgac gaaagcctgg ctggagtccc tgtggctcgg cgacggcgtt
     1501 tccagcgagg agaaggagct ggtcgcctgg cagaacaaca gcgacaacat gggaccggcc
     1561 attcgtgaac tcaagaatgc cgaacagcaa tccggcatca ggctggtcgc acagctgacg
     1621 tcctgacacc cgccgggtgc cgggattcac ctcaacatcg gaggtaagcc atgaccgctt
     1681 cgattcttca gcagtccgtc gtggacgccg acttccgcgc ggcgctgctc gagaaccccg
     1741 ccgccttcgg cgcttccgcc gcggccctgc ccacgcccgt cgaggcccag gaccaggcgt
     1801 cccttgactt ctggaccaag gacatcgccg ccacggaagc cttcgcctgc cgccagagct
     1861 gcagcttcgg cccgttcacc ttcgtgtgcg acggcaacac caagtaagtg gctgctgcct
     1921 ctaggcggta atgctcgccc ggtgcgatga cgcggtgggc cggtgacctg ccggcccacc
     1981 gcgttgcgcc gcgcggcggc gcccctgcca cgagggtcac gaggctcctt cgacttcgac
     2041 cgcaggagaa attcgcatat gggtatgggt aacgcgtatc cgctggacat cgcagcacgg
     2101 gcggccaatc tgaccgaacg gttacgggtc gtggccgcgg cgggcggcga ggcggccgtg
     2161 cgggacaaca cggtcgagct cgacgccttc gaccgctgga aggccgacac gctggccgga
     2221 aaactggccg acaagttcca ccaggaatcg ctccaccgcg gccggccgcc ccagcacacc
     2281 aaggacgaac tcgccggcgt gctgtccgcc taccgtcgtc tggaactcgg cctggacacc
     2341 gcggacgacg acgtccggac gcttctcggc gagctgcaga gcgcctggct gcccgcctac
     2401 cgtgcggccc tcgacgccca cgacgccgcc cgcgacgacg aacgggccga cgcacagccg
     2461 ggcgaggagc ccggctggcg cgggttcgac gtgtactacg gccggctggc gaaggcgtgc
     2521 gagccgttcc tgcgcgaact gggtcgcggc ctgggcgccg cgcgcgacgc cgcacagggc
     2581 gaaggcgccg cgctctcccc gcagttggcc gaggacatcc agcgccacct gctcgaccgc
     2641 ttcgagctga gcctggcctg ggccgtggag gccgacgcca acgtgcactg cacgcaggcc
     2701 gggatcgaca aggccgaggc cacccgcgag gactacctcg cctacctcga caccacgttc
     2761 tccgacagcg ccgcctacca ccgcttctac ctgaagttcc ccgtgctcgg ccgctggctc
     2821 gcccacacca ccgccctgct caccgcgttc ggccgcgacc tcttcgacag cctggccgcc
     2881 gacgcggagg ccatcggcac cgaattcttc gggcagcccg tcaccgcgtt cacctcgctg
     2941 cgcctcggcg actccgaccc ccacgcgggc gcgcgcaccg tcgcccgcgt cgccgtcgtg
     3001 ctcgccgacg gacgcaccgg cgaattcttc tacaagccgc gcagcgtccg gtccgaggcg
     3061 gcgctccagg acgtcctcgc caggctggcg gacgacgggg tcgtcgactt cgcgacccgg
     3121 cccgtcctgc cccgggacgg ctacggctac gaggcgctga tccccgccgg ccgcaaccgc
     3181 gtcgagaccc ccgaagaagt cacccggatc taccgggaac tgggcggcta cctggcgctg
     3241 ttctacgtcc tgggcggcag cgacctccac ttcgagaacg tcatcgtcgc cgacggacac
     3301 gccttcgtct gcgacgccga gaccgtcctc ggcgtccacc cccaggggcg ggcacagtcg
     3361 gagggcaccc tcctcgactc cgtcttcaag accggactcc tcgaatggcc gcgcgccgcg
     3421 agcccgggcg aggaggccgc cgccgagatg cgcatcagcg gctacgcggg cggcgagggc
     3481 tacgacgtcc ccgtcccggt ggcccgccgc accggcgagg ggctcacctt cgcggcctcc
     3541 gtcgtgcaca agaccggcgt ccacgtcgag accagcgcct ccaaccgcgt ctacctcggc
     3601 gaggagctcg tgcgtcccga ggaccacgtc gagtcgatca tggagggctt caaccgcgtc
     3661 tacgactggt tcgccgagga ccccgacgcg tccgtcgact acctgatgga gacgttcagc
     3721 tgggtcaccg cccgcttcat caactggggc acccagatct acgcccagct gctgagcgcc
     3781 gcccgccacc cgcgctgcct caccgaaccc ctcgaagtgg acctgctcgc caacaccgtc
     3841 cgcaccttcc cccgcacctg ggacgccgag ggcgtcctgg ccggacggga agtggccgcc
     3901 atgtggcaga tggacgtgcc gctgttcacc gcggccgccc acgccaggca actcgtccac
     3961 gggcacggcg acccgctgtc cgcgcgcctg gacagctccc cgatcgacca cgcggccgcc
     4021 cgcatccggc ggctgtcgca gcggaaccgt gaacagcaga gccagtacat cgccgccagc
     4081 ctctcgaccg gcgagatcag cagccccgcc ttcgtcgcca cctccctgga ctacgcggcc
     4141 aggatcggcg accgcctgtg cgacgagctg cgggcccccg ccgcccccgc cccctggacc
     4201 tcctaccagc tgtccggcga gtccctcgcc gaagtggaca tcgaggccga cctctaccag
     4261 ggctccgccg gcgtcgtcct cttcctcgcc tacctcgacc agctcgtgcc ccgccccgcg
     4321 taccgcaagg ccgcccggca ggccctcgac cacgtcctcg tccactggga ccgcgaccgg
     4381 ctcggcgcct tcgccggact cggcggcgtc gtctacctcc tcacccacct gcaccgcctg
     4441 tggggcgacg aggagctcct cgacctggcc gtgcggctca gcgacgagct gcccgcgcgc
     4501 atcgacgagg accggcactt cgacatcctg cacggcgcgg ccggcctcat ccccgtcctg
     4561 ctcggcctgg cccaggagac cggcggccac ggcatcgagc acgcccaccg ctgcgccgaa
     4621 cacctgctgc gccacgccga ggacgacggc accaccctca gctggccccc ctccgcggcc
     4681 gacgagacgt acggcaacct caccggcttc tcgcacggct ccggcggcat cggctgggcg
     4741 ctcatccagc tcggccggca caccggccgg tccgactaca tcgaggccgg gcgcaaggcg
     4801 ttcgcctacg aggaccggca cgtcgacgag caggagaagg actggtacga cctgcggatc
     4861 aacaacggat ccgcggtcaa gggcgcccgt cacttctcca acgcctggtg caacggcgcg
     4921 gcgggcatcg gcctcgcccg catcagcagc tgggccgcgc tcgaccgcag cgacgaacaa
     4981 ctgctgcgcg acgcacagca ggccctgtcg gcgaccctcc ggaacttccc ccgcctgaag
     5041 aaccacaccc tgtgccacgg cacctccggc aacgccgaac tcctcctgcg cttcgcccgg
     5101 ctgagcgacg aacccgcctt ccagctggag gccaacgtcc aggtccaggc gctgtggcgg
     5161 agcctcgacg aggccggcgg cggcgccggc gggggcagcg ccgacttctt cccgggactg
     5221 atgatcggca tctccgggtt cggcatgcac ttcctgcgac tggcggcccc ggaccgcgtc
     5281 ccgtccgtgc tgctcctcga cccgccgtcg caccacgaac agtaaggagt ggctccacca
     5341 tggccctgaa gacctgcgag gaattcctgc gcgacgccct cgacccggcc cggttcgggc
     5401 gcgagatgaa ggcggtcacg gaggtaccgg agatcgtcga gctcggccgc cgccacggct
     5461 acggcttcac cgcggaggag ttcctgacga aggccatgac cttcgacggc acggcggcgg
     5521 gcggcacggc cgcgggcggc ccggaggcgg gcgggcaaca ggccccccgg cagaccccgc
     5581 cccccgggac ccctgcgaac ggcgcgccgg caccggccac cgccaccagc ttcgcccact
     5641 acgagtaccg tctggacgac ctcccggagt tcgcgcccgt cgtggccgag ctgccccggc
     5701 tcaaggtcat gccaccctcc gcccgcctgg accggttcgc cgggcacttc cgcgaggagg
     5761 acgcccggac cgtctccacc tcgcccgccg accccgccta ccaggcatgg caccgcgacc
     5821 tcgccgcgcg gggctggcag gacgagggcg ccgcgcccgg cgccccgcgc cgcgacttcc
     5881 acctcgtcaa cctggacgaa cacgtcgact acccgggcta cgaggactac ttcgccgcga
     5941 agacgcgggt cgtggccgcc ctggagaacc tcttcggcgg cgaggtgcgg gcctcgggct
     6001 ccatgtggta tccgccgtcg agctaccggc tctggcacac caacgcggac cagccgggat
     6061 ggcgcatgta cctggtggac gtggaccggc ccttcgccga ccccggccag acctccttct
     6121 tccgctacct ccacccgcgc acccgcgaga tcgtcaccct caccgagagc ccgcgcatcg
     6181 tgcgcttctt caaggtggag caggacccgg agaagctctt ctggcactgc atcgccaacc
     6241 ccacggaccg gcaccgctgg agcttcggct acgtcgtgcc ggagacctgg atggacgccc
     6301 tccgccacca cggctgaccc ggcacccgtc gtccgcgcac cgcgcggcac caaggaggag
     6361 cgatgttcgg agcaggaccg cggacggcgc gggggcccgc ggcggggacg gacggcgacg
     6421 ccgcccaccg aagcggccgg ccggcaccgg ccgccggggc cgctggcggc ccgacggccg
     6481 ggtccggtcc gccggccgtc ctggcgcggg ggctgggcaa gtcgtacgcg ggagtggaag
     6541 ccgtgcgcgg catcgacctg accgtcgccc agggcgagac cttcggcttc ctcggcccca
     6601 acggggcggg caagaccacg acgatctcga tgctgaccac cctcgccacg cccaccacgg
     6661 gccggatcga gatcgcgggc cacgacaccc gcaccgcacc ccagcaggtg cgccgcaacc
     6721 tcgggctggt cttccaggag accacgctcg acccggagct gacggccgtg gagaacctgc
     6781 gcttccacgc cgacctctac gcactgccgc gggccggcct ggccgggcgc atcgccgaga
     6841 tgctggagct cgtcgggctc tccgcccgcg gcgacagcct cgggcgcacc ttctccggcg
     6901 gcatgcagcg ccgcctggag atcgcccgcg gcctgctgca ccggccgcgc ctgctcttcc
     6961 tcgacgagcc gaccatcggg ctcgacccgc agacccgcgc ccaggtgtgg gcgcacctgg
     7021 ccgaggtccg cgagcgcgag gcgacgacca tcttcctcac cacgcactac ctcgacgagg
     7081 ccgagcagtg cgaccgcatc gccatcatcg acgacggccg gatcgtcgcc cagggcagcc
     7141 cggccgagct gaagtccgtc atcggcgcgg accgggtgga cctgcgcacc ggtgacgaca
     7201 tggccgcggc cgccctgctg cacgagcgct tcggcctggc ggcggtccgg ggcccgaacg
     7261 gcctgagcgt caaggtcgcg gaaggcgccc ggctcgtccc ggcgctgtgc gccgccctcg
     7321 acgtggccgt ctacgaggtg acggtcaccc gccccagcct cgacgacgtc ttcctccacc
     7381 acacggggcg cggcatccgt gacgacgccc tgcccggcgc ggcgggcacg gcaggcacag
     7441 ccgaaccgtc ggactcagga gacagcacat gacgcacgcc acggtcgccc tgcccgcggc
     7501 cgaccgccac gcccccggcc ggctcgccgc cgaatggcgc gcgggcagca tggtgtggcg
     7561 gcgcgaaatg atccacttcc tgcgctcgcg cgccgggatc gccgtctccc tgctgcagcc
     7621 gctgctgttc ctctacgtgc tgggcatcgg cctgtcccgg atgttcagcg gcgccggctc
     7681 gtcggacgac tacatgatct tcctcttccc cggtgtgctg gtgatggcgg cacaggcccc
     7741 ggcgatctcg gtgggagcct cgatcgtctg ggaccggcag agcggcttcc tgcgcgagat
     7801 gctggtggcc cccgtccgcc gcagcaccct gctgatcggc aagtgcctgg gcggcgccac
     7861 cgtcgccgcc tgccagggcg cggtcgtcct ggccagcgcg ggcctggtgg gcgtgcccta
     7921 ccgcgtcgac ctcttcgccg ccctgctggc cgaactcctg ctcgcctccc tggcgatgac
     7981 ggtcctcggc gcggtgatcg ccgtgcggat ccagcggatc cagacgttcc acacagcgct
     8041 gaccgtcctg acggcaccga tggtcttcct gtcggggctg atgttccccg tcagcgccat
     8101 gccggcctgg atggcggcgc tcaccctggt caaccccctg acctacgccg tggacgccat
     8161 gcgtcagacg atcacggcct tccaccccgc gcccgcggcc ggggcatcgg gtgcgcccat
     8221 cttcgacccc gtctcctggg gcggctggga cgtaccgccg ggcctgtcgg tggtgctggt
     8281 ggccgtgttc tcggccctgg ccctggcggc ggcctcccgg cgcttctccc gcaccgactg
     8341 acggcgttcg cggaccgact gaaaacaccg tcgttcccac gcgtccaacc gtggatcatc
     8401 actcacgtcc agcgcccgga ttcacatctg aggagacatc accatgcgta gcaccagacg
     8461 cctttcgtta cgtcgccgtt ccgccctgct gatgggcgcc gcctccctcg cggcgccggc
     8521 gctgctgacg gtccaggccg gcgaggcgca ggcgttcggc acgatcaact cgctgggcca
     8581 gcgcgccgag cacgagcgca tcacccgggc ggcgctggcc tgcgccgccg gcacgtcgtc
     8641 cgacggatcg tgcttcgagg cccggtcgat cgatcaagtg gccggtcaca cggggacgtt
     8701 cggggccgtc gggtcgccgg actcggacga gatcttcacc cccgaggcgc actgcgacga
     8761 cgccgactac ctcacggcct ccggctaccc gcgcacccgt cagcaggcca gcgaccagct
     8821 cgtcgcctgc atatccaagc tgcagggacg tttcagccag ggcgtcgccg ccggctcggg
     8881 caccctgaac ggggacggca cggtctcccc gggcaacagc gacctgtccc aggactgcac
     8941 cttcaccggc ggcgtccccg ggcgcggcaa gtgcaacgcc atcgagggct tcggccgggc
     9001 cctgcacggt gtgcaggact tctactcgca cagcaactgg gcggacaagg cggaccccaa
     9061 ccaggccgtg ggcgtcaaca acccgcccgg cctcaacatg tcgggccccg ccccactgct
     9121 ctcgctcaag agcggccgcc ctccggcggc ctcctcggtg ccggcgcagc tgtccacggg
     9181 ctgtttctcg ctcaacccct ggggctgctc gggccgggtg acccacagca ccctcaacaa
     9241 ggacaccggc ctgatcgacc cggccagcgg cgccaccagt gacccgacga cgaaccgcgg
     9301 caggatcacc ggcaacttcg accgcgccgt caagggtgcc attgccgaca cccgccgtca
     9361 gtgggccgac ttccggaccg cgctgaccga gcgctacggc caggagcgcg gccagcgcat
     9421 cgcctgcgtc ctgacgcacg acaaccccgt gcgcgactgc cgctgatccc tcgcggcccc
     9481 gcgtcccgcc ggcccggtgc tccgcgccgg gccggccggc acgcaccgga ccggtcctcg
     9541 cgggtcaggc gtcgccgtac gcctcgccgc cgagctccag cacggccgtc ccggcggtgg
     9601 tgtccgccag ccaggcccgg aacccctcga cgtcggcctc gggcagcccg atcccgatgc
     9661 gcacgccctc gccgtaggcc acctcgcgca cctcgcgccc ggtggcccgc aggtcgttct
     9721 gcagcttccc ggcccgctgg tggtcgaccg tgaccgtggc cagccggaag cgcttgtggg
     9781 tcaccgtgcc gagctcgtcg agggcctcgc cgaccactcc gccgtacgcc cggatcagac
     9841 cgcccgcgcc gagcttgacg ccgccgaagt agcgggtgac gaccgccacg acgtagcgca
     9901 tgtcgcgccg gaggagcatc tgcagcatgg gcacgcccgc ggtgcccccg ggctcgccgt
     9961 cgtcgctggc cttctggacc gagccgtcgg cgccgaggac gtacgcccag cagtggtgcc
    10021 gcgcggtcgg gtgctccttg cggatgcgcg cgaggaacgc ctgcgcctcc tcctcggtgg
    10081 cggcgggcgc gagcgcgcag atgaagcgcg acctgctgat ctcgatctcg tgcacgcctt
    10141 cgagcgcgac cgtgcggtac tcgtcctgca ttccgccagc ctagacgtct ccgcggcgcc
    10201 gcccggaccc gggaatggtc cggcgaccta gatcgttgag ccggcatgtt cgcagaaccg
    10261 gggatcatcc agaagatcat cgaggggacc ggcgacacct gggcgctggt cggcctctcc
    10321 gccaacgagc agcgcgccgc gtacggcgtc gccgaggtgc tccagcgcca cggcaagcgc
    10381 atcgttcccg tccaccccaa ggccgagacg gtccacggcg agctgggcta cgcctccctc
    10441 gccgacatcc ccttcgacgt cgacgtcgtg gacgtcttcg tccggtccga gctcgcgggt
    10501 gccgtcgcgg acgaggcggt agagatcggc gccaaggccg tctggttcca gctcggggtg
    10561 atcgacgagg aggcgtacga ccgcacgcgc ggggcgggcc tgctgatggt catggaccgc
    10621 tgcccggcga tcgaactcgg ccggccgcgg ggacgggcgg tctgacatct tcctgcgaag
    10681 gtctccgcga acggttgtgc gaccatgccg gattcccttg gaatgtgctc ctcagtcctt
    10741 ttggtcaagg agtacagatg cgcaagtccc ttgctgttgc ggccgcttcg gcggttgccg
    10801 gcctcacgct gatggccggc accccggcga acgcggcgcc ggccgccgcc accaccgtac
    10861 cgagctgtgt gacgtctacc ttctcgacgc cgttcttcgc gatggtccgc gtcgacatgg
    10921 agaacaagtg caccaccgag cagcgggtga agccgtcgtt caactacgag ctgaaggacg
    10981 ttccgtgcta cgccctgcag cccggtcaga aggcggtgtt cagccgggac gtgatcttcg
    11041 cctccgggta cacgttcgcc ggcctcgtca gctgctgaca cccggcccgt agcggtcacg
    11101 gctcacaccg tcacaccgtc agtcccgcgt cgcgggcgca cagcgccgcc tgcaccctgt
    11161 tgccgacctc cagggcggcc aggatgcggc tgacgtgagc cttgaccgtg ctctcccgca
    11221 tgcccaggcc gtcggcgatc tccgcattgg aggcgccggc ggccaggagc cccaggacgt
    11281 ccgactcgcg gggggtcagc cgcgccaggc gctgctgggc ggcttggaca tcgcgggacg
    11341 ccgtgcggtg gtagcggtcg accagacggc gggccgcggc ggggtggagc atggcctggc
    11401 ccgccgcgac gacctgtatc gcccggatga tctcggccgg atcggtgtcc ttgaggagga
    11461 agcccgaggc gccggccgcc agcgcgtcgt acacgtactg gtcgaggtcg aacgtggtca
    11521 gcatgacgac ttccggcggg ctgggcagcg cgcgcagccg ctcggtggcc gctatcccgt
    11581 ccatgcgcgg catccggacg tccatcaggg ccacgtccac gcgcagggca ccggcccgct
    11641 ggacggcttc gaggccgtcg cccgcctgtg ccacgacctc aatgccgggg acgtcgtcga
    11701 ggatgtcggc gagggccagc cggaccaggc tgtcgtcgtc gacgatcaat gtacggatca
    11761 tgccgctccc ggcgcgaggt gttcttcgac agtgctgacg gggatgtcgg cggcgatgtt
    11821 ccagccaccg ccccccgaag gtccgtagtc cagccggccg cccagcgccg tgacgcgctc
    11881 ggccagtccg accagcccgt agccgctgct gaccggcggc tccccggcgg cggacgccgg
    11941 gtcgccggcg cggttgtgca cctcgacgct ggaggccggg ggaccgtagc gcacgacgac
    12001 ccgcacgggg gccccgggag cgtgcttgcg ggcgttggtc agcgcctcct gcaccagccg
    12061 gtggacggcg aggcggtgac tggccgggag cggcccggcc gcgccctcga cgaccgcgtc
    12121 gatctcctgg ccggccgcgc gcgcctcgtc gaagagggcg ggcagctcgc gcagccccgg
    12181 gacgcgctgc ccctgcagct ccgggtggtc gggatcgcgc aggacgccca ggacgtcccg
    12241 caggtcgccc agggcctcgg tggaagtggt gcgcagcagt gcgagccggt ccgccacggg
    12301 ctcgggaagg gtggcggccc gccgctgcag ggctccggcg tgcagggcca gcaggctcag
    12361 ccggtgggcg agcacgtcgt gcatctcggc ggcgatgcgg gcccgttcgc tcagccgcgc
    12421 ctgcttggcg cgcagctcgc gctcgacgcg caggtgctcg acctgcgccg tcaggctcgc
    12481 ctccagccgc ctacggctgt ccgcccacag ccccagcacc atgacgaggg cgaacggcag
    12541 cacggggccg tacgcacggg tgctccacag caactgctcc ggctgcgcga accagttgcc
    12601 ggccagcgcc accgcggcac acgcacagcc cagcgcgcgc cacccgcgcg aggcgaggta
    12661 gaagagcatg accagcaggg gcagcagggc gcccaccacg accgcggcgc agacggtcac
    12721 caccaccgtg accaacggga cgcggtagcg caccgccaag gagaggctgc cgacggcggc
    12781 gacggccgtg tccgggcccc acagcgtggc gccggccccc acgtaggcgt tctgtacggc
    12841 cagcacaccc acggcggcga ccagcagcgc ctccgcccat cccggccacc ttcggtcgtc
    12901 cgcactcagc acgggtaaat cgtagtcacc caccgttttt gatccctccg ccagtcggcc
    12961 tacgctaccc cctactttcg taccgatcga gcgtcgcaca acggccgatg gtgcgccccg
    13021 cggcggcccc tagtttcatg gtcatggatc tgacgcaagc caactccacg cccgtacagc
    13081 cgcgttcggc caccgggctg gccttcctcc gcgaggcgac ccgcaccttc cgcaccaccg
    13141 gcgcgatcgc gccgagcagc cggcagctcg ccgagcggct ggccgcgccc ctcgcccctg
    13201 cgagcagact gcgccggccc accgcggtgc tggaggtcgg cgccggcacg gggccggtga
    13261 cccgggttct ggccggtgcc gtgggccccg ccgaccggct cgacgtcgtc gagatcaacc
    13321 cccgcttcgt cgagatcctc aacggcgccc tgcgcacgga ccccgccatg tcggcggcct
    13381 cggaccgcat ccggatcatc cccgagtcga tcaccgagat gcccatcgac cacagctacg
    13441 acgtcgtcgt ctcctgcctg ccgttcacca acttcgcgcc ggagacggtc aggtccatcc
    13501 tggaccgcta cctgtcggtg ctcgtgccgg gcggacacct gacgttcttc ggctacctcg
    13561 gcacccacgc cacccgctcg ctgctcagca gccggaagga ggccgcccgc caccgcgaag
    13621 tgaccgacct gctgcacgac ttcacccgcc gctacgccag ccggcagagt gtcgtgtggc
    13681 gcaacatccc gcccgcccgg gtgtggcacg tgcgcgcccc cgagcacgcc acccgggcgg
    13741 cggacgccgc ctgatgccca ccgcggacga gctgttgcac ggagtgccgc ccgcggccgc
    13801 gtacggtctc gtgctcggcc tggtgctcct cgaatcggtg ctgctgctcg gttcgttcgt
    13861 gcccacgctc agcctgatgc tgtgcgccgg ggtcctggca caggagggaa cgctgcggct
    13921 gcccctggtg gtgctgtgcg ccacgacggg ggtggtggcc ggtgacctgc tcgcgcagcg
    13981 caccgggcgc cgcctcggcc ccggcctgcg gcgctcccgg ctggggaggc ggctgcccga
    14041 ggcggcctgg gagcgcgcct ggtcggtgct ccagcgccgc ggcggccccg cgctgctggt
    14101 ctgccgcttc gtgccggtcg tgcggacctt cgcgccgcac ctggcgggcg ccgccggcat
    14161 gccgtaccgg cggctggccc cgtacagcct ggtggcgggc ctggtctggg cgggcgggga
    14221 agccggtgcg ggatacgtgc tgggcgcctc ctacgaccgg ctgaccgcgc cgggcggcgg
    14281 gctgcccacg gtctgcgccg ccgccggcgt cctgctggcg gcagcggcgg ggctgctcgt
    14341 gcaccgccgg cgcgcgcgcc gggcggtggg cggctcaggc cgagcgggcc agcgacaggc
    14401 tgacgtcggt gcgcaggatc gcgacgtgca gatgacgcag ctcgcgcccg gggtccaccc
    14461 cgagctcgtc gcggaagacg ccgctgacct ccgcgtacgc ggccagggcc tcgcccctgc
    14521 ggccgcagcg gtagagggcg agcatcagcc gctgccacag gctctcgcgc agcgggtact
    14581 tcgcggtcag cgtccgcagg tcgccgacga tctcgtcgtg gcggccgagg gcgaggcagg
    14641 cgtcgtggta gcgctcgatg gcccggatcc actcctccat cagccccggc accacgtccc
    14701 ggtggagcgc gtccgagcgc acgccgccga gcggctggcc gtgccagagg gccagtgcct
    14761 cggtgagggc ggagtgctcc agtgcgcggt cgccgagctc ggcggcgagc cgggcgcggg
    14821 cggcggattc acggaaaaga gtgagatcca gacagccggt ggggacctcg atcaggtaac
    14881 cgctgggcga ggtgtgcagc agtccggaga gccccgcgcc ggctgcgtcc aggctctgtc
    14941 gtaagcgggt gaggagggtg tgcagggcgg ggcgcgggct gtgcggcagc tcgtcgcccc
    15001 acaccaggtc cacgagtttc tcgaccggga cgatctcgcc cgggtgcacg agcagggccg
    15061 ccaggaggga ccgttgccgg ccgctgggta gcgaaacgtt tttcctgccc accgtgacgc
    15121 tcagtggtcc gagaactcgg aaggatattg cccggttcat gaactctccc cttcgctcat
    15181 cgagccgcac cctgaagacg gctggggact gccgtgtccg ctgtccactc aagcggacgt
    15241 cgcggtcagc aagcgtacgg tgcgtacaga gttggttgtc aactatggcg tatgaatgtc
    15301 agggttgtct ggcgttatcc atacgctcaa gcggacagaa acagtcgacc gggcaacaac
    15361 tcccggggga gggacggggc atgagcgaca gtcgaccggc accggaccgc aacgaccggc
    15421 cacttctgcg ccagttcgac cagcggctca gtgaactgat cgccaccacc gccggggccg
    15481 aggggaacaa gcgccccgga tacgcgcgcc tggccaagga gatccgcgac accaccggcc
    15541 ggaccatctc cggcacctac ctgtgggagc tggccaccgg gaagaagcgc aacgtcacgc
    15601 tcgaacagct cgacgtcctc gcggagttct tcggtgtgcc cccggagtac ttcctcgacg
    15661 acgagaccgg ccgccgcatc gacgaccgcc gaagactggc catcgccctg cgcgacgcca
    15721 aggtgcgcaa cctcgccctg cgcgcggacg ggctctcgcc cgactgcctg gacgcgctga
    15781 tcgccatggt gaacgaggcg cgcaagaccc agaacctgtc gtccatcgac gatgacgacg
    15841 acaccgccac cacccttact tcttcagggt agtcaacgac ccgacgccgg tcccgtgggc
    15901 ctggaggacc gatgccacgc cgtacgtacg tcgcctaccg ccgctgcctg agaaagggtc
    15961 aacgggaacc cgagatgccg tacacgagcg acgccgccct ccgtcgacgc tgccgggccc
    16021 tgctggcccg cgtcagcctg cccgagccgt tctccgtcga ggtcctgtgc cggcacctcg
    16081 gcgaacagcg cggccggccc atccacctgc acccgctgcc ggaacaggcc gccctggccg
    16141 gggcctgcgg cctgtggctc gccaccgcca ccgacgacca catcttccac gagcgccaca
    16201 ccgtccgccc gcaccaggag cacatcgtcc tccacgagat cggccacatg ctcttcgacc
    16261 accactcgct ggccccggcc ggcggcccgg cgggcgccct cctggccgac ctcgaccccc
    16321 ggctcatccg ccgtctcctc gcgcgcacca actactccac gcgccaggaa cgcgaggcgg
    16381 agatgctcgc cagcctgatc cgcaccagcg tccgcgccgg caccggggaa cggccgccgg
    16441 gcgcgctggg ccggctgcag gcggcgctgg gcgtggtcgg gtcccatggc cgctgacgtc
    16501 ctcgattccg tcctggggac caccgggctg gtgtgcctgt ggaccgcggt ggtcctgcga
    16561 tgtccctacg ccgtgcgcca ccccgcacag cgcggactgt ggctggcggt ggccacggcg
    16621 gccctggcga tgaccctcac cacctccatc ggctccgtcg tccccgaagc ggcgctcggg
    16681 ctcgccggca acctcaccgg catggtctcc gcgggcgccg tcctcggctt cgtcatcacg
    16741 atcatgggcg ggcggcgcct gcacacctgg gcctgcggca cggtcgccgc cacggccctc
    16801 gccctgaccg tcctcggcgt cacctcccgg gcccacctct cctacggcac catcgccgag
    16861 atcccgccca ccgccaccgc ctaccggctg ctgctgatcg gcacccacct ggccgtgaac
    16921 gcggcctgca tcgcggtgtg ctggcggtac gggagggggc ccagccgctc cccgctcgcc
    16981 ctcggcctgc ggctcttcgg catcggcacc gtcctggcgg agctgtactg gctgcgcctg
    17041 ttcgccggcc tcttcaccac ctccgacgcc ctcctgcggt acc
//
