BGC0000504 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000504 (Plasmid pAD1)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	7,500	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide

BGC0000504 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 7,500 nt. (total: 7,500 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,501
Label		BGC0000504

Tailoring functions

Hydrolases: protease

clyA: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

clyM: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	1.00	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.56	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.54	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000502.5	0.53	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000516.4	0.50	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002698.2	0.48	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.46	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	1.00	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.56	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.54	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000502.5	0.53	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000516.4	0.50	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002698.2	0.48	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.46	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for clyM

clyLl

Leader:

MENLSVVPSFEELSVEEMEAIQGS

Core:

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

Core with dehydrations:

GDVQAEDhbDhbPVCysAVAADhbAAADhaDhaAACysGWVGGGIFDhbGVDhbVVVDhaLKHCys

antiSMASH-DB 4.0 matches for clyLl

100.0%

NZ_AP026721.1and 34 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide

Lanthipeptides: PO855_RS02210_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

93.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide

Lanthipeptides: BEH_RS02105_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVVSLK C

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVSLKSC

90.9%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide

Lanthipeptides: BEH_RS02110_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVV+LK C

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVTLKSC

with 107 more sequence matches

Only the first 10 are displayed here.

86.4%

NZ_JH791802.1and 5 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptideNZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide

Lanthipeptides: IKS_RS30065_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AAT AASSAACGWVGGGI TGVTVV++LK C

GDVQAETTPVCAIAATTAASSAACGWVGGGIATGVTVVITLKSC

84.1%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26130_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASS C GGGI TGVTVVVSLKHC

GDVQAETTPVCAIAATAAASSGICAATGGGIATGVTVVVSLKHC

81.8%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide

Lanthipeptides: COK11_RS25880_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCAVAATAAASS C G GI TGVTVVVSLK C

GDVQAETTPVCAVAATAAASSGVCAATGAGIATGVTVVVSLKSC

77.3%

NZ_MIFM01000001.1and 1 other:

NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide

Lanthipeptides: BHL22_RS00425_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCAV+ SSAACGWV GGI TGVTVVV+LK C

GDVQAETTPVCAVSVATMTSSAACGWVAGGIATGVTVVVTLKSC

72.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide

Lanthipeptides: JNUCC31_RS17165_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQ ETTPVCAVAAT AASSA C VGGGI GVT+V+++K C

GDVQPETTPVCAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

72.7%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11330_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

DVQ ETTPVCAVAAT AASSA C VGGG+ GVTVV++LK C

ADVQPETTPVCAVAATVAASSATCAAVGGGVAVGVTVVLTLKTC

70.5%

NZ_KB946334.1and 1 other:

NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide

Lanthipeptides: UC7_RS10245_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

GDVQAETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

68.2%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10240_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQ ETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

GDVQVETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

68.2%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08835_lanthipeptide

DVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

DVQ ETTP+CAVAAT AASSA C VGGGI GVT+V+++K C

DVQPETTPICAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

65.9%

NC_014098.1:

Lanthipeptides: BTUS_RS14190_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTP+C AAT ASSAAC VG GI GVT+V+++K C

GDVQAETTPICYTAATVTASSAACAGVGAGIVAGVTIVLTIKRC

clyLs

Leader:

MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS

Core:

GDVQAETTPACFTIGLGVGALFSAKFC

Core with dehydrations:

GDVQAEDhbDhbPACysFDhbIGLGVGALFDhaAKFCys

antiSMASH-DB 4.0 matches for clyLs

100.0%

NZ_AP026721.1and 35 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptideNZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide

Lanthipeptides: PO855_RS02215_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

85.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide

Lanthipeptides: BEH_RS02100_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFTIGLGVGAL SA C

GDVQAETTPVCFTIGLGVGALVSAAGC

77.8%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide

Lanthipeptides: IKS_RS03655_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFT+GLGVG+L SA C

GDVQAETTPVCFTVGLGVGSLVSASVC

with 108 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide

Lanthipeptides: IKS_RS03660_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFT+GLG+G+L SA C

GDVQAETTPVCFTVGLGIGSLVSASVC

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

GDVQAETTPAC-FTIGLGVGALFSAKFC

GDVQ ETTP C FTIG+G+GAL S K+C

GDVQPETTPICGFTIGIGIGALASVKWC

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

GDVQAETTPAC-FTIGLGVGALFSAKFC

GDVQ ETTP C FTIG+G+GAL S K+C

GDVQPETTPLCGFTIGIGIGALVSVKWC

70.0%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

GDV+ ETTPAC FTIGLG+GAL SA C

GDVKPETTPACLAGFTIGLGIGALASAAGC

66.7%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

GDV+ ETTPAC FT+GLG+GAL SA C

GDVKPETTPACLAGFTVGLGIGALASAAGC

63.0%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQ ET+PAC TIG+G+G S FC

GDVQPETSPACVTIGIGIGIGISKLFC

59.3%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

DVQ ETTPAC T L G +FS K+C

SDVQPETTPACVT-ALTTGIIFSIKWC

58.6%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

DVQ ETTPAC FTIG V +FS + C

SDVQPETTPACAVAFTIGATV--IFSVRNC

57.1%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11325_lanthipeptide

DVQAETTPAC-FTIGLGVGALFSAKFC

DVQ ETTP C F +G+G+GA+ SA C

DVQPETTPVCGFFVGVGIGAIISATAC

55.6%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

DV ETTPAC G LFS KFC

SDVAPETTPAC-VAAFATGLLFSIKFC

MIBiG 4.0 matches for clyLs

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TTPACFTIGLGVGAL-------FSAKFC

T PA + LG+ A+ SA FC

TDPAVTGLILGIVAIQAGVAVGVSAAFC

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

TPACFT

TP C T

TPGCKT

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

PACFTIG

PAC T+

PACHTLS

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

clyLl - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 4017.0 Da

Molecular weight: 4019.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4037.6 Da N = 1; 4055.6 Da N = 2; 4073.6 Da N = 3; 4091.6 Da N = 4; 4109.6 Da N = 5

clyLs - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 2630.3 Da

Molecular weight: 2632.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2650.0 Da N = 1; 2668.0 Da N = 2