LOCUS       BGC0000504              7500 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Plasmid pAD1 (from Enterococcus faecalis) cylLl, cylLs, cylM, clyB,
            cylA genes, complete cds.
ACCESSION   BGC0000504
VERSION     BGC0000504
KEYWORDS    .
SOURCE      Plasmid pAD1
  ORGANISM  Plasmid pAD1
            other sequences; plasmids.
COMMENT     Original source text: Plasmid pAD1 (plasmid Plasmid pAD1, kingdom
            Prokaryotae) DNA.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:42:38
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7500
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..7500
                     /db_xref="taxon:2520"
                     /host="Enterococcus faecalis"
                     /mol_type="genomic DNA"
                     /organism="Plasmid pAD1"
                     /plasmid="Plasmid pAD1"
     subregion       1..7500
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7500
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            607..813
                     /gene="clyLl"
     CDS             607..813
                     /codon_start=1
                     /gene="clyLl"
                     /protein_id="AAA62648.1"
                     /transl_table=11
                     /translation="MENLSVVPSFEELSVEEMEAIQGSGDVQAETTPVCAVAATAAASS
                     AACGWVGGGIFTGVTVVVSLKHC"
     gene            847..1038
                     /gene="clyLs"
     CDS             847..1038
                     /codon_start=1
                     /gene="clyLs"
                     /protein_id="AAA62649.1"
                     /transl_table=11
                     /translation="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGSGDVQAETTP
                     ACFTIGLGVGALFSAKFC"
     gene            1099..4080
                     /gene="clyM"
     CDS             1099..4080
                     /codon_start=1
                     /gene="clyM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     841.1; E-value: 2.1e-254)"
                     /gene_kind="biosynthetic"
                     /protein_id="AAA62650.1"
                     /sec_met_domain="LANC_like (E-value: 5.6e-53, bitscore:
                     168.3, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 5.7e-96, bitscore:
                     310.2, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDNLINVLSINERCFLLKQSGNEKYDIKNLQAWKERKSVLKQDD
                     LDYLIKYKYESLDNFGLGITPIENFPDKEVAIQYIKDQSWYIFFESILDSYNDSEEQLL
                     EVDASYPFRYFLQYARLFLLDLNSELNICTKEFIINLLENLTQELIHLTSKTLVLDLHT
                     FKKNEPLKGNDSSKRFIYYLKKRFNSKKDIIAFYTCYPELMRITVVRMRYFLDNTKQML
                     IRVTEDLPSIQNCFNIQSSELNSISESQGDSHSRGKTVSTLTFSDGKKIVYKPKINSEN
                     KLRDFFEFLNKELEADIYIVKKVTRNTYFYEEYIDNIEINNIEEVKKYYERYGKLIGIA
                     FLFNVTDLHYENIIAHGEYPVIIDNETFFQQNIPIEFGNSATVDAKYKYLDSIMVTGLV
                     PYLAMKDKSDSKDEGVNLSALNFKEQSVPFKILKIKNTFTDEMRFEYQTHIMDTAKNTP
                     IMNNEKISFISYEKYIVTGMKSILMKAKDSKKKILAYINNNLQNLIVRNVIRPTQRYAD
                     MLEFSYHPNCFSNAIEREKVLHNMWAYPYKNKKVVHYEFSDLIDGDIPIFYNNISKTSL
                     IASDGCLVEDFYQESALNRCLNKINDLCDEDISIQTVWLEIALNIYNPYKYINDLKNQN
                     SNKYIYTGLELNSKIIQACQKIEKKIFKRAIFNKKTNTVNWIDIKLDQDWNVGILNNNM
                     YDGLPGIFIFYVALKYITKNHKYDYVIECIKNSIYTIPSEDILSAFFGKGSLIYPLLVD
                     YRLNNDINSLNVAVEIADMLIEKKPINNGELKNDWIHGHNSIIKVLLLLSEITEDEKYR
                     KFSLEIFEKLSEEPYFNFRGFGHGIYSYVHLLSKFNRIDKANSLLHKIKESYFEEEPKN
                     NSWCKGTVGELLATIELYDDNISNIDINKTIEYKNKDCLCHGNAGTLEGLIQLAKKDPG
                     TYQYKKNKLISYMLKYFEKNNTLKVAGSEYLESLGFFVGISGVGYELLRNLDSEIPNAL
                     LFEL"
     gene            4092..6236
                     /gene="clyB"
     CDS             4092..6236
                     /codon_start=1
                     /gene="clyB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 237.5; E-value: 5e-72)"
                     /gene_kind="transport"
                     /protein_id="AAA62651.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-44, bitscore:
                     139.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLKYVAQGEHSECALACITMLLNYYGNQSTLVELREKYGVPKG
                     GLTIKNIRTVFDEYGFDVSTFKSSFSNYLDLPTPVISYWNNQHFVVIEKIKKKKVLILD
                     PASNKRWIDISEFKKNFSNILIYAHKKKTKKEGKRKQFFLKSFIFTKFKRYFFSLIILS
                     FVSQLLLLLIPIATKYSIDNIRSFQEIPTYVLLLILTSFFSVLYVVQYLKSSVVAEFQY
                     EFDFKLMFSYIDKLFSMPLMYFSNRSTGELVFRANLNIYIRQILSQKVITTLIDSLFLG
                     IYLFLMVNYSILLTIIALVLISLIAFLSIINSHTIKRFVDKEIMEQGNVQRIITEAIEG
                     IETIKSANAKKSFLLNWKNMFTSQLLITKNKNRYIAIFGILPEIIQSVMPALFLIIGIK
                     LIINNSLSLGSLIGFVSIVTMVMKPILSLVSSYNDFLLLNVYFQKLSEVLTYEEKNDFN
                     NKKGNVGKEEFIYRVNNVYYTISVFEKNILNGISFDIRKGDKVAIVGRSGSGKSTLLKL
                     LAGLLQPSNGEILYEGYPLSNNSNNRRNIFYVNQNAHIFNETIEKNISLEFKPNSSINE
                     KKRLKGSMSKSKMDEVLLGIPQYEKTIVSENGSNFSGGQRQKIALARAFYSNVNTLLLD
                     EPTSAMDNISEFEVFSNLLDEKRTVITVAHRISTVKNFDKIILMDNGEIVCIGKHEDLI
                     ENSELYRSLYYKKQQFGGTK"
     gene            6233..7471
                     /gene="clyA"
     CDS             6233..7471
                     /codon_start=1
                     /gene="clyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 216; E-value: 1.9e-65)"
                     /gene_kind="biosynthetic-additional"
                     /protein_id="AAA62652.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.7e-38, bitscore:
                     120.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRGLTYILISYIFLILGTTGYASDLSNNISFFIDNSQTTAIEE
                     IESELSSEKVDYIQEIGLVSFKNLDDSDRKFIGKYFNVSEGKKLPDFKPEEVNSSILNI
                     NILNKDFKSFNWPYKKILSHIDPVKEQLGKDITIALIDSGIDRLHPNLQDNNLRLKNYV
                     NDIELDEYGHGTQVAGVIDTIAPRVNLNSYKVMDGTDGNSINMLKAIVDATNDQVDIIN
                     VSLGSYKNMEIDDERFTVEAFRKVVNYARKNNILIVASAGNESRDISTGNEKHIPGGLE
                     SVITVGATKKSGDIADYSNYGSNVSIYGPAGGYGDNYKITGQIDAREMMMTYYPTSLVS
                     PLGKAADFPDGYTLSFGTSLATPEVSAALAAIMSKNVDNSKDSNEVLNTLFENADSFID
                     KNSMLKYKEVRIK"
ORIGIN
        1 ttttattcag gttgccattg aaaaatatct tctagtggag tattcaggta gtaagcaatt
       61 tttaatgcta actgtaaaga agggttatat ttattttttt ctataccatt aatagtttgt
      121 ctgctaactt ctaataaagc agctaattca ctttggctaa tttttttttt ctctctaatt
      181 aattttaagt tattgattat catttatgaa gtcctcttgt tgaaaaaaag tagtaacaga
      241 gagtgcaata tcattgatag agagaagtaa tagtagacaa aattaaagag atagttttta
      301 gtaataacat taggtagaaa aagaaaaata gcaactacta taagtatgga aaagttaata
      361 aataagtaca tgtaagtaga tgttaaggaa attgtatata aaattcgctc atcttttttt
      421 gaatcagtca gattaaaaac aaagtagact acagaaatga tatccaataa aaaaataaaa
      481 atagccattt tggttcctcc tttttgtcaa gtgacacttg gcaaaagatt aaaagctcta
      541 taatattaaa ttgtaacata ttatgttatg caatatacaa caattttatg atggagggta
      601 agaattatgg aaaatttaag tgtagttcct agttttgaag aactaagtgt tgaggaaatg
      661 gaagcgattc aaggtagtgg agatgttcag gctgagacaa caccggtgtg tgctgttgcg
      721 gcgacagctg cagcaagtag tgctgcttgt ggctgggttg gtggcggtat ttttactgga
      781 gtaactgtag ttgtgtcttt aaaacattgt taaaatatac tataaaactt agtgaggtga
      841 agcacagtgc taaataagga aaatcaagaa aactattact ctaataaatt agaacttgtt
      901 ggtccttctt ttgaagagtt aagtttagaa gaaatggaag cgattcaagg tagtggagat
      961 gttcaggctg agacaactcc agcatgtttt accataggct taggagtagg tgcattattt
     1021 tcagctaaat tttgctaatt tatatattaa gagggctagt gaaactagcc ctcttataca
     1081 taaaaaagga gtgcttacat ggaagataat ttaataaatg ttttaagcat aaatgaaaga
     1141 tgctttttac taaagcaaag tggtaacgag aagtacgaca ttaaaaattt acaagcttgg
     1201 aaagaaagaa aaagtgttct taaacaagat gatttagact acttgattaa atataaatat
     1261 gaatcactgg ataattttgg attaggaata acacctattg aaaactttcc tgataaagaa
     1321 gttgcaattc aatacattaa agatcaatca tggtatattt tttttgaatc cattttagat
     1381 tcttataatg atagtgaaga gcaattatta gaagtagatg ctagttatcc ttttagatat
     1441 ttcttacaat atgctcgttt atttttactt gatttaaact cagagttaaa tatttgtaca
     1501 aaagaattca ttattaattt attagaaaat ctaacacaag agcttattca cttgacaagt
     1561 aaaacattag tgctagattt gcatactttt aaaaaaaatg aacctctaaa gggaaatgat
     1621 agtagcaagc gatttatcta ttatctaaaa aaaagattta actctaaaaa agatataata
     1681 gctttttata catgctatcc tgagttgatg cgtattactg ttgttagaat gagatatttt
     1741 ttagataata ctaaacaaat gcttataaga gtgactgaag atttacctag catacaaaat
     1801 tgttttaaca tacaatcctc agagcttaac tctatatcag aatcacaggg agactctcat
     1861 agtcgcggaa aaactgtttc tacactaact ttttctgatg gaaagaagat agtatacaag
     1921 ccaaagatta atagcgagaa taaattaaga gatttttttg aatttttaaa taaagaatta
     1981 gaggcagata tttatatagt taaaaaagtt actagaaata cctatttcta tgaagaatat
     2041 atagataata tagaaataaa taacatagaa gaagtaaaaa aatattatga aaggtatggt
     2101 aaactaatcg gaatagcttt cttatttaat gtaacagact tacactatga gaatataatc
     2161 gctcatggag aataccctgt tatcatagat aacgaaactt tttttcaaca aaatattcct
     2221 atagagtttg gtaatagcgc aacagtagat gctaaatata aatatttaga ttctataatg
     2281 gtgacagggc tagtaccata tttagcgatg aaagataagt cagattcgaa agatgaaggg
     2341 gttaacctta gtgcgttaaa ctttaaagag caaagcgtac cgttcaagat attaaaaatt
     2401 aaaaatacat ttactgatga aatgcgtttt gaatatcaaa cacacattat ggatactgca
     2461 aaaaatactc caattatgaa taatgaaaaa attagtttta tcagctatga aaaatatata
     2521 gttactggta tgaaaagtat tttaatgaaa gcaaaggatt ctaagaaaaa aatattggca
     2581 tatattaata ataatttaca aaatcttata gttagaaatg taatcagacc aactcaaaga
     2641 tatgctgata tgttggaatt ttcataccat cctaattgct tttctaatgc aatagagaga
     2701 gaaaaagtac ttcataatat gtgggcctat ccatataaga ataaaaaggt agttcattac
     2761 gaattttcag acttaataga tggagacata cccatttttt ataacaatat ctcaaaaaca
     2821 tcattaatag ctagtgacgg gtgcttagta gaagattttt atcaagaaag cgctctgaat
     2881 agatgcctaa ataaaataaa tgatctttgt gatgaagata tttctattca aaccgtttgg
     2941 ctagaaattg ctttgaatat ttataatcca tataaatata ttaatgattt gaaaaatcaa
     3001 aattcaaata aatatattta tactggctta gagctaaaca gtaaaattat tcaagcatgt
     3061 cagaagatag agaaaaaaat tttcaagaga gctattttta ataaaaaaac caatactgta
     3121 aattggattg acataaagtt ggatcaagat tggaatgtgg gaatcctaaa taataatatg
     3181 tacgatggat tgcctggtat attcatattt tatgtggctc ttaaatacat tacaaagaat
     3241 cataaatatg actatgtaat tgaatgtata aaaaattcaa tttatacaat accatctgaa
     3301 gatatattgt cagctttttt tggaaaagga agtttaatat atcctttact tgtagattac
     3361 cgcttaaata atgatataaa ctctttaaat gtagccgtag aaattgcaga catgttgatt
     3421 gaaaagaaac cgataaataa tggcgagtta aaaaatgatt ggatccacgg gcataatagt
     3481 ataataaaag ttttattatt gttatccgag ataacagagg atgaaaaata tagaaaattt
     3541 tcattagaaa tttttgaaaa attatccgaa gaaccctatt ttaatttcag aggattcgga
     3601 cacggtatat atagctatgt ccatcttcta tcaaaattca ataggataga taaggcaaat
     3661 tctttacttc ataaaattaa agaatcatac tttgaagaag aacctaaaaa caatagttgg
     3721 tgtaagggaa ctgtaggtga acttttagcg acaattgaat tatatgatga taacatttca
     3781 aatatagata ttaataaaac catagaatat aaaaataaag attgtctgtg ccatggaaat
     3841 gcaggtactt tagaaggtct aattcaatta gctaaaaaag atcctggaac ttatcagtat
     3901 aaaaaaaata aacttattag ctatatgtta aagtattttg aaaaaaataa tacactaaag
     3961 gttgccggaa gtgagtattt agaatcacta ggattctttg taggaatcag tggtgtgggt
     4021 tatgaattat tgagaaacct agattctgaa attccgaatg cattactttt tgagttataa
     4081 gaggtgtaat tatgaaaaga ttgaagtacg ttgcgcaagg agagcatagt gaatgtgctt
     4141 tggcatgtat cactatgcta cttaattatt atggtaatca aagtacacta gtagaactaa
     4201 gggaaaaata tggggtgccc aaaggaggac taactatcaa gaatattcgt actgtctttg
     4261 acgaatatgg atttgatgta tcgacattta aatcaagttt ttcaaattat ttagatcttc
     4321 cgactcctgt aataagttat tggaataatc aacattttgt ggtcatagag aaaataaaaa
     4381 agaagaaagt attaatctta gatcctgcaa gtaataaacg ctggattgat atttcagaat
     4441 tcaaaaaaaa tttttcaaat atattaatat acgcacataa gaaaaagact aaaaaagaag
     4501 gcaaaaggaa acagtttttt ttaaagtcat ttatttttac aaaattcaaa agatatttct
     4561 ttagtttaat aatattatca tttgtttcac aacttttatt actcttaatt cctattgcaa
     4621 caaagtattc gatagataat attagatctt ttcaagaaat tcctacctat gttctgttat
     4681 taatattaac tagttttttt tctgttttat atgtagttca atacttaaaa agctctgtag
     4741 tagcagaatt tcagtatgaa tttgatttta aattaatgtt ttcttatatt gataaacttt
     4801 ttagtatgcc actaatgtat tttagtaata gatcaactgg agaattagtg tttagagcga
     4861 acttaaatat ttatattagg caaatattgt ctcaaaaggt aataacaact ttaatagata
     4921 gtcttttttt agggatatat ttgtttttaa tggttaacta ttctatttta ctgacaataa
     4981 tagctcttgt tctaatctct ttaatagctt ttttaagtat tataaattcg catacaataa
     5041 aaagatttgt agataaagaa ataatggaac aaggaaacgt ccagagaatt attacagaag
     5101 caattgaagg aattgaaacc attaaatctg ctaatgcgaa aaagagtttt ttgttaaatt
     5161 ggaaaaacat gtttacgtct caactattaa ttacaaaaaa taaaaataga tatatagcta
     5221 tttttggaat attaccagaa atcatacaaa gtgtaatgcc agctctattt ttaataatag
     5281 gtattaaatt aataatcaac aattctttgt cattaggatc actaattggt tttgtttcta
     5341 tagtaacaat ggttatgaag ccaattctaa gtttggtttc ctcttataat gactttctac
     5401 tattaaatgt atattttcaa aaattatctg aagttttaac ttatgaagaa aaaaatgatt
     5461 ttaataataa aaaaggaaat gttggaaaag aagagtttat ttatagggtt aataatgttt
     5521 actatactat atctgttttt gaaaaaaata ttttaaatgg tatttctttt gacataagaa
     5581 aaggggataa agttgctatt gttggtagaa gtgggtcagg gaaatctact ttactaaaac
     5641 tattggctgg attgttacaa ccttctaatg gagaaatatt gtatgaaggc tatcctttat
     5701 caaacaactc caataataga agaaacattt tttatgttaa tcaaaatgcg catattttta
     5761 atgaaactat cgaaaaaaat atttctttag agtttaaacc gaattcttct ataaatgaga
     5821 aaaaaagact aaaaggaagt atgagtaaat caaaaatgga tgaggtactt ttaggaattc
     5881 ctcagtatga gaaaactata gtatcagaaa atggtagtaa tttctctggt ggtcaaaggc
     5941 aaaagattgc tttagctaga gcgttctatt ctaatgtgaa tacattactt ttagatgagc
     6001 ctacatctgc aatggataat atttcagaat ttgaagtttt ttctaattta ttagatgaga
     6061 aaagaacagt tattactgtt gctcacagaa ttagtaccgt gaaaaacttt gataaaatta
     6121 tattaatgga taatggtgaa atagtatgta ttggaaagca tgaagatctt attgaaaata
     6181 gcgagttata tcgttcactg tattacaaaa aacaacaatt tggaggtaca aaatgaaaaa
     6241 aagaggattg acttatattt taatctcata tattttttta atattaggaa caacaggtta
     6301 tgcatcagat ctctcaaata atatttcatt ttttattgat aattcgcaaa caactgctat
     6361 agaagaaatt gagtctgaat tatcttctga aaaagtagat tatatacagg aaataggatt
     6421 agttagtttt aaaaacctgg atgatagtga taggaagttt ataggtaaat attttaatgt
     6481 ttcggaaggg aaaaaattac cagattttaa acctgaagaa gttaatagtt ctattttaaa
     6541 cattaatatt ttaaacaaag attttaagtc ttttaattgg ccatataaaa aaattttatc
     6601 tcatattgat ccagtgaaag aacaactagg gaaagatata accatagctc taattgactc
     6661 ggggattgat aggcttcatc ctaatcttca agacaataac ctaagattaa aaaactatgt
     6721 taatgatatt gagttagatg aatatggtca tggtacacaa gttgctggag taatagacac
     6781 gattgctcca agagtgaatt taaattctta caaggtgatg gatgggacag atggaaactc
     6841 tataaatatg cttaaagcta tagttgatgc tacaaatgat caagtagata taataaatgt
     6901 gagtcttgga tcatataaaa atatggaaat agatgacgaa agatttactg tagaagcatt
     6961 cagaaaagtt gttaactatg caagaaaaaa taacattcta attgttgcat cagcaggaaa
     7021 tgagtcgcgt gatataagca ctggtaatga aaaacatata ccaggaggac tagagtctgt
     7081 aattaccgtc ggagctacaa aaaagagtgg tgatattgct gactattcta attatgggtc
     7141 taatgtatct atatatggtc ccgcaggagg atatggtgac aattacaaaa taacaggaca
     7201 aattgatgct cgtgaaatga tgatgactta ttaccctaca tcgctagttt ctccactagg
     7261 caaagctgct gactttccag atggttatac actttctttt ggaacaagtt tagcaactcc
     7321 agaagtaagc gcagctttag cagctattat gtcaaagaat gtagataatt ctaaagattc
     7381 aaatgaagta ttaaatactt tatttgaaaa tgctgattct tttatagata aaaatagcat
     7441 gcttaaatac aaagaggtga gaataaaata gatgaaattt atatctccga tgatctttac
//
