LOCUS       BGC0000507              7358 bp    DNA     linear   BCT 24-JUL-2016
DEFINITION  Staphyloccus epidermidis epicidin 280 gene cluster on pCH01.
ACCESSION   BGC0000507
VERSION     BGC0000507
KEYWORDS    .
SOURCE      Staphylococcus epidermidis
  ORGANISM  Staphylococcus epidermidis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:45:30
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7358
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(<1..30)
                     /gene="tnp1"
     CDS             complement(<1..30)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:O54217"
                     /gene="tnp1"
                     /product="transposase"
                     /protein_id="CAA74345.1"
                     /transl_table=11
                     /translation="MNYFRYKQFR"
     source          1..7358
                     /db_xref="taxon:1282"
                     /mol_type="genomic DNA"
                     /organism="Staphylococcus epidermidis"
                     /plasmid="pCH01"
                     /strain="BN 280"
     subregion       1..7358
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7358
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     repeat_region   60..87
                     /rpt_type=INVERTED
     gene            874..1617
                     /gene="eciO"
     CDS             874..1617
                     /NRPS_PKS="Domain: PKS_KR (3-114). E-value: 1.4e-09. Score:
                     29.9. Matches aSDomain: nrpspksdomains_eciO_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GOA:O54218"
                     /db_xref="HSSP:1Q7B"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="UniProtKB/TrEMBL:O54218"
                     /gene="eciO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     186.7; E-value: 8.6e-57)"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidoreductase"
                     /protein_id="CAA74346.1"
                     /sec_met_domain="adh_short_C2 (E-value: 3.8e-35, bitscore:
                     110.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRTVLITGGCKNIGKQIAQVFAENNYNVIVTSRNNNNKSIITYF
                     KKKNLKVFFYTLNVENEDEVVNVFKEINNDIGKIDILINNAGISQGNTLLEDSKTEDFK
                     SMINTNILGSYYCMKHVIPYMKRNRYGVIINIVSIAALRGIPYSILYGSTKNAVIALTK
                     GAAIENANNGIRVNAIAPGIIKTESLNTEIQNSEDELNEQTIAAIHPMQILGEEKDVAN
                     TAYFIANSSFMTGSIVNLDGGYTAQ"
     CDS_motif       883..978
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_eciO_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="eciO"
                     /protein_end="35"
                     /protein_start="3"
                     /score="11.6"
                     /tool="antismash"
                     /translation="TVLITGGCKNIGKQIAQVFAENNYNVIVTSRN"
     aSDomain        883..1215
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_eciO_PKS_KR.1"
                     /evalue="1.40E-09"
                     /label="eciO_PKS_KR.1"
                     /locus_tag="eciO"
                     /protein_end="114"
                     /protein_start="3"
                     /score="29.9"
                     /tool="antismash"
                     /translation="TVLITGGCKNIGKQIAQVFAENNYNVIVTSRNNNNKSIITYFKKK
                     NLKVFFYTLNVENEDEVVNVFKEINNDIGKIDILINNAGISQGNTLLEDSKTEDFKSMI
                     NTNILGS"
     gene            1690..1878
                     /gene="eciI"
     CDS             1690..1878
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:O54219"
                     /function="producer-self-protection"
                     /gene="eciI"
                     /product="EciI protein"
                     /protein_id="CAA74347.1"
                     /transl_table=11
                     /translation="MNIYLKIVITALFFSSIIFTVTYVSSKNLGMSLLFGLLSFIANLV
                     YDYVMGASERKSKKDNK"
     CDS             1940..2110
                     /codon_start=1
                     /db_xref="InterPro:IPR012519"
                     /db_xref="UniProtKB/TrEMBL:O54220"
                     /function="antimicrobial"
                     /gene="eciA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Antimicr18"
                     /gene_kind="biosynthetic-additional"
                     /product="epicidin 280"
                     /protein_id="CAA74348.1"
                     /sec_met_domain="Antimicr18 (E-value: 6.6e-40, bitscore:
                     124.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKKDLFDLEIKKDNMENNNELEAQSLGPAIKATRQVCPKATRF
                     VTVSCKKSDCQ"
     gene            1940..2178
                     /gene="eciA"
     mat_peptide     2018..2107
                     /function="antimicrobial"
                     /gene="eciA"
                     /product="epicidin 280"
     stem_loop       2134..2178
                     /gene="eciA"
     gene            2194..3096
                     /gene="eciP"
     CDS             2194..3096
                     /codon_start=1
                     /db_xref="GOA:O54221"
                     /db_xref="InterPro:IPR000209"
                     /db_xref="InterPro:IPR015500"
                     /db_xref="UniProtKB/TrEMBL:O54221"
                     /gene="eciP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 158.4; E-value: 5.7e-48)"
                     /gene_kind="biosynthetic-additional"
                     /note="subtilisin-like leader peptidase"
                     /product="protease"
                     /protein_id="CAA74349.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.2e-20, bitscore:
                     60.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNSDYINYTYDDRDFFEKILFIDSGCDYNHSELKNNIDLKNCKS
                     FVDNNLNDYTGHGTQIISVLTGKIYLRGLIPNASIVVYKVTDYRGKTSIEKIYKALSQG
                     VKKGFKVINVSFSGAIDSIFYTKKFQEIIDEARIKNIIICWSPMNNDNRLNNHKNNTNL
                     IPNDFKNLFQIGSINRLNQISNLVCNENEIDFFAPGGDLVSETIPIEESFILLANTQLL
                     CKLSDYYIGIPKGYTINMGNSIATSYASGCFMIIISKFKRKYKYYPSINEVLKLISKYS
                     NSEINLIKITRSVVENALI"
     gene            3083..6013
                     /gene="eciB"
     CDS             3083..6013
                     /codon_start=1
                     /db_xref="InterPro:IPR006826"
                     /db_xref="InterPro:IPR006827"
                     /db_xref="UniProtKB/TrEMBL:O54222"
                     /gene="eciB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     660.2; E-value: 7.7e-200)"
                     /gene_kind="biosynthetic"
                     /product="EciB protein"
                     /protein_id="CAA74350.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.9e-45, bitscore:
                     142.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.9e-09,
                     bitscore: 27.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.3e-20, bitscore:
                     60.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLFKWYMIREPILEINKLEDIQERRDNNEDKYLNKLIDFIFDNE
                     LALPLYHANSNLFNMINNYKRKELSKKKKKNLILSLYNYITRMIFRATPFGFMSSINIG
                     SIKPNEMTVWNNDTQKYNLDLDNRVLYPLLKNLNKDIKNKIYLRKNYYIYKDYTHYYIP
                     YQLNFDKLIVNANNNINIERNELSDFIFSNLDSILYVDLVDLIKTKFNVDSKTVENYLD
                     KLIQENFIISELEEVINHKNKDIYLINFLEKKGVSPTNKYYQMLKSVYQFRVSLKNNYN
                     NKSLNQLMKINETFKKTLGFDSSNIFKVDFVNKYSEINFKEKDIQNIKKVINMLLHLPE
                     NYADYLTNYKSEFSEIYGQDEYKNILELLNKNLGIEYTIDNKDNEKFKENIQKSKKNIY
                     SLFSEWEYKAISENQDIVLTDEKIQSIKSLGEPPVDASVDMIFTVTQNENSEYIYHLND
                     ELTSAKVTDMYGRFRYLMNEDFEKALNKFPHDIGIQKVNSNYKHPNPLIQNVKNSDYLS
                     SYSSDFKNYFVFLGNDLNFYLKNKKDETIFIPKISDMHNTDYSPYIIDFLSKIEKQFIK
                     EYWSIENYKSSFVFSPRIVYKNIVISPKKWKLTNFDKMDNYENFKKLFFEKKVELSIPD
                     QFYIINADLKIYIDTQNTWCLELLFKEFKKNEHLNIIEVESNLLNNKKIKEVVFSAKSD
                     ICQSINIYEENKNNINLPKEILYITDGWLSVNLYYNENNISKLIGDFFYRKLFENEIFK
                     NSIKYFIRYIDDKKHIRLRIKINIDEINKVAKILKEMVDINYIKSYKIVPYYRETARYG
                     GKEIIDIVEECFEKDSKIVSKYYADKNFSSDDALYFNITNIVDILSYLTNSIDAQIDIL
                     SDISHKKENKKIYRKYKNNLMKIVEGDVNKYNIYLNLRKYAYSKLKFVLSDKKINDKKD
                     IILSIVHMFNNRFIGTDRKYEEFVMELLSRTLIDYKNKKEHICNNS"
     CDS             5998..7191
                     /codon_start=1
                     /db_xref="InterPro:IPR007822"
                     /db_xref="InterPro:IPR020434"
                     /db_xref="UniProtKB/TrEMBL:O54223"
                     /gene="eciC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     260.7; E-value: 3.7e-79)"
                     /gene_kind="biosynthetic"
                     /product="EciC protein"
                     /protein_id="CAA74351.1"
                     /sec_met_domain="LANC_like (E-value: 1e-82, bitscore:
                     266.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQFLEAYIKKVENIDIVDDYIHRAYGKEPIYKVSLITGYPGIAM
                     TLFSIYQHTKNFKYYKLANKYLEKTIDLISSVPIYSTSLFEGAFGVIFSLLICSDLGNN
                     YSEIIKSLLSEYKKIASDEIRDLKKNIKEGKVESQDYDIVSGCSGTLSVLLLATDIYPS
                     LYDYLNIEISQLSSILEKLVYEYNEIDNEQNTLFSDLGYAHGMPGVINILCNSYKRGYK
                     TSKTKDILINSISKLNRSLKIDNGTIYIPTDTNNTNNFRDAWCYGMPSVAYTIYNIAKT
                     FQISSLLELSQNLLYQTWLRKEYETKLISPTLCHGFSGIVIISLIMNNEDLANKYIDKI
                     NNTDVDDKDMLFFDINSNSSIMKDIGLLNGNSGILLTMLSFNNKDIQLNHWSKFLIF"
     gene            order(5998..7191,7217..7245)
                     /gene="eciC"
     stem_loop       7217..7245
                     /gene="eciC"
ORIGIN
        1 acgaaattgt ttatatctga aatagttcat acagaagact cctttttgtt aaaattatac
       61 tataaattca actttgcaac agaaccttta atgttaactt taccatcaaa tgatgcgtaa
      121 atactctcat tcatttgttt atcatatttt gataattgtt gttgtgcttc attgagtcca
      181 ctttgatctt gtgtcagttt agactgtaat tgattattgt tcggactttg attaatcttt
      241 tgataatcgt cattcacttg ttgttgtgct tgatcaactt tattcgcaag ttgttgacgc
      301 ttactattat tcgtatcgta acttagaaga cggtcacctt gtttaacctt ttgaccatcg
      361 tctacagcag gactttggaa tgtgccaatt tggctattat tgttatatgt tttgactgat
      421 ttgggagatg atttaccttc caaactaatc ggtgtttctt ttttaactgt atatgtatca
      481 taacctttac tatccttatc atcagaatca gttgtttgtt ttacggtgaa tgctgcaacg
      541 ataagtagta atataattgc cacgccaata atactccata gtagtttctt attcatatct
      601 tatactcctt ataatatagt tgattttaat ttattactaa tataaaatac tataattttt
      661 acacaatagc taaaagtaat cgtagcacat taatttcatt tatatttata cacttttttt
      721 acccaatcat acacttttag taatagtttg tctctgttga ctagttaagt ataaaaaatt
      781 atcattataa taacgaatat actagataat aattacattt ataactttaa ttagtatgta
      841 ttctcattat aatcagaaaa aaggagatac aatatgggta gaacggtttt gataacaggt
      901 ggatgtaaga atattggaaa acaaattgct caagtgtttg ctgaaaataa ttataatgta
      961 atagttacta gtagaaataa taataataaa tctattataa cttattttaa aaaaaagaat
     1021 ttaaaagtgt ttttttacac cttaaatgta gaaaatgaag atgaagttgt gaacgttttc
     1081 aaggaaatta ataatgatat tggaaaaata gatatattaa ttaataatgc tggtatttcc
     1141 caaggaaata ctttgttaga agacagtaaa acagaagatt tcaaatcaat gattaacacc
     1201 aatatattag gtagttatta ttgtatgaaa cacgttatac cttatatgaa aagaaataga
     1261 tatggtgtta ttataaatat agtatccatt gctgctttaa gaggtattcc ttattcaata
     1321 ttatatggaa gtactaaaaa tgctgttatt gcattaacaa aaggtgcggc tatcgaaaat
     1381 gctaacaatg gtattcgtgt taatgctatt gcgccaggaa taattaaaac agagtcatta
     1441 aatacagaaa ttcaaaactc agaagatgag ttaaatgaac aaacgattgc agctatacat
     1501 cctatgcaga ttttaggaga agaaaaagat gtcgctaata ctgcatactt tatagcgaac
     1561 agttccttca tgacaggaag tatagtaaat ttagatggag gttatactgc tcaataatta
     1621 cttttctttt attcatctga ataaaggcaa agaatattct caaaataaat aagaaaagag
     1681 gtaaaatata tgaatatata ccttaagata gttataactg ctttattttt ttcaagtata
     1741 atttttacag taacttatgt atcatctaaa aatttaggta tgtctttatt gtttggacta
     1801 ttatcattta tagccaacct tgtttatgat tatgtaatgg gggcaagtga aaggaaatca
     1861 aaaaaagata ataaataaag gaaaagcgct tacttttcac gtatattgtg ttattataaa
     1921 tttacaggag ggatatatta tggaaaacaa aaaagattta tttgatttag aaatcaaaaa
     1981 agataatatg gaaaataata atgaattaga agctcaatct cttggtcctg caattaaggc
     2041 aactagacag gtatgtccta aagcaacacg ttttgttaca gtttcttgta aaaaaagtga
     2101 ttgtcaatag tagtgattgt aaatagtata gagaaaaacc accctcattt aatcttagat
     2161 gaaggtggtt ttctctatgt ttaggagaaa ataatgacca attcagatta tataaattat
     2221 acatatgacg atcgagattt ttttgaaaaa atattgttta tagatagcgg atgtgattat
     2281 aatcactctg aattaaaaaa taacatagat ttaaaaaact gcaaaagttt tgtagataat
     2341 aatttaaatg attatacagg acatggcact cagattatta gtgttttaac aggtaaaata
     2401 tatctaagag gattgattcc aaatgcctcc attgtggtat ataaagttac agactatcga
     2461 gggaaaacta gtatagaaaa aatatataaa gcgttatctc aaggggttaa gaaaggtttt
     2521 aaagttataa atgtaagttt ttctggagca attgattcta ttttttatac aaaaaaattc
     2581 caagaaatta tagatgaagc tagaattaaa aatattataa tttgttggag ccccatgaat
     2641 aatgataata gattgaacaa tcataaaaat aatacaaatt taatacctaa cgatttcaaa
     2701 aatctttttc aaattggatc aataaacagg ttaaaccaaa tatccaattt agtatgtaat
     2761 gaaaatgaaa tagacttttt cgcacctggt ggagatttag tcagcgaaac tattcctatt
     2821 gaagaatcat ttattttgtt agcaaacaca caattattat gtaagttatc tgattattat
     2881 ataggtattc ctaaaggata tactattaat atgggaaata gtatagctac ttcatatgca
     2941 tcagggtgtt ttatgataat aataagtaaa ttcaaaagaa aatataaata ttatcctagt
     3001 ataaatgaag tcttaaagtt gatatctaaa tatagtaata gtgaaatcaa tttaataaaa
     3061 attacaagga gcgttgttga aaatgcactt atttaagtgg tatatgataa gagaacctat
     3121 tttagaaata aataagctag aggatataca agaacgacga gacaacaatg aagataaata
     3181 tctcaataaa cttatagatt ttatttttga taatgaattg gcattacctt tatatcatgc
     3241 gaatagtaat ctgtttaata tgattaataa ttataaaaga aaagaattat ctaaaaagaa
     3301 aaagaaaaac ttaattttaa gtttgtataa ttatataaca cgaatgattt ttagagcaac
     3361 tccattcggt tttatgtcat ctataaatat aggttctata aaacccaatg aaatgacagt
     3421 atggaataat gacactcaaa aatataatct agatttagat aacagagtac tgtatccact
     3481 tttaaaaaat ttaaataaag acattaaaaa taaaatatac ctaagaaaaa attattatat
     3541 atataaagat tacacacatt attatatacc atatcaatta aattttgata aattaatagt
     3601 aaatgctaat aataatatta atatagaaag aaatgaacta tctgatttta tattcagtaa
     3661 cttagatagt attttatatg tagatttagt tgatttgata aaaacgaagt ttaatgtaga
     3721 ctctaaaacc gttgaaaatt atttagataa attaatccaa gaaaatttta ttatttctga
     3781 attagaagaa gtaataaatc ataaaaataa agatatttac ttaataaatt ttttagaaaa
     3841 aaagggggta tctccaacaa ataaatatta tcaaatgtta aaaagcgtgt accaatttcg
     3901 ggtttctttg aaaaataact ataataataa atctttaaat caattaatga aaataaatga
     3961 aacttttaaa aaaacattag gtttcgattc ttctaacatt tttaaagtag attttgtaaa
     4021 taagtatagc gaaattaatt ttaaagaaaa agatattcaa aatattaaaa aagttattaa
     4081 tatgctactt catttaccag aaaattatgc agattattta actaattata agagtgaatt
     4141 ttcagaaata tatggacaag acgaatataa aaatatttta gagttgctaa ataaaaattt
     4201 aggtattgaa tatacgattg ataataaaga taatgaaaaa ttcaaagaga atatacaaaa
     4261 aagcaagaaa aatatctatt ctcttttttc agaatgggag tataaagcta taagtgaaaa
     4321 tcaagatata gtacttaccg atgaaaaaat tcaatcaata aaatcattgg gtgaacctcc
     4381 tgttgatgca tcggttgata tgattttcac tgttacacaa aatgaaaata gcgaatatat
     4441 atatcattta aatgacgaac ttacttcagc taaagttaca gatatgtatg gtcgttttcg
     4501 atatctaatg aatgaagatt tcgaaaaagc tttaaataaa tttccacatg atattggtat
     4561 tcaaaaagtt aattcaaatt ataaacaccc taatccatta attcaaaatg tgaaaaatag
     4621 tgactattta agtagctatt caagtgattt taaaaactat tttgtttttt taggtaacga
     4681 tttaaatttt tatttaaaaa ataaaaagga tgaaacaata tttataccta aaatatctga
     4741 tatgcataac acagactatt ctccctacat aattgacttt ctttctaaaa tagaaaagca
     4801 gtttattaaa gaatattgga gcatagaaaa ttataaaagc agttttgttt tttctcctag
     4861 aattgtttat aaaaacatag taataagtcc taaaaaatgg aagttaacta atttcgataa
     4921 aatggataat tatgaaaatt tcaagaaact tttttttgaa aaaaaagttg aattatcaat
     4981 acctgatcaa ttttatataa taaatgcaga tttaaaaatt tatattgata ctcaaaacac
     5041 atggtgttta gagttattat tcaaagaatt taaaaaaaat gagcatctca atataattga
     5101 agttgaaagt aacttattaa ataataagaa aattaaagaa gtggtttttt cagcaaaatc
     5161 agatatatgc cagagtatta atatttatga agaaaataaa aacaatatta atttaccaaa
     5221 agaaatttta tatataacag atggttggtt aagtgttaac ttatattata atgaaaataa
     5281 tataagtaaa cttatcggtg atttctttta tagaaaatta ttcgaaaacg aaatctttaa
     5341 aaatagcata aaatatttca ttaggtatat tgatgataaa aaacatataa gattaagaat
     5401 aaaaataaat attgatgaaa taaataaagt ggcaaaaatt ttaaaagaaa tggtagatat
     5461 aaactatata aaaagttaca aaattgtacc ctattataga gaaacagcaa gatatggtgg
     5521 caaagaaatt attgatatag tggaagagtg ttttgaaaaa gattcaaaaa tagtatctaa
     5581 gtattatgct gataaaaatt tttcttcaga tgatgcttta tattttaata taacaaacat
     5641 tgtagatatc ttatcttacc ttacaaattc tatagatgct caaattgata ttttatctga
     5701 catttctcac aaaaaagaaa acaaaaaaat atatagaaaa tataaaaata atttaatgaa
     5761 aatagtggaa ggcgacgtta ataagtacaa catatattta aatttacgaa agtatgcata
     5821 tagcaagttg aaattcgttt tgagtgacaa aaaaattaat gataaaaaag atattatatt
     5881 gagtatagtc catatgttta ataatagatt tatagggaca gatagaaaat atgaagaatt
     5941 tgttatggaa ctactctcac gaacattaat agactataaa aataaaaagg agcatatatg
     6001 caacaattct tagaagctta tataaaaaaa gttgaaaata ttgatatagt agatgactat
     6061 attcatagag cttatggtaa agaaccaata tataaagtta gtttaattac aggatatcca
     6121 ggtattgcaa tgactctttt ctccatctat caacatacta aaaactttaa atattataaa
     6181 ctagcaaata aatatttaga gaaaactata gatttaatta gttctgttcc tatatattct
     6241 actagtttat ttgaaggagc ttttggtgtt attttttctt tattaatttg ttcagatcta
     6301 ggaaataact atagtgagat tattaaaagc ctattatcag agtataaaaa aatagcttct
     6361 gatgagataa gagatttgaa gaaaaatatc aaagaaggta aggtagaatc tcaagattac
     6421 gatatagtat caggatgctc tggaactctt tcagtattac ttcttgctac ggacatctat
     6481 cctagtttat atgattactt aaatattgaa atatcacaat tgagcagtat tttagagaaa
     6541 ctggtatatg aatataatga aatagataat gaacaaaaca ccttattcag tgatctaggt
     6601 tatgctcacg gaatgcccgg tgtaataaat attttatgca actcttataa aagaggatat
     6661 aaaacttcaa aaactaaaga tattttaatt aatagtattt cgaaacttaa tagaagttta
     6721 aaaatcgaca atggaacaat ttatattcca acagatacta ataatactaa taatttcaga
     6781 gatgcttggt gctatggtat gccatctgtt gcatatacta tttataacat tgcaaagaca
     6841 ttccaaatta gtagtttgct tgaactaagc caaaatttac tatatcaaac atggttaaga
     6901 aaagaatatg aaaccaagtt gatttctcca acactgtgtc acggtttttc tggaatagta
     6961 atcatatcat taataatgaa caatgaagat ttagctaata aatatattga taaaattaat
     7021 aatacagatg ttgatgataa agatatgtta ttttttgata taaatagtaa ttcttctatt
     7081 atgaaagaca taggtttatt aaacggaaac tcagggatat tattaactat gctttccttc
     7141 aataataaag acattcaact aaatcattgg tcaaaattcc tcatatttta aagtatataa
     7201 atggaacgtt aatgataaaa agagagcgta tttgcgctct ctttttttgt ctcattatta
     7261 aaaattcata ataaattgtt atcataagtt ttaggacgct gtgagaatct ttcatttgca
     7321 tccaaaaata gtttactaaa ccaaatcctt ttgaattc
//
