LOCUS BGC0000509 15487 bp DNA linear BCT 11-OCT-2012 DEFINITION Staphylococcus epidermidis Orf1, ElxO (elxO), ElxT (elxT), ElxA (elxA), ElxP (elxP), ElxB (elxB), ElxC (elxC), Elx1 (Elx1), Elx2 (elx2), Elx3 (elx3), and OrdA (orfA) genes, complete cds. ACCESSION BGC0000509 VERSION BGC0000509 KEYWORDS . SOURCE Staphylococcus epidermidis ORGANISM Staphylococcus epidermidis Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. COMMENT ##antiSMASH-Data-START## Version :: 6.2.0-924c3663(changed) Run date :: 2022-11-07 19:43:33 ##antiSMASH-Data-END## FEATURES Location/Qualifiers source 1..15487 /db_xref="taxon:1282" /mol_type="genomic DNA" /organism="Staphylococcus epidermidis" /strain="15X154" protocluster 1..15487 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[8714:12901]" /cutoff="20000" /detection_rule="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /neighbourhood="10000" /product="lanthipeptide-class-i" /protocluster_number="1" /tool="antismash" proto_core 8715..12901 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /neighbourhood="10000" /product="lanthipeptide-class-i" /protocluster_number="1" cand_cluster 1..15487 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /kind="single" /product="lanthipeptide-class-i" /protoclusters="1" /tool="antismash" subregion 1..15487 /aStool="externally annotated by: MIBiG" /contig_edge="True" /label="BGC0000509" /subregion_number="1" /tool="antismash" region 1..15487 /candidate_cluster_numbers="1" /contig_edge="True" /product="lanthipeptide-class-i" /region_number="1" /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /subregion_numbers="1" /tool="antismash" CDS 4196..4729 /codon_start=1 /note="ORF1" /product="recombinase" /protein_id="AFN69429.1" /transl_table=11 /translation="MIVGYARVSSIDQNLERQLENLKTFGAEKIFIEKQSGKSVENRPI FQEALNFLRRGDRFVVEAIDRLGRNYDEVIGNPLLDKFMKNIIIQILAMISEQERNESK RRQAQGIKVAKEKGVYRGRPLLYSVNAKDPQKRIIYHRVVEMLEEGQAISKIAQEVNIT RQTVYRIQRDNLLS" gene complement(4943..5689) /gene="elxO" CDS complement(4943..5689) /NRPS_PKS="Domain: PKS_KR (4-148). E-value: 9.5e-10. Score: 30.5. Matches aSDomain: nrpspksdomains_elxO_PKS_KR.1" /codon_start=1 /gene="elxO" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short_C2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001:short-chain dehydrogenase/reductase SDR (Score: 205.9; E-value: 1.2e-62)" /gene_kind="biosynthetic-additional" /note="oxidoreductase" /product="ElxO" /protein_id="AFN69430.1" /sec_met_domain="adh_short (E-value: 5.4e-36, bitscore: 113.8, seeds: 230, tool: rule-based-clusters)" /sec_met_domain="adh_short_C2 (E-value: 1.2e-33, bitscore: 106.6, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MKKNVLITGGFKGIGKQVALEFLKNDYHVCITSRYFEKEKRIPHL FSSYEENISFYQLDVTDEEQVNEIINKIVKKFGRLDVLVNNAGISLSDGLLTETKTTDF NKMINTNILGTYFCMKYALKHMQKVSCGAIVNISSITGLSGFPYSILYGSTKHAVIGLT KGAAVEFADKGIKINAVAPGIIKTETLQKEIDSGEFSEDSISSIHPMQKLGTTLDVAKG IYFLANEDNNFITGHVLSIDGGYLSQ" aSDomain complement(5246..5677) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_elxO_PKS_KR.1" /evalue="9.50E-10" /label="elxO_PKS_KR.1" /locus_tag="elxO" /protein_end="148" /protein_start="4" /score="30.5" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C1" /tool="antismash" /translation="VLITGGFKGIGKQVALEFLKNDYHVCITSRYFEKEKRIPHLFSSY EENISFYQLDVTDEEQVNEIINKIVKKFGRLDVLVNNAGISLSDGLLTETKTTDFNKMI NTNILGTYFCMKYALKHMQKVSCGAIVNISSITGLSGFPY" CDS_motif complement(5591..5674) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_elxO_0001" /evalue="1.60E-04" /label="PKSI-KR_m1" /locus_tag="elxO" /protein_end="33" /protein_start="5" /score="14.3" /tool="antismash" /translation="LITGGFKGIGKQVALEFLKNDYHVCITS" gene complement(5708..7429) /gene="elxT" CDS complement(5708..7429) /codon_start=1 /gene="elxT" /gene_functions="resistance (resist) ABC_efflux (Score: 257.2; E-value: 1.9e-78)" /gene_functions="transport (smcogs) SMCOG1288:ABC transporter related protein (Score: 330.7; E-value: 3e-100)" /gene_kind="transport" /note="ABC transporter" /product="ElxT" /protein_id="AFN69431.1" /transl_table=11 /translation="MKTIHNNPLFYLFKKIRWPKKIFFTAIIITSLGSLSELAVPLLTG KFIDILVSNGINYKFISLLTLVFILDALLNGVGMFLLIKAGEKIIYSIRLLLWNKIIYL EVPFFDKNDSGQLISRLTDDTALINNFISRKIPSVIPEMLTLLGSLIMLFVMDWKMTLL TFIIIPLFLLVIIPLSNIIESLSQSTQLEIAKFTGIINRALSAIRLVKISNTENKELIT AEKKLNAIYRLNIRHARITAILEPFSNILLIIMIGIILGFGGYRISTGVITSGTLVTMI FYVVQLSSPITSLSTLLTDYKNAKGATKRIFEILKEQQESFNGIPYNKKQSYDLSFSSV YFSYNKKHILKDISFNIPKNKTTAIVGPSGAGKTTIFSLITRMYKIDSGAIKVGNESIY NFNLAEWRENIGYVMQNNSMISGTIKENILYGIKQDVSKDVFEKYVRFSNSHNFIMSLE SQYNSEVGESGNKLSGGQKQRINIARNLIKDPEILLLDEATSSLDSDSETKIQKSLNFL SKNRTTIIIAHRLSTIKDADQIIFLDNGKITGIGKHTFLMETHPKYKKFVLNQKLS" gene 7589..7756 /gene="elxA" CDS 7589..7756 /codon_start=1 /gene="elxA" /gene_functions="biosynthetic-additional (rule-based-clusters) Antimicr18" /gene_functions="biosynthetic-additional (lanthipeptides) predicted lanthipeptide" /gene_kind="biosynthetic-additional" /note="precursor peptide" /product="ElxA" /protein_id="AFN69432.1" /sec_met_domain="Antimicr18 (E-value: 1.7e-09, bitscore: 27.4, seeds: 2, tool: rule-based-clusters)" /transl_table=11 /translation="MKKELFDLNLNKDIEAQKSDLNPQSASIVKTTIKASKKLCRGFTL TCGCHFTGKK" CDS_motif 7589..7660 /prepeptide="leader" /note="peptide class: lanthipeptide" /note="predicted sequence: MKKELFDLNLNKDIEAQKSDLNPQ" /locus_tag="elxA_lanthipeptide" /aSTool="lanthipeptides" /tool="antismash" CDS_motif 7661..7756 /prepeptide="core" /locus_tag="elxA_lanthipeptide" /peptide="lanthipeptide" /predicted_class="Class I" /score="18.10" /molecular_weight="3171.8" /monoisotopic_mass="3169.8" /core_sequence="SASIVKTTIKASKKLCRGFTLTCGCHFTGKK" /aSTool="lanthipeptides" /tool="antismash" /leader_sequence="MKKELFDLNLNKDIEAQKSDLNPQ" /leader_location="[7588:7660](+)" /alternative_weights="3189.8" /alternative_weights="3207.9" /alternative_weights="3225.9" /alternative_weights="3243.9" /alternative_weights="3261.9" gene 7793..8728 /gene="elxP" CDS 7793..8728 /codon_start=1 /gene="elxP" /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_S8" /gene_functions="biosynthetic-additional (smcogs) SMCOG1075:alkaline serine protease, subtilase family (Score: 135.6; E-value: 4.8e-41)" /gene_kind="biosynthetic-additional" /note="protease" /product="ElxP" /protein_id="AFN69433.1" /sec_met_domain="Peptidase_S8 (E-value: 1.9e-20, bitscore: 62.8, seeds: 43, tool: rule-based-clusters)" /transl_table=11 /translation="MFLYLPFIIQLGDFMDNFLSWPNKNKYFDEIKDEVKILYIDSGCD INHIEVKENILINESKSFVDNDSELYDYTGHGTQIISAITGKHNMIGLYPRSKIVIYKI TNYKGETKFEWLYKALYKAIKMDYKIINISYSGYTQNNYIISKFKRLIEQAVKKNIHIL CSASNDEVEKGFSIPSDFKGVYKIASINIEDKYSSYISKSNAEYFAPGGDNYLKTQNPQ SFILLANSSISNFNIGSDFGIDKRYTLNFGNSIACSYVSCCIGLVVTRRKIKFNKDTSK RYIDCLYNKYKHISLNVIKNTKEIITNEHI" gene 8715..11675 /gene="elxB" CDS 8715..11675 /codon_start=1 /gene="elxB" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_N" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_C" /gene_functions="biosynthetic-additional (rule-based-clusters) Lanthipeptide_LanB_RRE" /gene_functions="biosynthetic-additional (smcogs) SMCOG1155:Lantibiotic dehydratase domain protein (Score: 559.8; E-value: 1.7e-169)" /gene_kind="biosynthetic" /note="lantipeptide dehydratase" /product="ElxB" /protein_id="AFN69434.1" /sec_met_domain="Lant_dehydr_N (E-value: 3.2e-81, bitscore: 262.8, seeds: 73, tool: rule-based-clusters)" /sec_met_domain="Lant_dehydr_C (E-value: 5.1e-20, bitscore: 61.7, seeds: 35, tool: rule-based-clusters)" /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.4e-10, bitscore: 29.1, seeds: 20, tool: rule-based-clusters)" /transl_table=11 /translation="MNIFKKYMYRSPLLSLNEFNKIQRDDLTDKEYTKYLINYVEENNL YANIYSSSKVLYFALINFNNDTSDKKTKSILKSLYKYLVRMIFRATPFGMYSGVGINEI YESNYIEKESVTYYGYLNNHLLYYLIDRLHNNSKVLHKLKLNINPILHHDKKNIFLPYQ VDYSLTSIVSSDNISQRNNELIEKVINLAKNSIEFKELKEIIMYEFKANEEIAVNYLKK LIKEDFLMTDFKINLSKKNAFKGILFKLQEIDEIDNEVYEILDNLSIIINQIKNTIDRN SILELLIDADKIVKKFYPEFKENAINIDTKLQGKKINLTENDIDDIINVSTLISKLTVF KSSKVLENYKNKFLEIYGENEDVQLLKLLNSSTGLGIPKEYNLSSNLNDLKKANALSGL LENWKTEALIKNQDSIVLNNRRLKELKPYLLKDNINTSFDVFFIKFNKTSSKLYLKTNS GSLQSMQTYGRFMYMFNKQLKYEVNEFCKFYVPMMSHKEIIYNHPNPKLQNVMSSTFSS DAIDFLGVEGNLNIENLYVCLGEDFKFYIKDKQTGNIIFPDFKDMHNTNLSPVVIRFLS DISLQYSTGGYFLNYSATEHAYSPRIEYKNVVLSPRKWHMNFPKKLNFDAFLNELKKFK ELYNLDIVFYIINDDHKLYIDTRFDISLQILYDQYKKQEILEVEEVEEELSFNKDIGIN ELVFSVSNNENSISEKNIAMIDKDIRNYKEVILPGNNWICLNLYYDEYNFKEFMNKGIW NDLFKDIGKNHDIDTVFFIRYFDSDPHIRLRFRIKENINKNRNDILNKLNKFKNENFLK TFSIVPYYRESYRYGGLNCIHLAEKCFQIDSKIVARYYGELDDKSDKIDFAIDNIIEIL NLFTGKCIEENIKILSVFGKNKENKDLYREKRNRIFKSISNNDKYIYNYGISDFRKKVY LKYINELKKENKLNNHDIILSIIHMFCNRLFGIDREIESKVLEIIYRSLIDYKKIN" gene 11693..12901 /gene="elxC" CDS 11693..12901 /codon_start=1 /gene="elxC" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: LANC_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1140:Lanthionine synthetase C family protein (Score: 223.6; E-value: 6.8e-68)" /gene_kind="biosynthetic" /note="lantipeptide cyclase" /product="ElxC" /protein_id="AFN69435.1" /sec_met_domain="LANC_like (E-value: 9.1e-59, bitscore: 188.4, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MENSIQKSLSYLSDIKLVNKNIEDNIGSDVIFKISLAYGYPGIAL LFNEAYKLTKNIDYYEYCHNYLSETLNLIKHNPMYSTSLFTGVMGYLFTLASCSNDGEN YRNISYQILDEYNAFFNVSLNEVNIALLNKDFSKDSFDIINGAAGTLLSLLHIYDIYGN LHYNLEKWIQSLTNLLEKLIIKSISNNYPEHENVLTDLGVSHGITGIINIVNAAFKRDF GSYTLHNTLLRAKNFLLSLIEKYESSYIIPNFRHFSKENLNHRDAWCYGTPGVAMVLYN LGINLKDKEIINTSKKLASETLKRNKSTRLLISPTLCHGYSGIAIINKYLGNFYVEDYY YNQIENSKNTNLRLMFRNIDYNGENFVYDDNLGLLEGSSGVLLTLLSKKGFNSTWYKLF CFA" gene 12940..13158 /gene="elx1" CDS 12940..13158 /codon_start=1 /gene="elx1" /note="hypothetical protein" /product="Elx1" /protein_id="AFN69436.1" /transl_table=11 /translation="MIFLTKILDTLAYICVGLIFLKYLILTVNSCFDWHLRWYFLENIP YMAIILFVATFIFAVPSEMIKDKLKDK" gene 13183..13908 /gene="elx2" CDS 13183..13908 /codon_start=1 /gene="elx2" /gene_functions="biosynthetic-additional (rule-based-clusters) Abi" /gene_kind="biosynthetic-additional" /note="CAAX amino protease" /product="Elx2" /protein_id="AFN69437.1" /sec_met_domain="Abi (E-value: 6.6e-14, bitscore: 41.8, seeds: 823, tool: rule-based-clusters)" /transl_table=11 /translation="MILQLKSVNWPEFIFFPIVFFSSFLVNIILSLINNFFNINFFSVL GTKNVVIMSDFSINLIIIFLFLILEKKTKKNIVESLEYIKKNIFLFMFLFTLPKLVIIL INYLFNLSNVNFNLSKTENQMLIIDWIKEPNYFFMKIIIFLSIILVGPISEEILYRHLI IGELGKIFSYKLMAFISIILFSLIHVSDAKSSLEILTYLILSLSLVLIYLISKRNIFVS ITLHCFINITSYAYIYYFY" gene 13937..14152 /gene="elx3" CDS 13937..14152 /codon_start=1 /gene="elx3" /note="hypothetical protein" /product="Elx3" /protein_id="AFN69438.1" /transl_table=11 /translation="MTKILDFLSTACFVLLSSKYAISSINMIFDLKLRWYILEDIPHLS IILLILTLVFFVSSEMIKDNKEKNKK" gene complement(14476..15261) /gene="orfA" CDS complement(14476..15261) /codon_start=1 /gene="orfA" /note="membrane-spanning protein" /product="OrdA" /protein_id="AFN69439.1" /transl_table=11 /translation="MKCKMGTLVKQECFKLFKKKSTYILPIIIIIIMLSLAILGNHYSD VFNLKESFKGGFSSFSWVVFLMIIQASTIISMEFHYGTIKNLLYRNYSRTSIIVSKFIT LLIYSLIIFLVFIIISLLLHLIFNGETSLTEHSKNHISLLNSMLLTALGTFVGMWLVMS LTLLISCIMKSPGVSIAVGIVFYFAVSIISGLLTVVIDKWEWLKWNPLNMMNIMAQITD NDTFKKITKLELHELFIGNIIYIVIFLVLVVVAFKKKNV" ORIGIN 1 gatcttatac atttatacct ccatatataa ctcatattat atggatttgt attttctata 61 attatagtaa tcaaaatata ctatctagtt acgctgcatc tgctatcatt ttattcttta 121 tctcttcttg gataacattt attatttttg atttggaggg aaataatgaa aagcatttat 181 tatttataca attaaattct aaaattaaat ttctaaattt aaaaatattt ttttccttta 241 tttcttcaat acctttaata attatttctt tccttttccc tattgttact tataggtttt 301 ctgaagctat aactttccaa tacgcctttc taagtatata tttacatatt atcgtagtca 361 tattaggtat tattctcgga tcactgattc gtatacaaac tatattgtct agaaagtata 421 gttggttatt attagtgcta cttactttac tatcaattat taaatttata ttagttaaca 481 atcaacatat tttaaaatac gttttaatta ttgtgccttc cgtaggggaa tttttaaact 541 atttcaatca acctattgca aaattatggt gttttgactt tctaattctt aatactaata 601 tagcggtata tatagtaata actcttattt taattaacct tatatttaaa tattcagaga 661 atcattaatt aaccctatta ctaatttaaa atataattaa tatggttctg ttgcaaagtt 721 gaaaaataaa agaagttatt gaacacatat aaatcaagta gacaaaaatg attatgacaa 781 acgtattgaa catgaaaata aacttgataa taaaattaat cataaaaaaa gaagaagaaa 841 cacgagtaag aacagaagag aaataactaa ataagaagtt agtaagatat tgaaaatata 901 caagtttcat tctttagcaa taagaagctt aatcaaaagg gtacatttac tttgttttat 961 tgaagaattg gaaggttaac gtcaataaag cactatttct ttataatcta ttttcagtag 1021 aaaggaattt tttatgaata gtaattatat tacttttgct ttttttaatg aaataccgtt 1081 gtttgatttc aaatttctat tgttaaatca tgagattgag caatggaacc aggaatatga 1141 agcttttaat tttgaattta atggaattaa atttaaaagt agattggcta aaaaaactcc 1201 taaaaaagag gggtattttg ttgcatgctg gcgtaaaaat gagactaata aaaatagacc 1261 ttttaattgt aaagaatcaa aagataaatt gattattaat atattagaca gatctaaaaa 1321 aggccaattt attttcccta aagagttgtt ggttaaaaaa gggattatta gttctgaaaa 1381 acacaaaggt aaaatggcta ttcgcgttta tcctagttgg gaaaagaatt taaataaaac 1441 agctcttaat acacagaaat ggcaaattcc ttatttttta gattttacta agggatttaa 1501 tgagaaaaaa attaaggaat tgtatttaaa ttgactttaa ttttagaaaa gagtttcttc 1561 ttgtactgat aattaatatg cttatattag acagtatcat atatcttcat tttcaataaa 1621 catacaatta caaccataac ttttaagttt aagtaattgt aaatcaattg attcattttt 1681 aggtaaatgg cgaatataac caatttttga cattagatta gctcctttgg aatagtttag 1741 aaaatatgaa gttatctata ttttactaaa gtaaagttta ttatagttac tttttgatgt 1801 ttatttagac ataaaatgac ttatcggaag ttatctgtaa ctcatctagt acagatgata 1861 taatatacag gtcgcctatc tctcaggcgt caatttagag acgcagagag gaggtgcata 1921 tcagatggtc gaagctcttg ttcacatcat gaccacagtc atcagtggtt gtattgttgc 1981 gttatttacg cattggctac gtacacgtaa caataagaaa aaataggcga tattagccaa 2041 cacctaaaaa tcccctcact actcgcaata gtgaggggat tggtgcatat aatgcacgaa 2101 gctcttgtta tctaaattat aacactggtt agtagagtaa tgcaaaaatg tatataataa 2161 atattttatc atgattcaaa gtattcgtta tttctataaa tattagaatt atgacttaat 2221 gtctaaattg ttctaaatat tatttatact taacactgca agtgatactt ccaatcgcga 2281 atacggcgtt actatagtta atacaataat acagatgata ttataatcca tacagtaact 2341 acaataggaa ttaatgattt aaataaaaaa atgccatatt ttttctttct atacaagtcc 2401 attattagcc agataactat aataatgatt ccaacaaaaa taaatacagg gttcatcgac 2461 aaactgtcta ctttaatatc actaacaata tgtactttcg taagtattaa aagtacgata 2521 gcaattaaaa agtagtaaac ggatttaatt ttcgaaattt gtaagtctaa cttttgatat 2581 tctatatcat cttgatttgc attttccttt ttactaatta gatagttcaa aactttaggt 2641 tttgtccaaa aattcttgat tgcaaaatac atatacacaa atgaaccaat taaagtaaat 2701 gctatataat tacttaaatc atttcctgta agtttatttc caataaaatg aaaaataatc 2761 aacattatta caataacaaa atctaaaaaa atagataaaa ttgaaaaatt ttcagatttc 2821 agaagactgt caaatagagc taaataaaat ataataaata ctccaatcag tacaaaataa 2881 accaatactt acacttcctt aattattctc atataccttt gcttttgttt cacatcaacc 2941 tttatatcgt tcactattaa aacatttttt gatagagtag ggtcaacttt taacatatca 3001 atatattcta tgtttaattc agagatatgt tgtaacctgt catttaaaga aataaacact 3061 atattctgat attcattaat cccaataagc tccctttgaa atattatagg tcctgttagc 3121 tatttatagt tataaattat aaaattcatt tactgtatct aaacctttta accagttttc 3181 ttctttatta atttcaaatg ttattttgac gaaataaggc attacattca tacctaattc 3241 tattataatt tcatcccatc ttctttaatg tcataattta agagacctaa ataaaaatat 3301 gttcgtccaa ttaataaatg gctacaaaat aacattatca ttcccatcca aatcgttcta 3361 ttttcttcag aatcaacagg aagaattaat gatacataca gcaatagtcc aaatgataat 3421 aaaatagtta aaattccaat cattctaata aaactaccat tttggatacc aaacatctca 3481 aattcaccta gacaaaataa gaatagacct atagcagaga ctattatgag cccacaaatt 3541 aacaaccaat atgtaaaaat atcgtctcta gaatctgcaa aataaaaagc ataagcagaa 3601 ctaattaaaa atggaatatt gtatcctgaa agtagattga tggtcatata tattacaact 3661 ctgaatttat aattttttcg attataatgt ttaaaaatat actcacgttc ttgtaaataa 3721 agaagcaacc ataataataa tgatcctatt aaatatactt tcatatataa aggcatattc 3781 ccttttatac ctggacctgc atatataaaa tagtaaactg caaaaataat gaaattcact 3841 aatgataatc ctattaaatg tgaatgttga attgattcta ttgatttttt ttgtagattt 3901 acctccataa tatccacctt ccttttatca atataatatt atcacaactt atattaaata 3961 tcgttgctat ttggattaat tgctttttat ctatattatc tattgatatt tttagtatta 4021 ttatattttc agaaattctt tctaattggg atgacactac aaaacttaaa gctgctttaa 4081 aaaaacaatt tatatataaa ttaagggtac accctaatca tacaaatgaa gttgttgaat 4141 ttatagcaac taaaacgtat gattagggtg tatattaatt atgaggtgaa aatcaatgat 4201 tgttggctat gcgagagtat catctatcga tcaaaattta gaaagacagc ttgaaaattt 4261 aaagacgttt ggtgctgaaa aaatttttat agaaaaacag tctggtaagt ctgttgaaaa 4321 tagaccgata tttcaagaag cacttaactt tttgagaagg ggggatcggt ttgtagtcga 4381 agcaattgat cgtttaggtc gtaattacga tgaagtgatt ggcaatccat tattagataa 4441 atttatgaaa aacataatca ttcaaatatt agcaatgatt tcagaacaag agcgaaatga 4501 aagtaaacgt cgccaagcac aaggtattaa agttgcgaaa gaaaaaggtg tgtatagagg 4561 acgcccttta ttatattctg tcaatgcgaa agatcctcaa aaacgtatca tttatcatag 4621 agttgtagaa atgttagaag aaggccaagc aattagtaaa attgcccaag aagtaaatat 4681 tacaagacaa acagtatata gaattcaacg cgacaattta ttatcttaat aaattgtcgc 4741 gttgaattct atattgattt taagcctcat tgtatgttat tattcaaaat tagacacaga 4801 ttaaataaga tttaaatcaa ataattcttt attgcacttc ccacattttt ctatatgtaa 4861 tctaacaaag aaaaatgtgg gatttgtcat tcacaaaata cataaactca gtttttagta 4921 taatataaaa agataaatgt atttattggg ataaatatcc tccgtcaata cttaatacat 4981 gacctgtaat aaaattattg tcctcgtttg ctagaaagta tatcccttta gcaacatcta 5041 aagttgttcc taatttttgc ataggatgta ttgaagaaat agagtcttct gaaaattcac 5101 cagagtctat ctccttttgt aaagtttcag tttttataat tccaggagcc actgcgttta 5161 ttttaatccc tttatcagca aattcaacag ctgctccttt agttaaacca ataacagcat 5221 gttttgtgct accgtataat atagagtaag gaaatccgct taatcctgta atagaagaaa 5281 tatttactat tgctccacaa gaaacttttt gcatatgttt taatgcatac ttcatacaaa 5341 agtaagtgcc taaaatattt gtatttatca ttttattaaa gtctgtagtt ttagtttctg 5401 ttaataatcc atcacttaaa gaaataccgg cattgtttac taaaacatct aatcttccaa 5461 atttttttac tatcttattt attatttcgt ttacttgttc ttcgtctgta acatctaatt 5521 gataaaaaga aatgttttct tcatatgatg aaaataaatg aggaattctc ttttcctttt 5581 caaaatacct gcttgttata catacatgat aatcgttttt taaaaattct aaagctactt 5641 gttttccaat tcctttaaag ccgcctgtaa taagaacatt ttttttcaca ataattttcc 5701 tttctcatca tgataatttt tgatttaaaa caaatttttt atattttgga tgagtttcca 5761 ttaaaaaggt atgtttacca atgcctgtta tttttccgtt atctaaaaat ataatttggt 5821 ctgcatcttt aattgtagac aatcgatgtg caataataat tgtagttcta tttttagata 5881 gaaagtttaa agacttctgt atctttgttt cactatcact atcaaggcta gatgttgctt 5941 catctagaag taaaatttca ggatctttaa ttaaatttct agctatattg attctttgtt 6001 tttggcctcc agatagtttg ttgccacttt ctcccacctc tgaattatat tggctttcaa 6061 gggacattat aaagttatga gaattagaaa atcggacata cttttcgaaa acatctttcg 6121 aaacatcctg tttaataccg tataagatat tttctttaat tgttccactt atcatagaat 6181 tattctgcat cacataacct atattttcac gccattctgc cagattaaag ttgtaaatag 6241 actcatttcc aactttaata gctccactat caattttata catcctagta atcaagctaa 6301 atatagttgt tttaccagct cctgagggtc ctactattgc tgttgtttta tttttaggta 6361 tattgaaaga tatatctttc aatatatgtt tcttattata agaaaagtaa actgagctga 6421 aagataaatc gtatgattgt tttttattat atggaatacc attaaaggat tcttgttgtt 6481 ctttcaaaat ttcaaagatt cttttagtag ctcccttggc atttttatag tcagttagta 6541 atgtggacaa gctagttatc ggagaactaa gttgcactac ataaaaaatc atggttacta 6601 gtgtaccaga agttataaca cctgtagaaa ttctataacc tccaaagcct aaaataatac 6661 caatcataat tattaataaa atattagaaa aaggttctaa tattgcagtt attctagcat 6721 gtctaatatt taaacgataa atagcattta gctttttttc agcagttatc aattctttat 6781 tctctgtatt tgatatttta actaatctta ttgctgacaa cgccctatta attataccag 6841 tgaattttgc aatttctagt tgagtagatt gagataagga ctcaataatg ttactaagtg 6901 gaattattac tagtaaaaat aaagggatta ttataaaagt taaaagagtc attttccaat 6961 ccattacaaa caacattatt aatgaaccta ataaagttaa catttctggt ataactgagg 7021 ggattttacg tgaaataaaa ttatttatta gtgcagtatc gtcggttaat cgacttatta 7081 attgtccgct atcattttta tcgaaaaagg gtacttcaag ataaataatt ttattccaca 7141 atagtaatct tatagaataa attatctttt ctcctgcttt aatcaataaa aacattccca 7201 ctccatttaa taatgcatct aatataaaca ctaaagttaa tagtgagata aatttataat 7261 ttataccatt acttacaaga atatctataa acttaccggt taataaaggg acagctagtt 7321 cactcaaact acctaacgaa gttattataa tagcagtgaa aaatattttt ttaggccacc 7381 taattttttt aaataaatag aaaagagggt tattatgaat cgttttcata ggaaatcctt 7441 ttttttttta aattcaatta aataataaca taaaacaaga aaagcatata tatttatata 7501 tgagtataca caataattta atttttatta aaagtattga taatagtaat gcgataaatt 7561 atattaggat tataggaggt gagatattat gaaaaaagaa ttatttgatt taaatcttaa 7621 taaagatatc gaggcacaaa aaagtgacct aaatccgcaa tcagctagta ttgttaaaac 7681 aactatcaaa gcttctaaaa agctttgtag aggatttaca ctaacttgtg gatgtcactt 7741 tactggtaaa aaataatagg tgtttttagg taggtataaa agtatgttta tcatgttttt 7801 atatctacct tttataatac agttaggaga ttttatggat aattttctta gttggcctaa 7861 taaaaataaa tattttgatg aaataaaaga tgaagttaaa atattatata tagatagtgg 7921 gtgtgatata aatcatatcg aagttaaaga aaatatattg ataaatgaat ctaaatcttt 7981 tgtggacaat gatagtgaat tatatgacta tacgggacat ggaacacaaa ttattagtgc 8041 aataacaggt aagcataata tgattggact atatcctaga agtaaaattg taatatataa 8101 aataactaat tataaaggtg aaactaaatt tgaatggtta tataaagcat tatataaagc 8161 tataaaaatg gactataaaa ttattaacat aagttattca ggatacaccc aaaataatta 8221 cataatatct aaattcaaaa gattaataga acaagcagtt aaaaaaaata tacatatttt 8281 atgtagtgct agtaatgatg aagtggaaaa aggtttttca ataccttctg attttaaagg 8341 agtctataaa attgcgagta taaatattga agataaatat tctagttata tttctaaatc 8401 taatgctgaa tactttgctc ctggaggaga taattattta aagacacaga atccacaatc 8461 atttattttg ttagctaata gttctatttc taactttaat attggttctg attttggtat 8521 agataaaagg tatactttaa attttggtaa tagtattgca tgctcctatg tttcttgttg 8581 tattgggcta gtagtaacac gaagaaaaat taaatttaac aaagatactt ctaaaaggta 8641 tatagattgt ttatataata aatacaagca tataagtttg aatgtaatca aaaacacaaa 8701 ggagattatt actaatgaac atatttaaaa aatatatgta taggagtcct ttattatcac 8761 taaatgagtt taataaaatt cagagggacg atcttacgga caaggaatac actaaatatt 8821 taataaacta tgtagaggaa aacaatcttt atgcaaatat atactcatct agtaaagttt 8881 tatattttgc tttaataaac tttaacaacg atacttctga taaaaaaaca aaaagtattt 8941 tgaaatcttt atataaatat ctagtgagaa tgatttttag ggctacacct tttggtatgt 9001 actctggggt agggattaat gaaatatatg aatctaacta tatagaaaaa gaaagtgtaa 9061 catattatgg ttatttaaat aatcacttat tatattattt gattgatcga cttcataata 9121 attcgaaagt tttacataaa ttaaagttaa acataaaccc cattttgcat catgacaaaa 9181 aaaatatttt tctaccttat caagtagatt attctctaac ttcaatagta tcttctgata 9241 atattagtca aagaaataat gagttaattg aaaaggttat aaatctggct aaaaattcta 9301 ttgagtttaa agaattaaaa gaaatcatta tgtatgaatt taaagctaac gaagaaatcg 9361 ctgtaaacta tttgaaaaaa ttaataaaag aagatttttt gatgactgat tttaaaatta 9421 atttaagtaa aaaaaatgct tttaaaggca tattatttaa gctacaagaa attgatgaaa 9481 tagacaatga agtatatgaa attttagaca atttatcaat cattataaat caaataaaaa 9541 acacaataga tagaaatagt atactagaat tactaattga tgcagataaa atagtaaaaa 9601 aattttatcc tgaatttaaa gaaaatgcga taaatataga tactaaacta caaggtaaga 9661 aaataaatct aactgaaaat gatattgatg atattataaa tgtatctaca ttgatttcca 9721 aactaacagt ttttaaatct tctaaagtat tagaaaacta taaaaataaa tttttagaaa 9781 tttatggtga aaacgaagat gtacaattgt tgaaattatt aaatagcagc actggtttag 9841 gcatacctaa agaatacaat ttatctagca atttaaatga tttgaaaaaa gcaaatgctc 9901 tgtcaggatt attagaaaat tggaaaactg aggctttaat aaaaaatcaa gactctattg 9961 tattaaataa tcgaagatta aaagagttaa aaccttattt attaaaagac aatataaaca 10021 cgtcttttga tgtttttttt attaaattta ataaaactag cagcaaacta tatttaaaaa 10081 caaactcggg ttcattacaa tctatgcaaa catatggaag atttatgtat atgtttaata 10141 aacaattaaa gtatgaagtc aatgaatttt gtaaattcta tgttcctatg atgtctcata 10201 aagaaattat atataatcac cctaatccta aattacaaaa tgtgatgtcc tcaacattta 10261 gttcagatgc tatcgacttt ttgggagttg aaggaaattt aaatatagaa aatttatatg 10321 tttgtcttgg tgaggatttt aagttttaca taaaagataa acaaacaggt aatataattt 10381 ttcctgattt taaagatatg cataatacta atctatcacc tgttgtcatt agatttttat 10441 ctgatatctc tctacaatat agtactggtg gttatttctt gaattattct gctacagagc 10501 atgcttattc cccaaggata gaatataaaa acgtagttct ttctcctcgt aaatggcata 10561 tgaattttcc aaaaaagttg aattttgatg cctttctaaa cgaattgaaa aaatttaaag 10621 aactttataa tttagatata gttttttata taattaacga tgatcataaa ttatatattg 10681 atacaagatt tgatatctct ttacaaattt tatatgacca gtataaaaaa caagaaattt 10741 tagaagtaga agaagtagaa gaagaactat cttttaataa agatataggt attaacgaac 10801 ttgtattctc agtttctaat aatgaaaatt caatttcaga aaaaaatata gctatgattg 10861 ataaagatat aaggaattac aaagaggtta tattgcccgg taataattgg atatgtctaa 10921 acttatatta tgatgaatac aattttaaag agtttatgaa taaaggaata tggaacgatt 10981 tatttaaaga tataggaaaa aatcatgata ttgatactgt ttttttcatt aggtattttg 11041 attcagatcc tcacataaga ttaagattta gaataaaaga aaacattaat aaaaacagaa 11101 atgatattct aaataaacta aacaaattca aaaatgagaa ttttttaaaa actttctcta 11161 tagttccgta ttatcgagaa agctatcgtt acggaggatt aaactgtatt catctagccg 11221 aaaaatgctt tcaaatagat tctaaaattg tagctagata ctatggggag ctagatgata 11281 aatcagacaa aatagatttt gctatagata atattataga aattttaaat ttattcacag 11341 gtaagtgtat tgaagagaat ataaaaattt taagtgtttt tgggaaaaat aaagaaaata 11401 aagacttata tagagagaaa agaaatcgaa tctttaaatc tatttctaat aatgataaat 11461 atatatataa ttatggaatt agtgatttta gaaaaaaagt atatttaaag tatataaatg 11521 aactaaaaaa ggaaaataaa ttaaataatc atgatataat acttagtatc attcacatgt 11581 tttgcaatag attgttcgga attgatagag aaattgaaag taaagtatta gaaattatat 11641 atagaagttt aattgattat aaaaaaataa actgatttat aggagtataa tgatggaaaa 11701 tagtatccaa aaatccttat catacctttc agatataaag ttagttaaca aaaacattga 11761 agataatata ggatcggacg ttatatttaa aattagttta gcgtatggat atcctggcat 11821 agctttactt tttaacgaag catataaact cactaaaaac attgattatt atgaatattg 11881 ccataattat cttagtgaaa ctttaaatct aattaaacat aacccaatgt attctacttc 11941 attatttact ggtgttatgg gttacttatt cacactagca tcatgctcta atgatggcga 12001 aaattataga aatataagtt atcaaatttt agatgaatat aatgcttttt tcaatgtatc 12061 tttaaatgaa gttaacattg ctcttttaaa caaagatttt tcgaaagata gttttgatat 12121 tataaatgga gctgctggta ctttgctaag tttactacat atatatgata tttatggtaa 12181 tcttcattac aacttagaaa aatggataca aagtcttaca aacttgttag aaaaacttat 12241 aataaaatcc ataagtaata attatccaga acatgaaaat gttttaacag acttaggagt 12301 gtctcatgga ataactggta ttataaatat tgttaatgct gcatttaaaa gggattttgg 12361 tagctataca ttacataata cattattacg tgctaaaaac tttttactat ccctaataga 12421 aaaatatgaa agttcttata taatacctaa tttcagacat ttttctaaag aaaatttaaa 12481 tcacagagat gcttggtgtt atggtactcc tggagttgct atggtactgt ataatttagg 12541 aattaattta aaagacaaag aaattataaa tactagtaaa aaattggctt ctgaaacttt 12601 gaaaagaaat aaatctacta gacttctaat ttcaccaaca ctatgtcacg gttatagcgg 12661 aatagctatt attaataaat acttaggtaa tttttatgta gaagattatt attataatca 12721 aattgaaaat tctaaaaata ctaatttaag attaatgttt agaaacatag attataacgg 12781 agaaaatttt gtttatgatg acaatttagg tctattagag ggtagttctg gtgtactatt 12841 aaccttactt tcaaagaagg gttttaattc aacttggtat aaattgtttt gttttgcgta 12901 aacaatttta cattaaacat aattgaaagg tgatgtttta tgattttttt aacaaaaatt 12961 ttagacacct tagcatatat atgtgttggt ttgatattct taaaatattt aatattaaca 13021 gtaaatagtt gttttgattg gcatttaaga tggtattttt tagaaaatat accatatatg 13081 gctattatat tatttgtagc tacatttatt tttgcggtac cttctgagat gattaaagat 13141 aagttaaaag ataaataata cagattttaa aagaggtgct atgtgatttt acaactaaaa 13201 agcgtgaact ggcctgaatt tatatttttt cctatagttt ttttttcttc tttccttgtg 13261 aatattatac tttctttgat caacaatttt tttaatatca attttttttc agtattaggg 13321 actaaaaatg tagtgataat gtctgatttt tcaataaatt taataataat ctttttattt 13381 ttaattttag aaaaaaaaac aaaaaaaaat atagtggaat ctttagaata tattaagaaa 13441 aacatttttc tttttatgtt tctttttact ttaccaaaat tagtaattat tttgattaac 13501 tatttattta acttaagtaa tgtgaatttc aatttatcta agactgagaa tcaaatgcta 13561 ataatagatt ggataaaaga acctaattac ttctttatga aaataataat ttttttatca 13621 ataattctag tcggacctat atcagaagaa atactgtatc gtcatcttat tatcggagaa 13681 ttaggtaaaa tcttttctta taaactcatg gcttttattt caattattct attttcttta 13741 atacatgttt cagacgcaaa atcatctcta gaaatattaa cgtacttaat tttatcctta 13801 tctttagtct taatatactt gatatcaaaa agaaatattt ttgtttctat aacattacat 13861 tgttttatta atataacttc ttacgcgtac atatattatt tttattaata tttctatttc 13921 aggaaggagc agttttttga caaaaatatt agattttcta tcaactgcat gctttgtatt 13981 actgtcatct aaatatgcta tatcatcaat aaatatgata tttgacttaa aattacgttg 14041 gtacatctta gaagatatac ctcatttatc tataatatta ctaattttaa ctttagtttt 14101 cttcgtttct tcagaaatga taaaagataa taaagaaaaa aataaaaaat aaaaaatcat 14161 tttatagaca acctctataa tatatagagg ttgtctggtt ctgttgcaaa gttagaaaaa 14221 gtatagctaa tcatcatttt atcatgtcaa ggttcgttta actggctaac atatgactga 14281 tttcatggca tggagaaaaa ccgtaaatct gaagagtgga ctgaccccaa ttagtgggaa 14341 ttatataaaa cactttcgtt gaattcatat taaaatgaat catgcggagg tgttttttct 14401 atgaaaagag ttgcttattc attttgaatt acatttctaa taaattcata atctccaata 14461 tatcatctaa ataaactata cattcttctt cttaaaagca actacgacta atacaagaaa 14521 gataacaata tagataatat ttccaatgaa taactcatgt aattctaact ttgttatttt 14581 tttgaatgta tcgttgtcag taatttgcgc cataatattc atcatattca gaggattcca 14641 ttttaaccat tcccatttat ctataactac tgttaataaa ccagagataa ttgagacagc 14701 aaagtaaaac acaataccta cagcgattga tacgccagga cttttcataa tgcatgagat 14761 gagtaatgtt aagctcataa ctaaccacat tccaacaaat gtaccaaggg ctgttaataa 14821 catagagttt aatagtgata tatgattttt agagtgttca gttaaactcg tctctccatt 14881 aaagattaaa tgtagtaata atgaaataat aataaagacg agaaaaataa taagtgaata 14941 aataagtaat gtaataaatt tactgactat aatacttgta cgtgaataat ttctgtataa 15001 taaattttta atcgttccat aatgaaattc cattgaaata attgtacttg cttgaataat 15061 cattaaaaat acaacccaag aaaatgaaga aaaaccacct ttaaaacttt cctttaagtt 15121 aaaaacatca gaataatgat ttcccaaaat ggctaaagat aacataatta ttattataat 15181 aataggtaat atatatgttg atttcttctt aaataactta aaacattctt gtttaactaa 15241 tgtacccatc ttacatttca ccttctttat caataatatt taataagaca ttttccaaat 15301 cgtcttcatt ctcttgattt aattcttctt tagttgtttc tttaataatg gaaccatcat 15361 taataattaa aatagaatca gttattttta ctaattcact taaaatgtga cttgatatta 15421 aaaacgttgt tccttgctta gcagtttcta aaataagttc tcttacatct cttactgctt 15481 taggatc //