Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000511.1:
Cluster 1RiPP114150

BGC0000511, ericin A biosynthetic gene cluster from Bacillus subtilis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Ericin S
SMILES string: Copy to clipboard
Molecular formula: C149H224N40O38S5
Exact molecular mass: 3343.5 Da ([M+H]+)
Molecular activity: Antibacterial, Signalling

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lantipeptide (linear)
Peptides in this cluster:
ERIS
RiPP core peptide sequence(s): WKSESVCTPGCVTGVLQTCFLQTITCNC
Leader peptide length: 24
Follower peptide length: 28
Peptidase(s) involved in precursor cleavage:

Gene cluster description

ericin A (BGC0000511). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AF233755. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

eriSa leader / core peptide, putative Class I
MTNMSKFDDFDLDVVKVSKQDSKITPQ - VLDhaKDhaLCDhbPGCIDhbGPLQDhbCYLCFPDhbFAKC
eriSb leader / core peptide, putative Class I
MSKFDDFDLDVVKVSKQDSKITPQ - WKDhaEDhaVCDhbPGCVDhbGVLQDhbCFLQDhbIDhbCNCHIDhaK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Prof. Dr. Karl-Dieter Entian (Goethe University Frankfurt)

Literature references

1. Stein T et al. (2002) Two different lantibiotic-like peptides originate from the ericin gene cluster of Bacillus subtilis A1/3. J Bacteriol 184(6):1703-11.
2. Bochmann SM et al. (2015) Synthesis and succinylation of subtilin-like lantibiotics are strongly influenced by glucose and transition state regulator AbrB. Appl Environ Microbiol 81(2):614-22. doi: 10.1128/AEM.02579-14. Epub