Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000513.1:
Cluster 1RiPP16203

BGC0000513, erythreapeptin biosynthetic gene cluster from Saccharopolyspora erythraea. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Ery-9
Molecular formula: C119H173N35O35S2
Exact molecular mass: 2860.312 Da (None)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Lantipeptide (linear)
Peptides in this cluster:
RiPP core peptide sequence(s): SNLSLLASCANSTVSLLTCH
Leader peptide length: 26
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
1=4 AA (Other)
15=19 AA (Thioether)
1=9 AA (Thioether)
4=9 AA (Thioether)
12=15 AA (Other)

Gene cluster description

erythreapeptin (BGC0000513). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AM420293, positions 4704394-4710596. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
Contact for this cluster:Daniel Petras (TU Berlin / AK Suessmuth)

Literature references

1. Voller GH et al. (2012) Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing. Chembiochem 13(8):1174-83. doi: 10.1002/cbic.201200118. Epub 2012