BGC0000515

BGC0000515: geobacillin I biosynthetic gene cluster from Geobacillus thermodenitrificans NG80-2

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Location: 298,823 - 311,453 nt. (total: 12,631 nt).
This entry is originally from NCBI GenBank CP000557.1.

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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General

Compounds

Genes

RiPP

History

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000515
Short description	geobacillin I biosynthetic gene cluster from Geobacillus thermodenitrificans NG80-2
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: complete Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks	"Locus tags have been given to the genes described. As of now the genes have been given the automatic GeneID designation as either sunA, spaB and spaC. The entered GeneID designations are as follows: geoAI, geoB, geoC respectively to match what is reported in the literature. "
Biosynthetic class(es)	RiPP (Lanthipeptide)
Loci	NCBI GenBank: CP000557.1
Compounds	geobacillin I
Species	Geobacillus thermodenitrificans NG80-2 [taxonomy]
References	Lantibiotics from Geobacillus thermodenitrificans. Garg N et al., Proc Natl Acad Sci U S A (2012) PMID:22431611 Mode of action and structure-activity relationship studies of geobacillin I. Garg N et al., J Antibiot (Tokyo) (2014) PMID:24169799

Chemical products information

geobacillin I

(no structure information available)

C₁₃₆H₂₂₀N₄₀O₃₇S₈

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
GTNG_0265 ABO65649.1 sunA	298823 - 298993 (+)	Lantibiotic antimicrobial precursor peptide	Scaffold biosynthesis	Activity assay Sequence-based prediction	copy AA seq copy Nt seq
GTNG_0266 ABO65650.1 spaB	299768 - 302908 (+)	dehydratase	Scaffold biosynthesis	Activity assay Sequence-based prediction	copy AA seq copy Nt seq
GTNG_0267 ABO65651.1 spaT	303075 - 304904 (+)	Putative SpaT			copy AA seq copy Nt seq
GTNG_0268 ABO65652.1 spaC	304873 - 306180 (+)	cyclase	Scaffold biosynthesis	Activity assay Sequence-based prediction	copy AA seq copy Nt seq
GTNG_0269 ABO65653.1 spaR	306523 - 307221 (+)	Subtilin biosynthesis regulatory protein SpaR			copy AA seq copy Nt seq
GTNG_0270 ABO65654.1 spaK	307208 - 308626 (+)	Sensory transduction protein kinase SpaK			copy AA seq copy Nt seq
GTNG_0271 ABO65655.1 spaI	308720 - 309154 (-)	SpaI			copy AA seq copy Nt seq
GTNG_0272 ABO65656.1 spaG	309209 - 309823 (-)	SpaG			copy AA seq copy Nt seq
GTNG_0273 ABO65657.1 spaE	309999 - 310745 (-)	Putative SpaE			copy AA seq copy Nt seq
GTNG_0274 ABO65658.1 spaF	310764 - 311453 (-)	Putative ABC transporter ATP-binding protein			copy AA seq copy Nt seq

RiPP-specific information

Subclass	Lanthipeptide
Cyclic?	yes

Annotation changelog

MIBiG version	Submitter	Notes
1.0	Hidden contributor (ID: ZMZXFLPDGFEHMQPX76IB4OQ3, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

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