BGC0000515: geobacillin I biosynthetic gene cluster from Geobacillus thermodenitrificans NG80-2
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 298,823 - 311,453 nt. (total: 12,631 nt).
This entry is originally from NCBI GenBank CP000557.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000515
Short description geobacillin I biosynthetic gene cluster from Geobacillus thermodenitrificans NG80-2
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Locus tags have been given to the genes described. As of now the genes have been given the automatic GeneID designation as either sunA, spaB and spaC. The entered GeneID designations are as follows: geoAI, geoB, geoC respectively to match what is reported in the literature. "
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: CP000557.1
Compounds
  • geobacillin I
Species Geobacillus thermodenitrificans NG80-2 [taxonomy]
References
Chemical products information
geobacillin I
(no structure information available)
C136H220N40O37S8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • GTNG_0265
  • ABO65649.1
  • sunA
298823 - 298993 (+) Lantibiotic antimicrobial precursor peptide
  • Scaffold biosynthesis
Activity assay
Sequence-based prediction
copy AA seq
copy Nt seq
  • GTNG_0266
  • ABO65650.1
  • spaB
299768 - 302908 (+) dehydratase
  • Scaffold biosynthesis
Activity assay
Sequence-based prediction
copy AA seq
copy Nt seq
  • GTNG_0267
  • ABO65651.1
  • spaT
303075 - 304904 (+) Putative SpaT
copy AA seq
copy Nt seq
  • GTNG_0268
  • ABO65652.1
  • spaC
304873 - 306180 (+) cyclase
  • Scaffold biosynthesis
Activity assay
Sequence-based prediction
copy AA seq
copy Nt seq
  • GTNG_0269
  • ABO65653.1
  • spaR
306523 - 307221 (+) Subtilin biosynthesis regulatory protein SpaR
copy AA seq
copy Nt seq
  • GTNG_0270
  • ABO65654.1
  • spaK
307208 - 308626 (+) Sensory transduction protein kinase SpaK
copy AA seq
copy Nt seq
  • GTNG_0271
  • ABO65655.1
  • spaI
308720 - 309154 (-) SpaI
copy AA seq
copy Nt seq
  • GTNG_0272
  • ABO65656.1
  • spaG
309209 - 309823 (-) SpaG
copy AA seq
copy Nt seq
  • GTNG_0273
  • ABO65657.1
  • spaE
309999 - 310745 (-) Putative SpaE
copy AA seq
copy Nt seq
  • GTNG_0274
  • ABO65658.1
  • spaF
310764 - 311453 (-) Putative ABC transporter ATP-binding protein
copy AA seq
copy Nt seq
RiPP-specific information
Subclass Lanthipeptide
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZMZXFLPDGFEHMQPX76IB4OQ3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.