BGC0000515: geobacillin I biosynthetic gene cluster from Geobacillus thermodenitrificans NG80-2
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Location: 298,823 - 311,453 nt. (total: 12,631 nt).
This entry is originally from NCBI GenBank CP000557.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000515
Short description geobacillin I biosynthetic gene cluster from Geobacillus thermodenitrificans NG80-2
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Locus tags have been given to the genes described. As of now the genes have been given the automatic GeneID designation as either sunA, spaB and spaC. The entered GeneID designations are as follows: geoAI, geoB, geoC respectively to match what is reported in the literature. "
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
CP000557.1
298823 - 311453
via Enzymatic assays, Heterologous expression
Compounds
  • geobacillin I
Species Geobacillus thermodenitrificans NG80-2 [taxonomy]
References
Chemical products information
geobacillin I Evidence:
(no structure information available)
C136H220N40O37S8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • GTNG_0265
  • ABO65649.1
  • sunA
 298823 - 298993 (+) Lantibiotic antimicrobial precursor peptide
  • Scaffold biosynthesis
  • Activity assay
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  • GTNG_0266
  • ABO65650.1
  • spaB
 299768 - 302908 (+) dehydratase
  • Scaffold biosynthesis
  • Activity assay
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  • GTNG_0267
  • ABO65651.1
  • spaT
 303075 - 304904 (+) Putative SpaT
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    • GTNG_0268
    • ABO65652.1
    • spaC
    		 304873 - 306180 (+) cyclase
    • Scaffold biosynthesis
    • Activity assay
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    • GTNG_0269
    • ABO65653.1
    • spaR
    		 306523 - 307221 (+) Subtilin biosynthesis regulatory protein SpaR
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      • GTNG_0270
      • ABO65654.1
      • spaK
      		 307208 - 308626 (+) Sensory transduction protein kinase SpaK
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        • GTNG_0271
        • ABO65655.1
        • spaI
        		 308720 - 309154 (-) SpaI
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          • GTNG_0272
          • ABO65656.1
          • spaG
          		 309209 - 309823 (-) SpaG
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            • GTNG_0273
            • ABO65657.1
            • spaE
            		 309999 - 310745 (-) Putative SpaE
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              • GTNG_0274
              • ABO65658.1
              • spaF
              		 310764 - 311453 (-) Putative ABC transporter ATP-binding protein
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                Biosynthesis information
                Annotation changelog

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: ZMZXFLPDGFEHMQPX76IB4OQ3)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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