BGC0000516 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000516 (Geobacillus thermodenitrificans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	10,920	geobacillin II	ribosomal:RiPP:Lanthipeptide	100%

BGC0000516 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 10,920 nt. (total: 10,920 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,921
Label		BGC0000516

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516	1.00	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000525	0.27	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000500	0.27	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001576	0.25	RiPP	divamide A	Prochloron didemni
BGC0000504	0.24	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000623	0.24	RiPP	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001787	0.24	RiPP	suicin 3908	Streptococcus suis
BGC0002674	0.24	RiPP	enterocin F4-9	Enterococcus faecalis
BGC0000554	0.23	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002005	0.23	RiPP	RaxX	Xanthomonas oryzae pv. oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516	1.00	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000525	0.60	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000500	0.60	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001576	0.58	RiPP	divamide A	Prochloron didemni
BGC0000504	0.57	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000623	0.57	RiPP	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001787	0.57	RiPP	suicin 3908	Streptococcus suis
BGC0002674	0.57	RiPP	enterocin F4-9	Enterococcus faecalis
BGC0000554	0.56	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002005	0.56	RiPP	RaxX	Xanthomonas oryzae pv. oryzae

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for G11MC16DRAFT_3401

G11MC16DRAFT_3402

Leader:

MEKQEQTFVSKISEEELKKLAGG

Core:

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

Core with dehydrations:

YDhbEVDhaPQDhaDhbIVCysVDhaLRICysNWDhaLRFCysPDhaFKVKCysPM

antiSMASH-DB 4.0 matches for G11MC16DRAFT_3402

100.0% NZ_PIJH01000018.1: Lanthipeptides: CV632_RS18055_lanthipeptide

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

97.1% NC_009328.1: Lanthipeptides: GTNG_RS18990_lanthipeptide

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

YTEVSPQSTIVCVSLRICNWSLRFCPSFKV+CPM

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

67.6% NZ_FOHE01000009.1: Lanthipeptides: BMX40_RS20255_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

EV+PQST+VCVSLR+C WS+++CPSFK KC M

EVTPQSTVVCVSLRLCKWSIKYCPSFKRKCWM

with 21 more sequence matches

67.6% NZ_JALANL010000003.1and 3 others:

NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptideNZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptideNZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide

Lanthipeptides: MOC63_RS03255_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

E++PQST+VCVSLRIC WS+++CPSFK KC M

EITPQSTVVCVSLRICKWSIKYCPSFKRKCWM

64.7% NZ_CP023481.1and 2 others:

NZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptideNZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide

Lanthipeptides: COP00_RS24795_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

E++PQST+VCVSLR+C WS+++CPSFK KC M

EITPQSTVVCVSLRVCKWSIKYCPSFKRKCWM

64.7% NZ_JALAJI010000006.1and 3 others:

NZ_JALAOO010000008.1 Lanthipeptides: MOC69_RS16910_lanthipeptideNZ_JALAXE010000008.1 Lanthipeptides: MOF11_RS14910_lanthipeptideNZ_JALAXI010000013.1 Lanthipeptides: MOE73_RS14185_lanthipeptide

Lanthipeptides: MOB90_RS08905_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

E++PQST+VCVSLR+C WS+++CPSFK KC M

EITPQSTVVCVSLRLCKWSIKYCPSFKKKCLM

42.9% NZ_CP039297.1and 4 others:

NZ_CP040378.1 Lanthipeptides: D1120_RS00435_lanthipeptideNZ_CP040672.1 Lanthipeptides: FGE23_RS05605_lanthipeptideNZ_CP059318.1 Lanthipeptides: HZT45_RS00565_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS00585_lanthipeptide

Lanthipeptides: E4T61_RS00570_lanthipeptide

TEVSPQSTIVCVSLRICNWSLRFCPSFKVKC

T VSP T+V +R+ SL+ CP+FK+KC

TPVSPAPTVV---IRV---SLKVCPTFKIKC

41.7% NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

EVSPQSTIVC-VSLRIC-NWSLRFCPS

EV PQS VC V+L +C SL FCP+

EVRPQSGPVCAVTLAVCVPVSLAFCPT

32.4% NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

STIVCVSLRICNWSLRFCPSFKVKCP

+TI+ VSL +C + C SF CP

TTIIPVSLAVCPTTT--CRSFSSPCP

29.4% NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

EVSPQS-TIVCVSLRIC

E +P + TIV VSL IC

ETTPATPTIVAVSLGIC

29.4% NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKC

+V+P+ST VC + S++ + K KC

DVTPESTTVCAAFASFAGSIQLVKTLKSKC

26.5% NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKC

+V P+ST +C S+ + K KC

DVMPESTPICAGFATLMSSIGLVKTIKGKC

23.5% NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

TEVSPQSTIVCVSLRI-CNWSLRFC

++V P++T +CV + I S++ C

SDVQPETTPLCVGVIIGITASIKIC

23.5% NZ_JACSPU010000002.1: Lanthipeptides: H9630_RS06775_lanthipeptide

TEVSPQSTIVCVSLRICN--WSLRFC

++V+P++T CV+ +S++FC

SDVAPETTPACVAAFATGLLFSIKFC

23.5% NZ_JAMXMK010000009.1: Lanthipeptides: NGM22_RS28125_lanthipeptide

EVSPQSTIVC-VSLRICNWSLR

+V P+ST C V + I W

DVQPESTPACAVGVTIAAWGAH

23.5% NZ_LDKE01000067.1: Lanthipeptides: ABB04_RS19960_lanthipeptide

TEVSPQSTIVCVSLRI-CNWSLRFC

++V P++T +CV + I S++ C

SDVKPETTPLCVGVIIGITASIKIC

22.2% NZ_NUQX01000026.1: Lanthipeptides: COE81_RS20200_lanthipeptide

PQSTIVCVSLRICNWSLRFCPSFKVK

P S+I+C L+F VK

PNSSIICTDAFDNKMKLKFSSIIDVK

20.6% NZ_FTML01000041.1: Lanthipeptides: BW937_RS20030_lanthipeptide

EVSPQSTIVCVSLRI

+V P+ST CV I

DVQPESTPACVGAGI

20.6% NZ_JAQDYA010000001.1: Lanthipeptides: PGT72_RS00020_lanthipeptide

EVSPQSTIVCVSLRICNWSLRFCPSFKVKC

+++P+ST VC + + + K C

DITPESTPVCAAFATLASGIALVKTIKGNC

17.6% NZ_NHVL01000036.1: Lanthipeptides: CEU70_RS27675_lanthipeptide

EVSPQSTIVCVSL

+VSP++T VC+++

DVSPETTPVCITV

17.6% NZ_NWMU01000024.1and 1 other:

NZ_VMMF01000004.1 Lanthipeptides: allorf_21978_22148_lanthipeptide

Lanthipeptides: allorf_28318_28488_lanthipeptide

LRFCPSFKVKCPM

L FC FK+K +

LLFCGDFKIKIEL

14.7% NZ_CP119804.1: Lanthipeptides: allorf_2882648_2882830_lanthipeptide

SLRICNWSLR

+L++CN+S+R

TLKLCNFSVR

14.7% NZ_JAOVZP010000016.1and 1 other:

NZ_JAOVZP010000016.1 Lanthipeptides: OF830_RS26675_lanthipeptide

Lanthipeptides: OF830_RS26680_lanthipeptide

EVSPQSTIVCVSLRICNW

+VSP++T +C+++ +

DVSPETTPLCITIGVGGG

12.2% NZ_KB235949.1: Lanthipeptides: allorf_202920_203111_lanthipeptide

CNWSLRFCPS

C+WS RFC

CHWSWRFCAG

MIBiG 3.1 matches for G11MC16DRAFT_3402

14.7% BGC0000553 (SSGG_RS09925): Lanthipeptide: SRO15-2212

VSLRICNWS

VSL +C +S

VSLLVCEYS

14.7% BGC0001155 (AGY49587.1): Thiopeptide: GE2270

CNWSLRFCPS

CN FC S

CNCVCGFCCS

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

G11MC16DRAFT_3402 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3794.9 Da

Molecular weight: 3797.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3815.5 Da N = 1; 3833.6 Da N = 2; 3851.6 Da N = 3