Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000516.1:
Cluster 1RiPP110920

BGC0000516, geobacillin II biosynthetic gene cluster from Geobacillus sp. G11MC16. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: geobacillin II
Molecular formula: C139H215N39O29S5
Exact molecular mass: 3055.5229 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lantipeptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): STIVCVSLRICNWSLRFCPSFKVRCPM
Leader peptide length: 36
Follower peptide length: -1
Cleavage recognition site sequence(s): GG,EVSPQ
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
1=5 AA (Thioether)
7=11 AA (Thioether)
14=18 AA (Thioether)
20=25 AA (Thioether)

Gene cluster description

geobacillin II (BGC0000516). Gene Cluster 1. Biosynthetic class = RiPP. GenBank ABVH01000020, positions 8707-19626. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

G11MC16DRAFT_3402 leader / core peptide, putative Class II
MEKQEQTFVSKISEEELKKLAGG - YDhbEVDhaPQDhaDhbIVCVDhaLRICNWDhaLRFCPDhaFKVKCPM

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Wilfred Van Der Donk (University of Illinois at Urbana-Champaign)

Literature references

1. Garg N et al. (2012) Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A 109(14):5241-6. doi: