BGC0000517: haloduracin β biosynthetic gene cluster from Bacillus halodurans C-125
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Location: 476,922 - 486,037 nt. (total: 9,116 nt).
This entry is originally from NCBI GenBank BA000004.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000517
Short description haloduracin β biosynthetic gene cluster from Bacillus halodurans C-125
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The lantibiotic synthetases complete dehydration and cyclization so reaction type was marked as other. "
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: BA000004.3
Compounds
  • haloduracin β
  • haloduracin α
Species Bacillus halodurans C-125 [taxonomy]
References
Chemical products information
haloduracin β [synonyms: Hal beta]
(no structure information available)
C103H155N27O27S4
haloduracin α [synonyms: Hal alpha]
(no structure information available)
C130H196N36O37S6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAB04170.1
  • BH0451
476922 - 479096 (-) lantibiotic haloduracin protease and transporter
  • Unknown
Sequence-based prediction
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  • BAB04171.1
  • BH0452
479086 - 482058 (-) Class II lantibiotic synthetase
  • Scaffold biosynthesis (Unknown)
Activity assay
Other in vivo study
Sequence-based prediction
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  • BAB04172.1
  • BH0453
482191 - 482388 (-) lantibiotic haloduracin precursor
  • Precursor biosynthesis
Activity assay
Sequence-based prediction
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  • BAB04173.1
  • BH0454
482580 - 482789 (+) lantibiotic haloduracin precursor
  • Precursor biosynthesis
Activity assay
Sequence-based prediction
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  • BAB04174.1
  • BH0455
482858 - 486037 (+) Class II lantibiotic synthetase
  • Scaffold biosynthesis (Unknown)
Activity assay
Other in vivo study
Sequence-based prediction
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RiPP-specific information
Subclass Lanthipeptide
Cyclic? yes
Peptidases
  • BAB04170.1
Precursor genes
>BAB04173.1
Leader sequence: MTNLLKEWKMPLERTHNNSNPAGDIFQELEDQDILAGVNGA
Core sequences:
  • CAWYNISCRLGNKGAYCTLTVECMPSCN
Crosslinks:
  • 7x17 (Thioether)
  • 18x23 (Thioether)
  • 20x27 (Thioether)
Cleavage recognition sites:
  • GA
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZMZXFLPDGFEHMQPX76IB4OQ3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Similar known gene clusters
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