BGC0000519 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000519 (Actinomadura namibiensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-iii	1	6,400	labyrinthopeptin A2/labyrinthopeptin A1/labyrinthopeptin A3	ribosomal:RiPP:Lanthipeptide	100%

BGC0000519 - Region 1 - lanthipeptide-class-iii

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Location: 1 - 6,400 nt. (total: 6,400 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 6,401
Label		BGC0000519

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519	1.00	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000551	0.30	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000501	0.27	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000513	0.26	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002700	0.25	RiPP	bacinapeptin	Bacillus nakamurai
BGC0002111	0.25	RiPP	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000496	0.24	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553	0.21	RiPP	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002698	0.17	RiPP	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002630	0.17	RiPP	thatisin	Lysobacter antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519	1.00	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000551	0.63	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000501	0.60	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000513	0.60	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002700	0.59	RiPP	bacinapeptin	Bacillus nakamurai
BGC0002111	0.59	RiPP	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000496	0.57	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553	0.54	RiPP	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002698	0.49	RiPP	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002630	0.48	RiPP	thatisin	Lysobacter antibioticus

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for labKC

labA1

Leader:

MASILELQDLEVERASSAAD

Core:

SNASVWECCSTGSWVPFTCC

Core with dehydrations:

DhaNADhaVWECysCysDhaDhbGDhaWVPFDhbCysCys

antiSMASH-DB 4.0 matches for labA1

100.0% NZ_JACJIA010000004.1: Lanthipeptides: HNR61_RS17190_lanthipeptide

SNASVWECCSTGSWVPFTCC

81.8% NZ_BDDE01000019.1and 1 other:

NZ_CP044407.1 Lanthipeptides: F7P10_RS09640_lanthipeptide

Lanthipeptides: K4S16_RS30760_lanthipeptide

SNASVWECCSTGSWVPFTC

SN SVWECCSTGSWVPFTC

SNGSVWECCSTGSWVPFTC

65.0% NZ_JACJIA010000004.1: Lanthipeptides: HNR61_RS17195_lanthipeptide

SNASVWECCSTGSWVPFTCC

S+ S+WECCSTGS F CC

SDWSLWECCSTGS--LFACC

with 6 more sequence matches

60.0% NZ_BDDE01000019.1: Lanthipeptides: K4S16_RS30765_lanthipeptide

SNASVWECCSTGSWVPFTCC

S+ S+WECCS GS F CC

SDWSLWECCSHGS--LFNCC

60.0% NZ_CP044407.1: Lanthipeptides: allorf_2197860_2197985_lanthipeptide

SNASVWECCSTGSWVPFTCC

S+ S WECCS GS F CC

SDFSWWECCSQGS--LFNCC

28.0% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03750_lanthipeptide

ECCSTGSWVPFTCC

EC + +V FTCC

ECNTNSFYVAFTCC

27.3% NZ_CP020040.1: Lanthipeptides: allorf_275398_275505_lanthipeptide

STGSWVPFTCC

S + +PFTCC

SADNVLPFTCC

24.1% NZ_LN850107.1and 1 other:

NZ_LN850107.1 Lanthipeptides: BN1701_RS20075_lanthipeptide

Lanthipeptides: BN1701_RS20075_lanthipeptide

CSTGSWVPF

CSTGS PF

CSTGSNDPF

16.7% NZ_FUWS01000010.1: Lanthipeptides: B5D66_RS17810_lanthipeptide

ASVWECCSTGSWVPFT

+ ++ C ST S+ PFT

SEIYACASTCSFGPFT

labA2

Leader:

MASILELQNLDVEHARGENR

Core:

SDWSLWECCSTGSLFACC

Core with dehydrations:

DhaDWDhaLWECysCysDhaDhbGDhaLFACysCys

antiSMASH-DB 4.0 matches for labA2

100.0% NZ_JACJIA010000004.1: Lanthipeptides: HNR61_RS17195_lanthipeptide

SDWSLWECCSTGSLFACC

88.9% NZ_BDDE01000019.1: Lanthipeptides: K4S16_RS30765_lanthipeptide

SDWSLWECCSTGSLFACC

SDWSLWECCS GSLF CC

SDWSLWECCSHGSLFNCC

77.8% NZ_CP044407.1: Lanthipeptides: allorf_2197860_2197985_lanthipeptide

SDWSLWECCSTGSLFACC

SD+S WECCS GSLF CC

SDFSWWECCSQGSLFNCC

with 9 more sequence matches

65.0% NZ_JACJIA010000004.1: Lanthipeptides: HNR61_RS17190_lanthipeptide

SDWSLWECCSTGS--LFACC

S+ S+WECCSTGS F CC

SNASVWECCSTGSWVPFTCC

52.6% NZ_CP084585.1: Lanthipeptides: allorf_0614982_0615095_lanthipeptide

SDWSLWECCSTGSLFAC

S WSL C ST S+ AC

SSWSLIGCASTLSVGAC

45.5% NZ_BDDE01000019.1and 1 other:

NZ_CP044407.1 Lanthipeptides: F7P10_RS09640_lanthipeptide

Lanthipeptides: K4S16_RS30760_lanthipeptide

SDWSLWECCSTGS

S+ S+WECCSTGS

SNGSVWECCSTGS

44.4% NZ_AUFR01000008.1: Lanthipeptides: allorf_100347_100460_lanthipeptide

WSLWECCSTGSLFAC

WS W C ST S++ C

WSNWTCYSTHSIWFC

44.4% NZ_CP033719.1: Lanthipeptides: allorf_1492720_1492833_lanthipeptide

WSLWECCSTGSLFAC

WS W C ST S++ C

WSNWTCYSTRSIWFC

38.9% NC_016111.1: Lanthipeptides: SCAT_RS14735_lanthipeptide

SLWECCSTGSLFAC

SL C S GS+ C

SLLSCVSAGSVILC

36.8% NZ_CP084585.1: Lanthipeptides: LFM56_RS02715_lanthipeptide

CCSTGSLFAC

C STGS+F C

CFSTGSIFGC

25.0% NZ_AXVK01000021.1: Lanthipeptides: K332_RS23905_lanthipeptide

STGSLFACC

ST S+F CC

STNSMFVCC

13.2% NZ_CP029297.1: Lanthipeptides: allorf_5863229_5863468_lanthipeptide

WECCSTGSLFAC

+EC T ++F C

YECIFTVNIFHC

MIBiG 3.1 matches for labA2

14.7% BGC0000535 (ADJ56352.1): Lanthipeptide: nisin A

CSTGSLFAC

C TG+L C

CKTGALMGC

9.8% BGC0002120 (NQE92413.1): Lanthipeptide: nocathioamide A

CCSTGSLFACC

C T S CC

ACHTLSSLPCC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

labA1 - Class III

Cleavage pHMM score: 18.60

RODEO score: 0

Monoisotopic mass: 2057.8 Da

Molecular weight: 2059.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2077.3 Da N = 1; 2095.3 Da N = 2

labA2 - Class III

Cleavage pHMM score: 26.00

RODEO score: 0

Monoisotopic mass: 1906.7 Da

Molecular weight: 1908.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 1926.2 Da N = 1