BGC0000520 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000520 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	27,967	High	lacticin 3147 A1/lacticin 3147 A2	ribosomal:RiPP:Lanthipeptide

BGC0000520 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 27,967 nt. (total: 27,967 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 27,968
Label		BGC0000520

Tailoring functions

Oxidoreductases: dehydrogenase

ORF00040: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase

ORF00037: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

ORF00039: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	1.00	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.68	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.59	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001311.5	0.57	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000497.3	0.56	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.3	0.49	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000504.5	0.49	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	1.00	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.68	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.59	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001311.5	0.57	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000497.3	0.56	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.3	0.49	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000504.5	0.49	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for ORF00037

ORF00035

Leader:

MNKNEIETQPVTWLEEVSDQNFDEDVFGA

Core:

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYWGNNGAWCysDhbLDhbHECysMAWCysK

antiSMASH-DB 4.0 matches for ORF00035

93.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGNNG WCTL+HECMAWCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

90.0%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGN G WCTLTHECM+WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

90.0%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGN G WCTL+HECMAWCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

with 98 more sequence matches

Only the first 10 are displayed here.

86.7%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN G WCTLTHECM WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

86.7%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGNNG CT+THECM+WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

86.7%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGNNG WCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

86.7%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDY GNNG WCT++HECMAWCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

86.7%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGNNG WCT THECM+WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

83.3%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN G WCT THECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGN G WCT++HECM+WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN G WCT THECM+WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

80.0%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN+G+WC+L+HECM+WCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

80.0%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN+G+WCT THEC++WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

MIBiG 4.0 matches for ORF00035

66.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CSTNTFSLSDYWGNNGAWCTLTHECMAWC

C+TNTFSLS+ GNNG WCTLT EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

43.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNNGAWCTLTHECMAWC

+++S GN GA+CTLT ECM C

YNISCRLGNKGAYCTLTVECMPSC

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTHECMAWC

CTL+ EC C

CTLSKECQPNC

ORF00036

Leader:

MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGG

Core:

TTPATPAISILSAYISTNTCPTTKCTRAC

Core with dehydrations:

DhbDhbPADhbPAIDhaILDhaAYIDhaDhbNDhbCysPDhbDhbKCysDhbRACys

antiSMASH-DB 4.0 matches for ORF00036

72.4%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPAISIL-SAYISTNTCPTTKCTRAC

TPAISIL S +ISTNTCP+T CTRAC

TPAISILVSGFISTNTCPSTACTRAC

65.5%

NZ_JALAPU010000003.1and 7 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

TPA+S+++AYIS+NTCPTT CTRAC

TPALSVVTAYISSNTCPTTACTRAC

63.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPAISI----LSAYISTNTCPTTKCTRAC

TP +SI +S YIS+NTCPTT CTRAC

TPTVSIALTAVSGYISSNTCPTTACTRAC

with 92 more sequence matches

Only the first 10 are displayed here.

62.5%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

TPATPAISILSAYISTNTCPTTKCTRAC

TPATP I +SAY+S TCPTT CTRAC

TPATPVIVAVSAYVSDKTCPTTACTRAC

62.1%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

TPA+S+++ YIS+NTCPTT CTRAC

TPALSVITGYISSNTCPTTACTRAC

62.1%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

ATPAISI--LSAYISTNTCPTTKCTRAC

ATP I I ++ YIS N+CPTT CTRAC

ATPTIVITAITGYISANSCPTTACTRAC

58.6%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

TTPATPAIS-ILSAYISTNTCPTTKCTRAC

TT A A+S I+ A IS CPTTKCT C

TTWACVAVSTIVDASISL--CPTTKCTSQC

58.6%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

T I+ ++ YISTNTCPTT CTRAC

TIVITAVTGYISTNTCPTTSCTRAC

58.6%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

T IS++SAY+STNTCPTT CT C

TIVISVVSAYVSTNTCPTTSCTDEC

57.6%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

TPATP----AISILSAYISTNTCPTTKCTRAC

+PATP A ++A+IS NTCPTT CTRAC

SPATPWLVKASVAVTAFISANTCPTTSCTRAC

55.2%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

T +SI+SA+IS NTCP++ CTRAC

TVVLSIVSAWISNNTCPSSACTRAC

55.2%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

TTPATPAIS-ILSAYISTNTCPTTKCTRAC

TT A A+S ++ A IS CPTTKCT C

TTWACVAVSTVVEASISL--CPTTKCTSKC

54.8%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

TTPATPAISILSAYISTNTCPTTKCTRAC

TTPATP I +S I CPTTKCT C

TTPATPTIVAVSLGI----CPTTKCTSKC

MIBiG 4.0 matches for ORF00036

27.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTTKCTRAC

CPTTKCT C

CPTTKCTSKC

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

LSAYISTNTCPTTKCTRAC

++ +S CPTTKCT C

VAVGVSAAFCPTTKCTSRC

17.2%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPATPAIS

TPATP ++

TPATPTVA

with 1 more sequence matches

14.7%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

TPATPAISILSAYISTNTC

TP +++ + T TC

TPGCKTGALMGCNMKTATC

allorf_04328_04471

Leader:

MVVSKSKALSIKVFLLALSAA

Core:

GKKMKFVNQLKSIFIKEAINCKRIIK

Core with dehydrations:

GKKMKFVNQLKDhaIFIKEAINCysKRIIK

allorf_06121_06279

Leader:

MYKPFFCNFLNAAPIDGA

Core:

LSVTITFGSPNCFRNSFKKGIGSLGISFLPQPDI

Core with dehydrations:

LDhaVDhbIDhbFGDhaPNCysFRNDhaFKKGIGDhaLGIDhaFLPQPDI

antiSMASH-DB 4.0 matches for allorf_06121_06279

17.6%

NZ_CP061072.1:

Lanthipeptides: allorf_6661373_6661462_lanthipeptide

CFRNSFKKGIG

CF N K+G+G

CFMNRMKRGVG

12.2%

NZ_BMUZ01000004.1:

Lanthipeptides: allorf_271111_271338_lanthipeptide

KKGIGSLGISFLPQPD

+ G+G+ S +P PD

QAGVGACRASIMPPPD

allorf_09315_09479

Leader:

MFECRKAYRILALKQNIPYNSNYA

Core:

LIPCINVDYIYFLFHKLKNLLSIFNSFVIF

Core with dehydrations:

LIPCysINVDYIYFLFHKLKNLLDhaIFNDhaFVIF

antiSMASH-DB 4.0 matches for allorf_09315_09479

23.3%

NZ_PIOD01000016.1:

Lanthipeptides: allorf_242568_242714_lanthipeptide

HKLKNLLSIFNSFV

H+ KNL +IF S+

HQEKNLWTIFLSYT

17.4%

NZ_GG657754.1:

Lanthipeptides: allorf_06547918_06548142_lanthipeptide

IPCINVDYIYFLFHKLKNLLSIF

IPC+NV H K+L+++

IPCLNVLKTRR-QHGAKSLMTVI

allorf_09415_09513

Leader:

MELYGIFCFSANILYA

Core:

FLHSNITFKSLCVVWR

Core with dehydrations:

FLHDhaNIDhbFKDhaLCysVVWR

antiSMASH-DB 4.0 matches for allorf_09415_09513

37.5%

NZ_KB900375.1:

Lanthipeptides: allorf_35324_35401_lanthipeptide

FLHSNITFKSLCVVWR

+ H N T S C +R

YYHGNTTPTSQCNSYR

21.7%

NZ_CP072600.1:

Lanthipeptides: allorf_0836589_0836696_lanthipeptide

NITFKSLCVVWR

TF C WR

ETTFSRTCAGWR

20.0%

NC_014718.1:

Lanthipeptides: allorf_498762_498875_lanthipeptide

HSNITFKSLCVVWR

H N ++ C W+

HKNAPNRAACRPWK

allorf_19480_19560

Leader:

MDGQQSIPGS

Core:

LYRDCNIIESLRGQLN

Core with dehydrations:

LYRDCysNIIEDhaLRGQLN

antiSMASH-DB 4.0 matches for allorf_19480_19560

20.0%

NZ_NVEA01000022.1:

Lanthipeptides: COL15_RS32130_lanthipeptide

LYRDCNIIESLRGQLN

LY + +IE+L + N

LYEETQLIENLNEEFN

Lanthipeptide(s) for ORF00039

ORF00035

Leader:

MNKNEIETQPVTWLEEVSDQNFDEDVFGA

Core:

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYWGNNGAWCysDhbLDhbHECysMAWCysK

antiSMASH-DB 4.0 matches for ORF00035

93.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGNNG WCTL+HECMAWCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

90.0%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGN G WCTLTHECM+WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

90.0%

NZ_QGEE01000020.1and 5 others:

Lanthipeptides: DKP74_RS06160_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGN G WCTL+HECMAWCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

with 98 more sequence matches

Only the first 10 are displayed here.

86.7%

NZ_BLIS01000009.1and 7 others:

Lanthipeptides: GVO03_RS04820_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN G WCTLTHECM WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

86.7%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGNNG CT+THECM+WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

86.7%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGNNG WCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

86.7%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDY GNNG WCT++HECMAWCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

86.7%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGNNG WCT THECM+WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

83.3%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06515_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN G WCT THECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

CSTNTFSLSDYWGN G WCT++HECM+WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN G WCT THECM+WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

80.0%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN+G+WC+L+HECM+WCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

80.0%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CSTNTFSLSDYWGNNGAWCTLTHECMAWCK

C+TNTFSLSDYWGN+G+WCT THEC++WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

MIBiG 4.0 matches for ORF00035

66.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CSTNTFSLSDYWGNNGAWCTLTHECMAWC

C+TNTFSLS+ GNNG WCTLT EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

43.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNNGAWCTLTHECMAWC

+++S GN GA+CTLT ECM C

YNISCRLGNKGAYCTLTVECMPSC

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTHECMAWC

CTL+ EC C

CTLSKECQPNC

ORF00036

Leader:

MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGG

Core:

TTPATPAISILSAYISTNTCPTTKCTRAC

Core with dehydrations:

DhbDhbPADhbPAIDhaILDhaAYIDhaDhbNDhbCysPDhbDhbKCysDhbRACys

antiSMASH-DB 4.0 matches for ORF00036

72.4%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPAISIL-SAYISTNTCPTTKCTRAC

TPAISIL S +ISTNTCP+T CTRAC

TPAISILVSGFISTNTCPSTACTRAC

65.5%

NZ_JALAPU010000003.1and 7 others:

Lanthipeptides: MOD17_RS07925_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

TPA+S+++AYIS+NTCPTT CTRAC

TPALSVVTAYISSNTCPTTACTRAC

63.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPAISI----LSAYISTNTCPTTKCTRAC

TP +SI +S YIS+NTCPTT CTRAC

TPTVSIALTAVSGYISSNTCPTTACTRAC

with 92 more sequence matches

Only the first 10 are displayed here.

62.5%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

TPATPAISILSAYISTNTCPTTKCTRAC

TPATP I +SAY+S TCPTT CTRAC

TPATPVIVAVSAYVSDKTCPTTACTRAC

62.1%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

TPA+S+++ YIS+NTCPTT CTRAC

TPALSVITGYISSNTCPTTACTRAC

62.1%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

ATPAISI--LSAYISTNTCPTTKCTRAC

ATP I I ++ YIS N+CPTT CTRAC

ATPTIVITAITGYISANSCPTTACTRAC

58.6%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

TTPATPAIS-ILSAYISTNTCPTTKCTRAC

TT A A+S I+ A IS CPTTKCT C

TTWACVAVSTIVDASISL--CPTTKCTSQC

58.6%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

T I+ ++ YISTNTCPTT CTRAC

TIVITAVTGYISTNTCPTTSCTRAC

58.6%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

T IS++SAY+STNTCPTT CT C

TIVISVVSAYVSTNTCPTTSCTDEC

57.6%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

TPATP----AISILSAYISTNTCPTTKCTRAC

+PATP A ++A+IS NTCPTT CTRAC

SPATPWLVKASVAVTAFISANTCPTTSCTRAC

55.2%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

TPAISILSAYISTNTCPTTKCTRAC

T +SI+SA+IS NTCP++ CTRAC

TVVLSIVSAWISNNTCPSSACTRAC

55.2%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

TTPATPAIS-ILSAYISTNTCPTTKCTRAC

TT A A+S ++ A IS CPTTKCT C

TTWACVAVSTVVEASISL--CPTTKCTSKC

54.8%

NC_018499.1and 5 others:

Lanthipeptides: BCK_RS27845_lanthipeptide

TTPATPAISILSAYISTNTCPTTKCTRAC

TTPATP I +S I CPTTKCT C

TTPATPTIVAVSLGI----CPTTKCTSKC

MIBiG 4.0 matches for ORF00036

27.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTTKCTRAC

CPTTKCT C

CPTTKCTSKC

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

LSAYISTNTCPTTKCTRAC

++ +S CPTTKCT C

VAVGVSAAFCPTTKCTSRC

17.2%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPATPAIS

TPATP ++

TPATPTVA

with 1 more sequence matches

14.7%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

TPATPAISILSAYISTNTC

TP +++ + T TC

TPGCKTGALMGCNMKTATC

allorf_06121_06279

Leader:

MYKPFFCNFLNAAPIDGA

Core:

LSVTITFGSPNCFRNSFKKGIGSLGISFLPQPDI

Core with dehydrations:

LDhaVDhbIDhbFGDhaPNCysFRNDhaFKKGIGDhaLGIDhaFLPQPDI

antiSMASH-DB 4.0 matches for allorf_06121_06279

17.6%

NZ_CP061072.1:

Lanthipeptides: allorf_6661373_6661462_lanthipeptide

CFRNSFKKGIG

CF N K+G+G

CFMNRMKRGVG

12.2%

NZ_BMUZ01000004.1:

Lanthipeptides: allorf_271111_271338_lanthipeptide

KKGIGSLGISFLPQPD

+ G+G+ S +P PD

QAGVGACRASIMPPPD

allorf_09315_09479

Leader:

MFECRKAYRILALKQNIPYNSNYA

Core:

LIPCINVDYIYFLFHKLKNLLSIFNSFVIF

Core with dehydrations:

LIPCysINVDYIYFLFHKLKNLLDhaIFNDhaFVIF

antiSMASH-DB 4.0 matches for allorf_09315_09479

23.3%

NZ_PIOD01000016.1:

Lanthipeptides: allorf_242568_242714_lanthipeptide

HKLKNLLSIFNSFV

H+ KNL +IF S+

HQEKNLWTIFLSYT

17.4%

NZ_GG657754.1:

Lanthipeptides: allorf_06547918_06548142_lanthipeptide

IPCINVDYIYFLFHKLKNLLSIF

IPC+NV H K+L+++

IPCLNVLKTRR-QHGAKSLMTVI

allorf_09415_09513

Leader:

MELYGIFCFSANILYA

Core:

FLHSNITFKSLCVVWR

Core with dehydrations:

FLHDhaNIDhbFKDhaLCysVVWR

antiSMASH-DB 4.0 matches for allorf_09415_09513

37.5%

NZ_KB900375.1:

Lanthipeptides: allorf_35324_35401_lanthipeptide

FLHSNITFKSLCVVWR

+ H N T S C +R

YYHGNTTPTSQCNSYR

21.7%

NZ_CP072600.1:

Lanthipeptides: allorf_0836589_0836696_lanthipeptide

NITFKSLCVVWR

TF C WR

ETTFSRTCAGWR

20.0%

NC_014718.1:

Lanthipeptides: allorf_498762_498875_lanthipeptide

HSNITFKSLCVVWR

H N ++ C W+

HKNAPNRAACRPWK

allorf_19480_19560

Leader:

MDGQQSIPGS

Core:

LYRDCNIIESLRGQLN

Core with dehydrations:

LYRDCysNIIEDhaLRGQLN

antiSMASH-DB 4.0 matches for allorf_19480_19560

20.0%

NZ_NVEA01000022.1:

Lanthipeptides: COL15_RS32130_lanthipeptide

LYRDCNIIESLRGQLN

LY + +IE+L + N

LYEETQLIENLNEEFN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ORF00035 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3302.4 Da

Molecular weight: 3304.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3322.7 Da N = 1; 3340.7 Da N = 2; 3358.7 Da N = 3

ORF00036 - Class II

Cleavage pHMM score: 1.80

RODEO score: 0

Monoisotopic mass: 2787.5 Da

Molecular weight: 2789.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2807.2 Da N = 1; 2825.2 Da N = 2; 2843.3 Da N = 3; 2861.3 Da N = 4; 2879.3 Da N = 5; 2897.3 Da N = 6; 2915.3 Da N = 7; 2933.4 Da N = 8

allorf_04328_04471 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 3058.8 Da

Molecular weight: 3060.8 Da

Number of bridges: 1

allorf_06121_06279 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 3513.9 Da

Molecular weight: 3516.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3534.1 Da N = 1; 3552.1 Da N = 2; 3570.1 Da N = 3; 3588.1 Da N = 4; 3606.1 Da N = 5; 3624.2 Da N = 6

allorf_09315_09479 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 3597.0 Da

Molecular weight: 3599.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3617.3 Da N = 1

allorf_09415_09513 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 1895.0 Da

Molecular weight: 1896.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1914.3 Da N = 1; 1932.3 Da N = 2

allorf_19480_19560 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 1888.0 Da

Molecular weight: 1889.1 Da

Number of bridges: 1

ORF00035 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3302.4 Da

Molecular weight: 3304.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3322.7 Da N = 1; 3340.7 Da N = 2; 3358.7 Da N = 3

ORF00036 - Class II

Cleavage pHMM score: 1.80

RODEO score: 0

Monoisotopic mass: 2787.5 Da

Molecular weight: 2789.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2807.2 Da N = 1; 2825.2 Da N = 2; 2843.3 Da N = 3; 2861.3 Da N = 4; 2879.3 Da N = 5; 2897.3 Da N = 6; 2915.3 Da N = 7; 2933.4 Da N = 8

allorf_06121_06279 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 3513.9 Da

Molecular weight: 3516.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3534.1 Da N = 1; 3552.1 Da N = 2; 3570.1 Da N = 3; 3588.1 Da N = 4; 3606.1 Da N = 5; 3624.2 Da N = 6

allorf_09315_09479 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 3597.0 Da

Molecular weight: 3599.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3617.3 Da N = 1

allorf_09415_09513 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 1895.0 Da

Molecular weight: 1896.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1914.3 Da N = 1; 1932.3 Da N = 2

allorf_19480_19560 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 1888.0 Da

Molecular weight: 1889.1 Da

Number of bridges: 1