LOCUS BGC0000520 9481 bp DNA linear BCT 12-MAY-2020 DEFINITION Lactococcus lactis strain DPC3147 plasmid pMRC01, complete sequence. ACCESSION BGC0000520 VERSION BGC0000520 KEYWORDS . SOURCE Lactococcus lactis ORGANISM Lactococcus lactis Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Lactococcus. COMMENT ##antiSMASH-Data-START## Version :: False Run date :: 2022-11-07 19:45:20 NOTE: This is a single region extracted from a larger record! Orig. start :: 27743 Orig. end :: 37224 ##antiSMASH-Data-END## FEATURES Location/Qualifiers subregion 1..9481 /aStool="mibig" /contig_edge="False" /label="RiPP" /subregion_number="1" /tool="antismash" region 1..9481 /contig_edge="False" /product="unknown" /region_number="1" /subregion_numbers="1" /tool="antismash" gene 2..181 /gene="ORF00035" CDS 2..181 /codon_start=1 /gene="ORF00035" /gene_functions="biosynthetic-additional (rule-based-clusters) leader_eh" /gene_functions="biosynthetic-additional (rule-based-clusters) mature_ha" /gene_kind="biosynthetic-additional" /note="hypothetical protein; identified by GeneMark; putative" /product="L. lactis predicted coding region ORF00035" /protein_id="AAC56053.1" /sec_met_domain="leader_eh (E-value: 5.1e-09, bitscore: 25.0, seeds: 8, tool: rule-based-clusters)" /sec_met_domain="mature_ha (E-value: 2.1e-18, bitscore: 54.4, seeds: 5, tool: rule-based-clusters)" /transl_table=11 /translation="MNKNEIETQPVTWLEEVSDQNFDEDVFGACSTNTFSLSDYWGNNG AWCTLTHECMAWCK" gene 220..417 /gene="ORF00036" CDS 220..417 /codon_start=1 /gene="ORF00036" /note="hypothetical protein; identified by GeneMark; putative" /product="L. lactis predicted coding region ORF00036" /protein_id="AAC56054.1" /transl_table=11 /translation="MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGGTTPATPAIS ILSAYISTNTCPTTKCTRAC" gene 431..3373 /gene="ORF00037" CDS 431..3373 /codon_start=1 /gene="ORF00037" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: LANC_like" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: DUF4135" /gene_functions="biosynthetic-additional (smcogs) SMCOG1070:lanthionine synthetase C family protein (Score: 606; E-value: 2.1e-183)" /gene_kind="biosynthetic" /note="similar to SP:P37609 PID:433322 percent identity: 28.41; identified by sequence similarity; putative" /product="lacticin 481/lactococcin biosynthesis protein LCNDR2" /protein_id="AAC56011.1" /sec_met_domain="LANC_like (E-value: 3.3e-68, bitscore: 218.6, seeds: 47, tool: rule-based-clusters)" /sec_met_domain="DUF4135 (E-value: 1.8e-68, bitscore: 220.0, seeds: 79, tool: rule-based-clusters)" /transl_table=11 /translation="MKFNKNVFPEINETDFDNNIKPLLDELESRITIPQEELSFSSIND DLFRELTRNEEYPYQSICTIVANIVMDDGSEIWRKDIFVDSNSVREAVCDILSQTLFLY FIRCFSEQIKDIRKTDEDKESTYNRYINLLFSSNFKIFSDEYPVLWYRTIRIIKNRWYS IKKSLLLTQKHRVEIDKQLDIPHKMKIKGLKIGGDTHNGGATVTTIFFEKGYKLIYKPR STSGEFSYKKFIEKINPYLKKDMGAIKAIDFGEYGFSEYIECNTDEEDMKQVGQLAFFM YLLNASDMHYSNVIWTKQGPVPIDLETLFQPDRIRKGLKQSETNAYHKMEKSVYGTGII PISLSVKGKKGEVDVGFSGIRDERSSSPFRVLEILDGFSSDIKIVWKKQQKSSSSKNNL IVDHKKEREILQRAQSVVEGFQETSKIFMKHREEFISIILDSFENIKIRYIHNMTFRYE QLLRTLTDAEPAQKIELDRLLLSRTGILSISSSPYISLSECQQMWQGDVPYFYSKFSSK SIFDTNGFVDEIELTPRQAFIIKAESITNDEVDFQSKIIKLAFMARLSDPHTTNDNKLN KKVIIESNQQSNSSESGNKAILFLSDLLKNNVLEDRYSHLPKTWIGPVARDGGLGWAPG VLGYDLYSGRTGPALALAAAGRVLKDKDSIELSADIFNKSSQILQEKTYDFRNLFASGI GGFSGITGLFWALNAAGNILNNDDWIKTSNQSMLLLNENMLKVDKNFFDLISGNSGAIG MMYLTNPNFYLSRSKINDILLTTDCLITEMEKDETSGLAHGVSQILWFLSIMMQRQPSS EIKIRATIVDNIIKKKYTNSYGEIECYYPTDGHSKSTSWCNGTSGILVAYIEGYKANIV DKSSVYHIINQINVEQLQHDNIPIMCHGSLGVYESLKYASKYFEIETKYLLDVMRNGGC SSQEVLKYYGKGNGRYPLSPGLMAGQSGALLHCCKLEDNDISVSPISLMT" gene 3400..5526 /gene="ORF00038" CDS 3400..5526 /codon_start=1 /gene="ORF00038" /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_C39" /gene_functions="transport (smcogs) SMCOG1288:ABC transporter related protein (Score: 223.1; E-value: 1.1e-67)" /gene_kind="transport" /note="similar to GB:M38052 PID:148309 PID:559862 percent identity: 32.53; identified by sequence similarity; putative" /product="cytolysin B transport protein" /protein_id="AAC56012.1" /sec_met_domain="Peptidase_C39 (E-value: 8.6e-41, bitscore: 127.6, seeds: 36, tool: rule-based-clusters)" /transl_table=11 /translation="MKKLKSTFQVAQTECGLCCVRTILDYFGYETTVTKLRILKEPGRD GSSFNDIRKLLERFGVDSKLYKVKDNRIFSTLQLPIIIYWKNVHFVCVERISKKTVIIM DPSVGRTKMSLTEFFQNFSGLILIPKKNTEKFKKNTDNIINTWRKSYIWPSKTASLYML TGILSLFIIASSLLLPLATQYSIDNLMKENFSLIKIISGLGAFSIFMFIVYYFRTMLSI KIMYNFSWNLINRAFTRILSLPAKYFTVRAPGEITYRLGAMNNIREVLGPKLVQSVLDV FSTLLLLIYCFCVSIVLGGVILSVLLVILLFLVVTNNYVTAATDKEIREGGDAQNIQLD ALVSINNLKLGGYKEIYLNDWRNNYKSFLKATAKRMKIQDGYIGSSLYMIQAFMPLLLL VISLKMVQIGTISLGVALSIQTISSMIFIYANSIFNTITNLAVSTRYIELADDIFEYPL EDDSGTEKCGITFGSIVMKDVDFRYTPDSKDALKHISIDINAGQTVALVGISGSGKTTL GKIISTLFKPSKGQIFFDGVEIKNHNLDSLRKYVGYIPQEAHLHNRTIMENLLLGSNYP QQEVLNYCNSLKFLDFIQDLPMGYQTVVSEMGGNLSGGQKQRIHIARILLQKPKLLVMD EATSSLDNISQSEVYEALEKEINCTKVVIAHRLETILKADKIFVLENGRIIEQGNHDEL LNNKGIYKKIYTSK" gene 5614..8397 /gene="ORF00039" CDS 5614..8397 /codon_start=1 /gene="ORF00039" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: LANC_like" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: DUF4135" /gene_functions="biosynthetic-additional (smcogs) SMCOG1070:lanthionine synthetase C family protein (Score: 522.7; E-value: 3.1e-158)" /gene_kind="biosynthetic" /note="similar to SP:P37609 PID:433322 percent identity: 27.01; identified by sequence similarity; putative" /product="lacticin 481/lactococcin biosynthesis protein LCNDR2" /protein_id="AAC56013.1" /sec_met_domain="LANC_like (E-value: 8.3e-34, bitscore: 105.5, seeds: 47, tool: rule-based-clusters)" /sec_met_domain="DUF4135 (E-value: 1.1e-80, bitscore: 260.2, seeds: 79, tool: rule-based-clusters)" /transl_table=11 /translation="MDPSIKKLVDSIIEFYKKDIYLAYKELEREIKNIDKTIYNTSNDE ILRIFKESLISIITDDIYRLSIKTFIYEFHKFRIDNGFPAVKDSESAFNYYISTFDVKT IARWFEKFPMLESIISSSIKNDCTFMVDVCVNFILDLSECEKINLISEDSRLITISSSN SDPHNGGTRVLFFRFHNGDTILYKPRSLTVDKLISNIFEEVFEFDATNSKNPIPKVLDR GTYGWQEFIEKKSISSSEIKQAYYNLGIFSSIFTVLGSTDIHDENLIFKGTTPYFIDLE TALSPRIRYEGNEENLFYRMSSSLFTSIVGTTIIPAKLAVHSQEIMIGAINTPAKQKTK KDGFNIINFGTDAVDIAKQNIEVERIANPMRIKNNIVNDPLPYQNIFTRGFKEGIKSII LKKGSIISILNNFNSPIRYIMRPTAKYYLILDAAVFPENLYSEQTLNKTLNYLKPPKIV ENSLISKQLFLAEKRILSEGDIPSFYVLGKEKNIRAQNFISEQIFEETAVDNAIQILES ISQDWVNFNERLIAEGFSYIREQSRGYLSSDFENSDIFKSSLTETKKSGYTAMLKTIIS MSVKTSENKKIGWLPGIYDDYPISYMSAAFCSFHDSGGIITLLEHHFGHCSPEYNEMKR GLLELGKMLKINNSNLSIISGSESLEFLYTHREVECLELEYILNNSAEIMGDVFLGKLG LYLILASYLKTDLKIFQDFSIICQKNLEFKKFGIAHGELGYLWTIFRIQNKLKNKNACL SIYHEVLNIYKGKRIESVGWCNGLSGILMILSEMSTVLEKNQDYLFKLANLSTKLNEES VDLSVCHGASGVLQTLLFVYSNTNDKRYLSLANKYWKKVLDNSIKYGFYNGERDKDYLL GYFQGWSGFTDSALLLDKYNNNEQVWIPINLSSDIYQHNLNNCKEKNYEGDGCHKS" gene 8426..9481 /gene="ORF00040" CDS 8426..9481 /NRPS_PKS="Domain: PKS_ER (23-197). E-value: 5.7e-12. Score: 37.2. Matches aSDomain: nrpspksdomains_ORF00040_PKS_ER.1" /codon_start=1 /gene="ORF00040" /gene_functions="biosynthetic-additional (smcogs) SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase (Score: 130.4; E-value: 1.4e-39)" /gene_kind="biosynthetic-additional" /note="hypothetical protein; identified by GeneMark; putative" /product="L. lactis predicted coding region ORF00040" /protein_id="AAC56039.1" /transl_table=11 /translation="MGSTKFGETTINFGLVDLPKPKFDNKSKDNSNFVLVKINAISCNF RDKGILLDNYEKLIASDQLYLPFGSEFSGIVVDYGTNVNCFSINQRVIPDCSYPKENNN IRPGIPTNFASLGWLRIHKDKLLNAPRELTDSEAACFPLGVQTAHSMIRRSNILQSPDP KPLIFSAKSATSLFIIKELLAHGIKPTCLSTSKWNQKELKSILGSEVRNDYSCFEKDHT FFTHVFDPFFDVNIEKAVNLLSIYGTYITCGLNSQHPSLSNSKLDELECNLRSSILGAI VKDISIIGNCLGIKSDLEEPIAMLESKIDLKPILDSEYSLSDGLKFIEKSFFDSSKFGK CVLRYDTSYDT" aSDomain 8495..9016 /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ORF00040_PKS_ER.1" /evalue="5.70E-12" /label="ORF00040_PKS_ER.1" /locus_tag="ORF00040" /protein_end="197" /protein_start="23" /score="37.2" /tool="antismash" /translation="DNKSKDNSNFVLVKINAISCNFRDKGILLDNYEKLIASDQLYLPF GSEFSGIVVDYGTNVNCFSINQRVIPDCSYPKENNNIRPGIPTNFASLGWLRIHKDKLL NAPRELTDSEAACFPLGVQTAHSMIRRSNILQSPDPKPLIFSAKSATSLFIIKELLAHG IKPTCLSTSKW" ORIGIN 1 catgaacaaa aatgaaattg aaacacaacc agttacatgg ttggaagaag tatctgatca 61 aaattttgat gaagatgtat ttggtgcgtg tagtactaac acattctcgc tcagtgatta 121 ctggggaaat aacggggctt ggtgtacact cactcatgaa tgtatggctt ggtgtaaata 181 agttaataac aaatttttaa ttaattaagg agctttacga tgaaagaaaa aaatatgaaa 241 aagaatgaca ctattgaatt acaattggga aaataccttg aagatgatat gattgaatta 301 gctgaagggg atgagtctca tggaggaaca acaccagcaa ctcctgcaat ctctattctc 361 agtgcatata ttagtaccaa tacttgtcca acaacaaaat gtacacgtgc ttgttaatta 421 ggagtaaaaa atgaaattta acaaaaatgt ttttccagaa attaatgaga cagactttga 481 taataatata aaaccattat tggatgagtt agagagtaga attactattc ctcaagaaga 541 actatcgttt tcgtcaataa acgatgattt atttcgggag ttgactagaa atgaggaata 601 tccctaccag agtatatgta caatagtggc aaatatagtt atggatgatg gatctgaaat 661 ttggagaaaa gatatttttg ttgattcaaa ctctgtaaga gaagccgttt gtgatatttt 721 gtcacaaacg cttttcttat attttataag atgtttttct gaacaaatta aggatataag 781 aaagaccgat gaggataaag aatcaacata taatagatac attaatttac tgttttcttc 841 taattttaaa atattttcag atgaatatcc tgtactctgg tatagaacga ttagaattat 901 taaaaatagg tggtattcta taaaaaaaag tcttttactt acacaaaaac acagagtaga 961 aatcgataaa caattagata taccacataa aatgaaaata aagggattga aaattggggg 1021 ggatacccat aatggtggag caacagtaac tacaatattc tttgaaaaag gatataaatt 1081 aatttataaa ccaagatcta catcaggaga attttcatat aaaaaattca ttgagaagat 1141 aaatccatat ttaaaaaaag acatgggagc aattaaagcg attgatttcg gggagtatgg 1201 attttcagaa tatattgagt gtaatactga tgaagaagat atgaagcaag tgggacaatt 1261 agccttcttt atgtatctat taaacgcttc agatatgcac tatagtaatg tgatatggac 1321 caaacaggga cccgttccaa ttgatttaga aactctattt caaccagata gaataaggaa 1381 aggtttaaaa cagtcagaaa ctaatgcata ccataaaatg gagaaatctg tttacggcac 1441 aggtatcata ccaatttcgt tgagtgtaaa aggaaaaaaa ggagaagttg atgtaggttt 1501 ctcaggtatt agagatgaaa gaagctctag tccatttcga gtgcttgaaa tattagacgg 1561 atttagttca gatataaaaa tagtttggaa aaaacaacaa aaaagtagta gttcaaaaaa 1621 taatttaatt gtagaccaca aaaaggaacg cgaaatttta caaagagcac aaagtgttgt 1681 tgagggtttc caagagactt ctaaaatatt tatgaaacat agagaggaat ttataagtat 1741 aatactagac tcttttgaaa atataaaaat tagatatatt cataatatga catttcgtta 1801 cgagcagtta ctgcgaactc taacggatgc tgagccagca caaaaaattg aattagacag 1861 gctactgcta tcaaggactg gtatactaag tatatcaagt agtccgtata tatctttgtc 1921 agaatgccaa caaatgtggc agggagatgt cccttatttt tattctaaat tttctagtaa 1981 gagtattttt gatactaatg gttttgtgga tgaaattgaa ctaactccta gacaggcttt 2041 tattattaaa gcagaatcta taactaatga tgaggttgat tttcaatcta aaataataaa 2101 actagctttt atggctaggc tttcagatcc tcatacaact aatgataata aattaaataa 2161 aaaagttatt attgaatcta atcagcaatc taattctagt gaaagtggta ataaagcgat 2221 actttttctt tcagatttgt taaaaaataa tgttttagaa gataggtata gccatctacc 2281 taaaacgtgg ataggtccag tggcaagaga tggaggatta ggatgggctc caggggtttt 2341 ggggtacgat ttatattcag gaagaacagg tccagcccta gctttagcag ccgcaggaag 2401 agttctgaaa gataaagatt ctattgaatt gtcagctgat atttttaata agtcgtcaca 2461 aatattacaa gaaaaaacat atgattttag aaatttattt gcatcaggaa taggggggtt 2521 ttcagggata acaggactgt tctgggctct gaatgcagct ggtaatatat taaataatga 2581 tgactggata aaaacatcta atcagtctat gctcttgttg aatgaaaaca tgttaaaagt 2641 tgataaaaat ttttttgatt taatttcggg aaatagtggt gctattggaa tgatgtattt 2701 gacaaaccca aatttttatt tatcaagaag taaaataaat gatatattat taactaccga 2761 ttgcttaatt acagaaatgg aaaaagatga gacatcagga ttagcacatg gagtatcaca 2821 aatattatgg ttcttatcaa taatgatgca aaggcaaccc agcagtgaaa taaaaataag 2881 ggcaacaata gttgataata taattaagaa aaaatacact aattcatatg gagaaataga 2941 gtgctattat ccaacagatg ggcatagtaa atctacttct tggtgtaatg gaacaagtgg 3001 tattttggta gcttacatag aaggatataa ggcgaatata gttgataaat ccagtgttta 3061 tcatattata aaccaaatta atgtagagca acttcaacat gataatattc ctataatgtg 3121 tcatggaagc ctaggtgtat atgagtcatt aaaatatgca agtaaatatt ttgagatcga 3181 aacaaaatat ttacttgatg tgatgagaaa tgggggatgc tcgtcacaag aagtattaaa 3241 atattacgga aagggaaatg gtagatatcc attaagtcca ggtcttatgg cgggacaatc 3301 tggagcttta ctacattgtt gcaaactgga agataatgat atctcagtat ctcctatatc 3361 tttgatgaca taaagtaaaa tctttctaat ctattaatta tgaagaaatt aaaatcaact 3421 tttcaagtag cacaaactga atgtggactt tgctgtgtaa gaactatatt agattatttt 3481 ggttatgaaa ctacagtaac aaaattaaga atattaaagg aaccaggtag agatgggtca 3541 agttttaatg atattagaaa gttacttgaa cgttttggag ttgactccaa attatataag 3601 gtaaaagata atagaatatt ttcaacactt cagttaccta ttattattta ttggaagaac 3661 gttcattttg tttgtgtgga aagaatatca aagaaaacag taataataat ggatccatca 3721 gtaggtagaa ctaaaatgag cctgactgaa ttttttcaaa atttttcggg actaatacta 3781 atccccaaaa aaaatactga aaaatttaaa aaaaatactg ataatattat aaacacctgg 3841 agaaaaagtt atatttggcc gagtaaaaca gcctctcttt atatgttaac aggaatatta 3901 agcttgttta ttatagcttc ttccctatta ttacctttgg caactcagta tagtatagat 3961 aatttaatga aagaaaattt ttctcttatt aaaattattt caggattagg cgcattttct 4021 atttttatgt ttattgtcta ttattttaga accatgttgt caataaaaat aatgtataat 4081 tttagctgga atttaataaa tagagccttt accagaatat tatcattacc agcgaagtac 4141 tttactgtaa gggcgccagg cgaaataacg tatcgactgg gtgccatgaa taatattaga 4201 gaagtattag ggcctaagct agtacaatca gtattagatg tttttagtac tctattatta 4261 ttgatatatt gtttttgtgt ttcaatagtt ttaggaggtg taattttatc agtattactt 4321 gttatactct tatttttagt agttactaat aactatgtca ctgcagcgac agataaagaa 4381 ataagagaag gaggggatgc tcaaaatatt caattagatg ctcttgtctc aattaataat 4441 ttaaaattgg gaggatataa ggaaatatat cttaatgatt ggcgaaataa ttataaatca 4501 tttttaaagg caacagcaaa aagaatgaaa attcaagatg gctatattgg ttcatctctt 4561 tatatgattc aagcttttat gcctttatta ctgcttgtaa taagtttaaa aatggttcaa 4621 ataggaacaa tttcgttagg agttgctcta tcaattcaaa caatttcatc catgattttt 4681 atatatgcta attcaatttt caacactata acgaacttag cagtttccac gagatatatt 4741 gaattagcag atgatatatt tgaatatcca ttagaggatg atagtggaac tgaaaaatgt 4801 ggaattactt ttggaagcat tgttatgaaa gatgttgact ttaggtatac tccagatagt 4861 aaagatgcgt taaaacatat ttcaatagat atcaatgctg gacaaactgt tgcattggtt 4921 ggaatatcag gttctggaaa aactacttta ggtaaaatta taagtacatt attcaagcct 4981 agtaagggac aaattttttt tgatggagta gaaataaaaa atcataatct agacagtttg 5041 agaaaatatg tcggttatat tcctcaggaa gcacacttac acaatcgaac tataatggaa 5101 aatttgctcc tgggttcaaa ttaccctcaa caagaagttt taaattattg taattctcta 5161 aaatttcttg attttattca agatttacca atgggatatc agacagttgt ttcagaaatg 5221 ggagggaatc tctctggagg acaaaaacag agaattcata ttgctagaat attattacaa 5281 aaaccaaaat tattagtcat ggatgaggct acttcttcac tagataatat atctcaatca 5341 gaagtttatg aagctttgga aaaggaaatt aattgtacaa aagttgtaat tgcccacaga 5401 ttggaaacta tccttaaagc agataaaatt tttgttttag agaatggtag aatcattgag 5461 caaggaaatc atgacgagct attaaataat aaaggaatat ataagaaaat atatacttct 5521 aagtaattta ttattttata aataaaatac tataaaaaaa gaaagaatta tttttgtggt 5581 tctgccacat ataagtagtt aggttagtga attttggacc catcaataaa aaaattagta 5641 gacagcataa tagagtttta taaaaaagat atttacttgg cgtacaaaga attagaaaga 5701 gaaataaaaa atattgacaa aacgatttac aatacttcta atgatgaaat actgaggata 5761 tttaaagaat ctttaatttc aataattaca gatgatatat acagattatc aattaaaaca 5821 ttcatttatg aatttcacaa atttagaatt gataacggat tcccagcagt aaaagattct 5881 gagagcgcat ttaactatta tattagtaca tttgatgtaa aaactattgc gcgttggttc 5941 gaaaagttcc cgatgttaga aagtataatt tcatcaagta taaagaatga ttgtactttc 6001 atggttgatg tgtgtgttaa ttttattctt gatttatctg aatgtgaaaa aataaatctt 6061 ataagtgagg attcaagatt aattactatt tcttcctcta attccgaccc ccataatgga 6121 ggaacaagag ttttattttt taggtttcat aatggggaca ctattttata taaaccaaga 6181 tctttaacag ttgataaact cattagtaat atattcgaag aagtgtttga gtttgatgca 6241 actaattcaa aaaatccgat tccaaaagtc ttggatagag gaacctatgg ttggcaagaa 6301 tttatagaga agaaaagcat aagttcttct gaaatcaagc aagcatatta taatttagga 6361 attttttcat cgatatttac tgtcctaggg tcaactgata tccatgatga aaatttgata 6421 tttaaaggta caacaccata ttttattgac ttagagacag ccttaagtcc aaggattaga 6481 tacgaaggta atgaagaaaa tttattttat agaatgtctt cgtcactttt cacttcgatt 6541 gtcggtacaa caattattcc tgctaagtta gcagtacatt ctcaggaaat aatgattggg 6601 gctattaata cccctgctaa acaaaaaaca aaaaaagatg ggtttaatat aataaacttt 6661 ggtactgatg ctgttgatat tgctaaacaa aatattgaag ttgaaagaat agccaatccg 6721 atgaggatca aaaataatat agtgaatgat ccgttaccct accaaaatat atttactaga 6781 ggatttaaag aaggtataaa atctattatt cttaaaaaag gatctataat tagtattctt 6841 aataatttta atagtcctat acgttatata atgagaccaa ctgccaaata ctatttaatt 6901 ttagatgcgg cagtatttcc agaaaattta tatagtgaac aaactcttaa taaaactctg 6961 aattatctca aacctcccaa gattgtagaa aattcgctta tctcaaaaca actcttctta 7021 gctgaaaaaa gaatactatc tgaaggagat attcccagtt tttatgtact aggaaaagaa 7081 aaaaatatta gagcacagaa ttttatttca gaacagatat ttgaagaaac tgctgttgat 7141 aatgcaatcc aaatattaga atcaatatct caagattggg taaatttcaa tgagagattg 7201 attgcagagg ggttttcata tattagggaa caatcaagag gatatctttc aagtgacttt 7261 gaaaattcag atatatttaa aagttctctt actgaaacta aaaaatcagg gtacaccgca 7321 atgctgaaaa ctatcataag catgtctgtt aaaacttcag aaaataaaaa aataggctgg 7381 ctacctggta tatatgacga ttatccaatt tcttatatgt ctgcagcatt ttgctcattt 7441 catgattctg gtggaataat tactttattg gagcatcact tcggtcactg tagtccagaa 7501 tataacgaaa tgaaacgtgg gttattagag ttaggaaaaa tgttgaaaat taataattca 7561 aatttatcta ttatttcggg ttctgagtcc ttagaatttt tatataccca tagagaagtt 7621 gaatgtcttg aactagaata tatactgaat aattctgctg agattatggg agatgttttt 7681 ttgggaaaat tgggactata cttaatttta gctagttact taaagacaga cttaaaaatt 7741 tttcaagatt tttcgataat ttgtcaaaaa aatcttgaat ttaaaaaatt tggcattgct 7801 catggagagt tgggatattt atggactatt tttagaatac aaaataaatt gaaaaataaa 7861 aatgcttgtc tctctatata tcatgaggtt cttaatattt ataaaggcaa aagaattgaa 7921 agtgttggat ggtgcaatgg cctttcagga attctaatga ttttaagtga aatgtctact 7981 gtacttgaaa aaaaccaaga ttatttgttt aaactagcaa acttaagcac aaaattaaat 8041 gaggaaagcg tagatctttc ggtatgtcat ggagcatcag gtgtacttca gacccttctt 8101 tttgtttaca gtaacacaaa tgataaaaga tatttaagct tggcaaataa atattggaaa 8161 aaggtgttag ataattctat caagtatggc ttttataatg gagaaaggga taaagattat 8221 ttattgggat atttccaagg gtggagtggt tttacagatt ctgctttatt attggataaa 8281 tataataata atgaacaggt atggattcca ataaacttga gttcagatat ttatcaacat 8341 aatttaaaca actgtaagga gaaaaattat gaaggcgatg gttgccataa atcctaaatt 8401 taaacataaa ataaaatata cgaatttggg aagtacaaag tttggggaga caactattaa 8461 ttttgggttg gttgatttac ctaaaccaaa atttgataat aaaagtaagg ataatagtaa 8521 ttttgttctt gtaaaaatta atgcaatatc ttgtaatttt agagataaag gaatattatt 8581 agataattat gaaaaactta ttgctagtga tcaattatac cttccttttg ggtcagaatt 8641 ttcagggata gtggtagatt atggtactaa tgtaaactgt ttctctatta atcaaagagt 8701 aattccagac tgttcctatc ctaaagaaaa taataatata cgtccaggaa ttccgacaaa 8761 ctttgcttca ttgggttggc taagaattca taaagataag ctattgaatg caccaagaga 8821 attaacggat agcgaagcag cttgttttcc tttaggggtt caaactgccc attcaatgat 8881 acgtcgttca aatattttac aatctcctga tcctaaaccc ctaatattta gtgcaaagtc 8941 tgcaacttct ttgttcatta ttaaagaatt actggcacat ggtataaaac cgacatgttt 9001 atcaacttct aaatggaacc aaaaagagct taaaagtatt ttgggatctg aagtaagaaa 9061 tgattattct tgttttgaaa aagatcatac tttttttacc catgtatttg atccattttt 9121 tgatgttaat attgaaaaag ctgtaaattt actatcaata tacggtactt atataacttg 9181 tgggttaaat agtcaacatc catccctttc caatagcaaa cttgatgaat tagaatgtaa 9241 tttaagaagt tcaatacttg gcgctattgt taaagatatt tcaattatag gaaactgttt 9301 agggataaaa agtgatttag aagaaccaat tgccatgtta gagtctaaaa ttgatttaaa 9361 gccaatttta gattccgaat actcactatc agatgggtta aaatttattg aaaaatcatt 9421 ttttgattca tcaaaatttg gaaagtgtgt gctgagatat gatacttctt atgatacata 9481 a //