LOCUS       BGC0000520              9481 bp    DNA     linear   BCT 12-MAY-2020
DEFINITION  Lactococcus lactis strain DPC3147 plasmid pMRC01, complete sequence.
ACCESSION   BGC0000520
VERSION     BGC0000520
KEYWORDS    .
SOURCE      Lactococcus lactis
  ORGANISM  Lactococcus lactis
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:45:20
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 27743
            Orig. end    :: 37224
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..9481
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9481
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            2..181
                     /gene="ORF00035"
     CDS             2..181
                     /codon_start=1
                     /gene="ORF00035"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_eh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /note="hypothetical protein; identified by GeneMark;
                     putative"
                     /product="L. lactis predicted coding region ORF00035"
                     /protein_id="AAC56053.1"
                     /sec_met_domain="leader_eh (E-value: 5.1e-09, bitscore:
                     25.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="mature_ha (E-value: 2.1e-18, bitscore:
                     54.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKNEIETQPVTWLEEVSDQNFDEDVFGACSTNTFSLSDYWGNNG
                     AWCTLTHECMAWCK"
     gene            220..417
                     /gene="ORF00036"
     CDS             220..417
                     /codon_start=1
                     /gene="ORF00036"
                     /note="hypothetical protein; identified by GeneMark;
                     putative"
                     /product="L. lactis predicted coding region ORF00036"
                     /protein_id="AAC56054.1"
                     /transl_table=11
                     /translation="MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGGTTPATPAIS
                     ILSAYISTNTCPTTKCTRAC"
     gene            431..3373
                     /gene="ORF00037"
     CDS             431..3373
                     /codon_start=1
                     /gene="ORF00037"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     606; E-value: 2.1e-183)"
                     /gene_kind="biosynthetic"
                     /note="similar to SP:P37609 PID:433322 percent identity:
                     28.41; identified by sequence similarity; putative"
                     /product="lacticin 481/lactococcin biosynthesis protein
                     LCNDR2"
                     /protein_id="AAC56011.1"
                     /sec_met_domain="LANC_like (E-value: 3.3e-68, bitscore:
                     218.6, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 1.8e-68, bitscore:
                     220.0, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFNKNVFPEINETDFDNNIKPLLDELESRITIPQEELSFSSIND
                     DLFRELTRNEEYPYQSICTIVANIVMDDGSEIWRKDIFVDSNSVREAVCDILSQTLFLY
                     FIRCFSEQIKDIRKTDEDKESTYNRYINLLFSSNFKIFSDEYPVLWYRTIRIIKNRWYS
                     IKKSLLLTQKHRVEIDKQLDIPHKMKIKGLKIGGDTHNGGATVTTIFFEKGYKLIYKPR
                     STSGEFSYKKFIEKINPYLKKDMGAIKAIDFGEYGFSEYIECNTDEEDMKQVGQLAFFM
                     YLLNASDMHYSNVIWTKQGPVPIDLETLFQPDRIRKGLKQSETNAYHKMEKSVYGTGII
                     PISLSVKGKKGEVDVGFSGIRDERSSSPFRVLEILDGFSSDIKIVWKKQQKSSSSKNNL
                     IVDHKKEREILQRAQSVVEGFQETSKIFMKHREEFISIILDSFENIKIRYIHNMTFRYE
                     QLLRTLTDAEPAQKIELDRLLLSRTGILSISSSPYISLSECQQMWQGDVPYFYSKFSSK
                     SIFDTNGFVDEIELTPRQAFIIKAESITNDEVDFQSKIIKLAFMARLSDPHTTNDNKLN
                     KKVIIESNQQSNSSESGNKAILFLSDLLKNNVLEDRYSHLPKTWIGPVARDGGLGWAPG
                     VLGYDLYSGRTGPALALAAAGRVLKDKDSIELSADIFNKSSQILQEKTYDFRNLFASGI
                     GGFSGITGLFWALNAAGNILNNDDWIKTSNQSMLLLNENMLKVDKNFFDLISGNSGAIG
                     MMYLTNPNFYLSRSKINDILLTTDCLITEMEKDETSGLAHGVSQILWFLSIMMQRQPSS
                     EIKIRATIVDNIIKKKYTNSYGEIECYYPTDGHSKSTSWCNGTSGILVAYIEGYKANIV
                     DKSSVYHIINQINVEQLQHDNIPIMCHGSLGVYESLKYASKYFEIETKYLLDVMRNGGC
                     SSQEVLKYYGKGNGRYPLSPGLMAGQSGALLHCCKLEDNDISVSPISLMT"
     gene            3400..5526
                     /gene="ORF00038"
     CDS             3400..5526
                     /codon_start=1
                     /gene="ORF00038"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 223.1; E-value:
                     1.1e-67)"
                     /gene_kind="transport"
                     /note="similar to GB:M38052 PID:148309 PID:559862 percent
                     identity: 32.53; identified by sequence similarity;
                     putative"
                     /product="cytolysin B transport protein"
                     /protein_id="AAC56012.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.6e-41, bitscore:
                     127.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLKSTFQVAQTECGLCCVRTILDYFGYETTVTKLRILKEPGRD
                     GSSFNDIRKLLERFGVDSKLYKVKDNRIFSTLQLPIIIYWKNVHFVCVERISKKTVIIM
                     DPSVGRTKMSLTEFFQNFSGLILIPKKNTEKFKKNTDNIINTWRKSYIWPSKTASLYML
                     TGILSLFIIASSLLLPLATQYSIDNLMKENFSLIKIISGLGAFSIFMFIVYYFRTMLSI
                     KIMYNFSWNLINRAFTRILSLPAKYFTVRAPGEITYRLGAMNNIREVLGPKLVQSVLDV
                     FSTLLLLIYCFCVSIVLGGVILSVLLVILLFLVVTNNYVTAATDKEIREGGDAQNIQLD
                     ALVSINNLKLGGYKEIYLNDWRNNYKSFLKATAKRMKIQDGYIGSSLYMIQAFMPLLLL
                     VISLKMVQIGTISLGVALSIQTISSMIFIYANSIFNTITNLAVSTRYIELADDIFEYPL
                     EDDSGTEKCGITFGSIVMKDVDFRYTPDSKDALKHISIDINAGQTVALVGISGSGKTTL
                     GKIISTLFKPSKGQIFFDGVEIKNHNLDSLRKYVGYIPQEAHLHNRTIMENLLLGSNYP
                     QQEVLNYCNSLKFLDFIQDLPMGYQTVVSEMGGNLSGGQKQRIHIARILLQKPKLLVMD
                     EATSSLDNISQSEVYEALEKEINCTKVVIAHRLETILKADKIFVLENGRIIEQGNHDEL
                     LNNKGIYKKIYTSK"
     gene            5614..8397
                     /gene="ORF00039"
     CDS             5614..8397
                     /codon_start=1
                     /gene="ORF00039"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     522.7; E-value: 3.1e-158)"
                     /gene_kind="biosynthetic"
                     /note="similar to SP:P37609 PID:433322 percent identity:
                     27.01; identified by sequence similarity; putative"
                     /product="lacticin 481/lactococcin biosynthesis protein
                     LCNDR2"
                     /protein_id="AAC56013.1"
                     /sec_met_domain="LANC_like (E-value: 8.3e-34, bitscore:
                     105.5, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-80, bitscore:
                     260.2, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPSIKKLVDSIIEFYKKDIYLAYKELEREIKNIDKTIYNTSNDE
                     ILRIFKESLISIITDDIYRLSIKTFIYEFHKFRIDNGFPAVKDSESAFNYYISTFDVKT
                     IARWFEKFPMLESIISSSIKNDCTFMVDVCVNFILDLSECEKINLISEDSRLITISSSN
                     SDPHNGGTRVLFFRFHNGDTILYKPRSLTVDKLISNIFEEVFEFDATNSKNPIPKVLDR
                     GTYGWQEFIEKKSISSSEIKQAYYNLGIFSSIFTVLGSTDIHDENLIFKGTTPYFIDLE
                     TALSPRIRYEGNEENLFYRMSSSLFTSIVGTTIIPAKLAVHSQEIMIGAINTPAKQKTK
                     KDGFNIINFGTDAVDIAKQNIEVERIANPMRIKNNIVNDPLPYQNIFTRGFKEGIKSII
                     LKKGSIISILNNFNSPIRYIMRPTAKYYLILDAAVFPENLYSEQTLNKTLNYLKPPKIV
                     ENSLISKQLFLAEKRILSEGDIPSFYVLGKEKNIRAQNFISEQIFEETAVDNAIQILES
                     ISQDWVNFNERLIAEGFSYIREQSRGYLSSDFENSDIFKSSLTETKKSGYTAMLKTIIS
                     MSVKTSENKKIGWLPGIYDDYPISYMSAAFCSFHDSGGIITLLEHHFGHCSPEYNEMKR
                     GLLELGKMLKINNSNLSIISGSESLEFLYTHREVECLELEYILNNSAEIMGDVFLGKLG
                     LYLILASYLKTDLKIFQDFSIICQKNLEFKKFGIAHGELGYLWTIFRIQNKLKNKNACL
                     SIYHEVLNIYKGKRIESVGWCNGLSGILMILSEMSTVLEKNQDYLFKLANLSTKLNEES
                     VDLSVCHGASGVLQTLLFVYSNTNDKRYLSLANKYWKKVLDNSIKYGFYNGERDKDYLL
                     GYFQGWSGFTDSALLLDKYNNNEQVWIPINLSSDIYQHNLNNCKEKNYEGDGCHKS"
     gene            8426..9481
                     /gene="ORF00040"
     CDS             8426..9481
                     /NRPS_PKS="Domain: PKS_ER (23-197). E-value: 5.7e-12.
                     Score: 37.2. Matches aSDomain:
                     nrpspksdomains_ORF00040_PKS_ER.1"
                     /codon_start=1
                     /gene="ORF00040"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 130.4; E-value: 1.4e-39)"
                     /gene_kind="biosynthetic-additional"
                     /note="hypothetical protein; identified by GeneMark;
                     putative"
                     /product="L. lactis predicted coding region ORF00040"
                     /protein_id="AAC56039.1"
                     /transl_table=11
                     /translation="MGSTKFGETTINFGLVDLPKPKFDNKSKDNSNFVLVKINAISCNF
                     RDKGILLDNYEKLIASDQLYLPFGSEFSGIVVDYGTNVNCFSINQRVIPDCSYPKENNN
                     IRPGIPTNFASLGWLRIHKDKLLNAPRELTDSEAACFPLGVQTAHSMIRRSNILQSPDP
                     KPLIFSAKSATSLFIIKELLAHGIKPTCLSTSKWNQKELKSILGSEVRNDYSCFEKDHT
                     FFTHVFDPFFDVNIEKAVNLLSIYGTYITCGLNSQHPSLSNSKLDELECNLRSSILGAI
                     VKDISIIGNCLGIKSDLEEPIAMLESKIDLKPILDSEYSLSDGLKFIEKSFFDSSKFGK
                     CVLRYDTSYDT"
     aSDomain        8495..9016
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ORF00040_PKS_ER.1"
                     /evalue="5.70E-12"
                     /label="ORF00040_PKS_ER.1"
                     /locus_tag="ORF00040"
                     /protein_end="197"
                     /protein_start="23"
                     /score="37.2"
                     /tool="antismash"
                     /translation="DNKSKDNSNFVLVKINAISCNFRDKGILLDNYEKLIASDQLYLPF
                     GSEFSGIVVDYGTNVNCFSINQRVIPDCSYPKENNNIRPGIPTNFASLGWLRIHKDKLL
                     NAPRELTDSEAACFPLGVQTAHSMIRRSNILQSPDPKPLIFSAKSATSLFIIKELLAHG
                     IKPTCLSTSKW"
ORIGIN
        1 catgaacaaa aatgaaattg aaacacaacc agttacatgg ttggaagaag tatctgatca
       61 aaattttgat gaagatgtat ttggtgcgtg tagtactaac acattctcgc tcagtgatta
      121 ctggggaaat aacggggctt ggtgtacact cactcatgaa tgtatggctt ggtgtaaata
      181 agttaataac aaatttttaa ttaattaagg agctttacga tgaaagaaaa aaatatgaaa
      241 aagaatgaca ctattgaatt acaattggga aaataccttg aagatgatat gattgaatta
      301 gctgaagggg atgagtctca tggaggaaca acaccagcaa ctcctgcaat ctctattctc
      361 agtgcatata ttagtaccaa tacttgtcca acaacaaaat gtacacgtgc ttgttaatta
      421 ggagtaaaaa atgaaattta acaaaaatgt ttttccagaa attaatgaga cagactttga
      481 taataatata aaaccattat tggatgagtt agagagtaga attactattc ctcaagaaga
      541 actatcgttt tcgtcaataa acgatgattt atttcgggag ttgactagaa atgaggaata
      601 tccctaccag agtatatgta caatagtggc aaatatagtt atggatgatg gatctgaaat
      661 ttggagaaaa gatatttttg ttgattcaaa ctctgtaaga gaagccgttt gtgatatttt
      721 gtcacaaacg cttttcttat attttataag atgtttttct gaacaaatta aggatataag
      781 aaagaccgat gaggataaag aatcaacata taatagatac attaatttac tgttttcttc
      841 taattttaaa atattttcag atgaatatcc tgtactctgg tatagaacga ttagaattat
      901 taaaaatagg tggtattcta taaaaaaaag tcttttactt acacaaaaac acagagtaga
      961 aatcgataaa caattagata taccacataa aatgaaaata aagggattga aaattggggg
     1021 ggatacccat aatggtggag caacagtaac tacaatattc tttgaaaaag gatataaatt
     1081 aatttataaa ccaagatcta catcaggaga attttcatat aaaaaattca ttgagaagat
     1141 aaatccatat ttaaaaaaag acatgggagc aattaaagcg attgatttcg gggagtatgg
     1201 attttcagaa tatattgagt gtaatactga tgaagaagat atgaagcaag tgggacaatt
     1261 agccttcttt atgtatctat taaacgcttc agatatgcac tatagtaatg tgatatggac
     1321 caaacaggga cccgttccaa ttgatttaga aactctattt caaccagata gaataaggaa
     1381 aggtttaaaa cagtcagaaa ctaatgcata ccataaaatg gagaaatctg tttacggcac
     1441 aggtatcata ccaatttcgt tgagtgtaaa aggaaaaaaa ggagaagttg atgtaggttt
     1501 ctcaggtatt agagatgaaa gaagctctag tccatttcga gtgcttgaaa tattagacgg
     1561 atttagttca gatataaaaa tagtttggaa aaaacaacaa aaaagtagta gttcaaaaaa
     1621 taatttaatt gtagaccaca aaaaggaacg cgaaatttta caaagagcac aaagtgttgt
     1681 tgagggtttc caagagactt ctaaaatatt tatgaaacat agagaggaat ttataagtat
     1741 aatactagac tcttttgaaa atataaaaat tagatatatt cataatatga catttcgtta
     1801 cgagcagtta ctgcgaactc taacggatgc tgagccagca caaaaaattg aattagacag
     1861 gctactgcta tcaaggactg gtatactaag tatatcaagt agtccgtata tatctttgtc
     1921 agaatgccaa caaatgtggc agggagatgt cccttatttt tattctaaat tttctagtaa
     1981 gagtattttt gatactaatg gttttgtgga tgaaattgaa ctaactccta gacaggcttt
     2041 tattattaaa gcagaatcta taactaatga tgaggttgat tttcaatcta aaataataaa
     2101 actagctttt atggctaggc tttcagatcc tcatacaact aatgataata aattaaataa
     2161 aaaagttatt attgaatcta atcagcaatc taattctagt gaaagtggta ataaagcgat
     2221 actttttctt tcagatttgt taaaaaataa tgttttagaa gataggtata gccatctacc
     2281 taaaacgtgg ataggtccag tggcaagaga tggaggatta ggatgggctc caggggtttt
     2341 ggggtacgat ttatattcag gaagaacagg tccagcccta gctttagcag ccgcaggaag
     2401 agttctgaaa gataaagatt ctattgaatt gtcagctgat atttttaata agtcgtcaca
     2461 aatattacaa gaaaaaacat atgattttag aaatttattt gcatcaggaa taggggggtt
     2521 ttcagggata acaggactgt tctgggctct gaatgcagct ggtaatatat taaataatga
     2581 tgactggata aaaacatcta atcagtctat gctcttgttg aatgaaaaca tgttaaaagt
     2641 tgataaaaat ttttttgatt taatttcggg aaatagtggt gctattggaa tgatgtattt
     2701 gacaaaccca aatttttatt tatcaagaag taaaataaat gatatattat taactaccga
     2761 ttgcttaatt acagaaatgg aaaaagatga gacatcagga ttagcacatg gagtatcaca
     2821 aatattatgg ttcttatcaa taatgatgca aaggcaaccc agcagtgaaa taaaaataag
     2881 ggcaacaata gttgataata taattaagaa aaaatacact aattcatatg gagaaataga
     2941 gtgctattat ccaacagatg ggcatagtaa atctacttct tggtgtaatg gaacaagtgg
     3001 tattttggta gcttacatag aaggatataa ggcgaatata gttgataaat ccagtgttta
     3061 tcatattata aaccaaatta atgtagagca acttcaacat gataatattc ctataatgtg
     3121 tcatggaagc ctaggtgtat atgagtcatt aaaatatgca agtaaatatt ttgagatcga
     3181 aacaaaatat ttacttgatg tgatgagaaa tgggggatgc tcgtcacaag aagtattaaa
     3241 atattacgga aagggaaatg gtagatatcc attaagtcca ggtcttatgg cgggacaatc
     3301 tggagcttta ctacattgtt gcaaactgga agataatgat atctcagtat ctcctatatc
     3361 tttgatgaca taaagtaaaa tctttctaat ctattaatta tgaagaaatt aaaatcaact
     3421 tttcaagtag cacaaactga atgtggactt tgctgtgtaa gaactatatt agattatttt
     3481 ggttatgaaa ctacagtaac aaaattaaga atattaaagg aaccaggtag agatgggtca
     3541 agttttaatg atattagaaa gttacttgaa cgttttggag ttgactccaa attatataag
     3601 gtaaaagata atagaatatt ttcaacactt cagttaccta ttattattta ttggaagaac
     3661 gttcattttg tttgtgtgga aagaatatca aagaaaacag taataataat ggatccatca
     3721 gtaggtagaa ctaaaatgag cctgactgaa ttttttcaaa atttttcggg actaatacta
     3781 atccccaaaa aaaatactga aaaatttaaa aaaaatactg ataatattat aaacacctgg
     3841 agaaaaagtt atatttggcc gagtaaaaca gcctctcttt atatgttaac aggaatatta
     3901 agcttgttta ttatagcttc ttccctatta ttacctttgg caactcagta tagtatagat
     3961 aatttaatga aagaaaattt ttctcttatt aaaattattt caggattagg cgcattttct
     4021 atttttatgt ttattgtcta ttattttaga accatgttgt caataaaaat aatgtataat
     4081 tttagctgga atttaataaa tagagccttt accagaatat tatcattacc agcgaagtac
     4141 tttactgtaa gggcgccagg cgaaataacg tatcgactgg gtgccatgaa taatattaga
     4201 gaagtattag ggcctaagct agtacaatca gtattagatg tttttagtac tctattatta
     4261 ttgatatatt gtttttgtgt ttcaatagtt ttaggaggtg taattttatc agtattactt
     4321 gttatactct tatttttagt agttactaat aactatgtca ctgcagcgac agataaagaa
     4381 ataagagaag gaggggatgc tcaaaatatt caattagatg ctcttgtctc aattaataat
     4441 ttaaaattgg gaggatataa ggaaatatat cttaatgatt ggcgaaataa ttataaatca
     4501 tttttaaagg caacagcaaa aagaatgaaa attcaagatg gctatattgg ttcatctctt
     4561 tatatgattc aagcttttat gcctttatta ctgcttgtaa taagtttaaa aatggttcaa
     4621 ataggaacaa tttcgttagg agttgctcta tcaattcaaa caatttcatc catgattttt
     4681 atatatgcta attcaatttt caacactata acgaacttag cagtttccac gagatatatt
     4741 gaattagcag atgatatatt tgaatatcca ttagaggatg atagtggaac tgaaaaatgt
     4801 ggaattactt ttggaagcat tgttatgaaa gatgttgact ttaggtatac tccagatagt
     4861 aaagatgcgt taaaacatat ttcaatagat atcaatgctg gacaaactgt tgcattggtt
     4921 ggaatatcag gttctggaaa aactacttta ggtaaaatta taagtacatt attcaagcct
     4981 agtaagggac aaattttttt tgatggagta gaaataaaaa atcataatct agacagtttg
     5041 agaaaatatg tcggttatat tcctcaggaa gcacacttac acaatcgaac tataatggaa
     5101 aatttgctcc tgggttcaaa ttaccctcaa caagaagttt taaattattg taattctcta
     5161 aaatttcttg attttattca agatttacca atgggatatc agacagttgt ttcagaaatg
     5221 ggagggaatc tctctggagg acaaaaacag agaattcata ttgctagaat attattacaa
     5281 aaaccaaaat tattagtcat ggatgaggct acttcttcac tagataatat atctcaatca
     5341 gaagtttatg aagctttgga aaaggaaatt aattgtacaa aagttgtaat tgcccacaga
     5401 ttggaaacta tccttaaagc agataaaatt tttgttttag agaatggtag aatcattgag
     5461 caaggaaatc atgacgagct attaaataat aaaggaatat ataagaaaat atatacttct
     5521 aagtaattta ttattttata aataaaatac tataaaaaaa gaaagaatta tttttgtggt
     5581 tctgccacat ataagtagtt aggttagtga attttggacc catcaataaa aaaattagta
     5641 gacagcataa tagagtttta taaaaaagat atttacttgg cgtacaaaga attagaaaga
     5701 gaaataaaaa atattgacaa aacgatttac aatacttcta atgatgaaat actgaggata
     5761 tttaaagaat ctttaatttc aataattaca gatgatatat acagattatc aattaaaaca
     5821 ttcatttatg aatttcacaa atttagaatt gataacggat tcccagcagt aaaagattct
     5881 gagagcgcat ttaactatta tattagtaca tttgatgtaa aaactattgc gcgttggttc
     5941 gaaaagttcc cgatgttaga aagtataatt tcatcaagta taaagaatga ttgtactttc
     6001 atggttgatg tgtgtgttaa ttttattctt gatttatctg aatgtgaaaa aataaatctt
     6061 ataagtgagg attcaagatt aattactatt tcttcctcta attccgaccc ccataatgga
     6121 ggaacaagag ttttattttt taggtttcat aatggggaca ctattttata taaaccaaga
     6181 tctttaacag ttgataaact cattagtaat atattcgaag aagtgtttga gtttgatgca
     6241 actaattcaa aaaatccgat tccaaaagtc ttggatagag gaacctatgg ttggcaagaa
     6301 tttatagaga agaaaagcat aagttcttct gaaatcaagc aagcatatta taatttagga
     6361 attttttcat cgatatttac tgtcctaggg tcaactgata tccatgatga aaatttgata
     6421 tttaaaggta caacaccata ttttattgac ttagagacag ccttaagtcc aaggattaga
     6481 tacgaaggta atgaagaaaa tttattttat agaatgtctt cgtcactttt cacttcgatt
     6541 gtcggtacaa caattattcc tgctaagtta gcagtacatt ctcaggaaat aatgattggg
     6601 gctattaata cccctgctaa acaaaaaaca aaaaaagatg ggtttaatat aataaacttt
     6661 ggtactgatg ctgttgatat tgctaaacaa aatattgaag ttgaaagaat agccaatccg
     6721 atgaggatca aaaataatat agtgaatgat ccgttaccct accaaaatat atttactaga
     6781 ggatttaaag aaggtataaa atctattatt cttaaaaaag gatctataat tagtattctt
     6841 aataatttta atagtcctat acgttatata atgagaccaa ctgccaaata ctatttaatt
     6901 ttagatgcgg cagtatttcc agaaaattta tatagtgaac aaactcttaa taaaactctg
     6961 aattatctca aacctcccaa gattgtagaa aattcgctta tctcaaaaca actcttctta
     7021 gctgaaaaaa gaatactatc tgaaggagat attcccagtt tttatgtact aggaaaagaa
     7081 aaaaatatta gagcacagaa ttttatttca gaacagatat ttgaagaaac tgctgttgat
     7141 aatgcaatcc aaatattaga atcaatatct caagattggg taaatttcaa tgagagattg
     7201 attgcagagg ggttttcata tattagggaa caatcaagag gatatctttc aagtgacttt
     7261 gaaaattcag atatatttaa aagttctctt actgaaacta aaaaatcagg gtacaccgca
     7321 atgctgaaaa ctatcataag catgtctgtt aaaacttcag aaaataaaaa aataggctgg
     7381 ctacctggta tatatgacga ttatccaatt tcttatatgt ctgcagcatt ttgctcattt
     7441 catgattctg gtggaataat tactttattg gagcatcact tcggtcactg tagtccagaa
     7501 tataacgaaa tgaaacgtgg gttattagag ttaggaaaaa tgttgaaaat taataattca
     7561 aatttatcta ttatttcggg ttctgagtcc ttagaatttt tatataccca tagagaagtt
     7621 gaatgtcttg aactagaata tatactgaat aattctgctg agattatggg agatgttttt
     7681 ttgggaaaat tgggactata cttaatttta gctagttact taaagacaga cttaaaaatt
     7741 tttcaagatt tttcgataat ttgtcaaaaa aatcttgaat ttaaaaaatt tggcattgct
     7801 catggagagt tgggatattt atggactatt tttagaatac aaaataaatt gaaaaataaa
     7861 aatgcttgtc tctctatata tcatgaggtt cttaatattt ataaaggcaa aagaattgaa
     7921 agtgttggat ggtgcaatgg cctttcagga attctaatga ttttaagtga aatgtctact
     7981 gtacttgaaa aaaaccaaga ttatttgttt aaactagcaa acttaagcac aaaattaaat
     8041 gaggaaagcg tagatctttc ggtatgtcat ggagcatcag gtgtacttca gacccttctt
     8101 tttgtttaca gtaacacaaa tgataaaaga tatttaagct tggcaaataa atattggaaa
     8161 aaggtgttag ataattctat caagtatggc ttttataatg gagaaaggga taaagattat
     8221 ttattgggat atttccaagg gtggagtggt tttacagatt ctgctttatt attggataaa
     8281 tataataata atgaacaggt atggattcca ataaacttga gttcagatat ttatcaacat
     8341 aatttaaaca actgtaagga gaaaaattat gaaggcgatg gttgccataa atcctaaatt
     8401 taaacataaa ataaaatata cgaatttggg aagtacaaag tttggggaga caactattaa
     8461 ttttgggttg gttgatttac ctaaaccaaa atttgataat aaaagtaagg ataatagtaa
     8521 ttttgttctt gtaaaaatta atgcaatatc ttgtaatttt agagataaag gaatattatt
     8581 agataattat gaaaaactta ttgctagtga tcaattatac cttccttttg ggtcagaatt
     8641 ttcagggata gtggtagatt atggtactaa tgtaaactgt ttctctatta atcaaagagt
     8701 aattccagac tgttcctatc ctaaagaaaa taataatata cgtccaggaa ttccgacaaa
     8761 ctttgcttca ttgggttggc taagaattca taaagataag ctattgaatg caccaagaga
     8821 attaacggat agcgaagcag cttgttttcc tttaggggtt caaactgccc attcaatgat
     8881 acgtcgttca aatattttac aatctcctga tcctaaaccc ctaatattta gtgcaaagtc
     8941 tgcaacttct ttgttcatta ttaaagaatt actggcacat ggtataaaac cgacatgttt
     9001 atcaacttct aaatggaacc aaaaagagct taaaagtatt ttgggatctg aagtaagaaa
     9061 tgattattct tgttttgaaa aagatcatac tttttttacc catgtatttg atccattttt
     9121 tgatgttaat attgaaaaag ctgtaaattt actatcaata tacggtactt atataacttg
     9181 tgggttaaat agtcaacatc catccctttc caatagcaaa cttgatgaat tagaatgtaa
     9241 tttaagaagt tcaatacttg gcgctattgt taaagatatt tcaattatag gaaactgttt
     9301 agggataaaa agtgatttag aagaaccaat tgccatgtta gagtctaaaa ttgatttaaa
     9361 gccaatttta gattccgaat actcactatc agatgggtta aaatttattg aaaaatcatt
     9421 ttttgattca tcaaaatttg gaaagtgtgt gctgagatat gatacttctt atgatacata
     9481 a
//
