LOCUS       BGC0000525              3837 bp    DNA     linear   BCT 31-AUG-2010
DEFINITION  Bacillus licheniformis strain VK21 lantibiotic gene cluster,
            complete sequence.
ACCESSION   BGC0000525
VERSION     BGC0000525
KEYWORDS    .
SOURCE      Bacillus licheniformis
  ORGANISM  Bacillus licheniformis
            Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:45:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3837
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..3837
                     /db_xref="taxon:1402"
                     /mol_type="genomic DNA"
                     /organism="Bacillus licheniformis"
                     /strain="VK21"
     misc_feature    1..3837
                     /note="lantibiotic gene cluster"
     subregion       1..3837
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3837
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(37..255)
                     /gene="lchA2"
     CDS             complement(37..255)
                     /codon_start=1
                     /gene="lchA2"
                     /note="lantibiotic precursor; preLchA2"
                     /product="LchA2"
                     /protein_id="ADM36017.1"
                     /transl_table=11
                     /translation="MKTMKNSAAREAFKGANHPAGMVSEEELKALVGGNDVNPETTPAT
                     TSSWTCITAGVTVSASLCPTTKCTSRC"
     gene            393..617
                     /gene="lchA1"
     CDS             393..617
                     /codon_start=1
                     /gene="lchA1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /note="lantibiotic precursor; preLchA1"
                     /product="LchA1"
                     /protein_id="ADM36018.1"
                     /sec_met_domain="mature_ha (E-value: 8e-15, bitscore: 42.1,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKKEMILSWKNPMYRTESSYHPAGNILKELQEEEQHSIAGGTIT
                     LSTCAILSKPLGNNGYLCTVTKECMPSCN"
     gene            679..3837
                     /gene="LchM1"
     CDS             679..3837
                     /codon_start=1
                     /gene="LchM1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     993.5; E-value: 1.8e-300)"
                     /gene_kind="biosynthetic"
                     /note="lantibiotic modifying enzyme"
                     /product="LchM1"
                     /protein_id="ADM36019.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-91, bitscore:
                     294.8, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 1e-115, bitscore: 374.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEKSAGYHERLPVAQTQSPLVNDKIKYWRSLFGDDDKWLNKAVS
                     LLSHDPLSSIAQSSVSQSVGLKDSRRGPWQKMQKRIFETPFSYKDSALQDSELLFDSLL
                     TRFASAAQDALEEQNIILSPPLCRQVLTHLKQTLLQIAHQTLILELNILRLEDQLKGDT
                     PEMRYLDFNDNFLVNPGYLRTLFNEYPVLLRLLCTKTDYWVQNFSELWKRLRQDREQLQ
                     AAFHIAGDPVHIELGVGDSHNKGKMAAILTYSDGKKIVYKPRSHDVDDAFQLLLSWIND
                     RNSGSPLKTLRLINKKRYGWSEFIPHETCHTKKELEGYYTRLGKLLAVLYSIDAVDFHH
                     ENIIASGEHPVLIDLESIFHQYKKRDEPGSTAADKANYILSRSVRSTGILPFNLYFGRK
                     NRDKVVDISGMGGQEAQESPFQALQIKGFFRDDIRLEHDRFEIGEAKNLPTLDHQHVPV
                     ADYLHCIIEGFSAVYRLISDHGESYLATIEHFKNCTVRNILKPTAHYASLLNKSYHPDF
                     LRDAVDREVFLCRVEKFEDADTDIAAAKTELKELIRGDIPYFLSKPSDTYLLNGEEEPI
                     AAYFETPSFTRVIKKISSFSDQDLKEQANVIRMSILAAYNARHEKDAIDIDQNHPSPRS
                     GALQPLAIAEKAADDLAEKRIEGNDGKDVTWISTVIEGVEEISWTISPVSLDLYNGNAG
                     IGFFMSYLSRFAKRPETYSHITEQCVFAIQRALNELKEKEEFLKYADSGAFTGVSGYLY
                     FLQHAGTVQKKNEWIELVHEALPVLEAVIEQDENCDIISGSAGALMVLMSLYEQLDDPV
                     FLKLAERCAGHLLQHKTNIENGAAWKDPHTQNYYTGFAHGTSGIAAALSRFNKVFDSQS
                     LKKIISQCLAFEKQLYIASEKNWGSKGREQLSVAWCHGAAGILLSRSILRENGVNDPGL
                     HTDILNALETTVKHGFGNNRSFCHGDFGQLEILRGFREEFSELNTIIQNTEDRLLTYFQ
                     ENPFSKGVSRGVDSAGLMLGLSGVGYGMLQCQYGEELPELLQLSPPQALIKKNSKAFKR
                     ENVF"
ORIGIN
        1 tgcaaggatg gattcttttg aattttttat gattccctag catcggcttg tacacttagt
       61 tgttgggcat aatgaagcag aaaccgttac accggctgtg atgcaagtcc aagaagaggt
      121 tgtagcagga gttgtttcag gattgacgtc atttcctcct accaaagctt tcaattcctc
      181 ttcggaaacc atccctgccg gatgattggc tcctttgaag gcttcacggg cagctgaatt
      241 tttcattgtt ttcatgattc tcacctccta gaacgggcaa actatcgaaa ttttcctata
      301 atttagaatt gactcgccgt tccagtcaaa ttatactata agtacatcaa gaaatcgaca
      361 aaaaattata aattttctag gaggtggaat atatgtcaaa aaaggaaatg attctttcat
      421 ggaaaaatcc tatgtatcgc actgaatctt cttatcatcc agcagggaac atccttaaag
      481 aactccagga agaggaacag cacagcatcg ccggaggcac aatcacgctc agcacttgtg
      541 ccatcttgag caagccgtta ggaaataacg gatacctgtg tacagtgaca aaagaatgca
      601 tgccaagctg taactaagtt cccaacgcgg gggccctgct cccgcgttgg catattgata
      661 gaaaaagagg tcgatagaat gaatgaaaaa tccgccggat atcacgaacg gcttcccgtc
      721 gcccaaactc aatccccgct cgtaaacgat aagataaagt attggcgttc ccttttcggc
      781 gatgatgata aatggctcaa taaagcagtt tcattattaa gccatgaccc tttgtcctcc
      841 atcgcacaat cctcggtatc ccagtcagtc gggctgaaag acagccgtcg cggcccatgg
      901 cagaagatgc aaaagcggat ctttgaaacg cccttttcct acaaggattc tgctctgcaa
      961 gattcagaat tgctgttcga ctccctgctg acccgttttg cgtctgcagc acaagatgct
     1021 ttggaggaac aaaatatcat actttctcct cctctttgcc ggcaggtgct gacacattta
     1081 aaacagacgc ttcttcaaat tgcccatcaa acattaatac tggaactaaa cattttaagg
     1141 cttgaagatc aattgaaggg cgacaccccc gaaatgcgct atcttgattt caatgataac
     1201 tttttagtca atccaggata cctgcggacc ctgttcaacg agtatcccgt attgctgcgc
     1261 cttctgtgca caaaaaccga ttactgggtt caaaactttt ctgaactgtg gaagaggctg
     1321 aggcaggacc gcgaacagct gcaggctgca tttcatattg ccggcgatcc tgtccatatt
     1381 gagcttgggg tgggagactc gcacaataaa ggaaagatgg cagccatcct tacatattcc
     1441 gatggaaaaa agattgtcta taaaccgaga agccatgatg ttgacgacgc atttcaactt
     1501 cttctatcat ggatcaatga ccgaaattca ggcagccctt taaaaacttt gagattaatc
     1561 aataaaaaac ggtacggatg gtccgagttt attcctcacg aaacgtgcca tacgaaaaaa
     1621 gaactggaag gctactatac acgcctcggc aaacttttgg ccgttttata cagcatcgat
     1681 gccgttgact ttcaccacga aaacattatc gcctccggcg agcatcctgt tttaatcgat
     1741 cttgaatcaa tttttcatca atataaaaaa cgagacgaac ccggctcgac cgccgctgac
     1801 aaagcaaact acattctttc cagatccgta cggtctactg gaatcctgcc gttcaacctt
     1861 tacttcggaa ggaaaaaccg ggataaagtt gtggacatca gcggaatggg ggggcaggaa
     1921 gctcaggaat caccgtttca ggcgcttcaa atcaaaggat ttttccgcga tgacattcgc
     1981 ctggagcatg accgctttga aatcggcgag gcgaaaaatc tgccgacttt agatcaccag
     2041 catgtccctg tcgcagatta tcttcattgt atcatcgaag gattttcagc agtataccgt
     2101 ctgatttctg atcatggcga aagctacctg gctacgattg aacattttaa aaactgcacc
     2161 gttcgaaata ttttgaagcc gacagcgcac tacgcctctc ttttgaataa aagctaccac
     2221 cctgattttc tcagggatgc ggtagaccgt gaagtgtttt tatgccgggt ggaaaagttt
     2281 gaagatgcag acacagatat tgcagcggca aaaacagagc tgaaagagct cattcgggga
     2341 gacatcccct attttctgtc gaagccttca gatacctatt tgctcaatgg cgaagaagaa
     2401 ccgattgccg cttattttga aacgccgtcc ttcacaagag taattaagaa gatctcatca
     2461 ttttcagacc aggacttaaa ggaacaagcg aatgtcatac gcatgtcgat tctggctgca
     2521 tataacgcga gacatgaaaa agacgcaatt gatatagacc aaaatcaccc gagtcctaga
     2581 tcaggcgcct tgcagccgct cgccatcgct gagaaagcgg ctgacgattt ggctgaaaag
     2641 cgaattgagg gcaatgatgg aaaggacgtc acttggatca gtacagttat tgaaggcgtc
     2701 gaagaaatct cttggacgat ctcccctgtc agtcttgatt tatataatgg caatgcaggc
     2761 atcggatttt ttatgagcta tctgagccgc ttcgcaaaac ggccggagac ttactcgcat
     2821 ataaccgagc agtgtgtatt tgcgattcag cgagcgttga atgaactgaa ggaaaaagaa
     2881 gaattcctga agtacgccga ctctggggca ttcacggggg tttccggcta tctgtatttt
     2941 ctgcagcatg cgggaacggt tcagaaaaaa aacgaatgga tcgaactcgt acatgaagct
     3001 ctgccagtcc ttgaagctgt catcgaacaa gacgaaaact gcgatatcat cagcggttct
     3061 gccggtgctc taatggttct gatgtcattg tatgaacaac tggatgaccc ggtttttcta
     3121 aagctcgccg aaaggtgcgc cggccatttg cttcagcata aaacaaatat tgaaaacgga
     3181 gcggcctgga aagatcctca tacacaaaac tattacacag gatttgccca cggcacttcc
     3241 ggcatcgccg cagctttatc ccgattcaat aaagtgtttg attcgcaatc actgaaaaaa
     3301 atcatttcgc aatgcctggc atttgaaaag cagctgtaca tcgcttccga aaaaaattgg
     3361 ggatcaaaag gaagagaaca actgtcagtt gcatggtgcc atggcgctgc cggcatattg
     3421 ttgtcgagaa gcatcctccg agaaaacgga gtcaatgatc ccgggctgca taccgacatc
     3481 ttgaacgctc ttgaaacaac tgttaagcat gggttcggca ataaccgctc attctgtcac
     3541 ggcgatttcg gccaactcga aatcctaaga gggttcaggg aagaattcag cgaactgaac
     3601 accattatac agaatacgga agatcggctg ttgacatatt ttcaagaaaa tccattcagt
     3661 aaaggggtat cacgaggtgt ggattcagcc gggctcatgc ttggtttaag cggagtcggc
     3721 tacggcatgc tgcaatgcca atatggagaa gaactgccgg aactgcttca gctcagtccg
     3781 cctcaagcgc ttatcaaaaa gaacagcaaa gcttttaaaa gagaaaacgt gttttaa
//
