BGC0000526 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000526 (Streptococcus macedonicus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	15,171	High	macedocin	ribosomal:RiPP:Lanthipeptide

BGC0000526 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 15,171 nt. (total: 15,171 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 15,172
Label		BGC0000526

Tailoring functions

Lyases: cyclase

mcdM: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000526.5	0.98	ribosomal	macedocin	Streptococcus macedonicus
BGC0001788.3	0.81	ribosomal	suicin 65	Streptococcus suis
BGC0000550.3	0.78	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000557.5	0.78	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000562.3	0.75	ribosomal	variacin	Kocuria varians
BGC0000547.5	0.68	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000534.3	0.64	ribosomal	mutacin K8	Streptococcus mutans
BGC0000521.3	0.60	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000499.3	0.60	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000532.3	0.57	ribosomal	mutacin II	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000526.5	0.98	ribosomal	macedocin	Streptococcus macedonicus
BGC0001788.3	0.81	ribosomal	suicin 65	Streptococcus suis
BGC0000550.3	0.78	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000557.5	0.78	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000562.3	0.75	ribosomal	variacin	Kocuria varians
BGC0000547.5	0.68	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000534.3	0.64	ribosomal	mutacin K8	Streptococcus mutans
BGC0000521.3	0.60	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000499.3	0.60	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000532.3	0.57	ribosomal	mutacin II	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for mcdM

mcdA

Leader:

MEKETTIIESIQEVSLEELDQIIGA

mcdA_

Leader:

MEKETTIIESIQEVSLEELDQIIGA

Shared core:

GKNGVFKTISHECHLNTWAFLATCCS

Core with dehydrations:

GKNGVFKDhbIDhaHECysHLNDhbWAFLADhbCysCysDha

antiSMASH-DB 4.0 matches for mcdA

100.0%

NZ_ALSD01000046.1and 49 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptideNZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide

Lanthipeptides: SAG0161_RS120605_lanthipeptide

GKNGVFKTISHECHLNTWAFLATCCS

96.2%

NZ_CAAHKQ010000003.1:

Lanthipeptides: E9664_RS02165_lanthipeptide

GKNGVFKTISHECHLNTWAFLATCCS

GKNGVFKTISHECHLNTWAFLA CCS

GKNGVFKTISHECHLNTWAFLAICCS

96.2%

NZ_CP060646.1:

Lanthipeptides: H7789_RS06845_lanthipeptide

GKNGVFKTISHECHLNTWAFLATCCS

GKNGVFKTISHECHLNTWA LATCCS

GKNGVFKTISHECHLNTWASLATCCS

with 78 more sequence matches

Only the first 10 are displayed here.

92.3%

NZ_CP018188.1and 17 others:

NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide

Lanthipeptides: BSR19_RS11180_lanthipeptide

NGVFKTISHECHLNTWAFLATCCS

84.6%

NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

GKNGVFKTISHECHLNTWAFLATCCS

GKNGVFKTISHECH+N+W FL TCCS

GKNGVFKTISHECHMNSWQFLFTCCS

76.9%

NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

GKNGVFKTISHECHLNTWAFLATCCS

GKNG KTISHECH+N+W FL TCCS

GKNGAIKTISHECHMNSWQFLFTCCS

76.9%

NZ_AP025017.1:

Lanthipeptides: MANAM107_RS05920_lanthipeptide

NGVFKTISHECHLNTWAFLATCCS

NGV TISHECHLNTWAF TCCS

NGVITTISHECHLNTWAFAFTCCS

76.9%

NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

GKNGVFKTISHECHLNTWAFLATCCS

GKNGVFKTISHECH+N++ F TCCS

GKNGVFKTISHECHMNSFQFFFTCCS

69.2%

NZ_CP023483.1:

Lanthipeptides: CNY62_RS11970_lanthipeptide

NGVFKTISHECHLNTWAFLATCCS

NG +TISHECH+NTW FL TCCS

NGAIRTISHECHMNTWQFLFTCCS

69.2%

NZ_CP084014.1and 6 others:

NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptideNZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptideNZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide

Lanthipeptides: LCQ72_RS00105_lanthipeptide

NGVFKTISHECHLNTWAFLATCC

NGV KTISHEC++NTW FL TCC

NGVLKTISHECNMNTWQFLFTCC

69.2%

NZ_FOZB01000002.1:

Lanthipeptides: BM306_RS07850_lanthipeptide

NGVFKTISHECHLNTWAFLATCCS

+GVF+TISHECH+NTW F+ TCCS

DGVFRTISHECHMNTWMFIFTCCS

69.2%

NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

NGVFKTISHECHLNTWAFLATCCS

NGV KTISHEC +NTW F+ TCCS

NGVIKTISHECAMNTWQFIFTCCS

69.2%

NZ_WBPF01000002.1:

Lanthipeptides: F8162_RS00195_lanthipeptide

KNGVFKTISHECHLNTWAFLATCCS

G F TISHECH NTW FL TCCS

DKGQFDTISHECHWNTWQFLFTCCS

MIBiG 4.0 matches for mcdA

23.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GKNGVFKTISHECHLN

G NG + T++ EC N

GNNGGWCTLTKECQPN

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TISHECHLN

T+S EC N

TLSKECQPN

mcdA1

Leader:

MKNNNKICQDALESLQELKLEEVDELLGG

Core:

AGHGVNTISAECRWNSLQAIFSCC

Core with dehydrations:

AGHGVNDhbIDhaAECysRWNDhaLQAIFDhaCysCys

antiSMASH-DB 4.0 matches for mcdA1

100.0%

NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

AGHGVNTISAECRWNSLQAIFSCC

95.8%

NC_012470.1and 15 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

AGHGVNTISAECRWNSLQAIFSCC

AGHGVNTISAECRWNSLQAIF+CC

AGHGVNTISAECRWNSLQAIFTCC

91.7%

NZ_CAAHGW010000010.1and 12 others:

NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptide

Lanthipeptides: E9435_RS08895_lanthipeptide

GHGVNTISAECRWNSLQAIFSCC

GHGVNTISAECRWNSLQAIF+CC

GHGVNTISAECRWNSLQAIFTCC

with 45 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_CAAHHE010000002.1and 13 others:

NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide

Lanthipeptides: E9499_RS02930_lanthipeptide

AGHGVNTISAECRWNSLQAIFSCC

GHGVNTISAECRWNSLQAIF+CC

GGHGVNTISAECRWNSLQAIFTCC

75.0%

NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

AGHGVNTISAECRWNSLQAIFSCC

G NTIS++CRWNSLQAIFSCC

GGRASNTISSDCRWNSLQAIFSCC

60.0%

NZ_JAEEGA010000010.1:

Lanthipeptides: I6N95_RS15660_lanthipeptide

GHGV-NTISAECRWNSLQAIFSCC

G+GV TIS EC NS Q IF+CC

GNGVIKTISHECHMNSWQWIFTCC

58.3%

NZ_GL985606.1:

Lanthipeptides: HMPREF9062_RS00700_lanthipeptide

GHGV-NTISAECRWNSLQAIFSCC

G+GV +TIS EC +NS IF+CC

GNGVFHTISHECYYNSWAFIFTCC

58.3%

NZ_QTVL01000002.1and 5 others:

NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide

Lanthipeptides: DWZ44_RS04155_lanthipeptide

GHGV-NTISAECRWNSLQAIFSCC

G GV TIS EC N+ Q IF+CC

GDGVFRTISHECNMNTWQFIFTCC

56.0%

NZ_GL882519.1:

Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GHGVN-TISAECRWNSLQAIFSCC

G+GV T+S EC NS Q IF+CC

GNGVYYTLSHECHMNSWQFIFTCC

56.0%

NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

GHGV-NTISAECRWNSLQAIFSCC

G+GV TIS EC N+ Q IF+CC

GNGVIKTISHECAMNTWQFIFTCC

54.2%

NZ_CP084014.1and 6 others:

Lanthipeptides: LCQ72_RS00105_lanthipeptide

GHGV-NTISAECRWNSLQAIFSCC

G+GV TIS EC N+ Q +F+CC

GNGVLKTISHECNMNTWQFLFTCC

54.2%

NZ_MSRJ01000005.1:

Lanthipeptides: BKH06_RS03755_lanthipeptide

VNTISAECRWNSLQAIFSCC

V TIS EC NS Q IF+CC

VTTISHECNMNSWQFIFTCC

52.0%

NZ_FOZB01000002.1:

Lanthipeptides: BM306_RS07850_lanthipeptide

GHGV-NTISAECRWNSLQAIFSCC

G GV TIS EC N+ IF+CC

GDGVFRTISHECHMNTWMFIFTCC

MIBiG 4.0 matches for mcdA1

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TISAECRWN

T+S EC+ N

TLSKECQPN

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

GVNTISAECR

G N +A C

GCNMKTATCH

allorf_14551_14658

Leader:

MGLSYLSSNLVRYAVIGA

Core:

KIISYKIEWFSICHNHK

Core with dehydrations:

KIIDhaYKIEWFDhaICysHNHK

antiSMASH-DB 4.0 matches for allorf_14551_14658

94.1%

NZ_GL636070.1:

Lanthipeptides: allorf_1704584_1704691_lanthipeptide

KIISYKIEWFSICHNHK

KIISYKIEWFSICH+HK

KIISYKIEWFSICHDHK

9.6%

NZ_CP110813.1:

Lanthipeptides: allorf_5686039_5686266_lanthipeptide

YKIEWFSICHNH

+K W S+C H

WKCAWCSVCEAH

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

mcdA - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2776.3 Da

Molecular weight: 2778.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2796.2 Da N = 1; 2814.2 Da N = 2

mcdA_ - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2776.3 Da

Molecular weight: 2778.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2796.2 Da N = 1; 2814.2 Da N = 2

mcdA1 - Class II

Cleavage pHMM score: 0.40

RODEO score: 0

Monoisotopic mass: 2494.2 Da

Molecular weight: 2495.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2513.8 Da N = 1

allorf_14551_14658 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 2109.1 Da

Molecular weight: 2110.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2128.5 Da N = 1