LOCUS BGC0000526 15171 bp DNA linear BCT 14-JUL-2016 DEFINITION Streptococcus macedonicus strain ACA-DC 198 putative relaxase gene, complete cds; macedocin gene cluster, complete sequence; McdK (mcdK), McdR (mcdR), and hypothetical protein genes, complete cds; and hypothetical protein gene, partial cds. ACCESSION BGC0000526 VERSION BGC0000526 KEYWORDS . SOURCE Streptococcus macedonicus ORGANISM Streptococcus macedonicus Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. COMMENT ##antiSMASH-Data-START## Version :: False Run date :: 2022-11-07 19:46:08 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 15171 ##antiSMASH-Data-END## FEATURES Location/Qualifiers CDS 1..1866 /codon_start=1 /note="mobilization nuclease domain" /product="putative relaxase" /protein_id="ABI30222.1" /transl_table=11 /translation="MVVTKHFATHGKKYRRRLIKYILNPDKTDNLKLVSDFGMSNYLDF PSYEEMVEMYNVNFTNNDKLYESRNDRQEKHQQNIHAHHLIQSFSPEDNLTPEEINRIG YDTMMELTGGRFKFIVATHTDKDHVHNHILINAIDRNSDKKLIWNYALERNLRMISDRI SKMAGAKIIEKRFSYRDYQKYRQSSHKFELKQRLYFLMRQSKSFEDFLEKAEQLHVHID FSQKHSRFMMTDRAMTKPIRGRQLSKRYLYDEEFFRTHFAKQEIESRLEFLLNRVNSLE ELLTKAKELNLTIDLKQKNVIFILEESGKQFSLSHKKISDKKLYDVNFFQDYFKNMEVG DSEGLENLQEQYHAFQEERDKDKVATEEIEEAFEGFKKRRDAVHEFEVELAEHQIEKLV DEGIYIKVSFGIKQSGLVFIPNYQLDIIEEDKQKKYKVYIRETTSYFVYNKENSDKNQY IKGRPLIRQLTNDSRMIPYKRPTVESLQKKISEINLLIELTETDKKYQDIKDELVAEIA ELDIKLTQTNEKIATLNKMAEVFINLKGAELSSQKLARYDFSKLNLTESISLEQVNEEI GVLQEELGHYLDEYEGLARRLERFVKVLNARRDVGSKLRDGIQIE" source 1..15171 /db_xref="taxon:59310" /mol_type="genomic DNA" /organism="Streptococcus macedonicus" /strain="ACA-DC 198" subregion 1..15171 /aStool="mibig" /contig_edge="True" /label="RiPP" /subregion_number="1" /tool="antismash" region 1..15171 /contig_edge="True" /product="unknown" /region_number="1" /subregion_numbers="1" /tool="antismash" gene complement(1946..3307) /gene="mcdK" CDS complement(1946..3307) /codon_start=1 /gene="mcdK" /gene_functions="regulatory (smcogs) SMCOG1003:sensor histidine kinase (Score: 109.1; E-value: 5.3e-33)" /gene_kind="regulatory" /note="putative histidine kinase; similar to ScnK" /product="McdK" /protein_id="ABI30223.1" /transl_table=11 /translation="MNIFKKSVLKFILSFLTIIFIDIFLLVITTNYIRSQQSAMDIIKT VSSNIIPENNTYKVSLKGKELIEMNNLWVMIIDQDSGKEKFNINKPTNIKSNFDYADVI RFSRYYLEDYPVFTQINEEQKDIYIIAFPKDSIIRYGNNYFDLKRVQIFPILILAIIFV NCLFCLFLYMYSITFLNRNIQPIISAIGNLPLGLNKQVDSVKELDRLTLAVNSANRKLR ENEEFKENWISGIAHDIKTPLSVIVSNTSLAIEKTDNENLLKHLKPTLVESHYIQNLLN DLNIFARLTNGNFKLNLEIVEIIPFFKEIIIQIINQEIWEEFNFEFSHDSNLFRKKMYV EKALISRVIHNLIYNSVLHNRSGCKISIILECTSNNEFSITVLDNGVGVSPDRLKSISI SNIEEFNFDISGVRRSGMGLKISKQIINRHGGSFIITSQQNKYFQSKIILPLKK" misc_feature 1946..14006 /note="macedocin gene cluster" gene complement(3324..4022) /gene="mcdR" CDS complement(3324..4022) /codon_start=1 /gene="mcdR" /gene_functions="regulatory (smcogs) SMCOG1008:response regulator (Score: 175.7; E-value: 1.7e-53)" /gene_kind="regulatory" /note="putative response regulator; similar to ScnR" /product="McdR" /protein_id="ABI30224.1" /transl_table=11 /translation="MNFETQFLNKRILIIDDDVSLSQSIKEVLVNRGFKNISNAYSISE GTDIFSVSKIDFIILDVMLPDGEGYLLAKYVRKTSDIPILFLTAKNNPDDEVKGLGSGG DDFVTKPFLPKTLIYRIIALLRRAYKNESELITLSSCTIDLNNASVNKNGNQLSLTPTE IQILRKLYSNKNYIVSTETICDTIWGLDSSGYEKSLMVHIRNIREKIESSPSKPDHLIT VKGLGYKLVV" repeat_region 4089..4116 /rpt_type=inverted mobile_element 4089..5401 /mobile_element_type="insertion sequence:IS1191-like" gene complement(4137..5312) /gene="tnp" CDS complement(4137..5312) /codon_start=1 /gene="tnp" /gene_functions="other (smcogs) SMCOG1130:transposase (Score: 419.8; E-value: 1.3e-127)" /gene_kind="other" /product="putative transposase" /protein_id="ABI30225.1" /transl_table=11 /translation="MTQFTTELLNFLAQKQDIDEFFRTSLETAMNDLLQAELSAFLGYE PYDKLGYNSGNSRNGSYARKFETKYGTVQLSIPRDRNGNFSPALLPAYGRRDDHLEEMV IKLYQTGVTTREISDIIERMYGHHYSPATISNISKATQENVATFHERSLEANYSVLFLD GTYLPLRRGTVSKECIHIALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQI SLVVTDGFKGLEEIINQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAEN LEMAVQILENFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEI KRQTKKKVLFPNEEALERYLVTLFEDYNFKQNQRIHKGFGQCADTLESLFD" repeat_region 5374..5401 /rpt_type=inverted gene 5556..5711 /gene="mcdA" CDS 5556..5711 /codon_start=1 /gene="mcdA" /gene_functions="biosynthetic-additional (rule-based-clusters) L_biotic_A" /gene_functions="biosynthetic-additional (rule-based-clusters) leader_d" /gene_kind="biosynthetic-additional" /note="lantibiotic macedocin precursor" /product="McdA" /protein_id="ABI30226.1" /sec_met_domain="L_biotic_A (E-value: 3.5e-28, bitscore: 87.3, seeds: 15, tool: rule-based-clusters)" /sec_met_domain="leader_d (E-value: 4.3e-08, bitscore: 23.1, seeds: 16, tool: rule-based-clusters)" /transl_table=11 /translation="MEKETTIIESIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF LATCCS" gene 5740..5895 /gene="mcdA'" CDS 5740..5895 /codon_start=1 /gene="mcdA_" /gene_functions="biosynthetic-additional (rule-based-clusters) L_biotic_A" /gene_functions="biosynthetic-additional (rule-based-clusters) leader_d" /gene_kind="biosynthetic-additional" /note="lantibiotic macedocin precursor" /product="McdA'" /protein_id="ABI30227.1" /sec_met_domain="L_biotic_A (E-value: 3.5e-28, bitscore: 87.3, seeds: 15, tool: rule-based-clusters)" /sec_met_domain="leader_d (E-value: 4.3e-08, bitscore: 23.1, seeds: 16, tool: rule-based-clusters)" /transl_table=11 /translation="MEKETTIIESIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF LATCCS" gene 6359..6520 /gene="mcdA1" CDS 6359..6520 /codon_start=1 /gene="mcdA1" /gene_functions="biosynthetic-additional (rule-based-clusters) L_biotic_A" /gene_kind="biosynthetic-additional" /note="putative type-A lantibiotic; similar to ScnA1" /product="McdA1" /protein_id="ABI30228.1" /sec_met_domain="L_biotic_A (E-value: 2.2e-26, bitscore: 81.5, seeds: 15, tool: rule-based-clusters)" /transl_table=11 /translation="MKNNNKICQDALESLQELKLEEVDELLGGAGHGVNTISAECRWNS LQAIFSCC" gene 6540..9326 /gene="mcdM" CDS 6540..9326 /codon_start=1 /gene="mcdM" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: DUF4135" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: LANC_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1070:lanthionine synthetase C family protein (Score: 678.1; E-value: 3.5e-205)" /gene_kind="biosynthetic" /note="putative lantibiotic modifying enzyme; similar to ScnM; posttranslational modifications of macedocin propeptide" /product="McdM" /protein_id="ABI30229.1" /sec_met_domain="LANC_like (E-value: 1.9e-50, bitscore: 161.4, seeds: 47, tool: rule-based-clusters)" /sec_met_domain="DUF4135 (E-value: 4.1e-82, bitscore: 266.1, seeds: 79, tool: rule-based-clusters)" /transl_table=11 /translation="MNQKEQLYSQFDKFPKVVIERLIPEVLNESDSLIKQIEEKISDYY RSTLIYLINEKRINGTLVGETAELRYDFFNNVLCRNGTILDEIEERFPKINQRVFISIK HYLDLLNCVKKHFVSDFLELKKLKFLKSNDESPDLNVLDIKVTGDIHNGSGVCILDYNR QKLVYKKKSSRPNILLKELDSQASNYLKKEIRFIPDFLDKNEYFWEVFVESKPVSSLKE ANEFYKRMGYLLVYSYILNISDLHLENLISHSIQPILVDAETVFSTNPYETVAENDATL KIVENSRNSVLSTGLLPISEADKIFGGDTSGVLGGTLIGEAKVIINHNRDDIHVEKQKY KTENQNHLPYFESNLGIKTYLNAEEYVEYIKEGFIELSKFIINNKEALKKLYLSFSDIK TRVLFRNTRDYSLVRQLLLSPVYCNQDNILLEKMSNKLTNYDSHNLCQSEVKQLLNMDI PYFYVCASDINVKDKDGNTNIWKLKKSSLSDTIEKLEKFDLDTMEEQLDLVEFSIKTPN ALYSTELQESYKIFQNSNSNHSILFTGINTIVDTILKNEKFSKLDGSTNWLTLKVTDYD AFQLEPMDSSIYEGIAGLSIALCEVYELVDDDRQQRIYNCLRRIFMTLMKAYYSTQNQS YYVGKLGILSAMIRTQSITGQEIPVSIFDINNKYILDLNVQSADFLSSFPSEIVALRNS NVSIGNLQQSFEKLVDLKIISEDYIAWDKLESNNVSLAHGNLGIELGLLYLAVALNSSE AVELFYQATNFDSHQKLSNGWIDKRNNSTSANWCHGSTGVLAARLAQLQLDKKFHTISK TKRSELEADMKHAASQIIEIGFDMTNFSICHETSGNLLALSYYCSYLSGNEREELEKIL DIEYRKLHSFGLENGWMCSFNTKYNVYGIMNGLSGILYSTAKYLKKDDSLDILIPTL" gene 9353..11425 /gene="mcdT" CDS 9353..11425 /codon_start=1 /gene="mcdT" /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_C39" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 128.8; E-value: 4.3e-39)" /gene_kind="transport" /note="putative ABC transporter; similar to ScnT; cleavage of the leader peptide and export of mature macedocin" /product="McdT" /protein_id="ABI30230.1" /sec_met_domain="Peptidase_C39 (E-value: 5.3e-39, bitscore: 123.0, seeds: 36, tool: rule-based-clusters)" /transl_table=11 /translation="MKIILQNNEEDCLLACYTMLLNDLGHKVPLYEVYDKDSLPADGLN VSYLLSLNKRFGVALKAYHASFRDLLQVYNEKKQRIILHWNQDHFVVLDKITEKQVTIV DPAIGRVKYSHDEFLNHYSETIVLINKDENFQTQKYKQIFWKYFKLTLKTKTIILFLLS LVLIQISVLAFSILLRYMLSEKFQFLSNILVLFGVVLFQLLGYFIKNSALNEYNLDFDD NYSKALFPKLLKKPLLYFRNHLSGGISEKINFKSTLRDNVTLKIIPSCVSFISAIVIFT YLITISVRLTIILIIIILVYSVISIILYRKQNEYNQTYLQYLIDFNSELQTDLDDIDYI KIMRREGLTFASWMKINQQVTEKYSQILKFENLSQLVSTIFNYISLSVIIVIATYYNKY IKVSISDLLVYQTSISLLISAIEQVKGAVFEVVKLGIYAEKQSDLLKDSRPILVQSSDS DEYLIKAESLNFSYGMSPIYKDINLTINRGEKIAIIGKSGSGKSTLLLLLAGMLRFSGS LKYGIKNFEDSLSVVLQNMTLRKGSVLENLEWDTDNLEPLYQVLKDTSADEVIAQLPNK IHSKLLKQGKNLSGGQIQKMLIAKSLLKKNSIIFWDEAFSNLDEQSKNRIYLNILQNSQ YSERTMLIVSHHLDIVDYVDYVIYIDNEMGDVYKDTHINLMESNENYRNFINSKI" gene 11526..12440 /gene="mcdF" CDS 11526..12440 /codon_start=1 /gene="mcdF" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 173.7; E-value: 8e-53)" /gene_kind="transport" /note="similar to ScnF; putative ABC transporter involved in peptide antibiotic resistance" /product="McdF" /protein_id="ABI30231.1" /transl_table=11 /translation="MMMNNIIELKKVKKVYKDITTVDIEKITVREGEIYGFLGPNGAGK TTTMKMILSLVDPTSGEIFVNKKDIRKDKNYLSQIGSMIEEPSYYPNLTGYENLLVFQK MVGFDENNIWPTLELVGLADEKNRKKLVKAYSLGMKQRLSLAFALVKKPKILLLDEPTN GLDPAGIHEIRELIVELAKEKGLTVFISSHILPEIEHIADRVGIINHGRLVYEGEIEAI KSNTWIEIGGDFSQSNIVHTLVELGTVEILGASTSHVKLSNIDNNQLANAVSYLTENGY RIFRVVRESETLEDIFLSLTKEA" gene 12442..13206 /gene="mcdE" CDS 12442..13206 /codon_start=1 /gene="mcdE" /note="similar to ScnE; putative ABC transporter involved in peptide antibiotic resistance" /product="McdE" /protein_id="ABI30232.1" /transl_table=11 /translation="MIKVLQIELLKCKRTKSFMISFLMMFVAVTWSLLAASRSIGVPKL RTIGLFFNNLQATPIFLPIAISLFVSRIVSNEKEGNTFKLQEANNINLITIFKRKLIFT NTIFLLLNVVQVLIVYLYAVRYGIDVAVSNLLLQVVGLTMSSFTLITFFLFLSMILEKH GMVLGIGFVSGFLGMVLSEASKWLNLIFPFGGSSFLALYRIKVLHSGDKLDYIFVWDKS VPLNYLIYLFYCIFVYFIIKYLLVKKKEENYD" gene 13269..14006 /gene="mcdG" CDS 13269..14006 /codon_start=1 /gene="mcdG" /note="similar to ScnG; putative ABC transporter involved in peptide antibiotic resistance" /product="McdG" /protein_id="ABI30233.1" /transl_table=11 /translation="MIDYFKAEWIKNRKVVILAIGLIFLALSSFIGLANFFLDYDVLIE EQMSRVLWGQLTFYNGQLLFPAMLAIFSGLIILPEFERKTLEMLRANQASVKKMVLSKF LLALFLVSVVQAVLFAIYLLTLYLSQIPFQIEDLLLFLRATILSVIGSSSVLMIHSYLM AKTRNFAKSVGVAAIGSFSGFIFIMLGGFINQLFPYSQPMIGLRSRALNDMSFLEFMLF ITVNSLYSFIFYWLTVKKLENNE" CDS 14286..14510 /codon_start=1 /note="similar to helix-turn-helix XRE family-like proteins" /product="hypothetical protein" /protein_id="ABI30234.1" /transl_table=11 /translation="MYQRIRDLREDHDFTQRFVANLLSFSHTNYAKIERGEVALTADVL VQLSKLYNVSTDYLLGLTDYPDRIKHKIK" CDS 14971..>15171 /codon_start=1 /note="putative resolvase; N-terminal: recombinase" /product="hypothetical protein" /protein_id="ABI30235.1" /transl_table=11 /translation="MKTNNVEIIKADSLVRRRGVNVERHLKRVAAYCRVSSDSEDQKNS YESQVKHYKDYISQRSDWELAD" ORIGIN 1 atggtagtca ctaaacactt tgcgacacac ggaaaaaaat atcgtaggcg tctgattaag 61 tatatcctca atcccgataa aacggacaat ttgaaattgg tatctgattt tggcatgagc 121 aattacttag actttcctag ctatgaagaa atggtagaaa tgtacaatgt caactttacc 181 aataacgaca agttgtacga atctagaaat gaccgacaag aaaaacacca gcaaaatatt 241 catgcccatc atctcatcca atcattttct cctgaggata atctgacacc tgaagaaata 301 aaccgcattg gttatgatac catgatggaa ttaacaggag gtcgctttaa gtttatcgta 361 gcgactcata cagacaaaga tcatgttcat aatcacatcc taatcaacgc cattgaccgt 421 aattcagata aaaagttgat atggaattat gccttggaac gaaatttacg tatgatttca 481 gaccgtattt ctaaaatggc gggggcaaaa attattgaaa agcgtttctc ttaccgtgac 541 tatcaaaaat ataggcagtc tagtcataaa tttgaattga agcaacgtct ttattttttg 601 atgcggcagt caaagtcctt tgaggatttt ttggaaaaag cagagcaatt gcatgttcat 661 attgatttta gtcagaagca tagtcgattc atgatgacag atagagcaat gacaaaacca 721 attcgaggac gccaactcag taaacgatat ttatatgatg aagaattttt tcgtacacat 781 ttcgccaaac aagagattga aagtcgttta gaatttttgt tgaaccgtgt taattcttta 841 gaagagttac taacaaaagc aaaagaattg aatctaacca ttgacttaaa acaaaaaaat 901 gtaatcttta tacttgaaga aagtggaaag caattcagtc tgagtcataa aaaaataagt 961 gataagaaat tatatgatgt caattttttt caagattact ttaaaaatat ggaagttggt 1021 gattcagaag gattagagaa tttacaggaa cagtaccatg cttttcaaga agaacgagat 1081 aaggacaagg tagccactga agaaattgag gaagcctttg agggatttaa gaagaggcga 1141 gatgccgttc atgagtttga agtggagctt gcagaacacc aaattgagaa gttagttgat 1201 gaagggattt atatcaaggt gtcttttggt attaagcaga gtggccttgt tttcattccc 1261 aactatcaac tagatattat tgaagaagac aaacagaaaa aatataaagt ttatattcgt 1321 gagacaactt catactttgt ctataacaaa gaaaactcgg ataagaatca gtacatcaaa 1381 gggcgaccct tgattagaca gttgaccaat gatagtcgga tgataccata caaaagacca 1441 acagttgaaa gtttacagaa aaagatttct gagattaacc tcttgattga attaactgaa 1501 actgataaga aataccaaga cattaaagac gaactagtcg cagaaatagc agagctagat 1561 ataaaactga ctcaaacaaa cgaaaaaatc gccaccttaa acaagatggc ggaagtattt 1621 atcaatctga agggtgctga attgagcagt caaaaactag caaggtatga tttttcaaag 1681 ttaaatttaa ccgaatcaat ttcattagaa caggtaaatg aggaaatagg agtattacaa 1741 gaggagctag gtcattatct tgatgagtat gagggactag ctagaaggtt ggaaaggttt 1801 gtgaaagtgt tgaatgctag gagagatgta ggttcaaaat tacgggatgg tattcagata 1861 gaataaatat aaggaaatct caacaaacta aatttgagtt aatagagatt ctctaaaata 1921 ttaattatta attctgtgaa gtagattatt ttttgagtgg aagtatgatt ttcgattgga 1981 aatatttatt ctgctgactt gtaataataa aactgcctcc gtgtcgatta ataatttgtt 2041 tagaaatttt taatcccata ccacttcttc taacgcctga tatgtcaaaa ttaaattctt 2101 caatattaga gatgctaata ctcttgagtc tatcaggaga aacccctact ccgttatcta 2161 gaactgttat agaaaattca ttatttgaag tacattctag aattatacta attttgcatc 2221 ctgatctatt atgaagtact gagttataga ttaagttatg gataactcga gaaatgaggg 2281 ccttttcaac atacattttt tttctaaaga ggttggaatc gtgtgaaaac tcaaagttaa 2341 attcttccca aatttcttga ttaataattt gaataattat ttctttaaag aaaggaataa 2401 tttcaacaat ctccaagttc aatttgaaat taccatttgt taatcttgca aaaatattga 2461 ggtcgttcaa taaattttgg atgtaatgac tctcaactaa agtgggtttg agatgtttta 2521 gaagattttc attatctgtt ttttcgatag ctaaagatgt attggacacg ataactgaaa 2581 gtggagtttt tatatcatgt gctattccgg aaatccaatt ttccttaaac tcttcatttt 2641 cacgtaattt cctgttggcg gaattaactg ctaaagtcaa tcgatctaac tctttgactg 2701 agtcaacctg cttatttaaa cctaatggta agttaccaat tgcactgata atgggttgta 2761 tattacgatt taagaacgta atactataca tatatagaaa taaacaaaat aagcaattga 2821 caaaaattat agctagaata agaattggaa aaatttgaac tctctttaaa tcaaagtaat 2881 tattaccata tcgaataatg ctgtcttttg gaaaggcaat aatgtaaata tctttctgct 2941 cctcattaat ttgggtaaag acaggataat cttctaaata gtatcgagag aacctgataa 3001 catcagcata atcaaagtta ctttttatat tagtaggttt atttatatta aatttttcct 3061 tcccgctatc ttgatcaatg atcatgaccc ataaattatt catctcgatt agttcttttc 3121 cttttaaact aactttataa gtattatttt cagggatgat gttggaggaa actgttttta 3181 taatatccat agctgattgt tgactacgaa tataatttgt agtgataact aatagaaaaa 3241 tatcaataaa tatgatggtt aaaaatgaaa gaataaattt taatacgctt tttttgaaaa 3301 tattcattaa aaactccgtt acctcagaca acaagcttat atccaagacc tttaacggta 3361 ataagatgat ccggtttaga agggcttgat tctatttttt ctcttatatt tcgaatgtgt 3421 accattaatg acttttcata tccagaacta tcaagtcccc aaatagtatc acaaattgtt 3481 tctgttgaaa caatgtagtt cttattactg tatagttttc gtagtatctg tatttcagta 3541 ggagttagtg aaagttgatt tccattttta tttacacttg cattatttaa atcaatggta 3601 caagaagaca atgtaattaa ttcggattca tttttgtatg ctcttcttaa tagagcaatg 3661 atacgatata ttaaggtttt cgggagaaat ggtttagtga caaaatcatc accacctgat 3721 ccaaggcctt taacttcatc atcaggatta ttttttgctg ttaaaaataa tattggaata 3781 tcagaagttt ttctaacata tttggcaagt aaatacccct caccatcagg taacattaca 3841 tctaatatga tgaaatcaat cttggataca gaaaaaatat cagtgccctc gctaatacta 3901 taagcgttac taatattttt aaatcctcta ttgactaata cctctttgat agattgacta 3961 agtgagacat cgtcatctat tattaatatc cgtttgttta aaaactgtgt ttcaaaattc 4021 atataaatac ctccttaatt ttttaattat atcataaagg attttatttt aacggtatgg 4081 agtaaaatga tactgtcaat aattatgtgt aaacactcaa gtagagttga agaatgttaa 4141 tcaaataagc tttcaagtgt gtcagcacat tggccaaacc ctttatggat gcgttgattt 4201 tgtttgaaat tataatcttc aaacagggta actaaataac gttccagagc ctcctcgtta 4261 ggaaaaagaa ccttcttttt cgtttgacgt ttgatttctt tgttaagaga ctcaatgagg 4321 tttgtcgaat aaatgctatg ccaaatctgg tagggaaact gataaaaagt taaaagatta 4381 tccgtattct ccagactttc catgactttc ctatactttg gtttccattc ggcgataaag 4441 ttctctaaaa tttgcactgc catttctaaa ttttcagcac gataaatcgt tttaaattgc 4501 tccagaataa ccgctctatc tgctcgtttc actttactag ctagatttcg actaatatga 4561 attaagcaac gttgttgttt agctaatggg taagcctgat tgataatctc ttcaagcccc 4621 ttgaagccat cggtcactac aagagaaatc tgttggattc cttggttttg aagcttgtct 4681 aacagggtgg accaagaagc attgttttca tttggggcga tttcatatcc aagaacagcc 4741 ttctgtcctt ctggtgtaat gccaagtgcg atatgaatac attctttact aacggttcca 4801 cgtcttaatg gaagataggt tccgtcaaga aataaaacag agtaattggc ttctaagctt 4861 cgctcatgaa aagtagcgac attctcctga gttgcttttg agatattaga aattgtggca 4921 ggactatagt gatgaccata cattcgttcg atgatatcac taatttctcg agtcgttaca 4981 ccggtttgat agagtttgat aaccatctct tccaagtggt catctcgacg tccataagcg 5041 ggaagcaaag ctggactaaa gttcccatta cgatctctag gaatactcaa ctgaacagtc 5101 ccatatttgg tttcgaattt ccgtgcatag cttccgttac gactattccc agaattatag 5161 cctaatttat cgtaaggttc ataccctaaa aaggctgata actctgcttg aagcagatca 5221 ttcatagctg tttcaagaga agtacggaaa aattcatcaa tatcctgctt ttgggctagg 5281 aagttaagta gttctgtggt aaactgagtc ataggaataa atctctttct agtaatgttt 5341 tgcaactcta ctataacgga tttattcctt tttgtgttta cacaacttat tttacactac 5401 cagtaaaatc aaagatttaa aatctttaaa ataactttat gatttcttta atatatctta 5461 aagtcaactt tgtaaaattt acttgtaaca aagataaaga cacttggtct caaaataaga 5521 acggcactca aataaaatta agaaaaggat aaattatgga aaaagaaaca acaattattg 5581 aatcaattca agaagttagt cttgaagagc ttgaccaaat tatcggtgca ggaaaaaatg 5641 gcgtatttaa aaccatctca catgaatgtc acctaaatac atgggcattt cttgctacat 5701 gttgctcata agttaagaaa ttttagaaag aggaaaacta tggaaaaaga aacaacaatt 5761 attgaatcaa ttcaagaagt tagtcttgaa gagcttgacc aaattatcgg tgcaggaaaa 5821 aatggcgtat ttaaaaccat ttcgcacgaa tgtcacctaa atacatgggc gtttcttgcc 5881 acatgttgtt cttgattttg gatgactaag tgtctaatat gttacattaa aaaaggaggg 5941 aaacctcttt tttatattca gaaattttaa ttcttaaaga taatagaatt gcttatcgaa 6001 aaatagaatc taggagtaaa gatttgtaaa gtattttgtg tcaagacgag attctaccca 6061 ctaaatattc tccgttgtat tcactaaagt ttacgattta atgatgaagg ataaaatgtg 6121 atgtgtattt aaagaaagta tatgatttac aacttatgta aaaatattaa gaagaggtat 6181 aaattagtaa tgtgaagtta ctttatcctt gtttgattct gaactaacaa gatttatcaa 6241 taaattaaca ttagctttag attagcttta acttttcttt atgttgcgat tttaaaatta 6301 aagcataaat aaaaatattt tcgagttatg ctcggtataa catatgaggt gataaattat 6361 gaaaaataat aataaaattt gtcaagatgc tttggaatcc ttacaagaac ttaagttaga 6421 agaagttgat gaacttttag gtggagcagg ccatggagta aatactattt cagcagaatg 6481 tcgttggaat agtttacaag caatcttttc atgttgctaa tttttagaga ggtaatatta 6541 tgaatcagaa agagcaacta tatagtcagt ttgataaatt tcctaaagta gtaattgaaa 6601 ggctcatccc tgaagtttta aatgaaagtg actcgctaat taagcaaatt gaggaaaaaa 6661 tttcagatta ttatagatct acattgattt atttaattaa tgaaaagcgc attaatggga 6721 cattggttgg tgaaacagca gaacttcgat atgacttttt taataatgta ttatgtagaa 6781 acggtactat tttagatgaa atagaggaac gatttcctaa gattaatcag cgtgtattta 6841 tcagtattaa acactattta gacttactaa attgcgtgaa aaagcacttt gtgagtgatt 6901 tcttagaatt aaaaaaatta aaatttttaa agtctaatga tgagagtcct gatttaaatg 6961 ttttagatat aaaagtcaca ggagatattc acaatggaag cggagtctgt attctagatt 7021 ataatagaca aaaattggtt tataagaaaa aatcatcaag accaaatatt cttttaaaag 7081 aattagatag tcaagcaagt aattatttga aaaaggaaat taggttcatt cctgattttt 7141 tagataaaaa tgaatatttt tgggaagtat ttgtcgagag taagccagta tcctcactta 7201 aagaagcaaa cgagttttat aagagaatgg ggtatctttt agtttactcc tatattctta 7261 atatctctga tttacacctt gaaaatctta tatctcatag tatccaacct atattagtag 7321 atgctgaaac tgttttttca actaatccat atgagacagt agctgaaaat gatgcaacat 7381 taaaaattgt tgaaaatagt cggaattcag ttctttctac gggattatta cctatttctg 7441 aggctgacaa aattttcgga ggtgatacga gtggtgtttt aggaggaacg cttattggtg 7501 aagcaaaagt tattataaat cataatagag atgatataca tgttgaaaaa cagaagtaca 7561 agactgaaaa ccagaatcac ttaccatact ttgagagtaa tttgggaata aaaacgtatt 7621 taaacgctga agaatatgta gaatatatta aagaaggctt catagaatta agtaaattta 7681 ttattaataa taaggaagca ttgaagaaac tttacttaag ttttagtgat ataaaaacac 7741 gtgttttatt tagaaatact agagattata gtctagttag acaattattg ctttcaccag 7801 tttactgcaa ccaggataat attttgcttg aaaaaatgtc aaataaatta acgaactacg 7861 atagtcataa tttatgtcaa tctgaagtaa aacaactttt gaacatggat attccgtatt 7921 tttacgtttg tgcaagtgat attaatgtta aagataagga cggtaatact aatatttgga 7981 aactaaaaaa atcttcactg agtgatacaa ttgaaaaatt ggaaaaattt gatttagata 8041 ctatggaaga acagttagat ttagtagaat tttcaattaa aaccccaaat gctttataca 8101 gtacagagtt gcaagagtca tataaaattt ttcaaaattc aaactcaaat catagcatat 8161 tatttactgg tattaatact atagttgata caattttaaa aaatgaaaaa ttttctaaat 8221 tagatggaag tacaaattgg ttaactttga aagttacaga ctatgatgca tttcaactag 8281 aacccatgga ttcatcaatt tatgagggta ttgcaggact gtctattgcg ttatgtgaag 8341 tttatgaatt ggtcgatgat gatagacaac agagaattta taactgttta cgcagaattt 8401 tcatgacttt aatgaaggct tattattcta cacaaaatca atcgtattat gttggcaagt 8461 taggaatttt atctgcaatg attaggacac agtcaattac tggtcaagaa ataccagtat 8521 ctatttttga tattaataac aaatatatct tagatttgaa tgttcagagt gcagactttc 8581 tatcaagttt tcctagtgag attgtagcct tacgaaatag taatgtatca attggaaatc 8641 ttcaacaatc ttttgagaaa ttagttgatt tgaaaattat ttctgaagat tatattgcgt 8701 gggataaatt ggaatctaat aatgttagtt tagcacatgg gaatttagga atagaactgg 8761 gattacttta tcttgcggtg gcattgaata gttctgaagc agtggaattg ttctatcaag 8821 ctacaaattt tgatagtcat caaaaattat caaatggatg gatagataaa agaaataatt 8881 cgactagtgc taattggtgt catggttcta caggggtgtt agctgcaaga ttagctcaat 8941 tacagctgga taaaaaattc catactatat ctaaaacaaa gagaagcgaa ttagaggctg 9001 atatgaaaca tgcagcatct cagataattg aaattggttt cgatatgaca aatttttcta 9061 tttgtcatga aacaagtgga aatttgttag cacttagtta ttattgctcg tatctatcag 9121 gaaatgaaag agaagaattg gaaaaaattt tagatataga gtatagaaaa ttacattcat 9181 ttggtttaga gaatggatgg atgtgcagct ttaatactaa atataatgtt tatggaataa 9241 tgaatggttt gtcaggaatt ttatattcta cagcaaaata tttaaaaaaa gatgattcgt 9301 tggatatttt aatccctact ctttaaaaag agatagaaag gaaaactcaa gtatgaagat 9361 tattttacaa aacaacgaag aggattgtct gttagcgtgt tacacaatgt tattaaatga 9421 tttaggtcat aaagttccac tatatgaagt atacgataaa gactcattac cagcagacgg 9481 acttaatgta tcatacttgc tatctctaaa caaaagattt ggagtggctt tgaaggcgta 9541 tcacgcgtcg tttagagatt tattacaagt ctacaatgaa aaaaagcaaa gaataattct 9601 tcactggaat caagatcatt tcgtagtatt agataaaatt actgaaaaac aagttacgat 9661 tgtagatccc gctattggtc gtgtaaaata cagtcatgat gagtttctaa accactattc 9721 tgaaactata gtgttaataa ataaggatga aaattttcaa actcaaaaat acaaacagat 9781 attttggaaa tattttaaac ttactttgaa aacaaaaaca attattctat ttttgctttc 9841 gttggtacta atccagataa gcgttttagc attttctatc ttattaagat atatgttatc 9901 agaaaagttt caattcttgt caaacatact agttctattt ggtgttgttc tttttcaact 9961 attaggctat tttattaaga atagtgcctt aaatgaatat aacttagatt ttgatgataa 10021 ctatagtaaa gcacttttcc caaaattgtt aaaaaaacca ctattatatt ttagaaatca 10081 tttaagtggc ggtatttcag agaagataaa tttcaagtct actttaaggg ataatgtgac 10141 attgaagatt atcccctctt gtgtaagttt catctcagca attgttattt ttacatattt 10201 aataacaatt tctgtaaggt taacaataat cttgatcata ataattttgg tttacagtgt 10261 aatttctatt atactttatc gtaaacagaa tgaatataac caaacttatc tgcaatattt 10321 gattgacttt aattcagagt tacaaacaga tttagatgat attgattata tcaaaataat 10381 gagacgagaa ggtctaactt ttgcatcgtg gatgaaaatt aatcaacaag ttactgaaaa 10441 atattcacag attttaaagt ttgaaaactt atcacagtta gttagcacga tttttaatta 10501 cattagtttg tctgtaatta tagttatagc gacttactat aataaatata ttaaagtatc 10561 catctcggat ttactagtct atcaaacaag tatttcatta ttaatatctg caattgaaca 10621 agtgaagggt gcagtttttg aagtagtaaa gttggggata tatgctgaaa aacaaagtga 10681 tttattaaaa gatagtagac caattttagt acaaagttca gattcggatg agtatttaat 10741 taaggctgaa agcctaaatt tttcttatgg catgagtccg atttataagg atattaactt 10801 gacaattaat agaggtgaaa agattgcaat cataggtaaa tcaggtagtg gaaaatcaac 10861 gttactatta cttttagcgg gtatgctacg atttagtgga tcgttgaaat atggtattaa 10921 aaattttgag gatagtttga gtgttgttct acagaatatg acattaagaa aaggaagcgt 10981 gttagaaaat ttagaatggg atacagataa tttagagcca ttgtatcaag tattaaaaga 11041 tacttcagct gatgaggtta ttgcccagtt accaaataaa attcattcaa agttattgaa 11101 acaggggaaa aatttatctg gaggacagat tcaaaaaatg ttaattgcta agtctttatt 11161 gaaaaaaaac tctattattt tctgggatga agctttcagt aatcttgatg aacaaagtaa 11221 aaatagaatc tatcttaata ttcttcagaa cagtcaatac tctgaaagga caatgttgat 11281 tgttagtcat catctagata ttgtcgacta tgttgactat gttatttaca tagataacga 11341 aatgggtgat gtttataagg atacacatat taatcttatg gaaagtaacg aaaactatag 11401 aaattttatt aattcaaaaa tttgagactt gcgttataca ttcttaatgt tatctttaag 11461 atgaacaggt acaattatta atgtaaagaa aggagtagtc taataaaata gattgctaaa 11521 ggataatgat gatgaataat attattgagc tgaaaaaagt aaaaaaagtt tacaaagata 11581 ttactactgt agatattgaa aaaattactg tacgggaggg agaaatttat ggttttctag 11641 ggccaaacgg tgctgggaaa acgacaacga tgaaaatgat tctatccctt gtagatccga 11701 cttcaggtga gatttttgtt aataaaaaag acattcgaaa agacaaaaat tacctgagtc 11761 agattggatc tatgatagaa gagccttcat attatcctaa tttaacaggt tacgaaaatt 11821 tattagtgtt tcaaaaaatg gtgggatttg atgaaaataa tatctggcca acattagaac 11881 ttgttggatt agctgatgaa aaaaatcgaa aaaaattagt taaggcctat tctctaggta 11941 tgaaacaacg tctttcttta gcgtttgcat tagtaaaaaa gcctaaaatc ttattattag 12001 atgagcctac taatggtctt gatccagcag gtattcatga aattcgtgaa ttgattgttg 12061 agttagccaa agaaaaaggt ctgacagtct ttatttctag tcatattctt ccagaaattg 12121 aacacattgc agatcgagtg ggtattatca atcatggtcg tctagtttat gaaggagaaa 12181 ttgaagctat taaatcaaat acctggattg agattggtgg tgatttttca cagagtaata 12241 ttgttcacac tttagttgaa ctagggactg tagaaatttt gggtgcatcc acaagtcatg 12301 taaaattaag taatattgat aataatcaat tagctaatgc ggtgagctat ttgacagaaa 12361 acggataccg tattttccga gtggttagag aaagtgagac cctagaagat attttccttt 12421 cgttaacgaa ggaggcttaa aatgataaag gtattacaaa tcgaattatt gaagtgtaaa 12481 cgaacaaaat catttatgat atcgtttttg atgatgtttg tagcagtaac ttggtcatta 12541 ctagcagcat caagaagcat aggtgtacca aagttaagga caattggatt atttttcaat 12601 aatttacaag ctactcctat ttttttacca attgcgatta gtctttttgt atcccgaatt 12661 gttagtaacg aaaaagaagg aaatacattt aaactacaag aagcgaataa tataaatctt 12721 ataaccattt tcaaacgaaa gcttattttt acgaatacta tttttctatt attgaatgta 12781 gtacaagtat tgattgtata tttatatgct gttagatacg gtatagatgt tgctgtttca 12841 aatttactat tacaagttgt aggtttgacg atgtctagtt ttactttaat tacttttttt 12901 ctatttctat ctatgatatt agaaaaacat ggtatggttt taggaattgg atttgtatca 12961 gggtttttag ggatggttct atccgaagca tctaaatggt taaatctaat ctttcctttc 13021 gggggttcaa gttttcttgc actttatcgc ataaaagttt tacattctgg agataaatta 13081 gattacatat ttgtttggga caagagtgta ccactcaact atcttatcta tctattttat 13141 tgtatatttg tctattttat tattaagtac ctattggtta aaaagaagga ggaaaactat 13201 gattgattat tttaaagctg agtggattaa gaatcgtaaa gtagtggtta aaaagaagga 13261 ggaaaactat gattgattat tttaaagctg agtggattaa gaatcgtaaa gtagttattt 13321 tagctattgg tcttattttt cttgctttgt ccagttttat tggattagct aattttttct 13381 tggactacga tgtgttgatt gaagaacaga tgagtagggt tctttgggga cagctgactt 13441 tttataacgg gcagttactt tttccagcta tgttagctat attctcaggt ctaattatcc 13501 ttcctgaatt tgaacgaaaa acacttgaaa tgctacgagc taatcaagca tcagttaaga 13561 agatggtact aagtaagttt ttattagctt tgttcttggt atctgtagtt caagcagtgc 13621 tgtttgctat ctatttatta actctttatc ttagtcaaat tccatttcag atagaggatt 13681 tattattatt tttgagagct acaatattat cagttattgg ttcaagttct gttttgatga 13741 ttcacagtta tcttatggca aaaactagga attttgctaa atcggttgga gttgcagcaa 13801 ttggttcctt ctcaggtttt atttttatta tgctaggtgg ttttattaat caattatttc 13861 catattctca gccgatgatt ggtttacgaa gtagggcatt gaatgatatg tcatttttag 13921 agtttatgtt atttattaca gtgaactcct tgtatagttt cattttttat tggttaactg 13981 ttaagaaatt ggagaataat gaataacgtg atgataaatt ttttgtgtag ttcttcaaca 14041 tagtagataa aatgaaactc agatctataa aataatcgct atgctgattt tcgatttgtt 14101 cttgaaatga tagtaagcct gatttacgta aagaatagaa caacaacttt cttgcaaaat 14161 taaatgataa atttgcacga gctattatca taattacagg aatgacgcaa taattactgt 14221 catattatga caatttccca gcttttttct gaaagtgaca tatacttttc ttaggagaaa 14281 gctatatgta ccaacggata agggatttga gggaagatca tgatttcact caaaggtttg 14341 ttgcaaattt actttccttc tctcatacaa attatgcaaa aattgagaga ggagaggttg 14401 ccttaacggc agatgttcta gtgcaacttt ctaaactcta taacgttagt acagattacc 14461 tattagggtt aacagattat ccagatagga taaaacataa aataaaatag tctctccttg 14521 atttattcat tgacaattga ataaaccgag gtgggacttt cttatttgtc gagcaattta 14581 gtgagatacg ccgtgatagg agcgaaaatt attagctata aaatagagtg gttctctatc 14641 tgccataacc acaaataagg acaatgatac ttctgaacgt tcaggctgcc atcgtaaaag 14701 gacagcgggt gaaatgccca tgaatgattt aaccaatcat acctactgag gaaattatag 14761 agtaacacgt tatcaggagg aaaagttttg gaacaatcag tagtaatata tagtatgcaa 14821 ttatcaatgc ttaacttttt atactcaaga aatatgctat ctaaaaatga gtatgaaaaa 14881 atcagaaaca aactgcgtat taagtacaca aaatcgctga cctttttatt tgaacgcggt 14941 aatatagaat caaaaggagg aatttcagtt atgaaaacaa ataatgttga aataataaaa 15001 gctgattctt tagttcgacg tagaggtgtc aatgttgaaa gacatttaaa aagggttgct 15061 gcttattgcc gagtgagttc tgatagtgag gatcagaaga acagttatga atctcaggtg 15121 aaacattata aagattacat ttctcagcgt tcagattggg aactcgctga t //