LOCUS       BGC0000529             21407 bp    DNA     linear   BCT 21-JUL-2010
DEFINITION  Microbispora corallina strain NRRL 30420 putative DNA-binding
            protein gene, complete cds; microbisporicin gene cluster, complete
            sequence; and hypothetical protein, pyrimidine reductase,
            hypothetical protein, oxidoreductase domain protein,
            glyoxalase/bleomycin resistance protein, esterase, putative
            xylanase, beta-1,4-xylanase, hypothetical proteins, secreted
            endo-1,4-beta-xylanase, and prephenate dehydratase genes, complete
            cds.
ACCESSION   BGC0000529
VERSION     BGC0000529
KEYWORDS    .
SOURCE      Microbispora corallina
  ORGANISM  Microbispora corallina
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Microbispora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:47:25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1655
            Orig. end    :: 23062
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..639
                     /gene="mibJ"
     CDS             1..639
                     /codon_start=1
                     /gene="mibJ"
                     /product="MibJ"
                     /protein_id="ADK32546.1"
                     /transl_table=11
                     /translation="MEMVSVELWRHEVRRCGLVALVTPLAVVASTTLLSALAGGGMHDF
                     LAVWLPAALLPLVAGVCAVGVVSREVMPELQATFPTPYPVTVRRRLRLLIVAVGAGVVV
                     LAVSAATGAGHDPVTGQGASGPVLSSLFSAASSAAFSLLLIGMGAYAAAGRTRNRGGPA
                     SALVMTAWLAKLLVLDRIPLPPAAVAVAFAAAGVWSMVRGSTRAGGEAV"
     misc_feature    1..21407
                     /note="microbisporicin gene cluster"
     subregion       1..21407
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21407
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            636..1412
                     /gene="mibY"
     CDS             636..1412
                     /codon_start=1
                     /gene="mibY"
                     /note="MibY"
                     /product="putative ABC permease"
                     /protein_id="ADK32547.1"
                     /transl_table=11
                     /translation="MTGRWLVPLTASARSEITMILRSRMLWMAVAPLAALSLLLAFTST
                     HGADVGPGGRVADTAVMVNLLAGFGLAMAMADRFRWHRRTGLADLLAATPGSASARMAG
                     TLTGSVAVALAPPAAALLVYAVVTAVREGSLSPVGASLASVVVILLPGGLLIAAFSALA
                     GLVLPVTVARIGAAGVWGWATVLNSRVLPIPTVSYTMFSPAGGFPAVAWLGAPRSNAVL
                     NGREVAASAAAVNILVVLACTLVLLAVARIWTERYR"
     gene            1409..2311
                     /gene="mibZ"
     CDS             1409..2311
                     /codon_start=1
                     /gene="mibZ"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 178.8; E-value:
                     2.3e-54)"
                     /gene_kind="transport"
                     /note="MibZ"
                     /product="putative ABC transporter ATP-binding protein"
                     /protein_id="ADK32548.1"
                     /transl_table=11
                     /translation="MNTSISITDLTKRYRRGGDRPALNGVSLTVDGGMTALLGANGAGK
                     TTLMRICVGVLRPDGGRVVVGGHDLGTAAGRRAVKRILGYLPQELSMYDDLTGREFLDY
                     IALLKGVDDKRVRRDQIEQMLELTGLSEHAGRRLGGYSGGMKRRLGIAQALLAEPELIV
                     VDEPTAGLDPSERMRFRSLLAGLGGARRTVVLSTHILDDAAQTCPNTIVLHQGRVAYQG
                     STAGLAAVAEGRTYLLPPGAQAPPEAVVVNAAAEVEGTRYRVISARPPIGGTLMTPTLE
                     DGYAALLQLGEPSPTGPRP"
     gene            2308..3552
                     /gene="mibO"
     CDS             2308..3552
                     /codon_start=1
                     /gene="mibO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 288.1; E-value: 1.7e-87)"
                     /gene_kind="biosynthetic-additional"
                     /note="MibO"
                     /product="cytochrome P450"
                     /protein_id="ADK32549.1"
                     /sec_met_domain="p450 (E-value: 1.1e-24, bitscore: 77.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFGPDFHRDPYPVYRRLRDEAPCHHEPALGLYALSRYEDVLAAL
                     RQPTVFSSAARAVASSAAGAGPYRGADTVSPERETAAEGPARSLLFLDPPEHQVLRQAV
                     SRGFTPQAVLRLEPAVRDIAAGLADRIPDRGGGEFVTEFAAPLAIAVILRLLGVPEADR
                     ARVSELLSASALSGAEAELRSYWLGLSALLRDREDAGEGDGEDRGVVAALVRPDAGLRD
                     ADVAAGPAVRAPLTDEQVAAFCALVGQAGTESVAMALSNALVLFGRHHDQWRTLCARPD
                     AIPAAFEEVLRYWAPTQHQGRTLTAAVRLHGRLLPAGAHVLLLTGSAGRDERAYPDPDV
                     FDIGRFHPDRRPSTALGFGLGAHFCLGAALARLQARVALRELTRRFPRYRTDEERTVRS
                     EVMNGFGHSRVPFST"
     gene            3585..3974
                     /gene="mibQ"
     CDS             3585..3974
                     /codon_start=1
                     /gene="mibQ"
                     /note="MibQ"
                     /product="putative lipoprotein signal peptide-containing
                     protein"
                     /protein_id="ADK32550.1"
                     /transl_table=11
                     /translation="MTNTTRARLSGAGLLAAALLLAGCTGGGRADPAHRSPVPLPSPTS
                     SKQDISEANLAYLWPLTVDHGTIECLPSDNAVFVAPDGTTYALNDRAEKAGHPPITPIR
                     AKGSGGGYISLGALLSTTLNLCGKG"
     gene            4283..5065
                     /gene="mibR"
     CDS             4283..5065
                     /codon_start=1
                     /gene="mibR"
                     /note="MibR"
                     /product="putative DNA-binding protein"
                     /protein_id="ADK32551.1"
                     /transl_table=11
                     /translation="MPDRQRTRRATGGSADARGRGEVVVACASLRDTNAPLAEWLGDLD
                     VGCTFCGDVYSAAETYDPRLALLPVLTEAQAQRLGRLMERCPGTSVLGIVMDVTGHHTH
                     RAIQNGASWVLNTLLPAACCRNLLRMVIQAVVLGPTVPEPLVAEPPVPEGVEPPTRPGT
                     ARAEPPAEARKVADAQEEELLALLCGPDSIAEIARRFYCSERSMYRQLRDLYRSYGVTG
                     RRELRRVIALRSVTRHQETLSTHLLAPPRPAGRGGLSC"
     gene            complement(5411..6178)
                     /gene="mibW"
     CDS             complement(5411..6178)
                     /codon_start=1
                     /gene="mibW"
                     /note="MibW"
                     /product="putative anti-sigma factor"
                     /protein_id="ADK32552.1"
                     /transl_table=11
                     /translation="MIDDEDQDALTAAVREADEELIGRLTVPAYDELLGRLPDIAASRK
                     APVSGPTLRASWRLTTGLVAAQARLMPRSLGPLTALGLVAAVLLALTAPTPGAVVQLFS
                     SVVTVVLLLGSVTACSHRSDPRLELLSAMPVSPATAFATRLALVLGIDLALSVVASGVL
                     VSAGATTGMLAVVAGWLGRALLAAGAGAVFAIWRSPAFGTMAGVVVWLLGWVRGPDDAV
                     VSGTHPWMLSCALALLAAAVWLARRPRLSGSDG"
     gene            complement(6168..6830)
                     /gene="mibX"
     CDS             complement(6168..6830)
                     /codon_start=1
                     /gene="mibX"
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 129.3;
                     E-value: 1.9e-39)"
                     /gene_kind="regulatory"
                     /note="MibX"
                     /product="RNA polymerase, sigma-24 subunit, ECF subfamily"
                     /protein_id="ADK32553.1"
                     /transl_table=11
                     /translation="MPLRRRSPRTGTAADATYERVQQLREPELSAEVSEDAVLMRRVAD
                     GEEVALRMLYERHAAGMLRLIRRLTSQREVAEEILQESWLAVWRSAGSFRGEAPVRAWL
                     LGVARRQAHNRLRRAEPVLVELEKAADVPDLEPAVDEQVLARAERRDLVAAVAELPEHL
                     REVLVLVLAEDLPYPQVAVILGIPTGTVKSRMHMARRLLTEALTKTTNPKGGRTGDR"
     gene            6961..7134
                     /gene="mibA"
     CDS             6961..7134
                     /codon_start=1
                     /gene="mibA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /note="MibA"
                     /product="microbisporicin structural preproprotein"
                     /protein_id="ADK32554.1"
                     /sec_met_domain="TIGR03731 (E-value: 7.3e-12, bitscore:
                     35.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADILETRTSETEDLLDLDLSIGVEEITAGPAVTSWSLCTPGCT
                     SPGGGSNCSFCC"
     gene            7252..10599
                     /gene="mibB"
     CDS             7252..10599
                     /codon_start=1
                     /gene="mibB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     857.8; E-value: 1.6e-259)"
                     /gene_kind="biosynthetic"
                     /note="MibB"
                     /product="lantibiotic dehydratase"
                     /protein_id="ADK32555.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6e-187, bitscore:
                     612.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.5e-10,
                     bitscore: 31.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.8e-32, bitscore:
                     102.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSPFRAWDVFMVRTPVGYAYPTPLSNSGFDSPASSPGFGEGEF
                     PPDAPVPSDVSGHGAGSSEASVRASGRPPAGDHLSLLRAACEDGPLMEAVELASPSLAG
                     LLARVARGDTGGLKDKRLRRAALALLRYDIRMRTRPTPFGLFAGVSGGRFDTSAKWLAG
                     TGHRTRTRADMEWLLSAVHRLERDRVLLAGVTVQAHQTLTVRGDRIVLDCPSALGKPLN
                     GSTRSTVSARRSPVVAEILGAARRPVLAGRLAQSVAQRFELPADRVTGLLADMAAQELL
                     ITALRPPLDGDDPLQHVLDVVAAAEARAGSPAEAMSSESAALVAALREVDARCHAYDRT
                     AVGQGRRELAELIQSTRRVHPHDTPLHVDLRIDLEVRLPEVVRTEIERAAEALWRLSPP
                     RRGMRALRRYHEAFLERYGADRAVPLLELLDDTRGLGPPAGYKWPPSETPAGPQEEPRR
                     SAALARLVAKAARRGEREIVIDEETIAELAYDEAAPADLPNSLELGVHVVAPSLDELSA
                     GTFRVVLAPGPGSHHAGATLGRFTGLLPDVDAESAARQAGRPLHIQDAVAADVAFIPRS
                     GRAANLAHTPSYSGRRISVGLPDSGRAQEIPLDELGVGANLERLCLVHLPTGREVVPAL
                     PNMVSAFAQAPNPARLLFELGLEGQRLWEPWDWGALSEMPFLPGVRYGRTLLAAPLWRM
                     DQLRGPADDSGPAADWDAALDRWRAEWNVPRRVLAVSMDQRLLLDLDDAWHRVLLRDEL
                     RRTPELIAQQVAGDEEGWLDRGDAGFPGHLAEIVVPLERRDRHAARPPHIRATVSGREP
                     TGAGGPWLYLRLRVPRRNQDDFLRDQVPVLVRAGIEHGADRWFFIRYSDTAGQHLRVRF
                     RGEREKLWAGLLPEIGARLVEWQRQGLLAGHELGQYDPEYERYGGDALAEFTETAFQHD
                     SAAAISLLRLTRRAGFRYTLDEVTAISAAALADAFGPPAPVVEPVPLVGGLQWAPDLFD
                     GDPAAAWMSSTGGRRELPPDYRRDPARWQKLIDPTGGWPLLRADEDGCQVLAALESRDE
                     AVRRFGTAYREAFRPTDSPSTQLRLVGSLLHMTCNRLIGGSAERERSVLGLARGAVQDN
                     LNRRRHLA"
     gene            10596..12053
                     /gene="mibC"
     CDS             10596..12053
                     /codon_start=1
                     /gene="mibC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     330.6; E-value: 2.1e-100)"
                     /gene_kind="biosynthetic"
                     /note="MibC"
                     /product="lantibiotic cyclase"
                     /protein_id="ADK32556.1"
                     /sec_met_domain="LANC_like (E-value: 2.5e-49, bitscore:
                     158.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVGRTSCGVTSDRHPARFLRGSAARRAARLVRLVAERLADPDA
                     VAGIAARPGNSVPVNGLSMWSPATLSHGFPGIAVFYAELGRIDPAWSAFAHRHLRAAAA
                     AVETAPSGGLFAGPASLLAAAQSCAGPAGHYRGLRRKLTAWLAADHAGRLAVARDRPGP
                     GVAWTDYDVVHGLSGTTRLLLDAACDPDDETAAVASGAVTDTLRHLVRLTEPITVDGHE
                     VPGWWVPSHLQPVEQDRRDYPRGDLNLGLAHGAAGPLSVLATATLHGMEVPGQREAVAR
                     LAEWLLGWTMTDDTGAYWPCRISWDEQIAAVRPDASFTRTAWCYGAPGVCAALHRAGLA
                     LGVTEWREVAVTALLDGLRRDRSAWRVDGSTVCHGYAGLLQVLSRVGAESGDPRLLDGC
                     LDVARMVLGEADESAPFVFPHLVPDSPDGWRNATGYLPLDGAGLLEGAAGVACALLSVI
                     PPSSLCGTDPAPERADLPPWDRCLALC"
     gene            12082..12765
                     /gene="mibD"
     CDS             12082..12765
                     /codon_start=1
                     /gene="mibD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /note="MibD"
                     /product="flavoprotein decarboxylase"
                     /protein_id="ADK32557.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.5e-25, bitscore:
                     79.3, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHSDAGGDPRPPERLLLGVSGSVAALNLPAYIYAFRAAGVARL
                     AVVLTPAAEGFLPAGALRPIVDAVHTEHDQGKGHVALSRWAQHLLVLPATANLLGCAAS
                     GLAPNFLATVLLAADCPITFVPAMNPVMWRKPAVRRNVATLRADGHHVVDPLPGAVYEA
                     ASRSIVEGLAMPRPEALVRLLGGGDDGSPAGPAGPVGRAEHVGAVEAVEAVEAVEAVEA
                     AEALA"
     gene            12762..13712
                     /gene="mibT"
     CDS             12762..13712
                     /codon_start=1
                     /gene="mibT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 193.6; E-value:
                     6.6e-59)"
                     /gene_kind="transport"
                     /note="MibT"
                     /product="ABC transporter ATP-binding domain"
                     /protein_id="ADK32558.1"
                     /transl_table=11
                     /translation="MTVPAFELSDLTVRYGPVTAVDGVSAGSAPGLVTALLGPNGAGKS
                     SLLRVLSTIAPPSSGTARVFGHDTRAEPLAARTRIGLVFQERALDTDLSAEQNLRFHAR
                     LFGVGRARAREDILVLLERFGLAGRGRDRVETLSGGLARRLEIARALLHRPGLLILDEP
                     TNGLDPEARQTVWDDLIRLRSELGVTVLYSTHYMDEAELADQIIILSEGRVAGFGSPGR
                     LKSELRSSRIVLVTHDDDTALARLAEAGFDAVIDSDGVAVRCREPESRMAEVIRAAGPL
                     VRAASVHHPSMNDVFLAHTAANRDREAADGTVSCP"
     gene            13690..14562
                     /gene="mibU"
     CDS             13690..14562
                     /codon_start=1
                     /gene="mibU"
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 109.8; E-value: 2.2e-33)"
                     /gene_kind="transport"
                     /note="MibU"
                     /product="ABC-type multidrug transport system permease
                     component"
                     /protein_id="ADK32559.1"
                     /transl_table=11
                     /translation="MALSAVRDTGGTAGSTPGGPTGGGSAGAGEARRLVSAALRSAVRG
                     TLVVAHRDVLRQVRHPGVVVAQAAQIVFFVLVYAVGFRSMIGSVGGVSFGAYVYPGIIA
                     IQVVMLGVGTGLTYAMDREFGVLREMQVAPVPRMCLPLGKILASCVLLTAQAMLMLLPA
                     PLLGLPLTPARYAAGTAVYLATAAAFSLIGLLLAVSVRRIETLQATVQLAMYPLLFLSG
                     SVFRPDAVPGWLAALMRLNPMMYAVDLARHVLLPSAPGVSYLPVWRDLLVIAALVAAAS
                     AALRLRVGR"
     gene            14570..15574
                     /gene="mibV"
     CDS             14570..15574
                     /codon_start=1
                     /gene="mibV"
                     /note="MibV"
                     /product="hypothetical protein"
                     /protein_id="ADK32560.1"
                     /transl_table=11
                     /translation="MTTATTTGPTGRETLLAGAVSWLAARLRWFDPEQWARHLQPRGFA
                     PSALLELLIICRNLNSVYGHPRPPDPEDGSRGSGVRTTGAAGPAVELIGRALDLAEEVV
                     GRPGFGAALYRGDAAFPHHVWLIALLAEGGRPVEPWPAVAQRVIDAGCAEPIRPGRPTA
                     ARLEARYVFDLAGLRHGLPAMDELAGRTALGPGADPLHLTDADLYVITHMLFYLTDFGR
                     RPFSADEAEGRRVRGLVEVLLGRQLAVGDLDLAAELLACAGLTGADDRLSGCAWNRLTA
                     ARRPDGSVPSPLFRQAALDRLSGEKAEAYAFGTCYHTTLAMVLAATLTDGADA"
     gene            16373..17122
                     /gene="mibE"
     CDS             16373..17122
                     /codon_start=1
                     /gene="mibE"
                     /note="MibE"
                     /product="putative lantibiotic ABC transporter permease
                     protein"
                     /protein_id="ADK32561.1"
                     /transl_table=11
                     /translation="MAALVSTELLRLRSGFVGWYLLLSPIVIAIPLYLGSIFSPEGRSG
                     RLWETFSNVTLEFWGVLIPMTAGLIAALAVRADTEPWRFLFSYAIPRWRYFTAKVAALA
                     VAQLLSATILVVMLAGGALLTGQLSNAASMILKVAYLPWAAGLAATALAVLVCTIWGLG
                     PGIALGVAGMMAGALISDKSFWYAIPPAWPMRVILPLADIRPNGLALDASSPLHDTTVI
                     PLAVALSAAATIVILLIGGRHMARKEV"
     gene            17124..17834
                     /gene="mibF"
     CDS             17124..17834
                     /codon_start=1
                     /gene="mibF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 169.5; E-value:
                     1.6e-51)"
                     /gene_kind="transport"
                     /note="MibF"
                     /product="putative lantibiotic ABC transporter ATP-binding
                     protein"
                     /protein_id="ADK32562.1"
                     /transl_table=11
                     /translation="MAALEIRDLHKHYDDFHALDGANLTVPDGSLYGLLGPNGAGKTTL
                     MKAVTGLRHPTSGHISLFGRPYERRLLTQVGALLESPGLWTQLDAVSHLRIHARLRGVP
                     ETRIGEVLSLMNLTEVSTRKVAKYSLGMRWRLGIAIALLGRPRLVVLDEPMNGLDPVGI
                     RDMRATLRALTAAGTTVMVSSHQLAEIAHICDHVGVLVAGRTAYEGPLHGLAVDGDLEQ
                     GFFRLLEKAGSAVR"
     gene            17867..19573
                     /gene="mibH"
     CDS             17867..19573
                     /codon_start=1
                     /gene="mibH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 77.9; E-value: 1.5e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="MibH"
                     /product="tryptophan-5-halogenase"
                     /protein_id="ADK32563.1"
                     /sec_met_domain="Trp_halogenase (E-value: 4.9e-115,
                     bitscore: 375.2, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.6e-11, bitscore: 34.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARSEESNTLARLFDVLGDDAAAAREWVTEPHRLIASNERLGTAP
                     EAPADDDPEAIRTVGVIGGGTAGYLTALALKAKRPWLDVALVESADIPIIGVGEATVSY
                     MVMFLHHYLGIDPAEFYQHVRPTWKLGIRFEWGSRPEGFVAPFDWGTGSVGLVGSLRET
                     GNVNEATLQAMLMTEDRVPVYRGEGGHVSLMKYLPFAYHMDNARLVRYLTELATRRGVH
                     HVDATVAEVRLDGPDHVGDLITTDGRRLHYDFYVDCTGFRSLLLEKALGIPFESYASSL
                     FTDAAITGTLAHGGHLKPYTTATTMNAGWCWTIPTPESDHLGYVFSSAAIDPDDAAAEM
                     ARRFPGVTREALVRFRSGRHREAWRGNVIAVGNSYAFVEPLESSGLLMIATAVQILVSL
                     LPSSRRDPLPSNVANQALAHRWDAIRWFLSIHYRFNGRLDTPFWKEARAETDISGIEPL
                     LRLFSAGAPLTGRDSFARYLADGAAPLFYGLEGVDTLLLGQEVPARLLPPRESPEQWRA
                     RAAAARSLASRGLRQSEALDAYAADPCLNAELLSDSDSWAGERVAVRAGLR"
     gene            19570..20106
                     /gene="mibS"
     CDS             19570..20106
                     /codon_start=1
                     /gene="mibS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 108.6; E-value: 4.1e-33)"
                     /gene_kind="biosynthetic-additional"
                     /note="MibS"
                     /product="flavin reductase"
                     /protein_id="ADK32564.1"
                     /transl_table=11
                     /translation="MTTGTTVAHAVEPDGFRAVMATLPAAVAIVTAAAADGRPWGMTCS
                     SVCSVTLTPPTLLVCLRTASPTLAAVVSGRAFSVNLLCARAYPVAELFASAAADRFDRV
                     RWRRPPGTGGPHLADDARAVLDCRLSESAEVGDHVVVFGQVRAIRRLSDEPPLMYGYRR
                     YAPWPADRGPGAAGG"
     gene            20103..21407
                     /gene="mibN"
     CDS             20103..21407
                     /codon_start=1
                     /gene="mibN"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 362; E-value:
                     5.9e-110)"
                     /gene_kind="transport"
                     /note="MibN"
                     /product="integral membrane ion antiporter"
                     /protein_id="ADK32565.1"
                     /transl_table=11
                     /translation="MNAEQLTGVVIADLGMIVVVSALFGALARRCGHPTVIGQIVAGIA
                     LGPTLLGRLPGDPAGWLFPAQVRPSLSVLSQIAIVIFMFAVGYEVDLRLLRRGGRSALC
                     VASLSLAVPMTLGAAVAVLFREVFTVGSLEGPGGPTFVLFMAVAISITALPVLAAIVRE
                     RGLAGTAAGTVATAAAGLMDVAAWTALAAVLAEAGDADETRVPQVPWMLALPALVAFAA
                     AMFLVVRPLLGWLTRRPGAMWGRLPAAFALALGSAWGTAALGLHPVFGGLLAGLVMPRR
                     DGAPEPEVLRPMEQTAELLLPLFFVMTGLSADISAIEPGGLFLLAVLLVAAIGGKLVPA
                     YAASRLTGLDSGESAVVAVLVNTRGLTELIVLNVGLSAHVIDERLFTVLVVMALITTAM
                     TAPLLSALRRREERRRPAPAIPMPPASVSRRSTMG"
ORIGIN
        1 gtggagatgg tctctgtcga gttgtggcgg catgaggtgc gcaggtgtgg tctggtcgcg
       61 ctcgtgacgc ccctggccgt cgtggcgtcc acgacactgt tgtccgccct ggccgggggc
      121 ggcatgcacg acttcctggc ggtctggctt ccggccgcat tgctgcccct ggtggcgggc
      181 gtctgcgccg tgggggtcgt gtcccgggag gtgatgccgg agttgcaggc caccttcccg
      241 actccgtacc cggtgacggt gcgccgccgg ctgaggttgc tcatcgtcgc cgtaggggcg
      301 ggcgtggtgg tcctggccgt gtccgccgcg acgggcgccg ggcacgaccc ggtcacggga
      361 cagggcgctt ccggaccggt tctgtcgtcc ctcttctccg cggcgtcgtc cgcggccttc
      421 tcgctgctgc tcatcggcat gggggcgtac gcggcggcgg ggcggacccg gaaccgcggc
      481 ggaccggcct cggccctggt gatgacagcc tggttggcga aactgctcgt gttggacagg
      541 attccgctgc cgccggcggc ggtggccgtc gcgttcgcgg cggcgggagt gtggtcgatg
      601 gtccgcggat cgacgagggc agggggagag gcggtatgac aggcaggtgg ctggtcccgc
      661 tcaccgcgtc ggcacggtcg gagatcacga tgatcctgcg gtcccggatg ctgtggatgg
      721 cggtggcgcc gctcgccgcg ctgagcctgc tgctcgcgtt cacgtccacg catggcgcgg
      781 acgtgggacc cggcggcagg gtggcggaca cggcggtcat ggtgaacctg ctcgccggct
      841 tcgggctggc gatggcgatg gccgacaggt tccgctggca tcgccgcacc ggactggcgg
      901 acctgctcgc ggcgacgccg ggcagcgcgt cggcgcggat ggcgggcacg ctcacgggct
      961 ccgtggcggt ggcgctcgct ccgccggcgg ccgccctgct cgtgtacgcc gtcgtcaccg
     1021 cggtacgcga gggctcgctc agtccggtcg gcgcgtccct ggcctccgtc gtcgtgatcc
     1081 tccttcccgg cggactgctg atcgccgcgt tcagcgcgct ggccggactc gtcctgccgg
     1141 tgacggtcgc ccggatcggc gcggcagggg tgtgggggtg ggccaccgtg ctcaactcac
     1201 gggtgctgcc gatacccacg gtgtcctaca cgatgttctc tccggccggc ggcttccccg
     1261 cggtggcctg gctgggggcg ccgcgcagca acgccgtcct gaacggccgg gaggtcgccg
     1321 cgagcgcggc ggcggtgaac atactcgtcg tgctggcgtg cacgctggtg ctgctggccg
     1381 tggctcggat ctggacggag cgttaccggt gaacaccagc atcagcatca ccgacctgac
     1441 gaagcgttac cggcgcggcg gcgacaggcc ggccctgaac ggggtgagcc tgaccgtgga
     1501 cggcgggatg accgcgctgc tcggggccaa cggcgccggc aagacgaccc tcatgcgcat
     1561 ctgcgtgggc gtcctgcggc cggacggagg ccgcgtggtg gtgggcgggc acgacctcgg
     1621 tacggcggcc ggccggaggg cggtcaagcg catcctgggc tacctgccgc aggaactgtc
     1681 catgtacgac gacctgaccg ggcgggagtt cctcgactac atcgccctgc tgaagggcgt
     1741 cgacgacaag cgtgtccgcc gcgaccagat cgagcagatg cttgagctga ccggcctgtc
     1801 ggagcatgcg ggccggagac tgggcggtta ctccggcggg atgaagcggc ggctgggaat
     1861 cgcccaggcg ctactcgccg agccggagct gatcgtcgtg gacgagccca cggcagggct
     1921 ggacccctcc gaacggatgc gattccgctc cttgctggcc ggcctcggcg gggcgaggcg
     1981 taccgtggtg ctgtccaccc acatcctcga cgacgccgcg cagacctgcc ccaacaccat
     2041 cgtgctgcac caggggcggg tcgcctacca gggcagcacc gccgggctcg ccgcggtcgc
     2101 cgaggggcgc acctacctgc tgccacccgg agcgcaggcg ccgcccgagg ccgtggtcgt
     2161 caacgcggcg gcggaggtgg aggggacgcg ctatcgcgtg atcagcgccc gaccgccgat
     2221 cggcggcacc ctcatgacgc cgacgctcga agacggatac gcggcactgt tacagctcgg
     2281 cgaaccctcc cccacgggtc cgcggccatg atcttcggac cggacttcca ccgggacccc
     2341 tatccggtct accgccggct gagggacgag gcgccgtgcc accacgagcc ggccctcggg
     2401 ctctacgccc tgtccaggta cgaggacgtg ctggccgcgc tccggcagcc gacggtgttc
     2461 tcctcggccg cccgcgctgt ggcgagctcg gcggcgggcg cgggaccgta ccgcggagcg
     2521 gataccgtgt cgccggagcg ggagaccgcc gcggaggggc cggcgcggtc gctgctcttc
     2581 ctggacccac cggagcacca ggtgctgcgg caggcggtgt cgcgggggtt cacgccccag
     2641 gcggtgctac ggcttgagcc ggccgtacgg gacatcgccg ccgggctggc cgaccggatc
     2701 cccgaccgcg gcggcggcga gttcgtcacc gaattcgccg ccccgctggc gatcgctgtg
     2761 atcctgcgcc tgctcggcgt ccccgaagcc gaccgggcac gcgtgagcga gttgctgtcc
     2821 gcctccgccc tctccggtgc cgaggccgaa ctgcgctcct actggcttgg cctgagcgcc
     2881 ctgctgcgcg accgtgagga cgcgggcgag ggcgacggcg aggaccgggg cgtggtggcg
     2941 gcactcgtcc ggcccgatgc cggcctgagg gacgccgacg tcgcggcggg cccggccgtc
     3001 cgcgcacccc tgaccgacga gcaggtcgcc gcgttctgcg cgctcgtcgg ccaggccggt
     3061 accgagtcgg tggcgatggc gttgtcgaac gctctggtgc tgttcggccg ccaccacgac
     3121 cagtggcgca cgctgtgcgc gaggcccgac gcgatccccg ccgccttcga ggaggtcctg
     3181 agatattggg cgccaaccca gcaccagggc cgtaccctca ccgctgctgt gcgcctgcac
     3241 ggccggctgc tcccggccgg agcacacgtg ctgctgctga ccggatcggc gggcagggac
     3301 gagcgcgcct accccgaccc ggacgtcttc gacatcggca ggttccaccc cgaccggcgt
     3361 cccagcaccg cgctcgggtt cggtctcggc gcgcacttct gcctgggggc ggcgctcgcg
     3421 cggctgcagg ccagggtcgc cctgcgagaa ctgacgcgtc gcttcccgcg ctaccggaca
     3481 gacgaggagc ggaccgtgcg atcggaggtc atgaacgggt tcggccacag ccgggtcccg
     3541 ttctccacgt gaaccggcgg gtggccggac gctacgtaca gggcatgacg aacacgacca
     3601 gagcccgtct gtccggcgcc ggtctcctcg ccgcggccct gctgctggcc ggctgcacgg
     3661 gcggcggcag agccgatccg gcgcacaggt cccctgtgcc gttgccgagt cccacgagca
     3721 gcaagcagga catcagcgag gcgaacctcg cctatctgtg gccgctcacg gtcgaccacg
     3781 gcacgatcga gtgcctgccc tccgacaacg ccgtcttcgt ggcgcccgac ggcacgacct
     3841 acgctctcaa cgaccgcgct gagaaggcgg ggcacccccc gatcacaccg attcgcgcca
     3901 agggcagcgg tggcggatac atcagcctcg gagccctgct cagcaccacg ctcaatctct
     3961 gcggaaaggg ctgagaccag attcgggacc gcaggagacg ggccgtccgg tgaggcggcg
     4021 gtccgaaaac ttacccgaac gcgggacgga aaatccggct cctgcgtgaa ccttcgtacg
     4081 ccatcccgct acgtacacct ccgaaagatc gaaactgccg gaggtaacag ggacaggtgc
     4141 acgggggaga tacgcgatgc cgatggtgcg cgagtgcggt gcgtcacaac cggccggaac
     4201 ggaggcgacg tgcgcgacac ggacagggcc tgtgacgggg ggacgaccag cgacaccggg
     4261 agggacatcg ggcacaccgc gggtgcccga ccggcaaagg acgaggagag cgaccggggg
     4321 gtccgccgac gcccggggcc gcggtgaggt cgtcgtcgca tgcgccagcc ttcgcgacac
     4381 gaacgcgccg ttggcggagt ggctgggaga cctggacgtc ggctgcacat tctgcggcga
     4441 cgtctattcg gccgcggaga cgtatgatcc gcggctggcc ttgctgcccg tcctcaccga
     4501 ggcccaggcg cagcgcctgg gcaggctgat ggagcggtgc ccgggcacgt cggtgctcgg
     4561 catcgtcatg gacgtgaccg gccaccacac tcaccgggcc atccagaacg gggcgagctg
     4621 ggtgctcaac acattgctcc cggccgcgtg ctgccgcaac ctgctgcgca tggtcattca
     4681 ggcggtggtg ctggggccga cggtcccaga gccgctggtc gccgagccgc cggttccgga
     4741 gggcgtggag ccgcccacgc ggccgggcac cgcccgtgcg gaaccgccgg cggaggcgcg
     4801 gaaggtcgcc gacgcgcagg aggaggaact cctcgcgctg ctgtgcgggc cggactccat
     4861 cgccgagatc gccaggcgct tctactgttc cgaacggtcg atgtaccgtc agctacgcga
     4921 tctgtaccga agttacggag tcaccggacg ccgggagctc cgccgggtga tcgctcttcg
     4981 gagcgtcacg cgccaccagg agacgctgtc gacccacctt ctcgccccgc ctcggcccgc
     5041 cggccggggc ggtttgtcgt gctgagggct acgcggttcg atgacgcggc cggtgtgaca
     5101 tggatggtga cgtggtttcg cgctgcccgg gcccaccgcg agtccccggc gagaccgccg
     5161 ggggtccggc gcgggcccgc ggtaccggtc accccggccc acgtccgcga cggtgccggt
     5221 gacggcgcgc accaccgccg ggctgcggca caccatggct gcggcacacc atggctgtgg
     5281 cacaccgcag ggctgtggca caccacgacg ccgggttgcg gctggcagct ttggcagagt
     5341 cggctgcgcg cccctgacgc cggccgcggc gtcccgcgta gcaggcccca gaacccgccc
     5401 cccgctcccg tcagccgtcc gacccggaca gccgcggccg gcgggccagc cagacggccg
     5461 cggccagcag ggccagagcg cacgagagca tccaggggtg cgtgccggac accacggcgt
     5521 cgtccggtcc gcgtacccag ccgagcagcc agaccacgac tcccgccatc gttccgaagg
     5581 cgggtgatcg ccagatcgcg aagacggcgc ccgcgcccgc cgccaggagg gcgcggccga
     5641 gccagccggc gacgacggcg agcatccccg tagtcgcacc ggcggacacg aggacgcccg
     5701 aggcgacgac cgagagcgcg aggtcgattc ccaggacgag cgcgagcctg gtggcgaacg
     5761 ccgtggcggg agagaccggc atcgccgaca gcagctccag gcgtggatcg gatcggtgtg
     5821 agcacgccgt gaccgagccg agcagcagca ccaccgtcac caccgagctg aacaactgca
     5881 cgaccgctcc cggggtgggc gccgtgagcg cgagcaacac tgccgcgacc aggcccagag
     5941 cggtcagcgg gccgagcgac cgcggcatca gccgtgcctg cgccgccacg agaccggtgg
     6001 tcagccgcca cgacgcgcga agcgtggggc cgctcacggg cgccttccgg cttgcggcga
     6061 tgtccggcag gcggccgagg agctcgtcgt acgccggaac cgtgagccgc ccgatcagtt
     6121 cctcgtcggc ttcgcggacc gcggccgtca gggcgtcctg atcctcgtca tctatcacca
     6181 gtccgccccc ctttcggatt tgtcgttttt gtcagtgcct ccgtcagcaa ccggcgggcc
     6241 atgtgcatcc ggctcttgac cgtgccagtt gggattccaa gtattacggc cacctgtgga
     6301 taggggagat cctcggcgag gacgagcacg agcacctcgc gcaggtgctc gggcagctcc
     6361 gccaccgcgg ccaccaggtc ccgccgctcg gcgcgggcga gcacctgctc gtcgaccgcc
     6421 ggctccagat cgggcacgtc cgcggccttc tccaactcca cgaggaccgg ttcggcccgc
     6481 cgcaggcggt tgtgcgcctg acgccgtgcc acccccagca gccaggctcg caccggcgcc
     6541 tcgccccgga aactgccggc cgagcgccac accgccagcc aggactcctg aaggatctcc
     6601 tccgccacct cgcgctgcga ggtgagccgg cggatgagcc gcagcattcc ggcggcgtgg
     6661 cgttcgtaca gcatgcgaag cgccacctcc tcgccgtcgg ccacgcgtct catgaggacg
     6721 gcatcctcgg acacctccgc ggagagctcc ggttcacgca actgctgcac acgttcgtat
     6781 gtagcgtcgg ctgccgtacc ggttcggggg gatctgcggc gtagcggcac gagtgcgctc
     6841 cgtcctcgtt tctgtcattc ctgccattca tcgaaccatt attgacacta gtagtccgaa
     6901 atgttcgact caatgcgatt ccggaatctt gtccgaacga acaccggaaa ggagcgagca
     6961 atgcccgctg acatcctgga gacccggact tccgagaccg aggacctgct cgacctcgac
     7021 ctctcgatcg gtgtcgagga gatcaccgcc gggccggcgg tgacgagctg gtcgctgtgc
     7081 acccccgggt gcaccagccc cggcggcggc agcaactgca gcttctgctg ctgacataac
     7141 cgcagacaac aggggctgta accagcccgg gccggagcgc gtcccgcccc ggtccgggcc
     7201 accggccgga acacgagcca gcgcggcagg gcagaaagga ccaggtggaa aatgacagat
     7261 tcgccatttc gtgcgtggga tgtctttatg gtccgtacgc cggttggtta tgcatatcct
     7321 actccactct cgaactccgg atttgattct ccggcgtcct ctcccggctt tggcgaaggg
     7381 gagttccccc ctgacgcgcc cgttccgtcc gatgtctccg gacatggagc cggctcgtcc
     7441 gaggcgtccg tacgcgcatc cgggcggccg ccggccggcg atcatctctc gctgctgcgg
     7501 gcggcgtgcg aagacgggcc gctgatggag gccgtggagc tggcctcacc cagcctggcc
     7561 ggtctgctcg ccagggtcgc gcgcggcgac acgggcgggc tcaaggacaa gcggctgcgc
     7621 cgggccgccc tcgcgctcct gcgctacgac atccggatgc gaacccggcc gactccgttc
     7681 ggcctgttcg ccggcgtcag cggcggccgg ttcgacacgt ccgcgaagtg gctggccggg
     7741 acggggcatc gcaccaggac gcgcgccgac atggagtggc tgctgtcggc ggtacaccgg
     7801 ctcgaacggg atcgtgtgct gctcgccggc gtcaccgtgc aggcgcacca gaccctgacc
     7861 gtgcgcggcg accgaatcgt ccttgactgt ccttccgctc tcggcaaacc cctcaacgga
     7921 tccacccgtt cgaccgtctc cgcgcggcgc tcgccggtgg tcgccgagat ccttggcgcc
     7981 gcccggcgtc ccgtcctcgc gggaaggctc gcgcagagcg tggcacagcg gttcgagctg
     8041 ccggccgacc gggtgacggg cctcctcgcg gacatggccg cccaggaact gttgatcacc
     8101 gcactgcggc cgcccttgga cggggatgac ccgctgcagc acgtgctcga cgtcgtggcg
     8161 gcggcggagg cgagggcggg ttcgcccgcc gaggcgatga gctccgaatc ggccgccctg
     8221 gtggcggcgc tgcgcgaggt ggacgcgcgc tgccacgcct acgatcgcac cgccgtcggg
     8281 caggggcgcc gggagctggc cgagctgatc cagtccacgc ggcgggtcca cccgcacgac
     8341 actccgctgc acgtcgacct ccggatcgac ctggaggtgc gactccccga ggtcgtgcgc
     8401 acggagatcg agcgggcggc cgaggcgctg tggcggttgt ccccgccgcg gcgtggcatg
     8461 cgggccctgc gccgttacca cgaggcgttc ctggagaggt acggcgcgga ccgtgcggtg
     8521 ccgctgctcg aactcctcga cgacacgcgc ggactcggcc cgcccgccgg ctacaagtgg
     8581 ccgccgagcg agacaccggc gggcccgcaa gaggagcctc gccgcagtgc ggcgctcgcc
     8641 cggctggtcg ccaaggcggc caggcgcggg gagcgtgaga tcgtcatcga cgaggagacg
     8701 atcgccgaac tcgcctacga cgaggcggct ccggccgacc tgccgaactc cttggagctg
     8761 ggggtgcacg tggtggcccc gtcgctggac gagctgtccg ccggaacctt ccgggtcgtc
     8821 ctggcgcccg ggccgggctc ccaccacgcg ggcgcgacgc tcggcaggtt caccgggctg
     8881 ctgcccgatg tggacgccga gtcggcggcc aggcaggccg gccggcccct gcacatccag
     8941 gacgcggtcg ccgccgatgt cgccttcatt ccacggtccg gccgggcggc caacctcgcg
     9001 cacaccccct cgtactccgg ccggcgcatc agcgtggggc tcccggacag cggacgcgcg
     9061 caggagatcc ccctcgacga gctgggggtc ggggccaacc tggaacgtct ctgcctcgtg
     9121 cacctgccga caggccgtga ggtggtcccc gcgctgccga acatggtcag cgccttcgcg
     9181 caggccccga accccgctcg cctgttgttc gagctgggcc tggaggggca gcggctctgg
     9241 gaaccgtggg actggggggc gctgagcgag atgcccttcc tgcctggtgt gcgttacggc
     9301 cgtacgcttc tggccgctcc gctctggcgg atggatcagc tccgcgggcc ggccgacgac
     9361 tccggtccgg cggcggactg ggacgcggcg ctcgaccggt ggcgggcgga gtggaacgtc
     9421 ccccggcggg tgctcgccgt cagcatggac cagcgcctgc tcctcgacct cgacgacgcc
     9481 tggcaccgcg tactgctccg cgacgagctg cgcaggaccc ccgagctgat cgcccagcag
     9541 gtggccggcg acgaggaggg ctggctggac cgcggtgacg cgggctttcc cgggcacctc
     9601 gccgagatcg tggttccgct ggaacgccgt gaccgccacg ccgcccggcc tccgcacatc
     9661 agggccaccg tcagcggccg cgagccgacc ggagcggggg gaccgtggct ctacctcagg
     9721 ctgcgggttc cgcgccggaa ccaggacgac ttcctgcgcg accaggtgcc cgttctggta
     9781 cgggcgggga tcgagcacgg cgccgaccgc tggttcttca tccgctacag cgacaccgcc
     9841 ggacagcacc tgcgggtcag gttccgcggc gagcgggaga aactgtgggc cgggctgctc
     9901 cccgagatcg gcgcgcggct cgtcgagtgg cagaggcagg ggctgctggc gggccacgag
     9961 ctcggccagt acgaccccga gtacgagcgg tacggcggcg acgcgctggc cgagttcacc
    10021 gagaccgcct tccagcacga cagcgccgcg gccatctcgc tcctgcgcct caccaggcgc
    10081 gccgggttcc gctacacgct cgacgaggtg acggcgatct cggccgcggc gctggcggac
    10141 gccttcggtc ctcccgcccc ggtcgtcgag ccggtgccgc tggtgggcgg cctccagtgg
    10201 gctccggatc tgttcgacgg cgacccggcc gccgcctgga tgagcagcac cggaggccgc
    10261 agggaactac cgcccgacta ccggcgcgat ccggcccggt ggcagaagct gatcgatccc
    10321 accggaggct ggccgctgct gcgggcggac gaggacggct gtcaggtcct ggcagcgctg
    10381 gaatccaggg atgaggccgt ccggcggttc gggacggcct accgcgaggc gttcagaccc
    10441 acggactccc cgtcgacgca gctcaggctg gtcggcagcc tgcttcacat gacctgcaac
    10501 cggctgatcg gcggatccgc ggaacgagag cgaagcgtgc tcgggctcgc ccggggcgcc
    10561 gtccaggaca acctgaaccg caggaggcac ctggcatgac cacagtcggt cgcacatcgt
    10621 gcggggtgac ctccgaccgg cacccggccc ggttcctgcg cggcagcgcg gcccgacggg
    10681 ccgcgcgcct ggtgcggctg gtcgccgaac ggctcgccga cccggacgcg gtcgccggga
    10741 tcgcggcccg tcccgggaac tccgtgccgg tgaacgggct gtcgatgtgg agcccggcca
    10801 cgctgtcgca cggatttccg ggcatcgcgg tcttctacgc ggagctgggg cggatcgacc
    10861 ccgcctggtc ggcgttcgca catcgccacc tcagggcggc ggccgcggcc gtggagacgg
    10921 cgccttcggg cggactgttc gccggtccgg cctctctcct ggccgccgcg cagagctgcg
    10981 ccggcccggc ggggcactac cggggcctgc ggcgcaagct gaccgcatgg ctcgccgccg
    11041 accacgccgg acggctcgcc gtcgcgcgtg accggcccgg ccccggtgtc gcctggaccg
    11101 actacgacgt cgtgcacgga ctgtccggga ccacccggct gctgctggac gccgcgtgcg
    11161 atcccgacga cgagacggcc gccgtggcct ccggcgcggt gaccgacacc ctgcggcacc
    11221 tggtgcggct caccgagccg atcacagtgg acggacacga ggttcccggc tggtgggtgc
    11281 cgtcccatct gcagccggtc gaacaggacc ggcgcgacta tccccgggga gacctgaacc
    11341 tgggattggc ccacggagcg gcggggccgc tgtccgtgct ggccacggcc acccttcacg
    11401 ggatggaggt cccgggccag cgtgaggccg tcgcgcggct ggccgaatgg ctgctgggct
    11461 ggacgatgac cgacgacacg ggcgcctact ggccctgccg gatcagttgg gacgagcaga
    11521 tcgccgccgt ccgcccagac gcctccttca cccgtacggc ctggtgctac ggagcccctg
    11581 gggtctgcgc ggcactccac cgggccgggc tggcgctcgg cgtgacggag tggcgcgaag
    11641 tcgcggtcac cgcgctgctg gacgggctgc gccgcgaccg gtccgcctgg cgggtggacg
    11701 gctcgaccgt ctgtcacggg tacgcgggcc tgctgcaggt gctgtcgagg gtcggcgccg
    11761 agtccggcga cccgcggctg ctggacggct gcctggacgt cgcgcgcatg gtcctcggcg
    11821 aggccgacga atcggctccc ttcgtcttcc cccatctcgt ccccgattcg cccgacgggt
    11881 ggcgcaacgc cacgggatac ctgccgctgg acggcgccgg cctgctggaa ggggcggccg
    11941 gagtcgcctg tgcgctgctg tcggtcatcc cgccgtcgtc gctctgtgga acggacccgg
    12001 ccccggagcg tgcggacctc ccgccctggg acaggtgcct ggccctgtgt tgacgccccg
    12061 acccatcagg agagccagac catgacagca cacagcgacg cgggcggcga cccccggcca
    12121 ccggagcggc tgctgctcgg cgtgagcggc tcggtcgccg cgctgaacct gcccgcctac
    12181 atctacgcgt tccgggccgc gggcgtcgcc cggctggccg tcgtcctgac cccggcggcc
    12241 gagggtttcc tgcccgcggg tgcgctgcgc ccgatcgtcg acgccgtcca cacggagcac
    12301 gaccagggaa aggggcacgt ggcgctgtcc cgatgggcgc agcacctgct cgtcctgccc
    12361 gcgacggcga acctgctcgg ttgcgcggcg tcggggctgg cgccgaactt cctggccacc
    12421 gtgctgctgg cggccgactg cccgatcacg ttcgtgcccg cgatgaaccc ggtgatgtgg
    12481 cgcaagcccg ccgtacggcg gaacgtcgcc accctccgcg cggacggtca ccatgtggtg
    12541 gacccgctgc ctggcgcggt gtacgaggcg gcctcgcggt cgatcgtcga gggtctggcc
    12601 atgcctcggc cggaggcgct ggtccggttg ctgggcggcg gggacgacgg cagccctgcc
    12661 ggtccggccg gtccggtcgg cagggcggag catgtggggg ccgtggaggc cgtggaggcc
    12721 gtggaggccg tggaggccgt ggaggccgcg gaggccttgg catgacggtc ccggcgttcg
    12781 agctcagcga cctgacggtc cgctacggcc cggtcacggc ggtcgacggc gtctcggccg
    12841 gttcggcgcc cggcctcgtc accgccctgc tcggacccaa cggtgcgggc aagtccagcc
    12901 tgctgcgggt gctgtcgacg atcgcgccgc cctcatcggg cacggcgagg gtgttcggcc
    12961 acgacacgcg tgcggagccg ctggccgcac gtacgcggat cggactggtg ttccaggaac
    13021 gcgcgctcga caccgacctg tccgcggagc agaacctgcg ctttcacgcg cggctgttcg
    13081 gggtggggcg ggcccgggcc agggaggaca tcctcgtgct gctggaacgc ttcgggctgg
    13141 ccggccgcgg ccgcgaccgg gtcgagaccc tttccggtgg gctggcccgc cggctggaga
    13201 tcgcgcgggc gctgctgcac cggcccggcc tgctgatcct ggacgagccg accaacggcc
    13261 tcgacccgga ggcgcgccag accgtatggg acgacctcat ccggctgcgc tccgaactcg
    13321 gcgtcacggt gctgtactcc acgcactaca tggacgaggc cgagctggcc gaccagatca
    13381 tcatcctcag cgagggccgc gtcgcggggt tcggctcgcc cggccggctg aagagcgagc
    13441 tgcggtcgtc gcgcatcgtg ctcgtcaccc acgacgacga cacggcgctc gcccggctcg
    13501 cggaggccgg cttcgacgcc gtgatcgact cggacggcgt cgccgtgcgc tgccgcgaac
    13561 cggagagccg gatggcggag gtcatacggg cggccgggcc gctcgtccgc gcggcgtccg
    13621 tgcaccaccc ctcgatgaac gacgtgttcc tggcccacac ggccgcgaac cgcgacaggg
    13681 aggcggccga tggcactgtc agctgtccgt gacaccggtg gcacggcggg gagcactccc
    13741 ggcggcccca ccggaggcgg gtcggccggc gcgggcgagg cgaggaggct cgtctctgcg
    13801 gcccttcggt ccgcggtccg cggaacgctc gtcgtggccc accgcgacgt gctgcggcag
    13861 gtgcggcatc cgggggtcgt ggtcgcccag gccgcgcaga tcgtcttttt cgtcctcgtc
    13921 tacgccgtgg gcttccggtc gatgatcgga tccgtcggcg gcgtgtcttt cggcgcctac
    13981 gtctatccgg ggatcatcgc catccaggtc gtcatgctgg gcgtcggcac gggcctgacg
    14041 tacgcgatgg accgcgagtt cggcgtgctg cgcgagatgc aggtcgcgcc cgtgccgcgc
    14101 atgtgcctgc ccctcggaaa gatccttgcg agctgtgtgc tgctcaccgc gcaggccatg
    14161 ctcatgctcc tgcccgcccc gctgctcggc ctgcccctga cgcccgcgcg atacgcggcg
    14221 ggcaccgcgg tctacctggc cacggcggcg gcgttcagct tgatcggcct gctgctcgcg
    14281 gtgagcgtac gccggatcga gacgctgcag gcgaccgtcc agctcgcgat gtacccgctg
    14341 ctgttcctgt cgggttcggt gttcaggccc gacgccgtgc ccggctggct ggcggccctc
    14401 atgcggctca atccgatgat gtacgcggtc gatctggcgc gccacgtgct gttgccgtcg
    14461 gccccgggcg tgtcgtacct gcccgtctgg cgggacctcc tggtgatcgc cgcgctggtg
    14521 gcggccgcgt cggcggcgct gcgactgcgg gtggggaggt gaccggccgg tgaccaccgc
    14581 gacgacgacc gggccgaccg gccgcgagac gctgctggcg ggcgcggtgt cctggctcgc
    14641 ggcgcgactg cgctggttcg accccgagca gtgggcgagg catctgcagc cgagaggctt
    14701 cgcgccgagt gcgctgctcg aactcctcat catctgccgc aacctgaact cggtctacgg
    14761 ccatccgcgc ccgccggacc cggaggacgg ctcccgcggg tccggcgtac ggacgacggg
    14821 tgcggccggc ccggccgtgg aactgatcgg gcgtgcgctg gacctggccg aggaggtcgt
    14881 gggacggccc ggcttcggcg cggccctcta ccgcggcgac gccgccttcc cccaccacgt
    14941 gtggctgatc gcgctgctcg cggagggcgg ccggcccgtc gagccgtggc ctgccgtcgc
    15001 ccagcgggtc atcgacgcgg gctgcgccga gccgatccgg ccgggacggc cgacggcggc
    15061 ccggctggag gcccgctacg tcttcgacct cgccggcctc cgccacgggc tgcccgccat
    15121 ggacgaactg gccggtcgta cggctctggg ccccggtgcg gacccgctgc acctcaccga
    15181 cgcggacctc tatgtgatca cccacatgct cttctacctc accgacttcg ggcggcgccc
    15241 cttctccgct gacgaggccg aaggccggcg ggtccgcggg ctcgtcgagg tgctcctcgg
    15301 ccgtcagctc gcggtcggcg acctcgatct ggcggccgag ctgctcgcct gcgcgggcct
    15361 caccggcgcc gacgaccggc tgtccggctg cgcgtggaac cggttgacgg ccgcgcgccg
    15421 tccggacggc tcggtgccca gcccgctgtt ccggcaggcc gcgctggacc ggctgagcgg
    15481 ggagaaggcc gaggcgtacg cgttcggaac ctgctaccac accaccctcg ccatggtgct
    15541 cgcggcgacg ctgacggacg gcgccgatgc gtgacccgtt gctgaccggg gccctcgcac
    15601 gcgtcgtgcc ggcgctggag aagctggaag gcgagcgcgc cgtggcggtg ctccggctgt
    15661 gccgggcggc tctcgacggc ccaccgcggc ccatgccggg cggccgccgg cctgacgcgc
    15721 caccggttcc cgatcggtgg acccggcttt ccgacctgct ccacgacgct ccaggaaccg
    15781 cacagggcct cgcccggcag atcgccgaga cgaccgcttt cggggccgtc cggcccgccg
    15841 ccgccgtccg ggaggtctgg gagctcgccg tgcccgcgct gctggccgcc gccgcgcgca
    15901 gggccgacct gatgaccctg gccccgctcg tccgggccgg cgtcttcctc caggcggttt
    15961 ccgccggcga cgcgcccgag cgggacggcc ggcccgctcc tgcgggcctg accacacgcg
    16021 ccgcctggcg cctggcggcg tggcagcgtc cggacggcgg gttcggggcg ccggcctcga
    16081 cgaccgactg tgcctgggcg ctcgcggagg ccgcggttcc cgggctgacc gcctcgcagc
    16141 gtgagttcgc cgtgcccctg ccggacggga agcctccggc acggccgcga accgcccact
    16201 ccccacccgc tacgtacggc gggaaggagt gatgcagatg aacgaccatg acgcggccgg
    16261 cgtcccgtcc ggcagcccgg ccccccacag accggcggat cccgccgcaa ccctggccgc
    16321 ggggaccaca ggggcgcccg gcgggaccgc cggcccgacc gactccccct cgatggcggc
    16381 cctggtatcc acggagttgc tcagactgcg ttccggcttc gtcggctggt acctcctgct
    16441 gtcgccgatc gtgatcgcca tcccgctcta cctggggtcg atcttctctc cggaaggccg
    16501 gtccggccgc ctctgggaga ccttcagcaa cgtgacgctg gagttctggg gcgtgctgat
    16561 cccgatgacg gccggtctga tcgcggccct cgcggtccgt gccgacaccg aaccctggcg
    16621 tttcctgttc tcgtatgcga tcccacgctg gcgctacttc accgcgaagg tcgccgcgct
    16681 ggccgtcgcc cagttgctgt cggcgaccat cctggtggtg atgctggccg ggggagcgct
    16741 gctgaccggg cagctctcca acgccgcctc gatgatcctc aaggtcgcct acctgccgtg
    16801 ggcggcgggg ttggcggcga ccgcgctcgc cgtcctcgtc tgcaccatct ggggactcgg
    16861 ccccggcatc gcccttggtg tggccgggat gatggccggc gcactcatct ccgacaagtc
    16921 gttctggtac gccatcccgc ccgcctggcc gatgcgggtc atcctcccgc tggcggacat
    16981 ccgccccaac ggcctggcgc tcgacgcgag cagcccgctc cacgacacca cggtcatccc
    17041 gctggccgtc gcgctctcgg ccgcggcgac gatcgtgatc ctgctgatcg gcggccggca
    17101 catggcgcgg aaggaggtct gacatggccg ctctcgagat cagggacctg cacaagcact
    17161 acgacgactt ccacgcgctc gacggcgcga acctgaccgt gccggacggc tccctctacg
    17221 gcctgcttgg cccgaacggc gcgggcaaga ccaccctgat gaaggcggtc accgggctgc
    17281 ggcatccgac ctcgggccac atcagccttt tcgggcggcc ctacgaacgg cggctgctga
    17341 cccaggtcgg cgcgctgctc gagtcgccgg gcctgtggac ccagctcgac gcggtgtccc
    17401 acctgcgcat ccacgctcgg ctgcgcggcg tgcccgagac ccggatcggc gaggtgctga
    17461 gcctgatgaa cctcaccgag gtcagcaccc gcaaggtggc gaagtactcc ctcggcatgc
    17521 ggtggcgtct cggcatcgcc atcgccctgc tcggccggcc ccggctggtc gtgctcgacg
    17581 agccgatgaa cggactcgac ccggtcggca tcagggacat gcgggcgacg ctgcgcgcgc
    17641 tgaccgccgc cgggaccacc gtcatggtct ccagccacca gctggcggag atcgcgcaca
    17701 tctgcgatca cgtcggcgtg ctggtggccg ggcggaccgc gtacgagggc ccgctgcacg
    17761 gcctcgccgt ggacggcgac ctcgaacagg gctttttccg cctgctcgag aaggcgggtt
    17821 ccgcagtgag atgacctgaa ccacgaacgg aaggacgatc gggaacatgg cgaggtccga
    17881 agagagcaac accctggcca ggctgttcga cgtgctcggc gacgacgccg cggcggcgag
    17941 ggaatgggtg accgagccgc accggctcat cgcctcgaac gagaggctcg gcaccgcccc
    18001 ggaagcgccg gccgacgacg accccgaggc gatccgcacg gtgggggtga tcggcggcgg
    18061 caccgccggt tacctcaccg cgctggcact caaggccaag cgtccctggt tggacgtggc
    18121 tctcgtcgag tccgccgaca tccccatcat cggcgtcggc gaggcgacgg tctcgtacat
    18181 ggtgatgttc ctgcaccact acctcggcat cgacccggcc gagttctacc agcacgtacg
    18241 ccccacgtgg aagctcggca tcaggttcga gtggggcagc cggccggagg gcttcgtcgc
    18301 gccgttcgac tgggggaccg gctctgtggg actggtcggc tctctgcgcg agacggggaa
    18361 cgtcaatgag gccaccctgc aggccatgct gatgaccgag gaccgcgtcc ctgtctaccg
    18421 gggggagggc gggcacgtct ccttgatgaa gtacctgccc ttcgcctacc acatggacaa
    18481 cgcccgcctc gtccgctacc tcaccgagct ggcgactcgg cgcggcgtgc accatgtgga
    18541 cgcgacggtc gccgaagtgc ggctcgacgg cccggaccac gtcggcgacc tgatcaccac
    18601 cgatggccgg cggctgcact acgacttcta cgtcgactgc acgggcttcc gctctctgct
    18661 gctggagaag gcgctgggca tcccgttcga gagctacgcg agcagcctgt tcaccgacgc
    18721 ggccatcacc ggcactctcg cacacggcgg ccatctcaag ccgtacacga cggcgaccac
    18781 gatgaacgcg gggtggtgct ggacgatccc gacgcccgag agcgaccatc tcggctacgt
    18841 gttctcgtcg gcggcgatcg atcccgacga cgcggcggcg gagatggccc gccgattccc
    18901 gggggtcacc agggaggcgc tcgtccggtt ccggtccgga cggcaccggg aggcctggcg
    18961 cggcaacgtc attgctgtcg gcaactccta cgcgttcgtg gagccgctgg agtccagcgg
    19021 cctgctgatg atcgccacgg cggtgcagat tctggtgagc ctgcttccct cctcccgccg
    19081 ggacccgctg ccgagcaacg tcgccaacca ggccctggca caccgctggg acgccatccg
    19141 ctggttcctc tcgatccact accggttcaa cggacggttg gacacgccgt tctggaagga
    19201 ggccagggcc gaaaccgaca tctccgggat cgagccgctc ctgcggctgt tctcagccgg
    19261 agcgccgctg accggccgcg actccttcgc ccgatacctc gcggacgggg cggcgccgct
    19321 gttctacggt cttgagggcg tcgacacgct gctgctcggg caggaggtac cggcccggct
    19381 gctgccaccc cgcgagtccc cggagcagtg gagggcacgg gcggcggcgg ccagaagcct
    19441 ggcttcacgg ggactgcggc agagcgaggc gctggacgcc tacgccgccg acccgtgcct
    19501 caacgccgaa ctgctcagcg actccgacag ctgggcgggc gagcgggtcg ccgtccgggc
    19561 cggcctgaga tgacgaccgg caccacggtc gcccatgccg tcgaaccgga cgggttccgg
    19621 gcggtcatgg ccacccttcc ggcagccgtg gcgatcgtca ccgcagcggc ggcggacggg
    19681 cggccctggg ggatgacctg cagttcggtc tgcagtgtca ccctgacgcc gccgaccctg
    19741 ctggtatgcc tgcggacggc gagccccact ctcgcggccg tcgtctccgg ccgggcgttc
    19801 tcggtgaacc tgctgtgcgc ccgggcgtac cccgtcgcgg agctgttcgc ctcggcggcg
    19861 gccgaccgct tcgaccgggt ccgctggcgg cggccccccg gtacgggcgg cccccacctg
    19921 gccgacgacg cccgtgccgt cctcgactgc cggctctcgg agtccgccga ggtgggagac
    19981 cacgtggtgg tcttcggcca agtgagggcg atccgcaggc tgtccgacga gccgccgctg
    20041 atgtacggct accgccgcta cgccccatgg cccgccgacc gaggaccagg agcggcgggg
    20101 gggtgaacgc cgagcagctc accggtgtgg tcatcgccga tctcgggatg atcgtcgtcg
    20161 tgtcggcgct cttcggggca ctggcacggc gatgcggcca cccgaccgtc atcggccaga
    20221 tcgtcgccgg gatcgcgctg ggaccgactc tgctgggccg gctgcccggc gacccggccg
    20281 ggtggctgtt ccccgcccag gtccggccgt cgctgtcggt cctgtctcag atcgccatcg
    20341 tgatcttcat gttcgcggtg ggttacgagg tcgacctgcg gcttctgcgc cggggtggcc
    20401 gcagcgcgct ctgcgtggcg tcgctgtcgc tggcggtgcc catgacgctc ggcgcggcgg
    20461 tcgccgtgct gttccgcgag gtgttcacgg tcggctccct tgaggggccg ggaggcccga
    20521 cgttcgtgct gttcatggcg gtggcgatct cgatcaccgc cctgccggtg ctggcggcga
    20581 tcgtgcggga gcggggcctc gcgggaaccg cggcgggaac ggtggccacg gcggccgccg
    20641 ggctgatgga cgtggccgcc tggaccgcac tggccgcggt tctggccgag gccggcgatg
    20701 ccgatgagac gagggtgcca caggtgccct ggatgctggc tctgccggcc ctcgtggcgt
    20761 tcgcggcggc catgttcctg gtcgtacgtc ccctgctggg gtggttgacc aggaggcccg
    20821 gagccatgtg ggggcggctg ccggcggcgt tcgcgctggc gctcggcagt gcctggggca
    20881 ccgccgcgct tggcctgcat ccggtgttcg gcggtctgct ggccgggctc gtcatgccgc
    20941 gccgcgacgg cgcccccgag ccggaggtgc tgcggccgat ggagcagacc gccgagttgc
    21001 tcctgccgct gttcttcgtg atgaccgggc tgtcggccga catatcggcg atcgaaccgg
    21061 gcgggctgtt cctgctggcg gtgctcctgg tcgccgccat tgggggcaag ctcgtgcccg
    21121 cctacgcggc ctcccggctg accggtctcg actccggtga gtcggccgtg gtcgccgtgc
    21181 tggtgaacac ccggggcctc accgagctga tcgtgctcaa tgtggggctg tcggcacatg
    21241 tcatcgatga gcggctgttc accgtcctgg tcgtcatggc cctgatcacc acggccatga
    21301 ccgcgcccct actgagcgcg ctgagaaggc gcgaagagcg gaggcggccg gcgcccgcga
    21361 ttccgatgcc accggcttcg gtctcccgaa gatctaccat gggatga
//
